+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Sticking It to Cancer with Molecular Glue for SHP2



Sticking It to Cancer with Molecular Glue for SHP2



Cancer Cell 30(2): 194-196



Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way forward for PTP inhibitor development.

(PDF emailed within 0-6 h: $19.90)

Accession: 058905229

Download citation: RISBibTeXText

PMID: 27505669

DOI: 10.1016/j.ccell.2016.07.010


Related references

Fibrin glue for the treatment of fistulae in ano--a method worth sticking to?. Colorectal Disease 12(4): 363-366, 2010

Glue-sniffing and distal renal tubular acidosis: sticking to the facts. Journal of the American Society of Nephrology 1(8): 1019-1027, 1991

Sticking to the facts: a systematic review of fibrin glue for pilonidal disease. Anz Journal of Surgery 82(4): 221-224, 2013

Upregulation of Src homology phosphotyrosyl phosphatase 2 (Shp2) expression in oral cancer and knockdown of Shp2 expression inhibit tumor cell viability and invasion in vitro. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117(2): 234-242, 2014

Molecular glue sticks it to cancer. 2011

Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. Plos Genetics 3(12): E225-E225, 2007

HSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway. Biochemical and Biophysical Research Communications 351(4): 979-985, 2006

IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro. Journal of Bone and Mineral Metabolism 32(4): 378-392, 2015

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood 120(13): 2669-2678, 2013

Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling. Biochemical and Biophysical Research Communications 469(4): 1133-1139, 2016

Sticking with carrots and sticks (sticking points aside): a response to ventakapuram, goldberg, and forrow. International Journal of Health Policy and Management 1(4): 317-318, 2014

Loss of the borehole stability is the cause of drill pipe sticking in ultradeep drilling, sticking preventing BHA for these conditions. International Geological Congress, Abstracts = Congres Geologique International, Resumes 29: 31, 1992

Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling 14(3): 219-229, March, 2002

The analysis of donkey-hide glue, antler glue and tortoise shell glue by means of circular dichroism. Zhong Yao Cai 21(2): 66-68, 2003