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Sticking It to Cancer with Molecular Glue for SHP2

Sticking It to Cancer with Molecular Glue for SHP2

Cancer Cell 30(2): 194-196

Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way forward for PTP inhibitor development.

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Accession: 058905229

Download citation: RISBibTeXText

PMID: 27505669

DOI: 10.1016/j.ccell.2016.07.010

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