+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm

Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm

Wound Repair and Regeneration 23(4): 575-582

Diabetes is one of the most common human diseases and 15% of the 200 million diabetics worldwide suffer from diabetic wounds. Development of new therapeutic agents is needed for treatment of diabetic wounds. Wound healing is mediated by multiple steps, including inflammation, epithelialization, neoangiogenesis, and granulation. Formyl peptide receptor 2 has been known to stimulate angiogenesis, which is essential for tissue repair and cutaneous wound healing. In this study, we explored the therapeutic effects of WKYMVm (Trp-Lys-Tyr-Met-Val-D-Met-NH2), a synthetic peptide agonist of formyl peptide receptor 2, on cutaneous wounds in streptozotocin-induced diabetic rats. Topical application of WKYMVm onto cutaneous wounds stimulated formation of von Willebrand factor-positive capillary and α-smooth muscle actin-positive arteriole with a maximal stimulation on day 6, suggesting WKYMVm-stimulated angiogenesis. Infiltration of immune cells could be detected on early phase during wound healing and WKYMVm treatment acutely augmented infiltration of CD68-positive macrophages. In addition, reepithelialization and granulation tissue formation were accelerated by treatment with WKYMVm. These results suggest that WKYMVm has therapeutic effects on diabetic wounds by stimulating angiogenesis and infiltration of immune cells.

(PDF emailed within 0-6 h: $19.90)

Accession: 058905912

Download citation: RISBibTeXText

PMID: 25973651

DOI: 10.1111/wrr.12315

Related references

A synthetic leukotriene B 4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. Journal of Diabetes and Its Complications 31(1): 13-20, 2016

A histological study of cutaneous thermal wounds using a Clostridium perfringens-derived wound healing substance with wound healing stimulation activity. Journal of Dermatology 22(2): 98-106, 1995

A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2. Plos One 9(10): E109516, 2015

The pyrazolone originally reported to be a formyl peptide receptor (FPR) 2/ALX-selective agonist is instead an FPR1 and FPR2/ALX dual agonist. Journal of Pharmacological Sciences 111(3): 317-321, 2010

WKYMVm-induced cross-talk between FPR2 and HGF receptor in human prostate epithelial cell line PNT1A. Febs Letters 587(10): 1536-1542, 2013

Immobilized thrombin receptor agonist peptide accelerates wound healing in mice. Clinical and Applied Thrombosis/Hemostasis 7(4): 325-329, 2001

Effect of SR58611A, a potent beta-3 adrenoceptor agonist, on cutaneous wound healing in diabetic and obese mice. European Journal of Pharmacology 529(1-3): 172-178, 2005

In situ gel-forming AP-57 peptide delivery system for cutaneous wound healing. International Journal of Pharmaceutics 495(1): 560-571, 2016

Cutaneous wound healing in the cat: a macroscopic description and comparison with cutaneous wound healing in the dog. Veterinary Surgery 33(6): 579-587, 2005

Electrical Stimulation and Cutaneous Wound Healing: A Review of Clinical Evidence. Healthcare 2(4): 445-467, 2014

Effects of high voltage stimulation on cutaneous wound healing in rabbits. Physical Therapy 67(5): 662-667, 1987

A frog cathelicidin peptide effectively promotes cutaneous wound healing in mice. Biochemical Journal 475(17): 2785-2799, 2018

Gastrin-releasing peptide, a bombesin-like neuropeptide, promotes cutaneous wound healing. Dermatologic Surgery 28(4): 314-319, 2002

Acceleration of wound healing by aqueous extract of Allium sativum in combination with honey on cutaneous wound healing in rats. Molecular Medicine and Advance Sciences 2(2): 231-235, 2006

Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. Biomaterials 122: 34-47, 2017