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Structural and functional analyses of the sixth site of neurexin alternative splicing


Structural and functional analyses of the sixth site of neurexin alternative splicing



Doklady. Biochemistry and Biophysics 463: 239-242



ISSN/ISBN: 1607-6729

PMID: 26335821

DOI: 10.1134/s1607672915040110

In this study, we found the sixth site of alternative splicing (SS6) of neurexin 1a from the rat brain. This site is located between the fifth LNS and the third EGF-like domains. The insertion in the SS6 site corresponds to the 9-residue peptide VALMKADLQ, which is conserved among animals. We demonstrated that the SS6 insertion regulates tissue-specific expression of neurexin 1α.

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Accession: 058914012

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