+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Study of light fluence rate distribution in photodynamic therapy using finite-element method

Study of light fluence rate distribution in photodynamic therapy using finite-element method

Proceedings of Spie--the International Society for Optical Engineering 6139(): -

NlmCategory="UNASSIGNED">In photodynamic therapy (PDT), it is desirable to determine the light fluence distribution accurately for treatment planning. Earlier studies have shown heterogeneous distribution of optical properties in patients' prostates. Finiteelement method (FEM) is suitable for dealing with heterogeneous media and irregular geometries. Cylindrical diffusing fibers (CDFs) were modeled as linear sources of finite lengths, using the same parameters as those used in the treatments. Meshes were generated in the three-dimensional (3D) prostate geometry, reconstructed using transrectal ultrasound images of the prostate. Heterogeneous optical properties measured in the prostate were applied in the calculation and the refractive-index mismatch boundary condition was studied. Compared with the measurements, the FEM calculations using heterogeneous optical properties show better agreements than those using homogeneous optical properties.

(PDF emailed within 0-6 h: $19.90)

Accession: 058921276

Download citation: RISBibTeXText

PMID: 26113755

DOI: 10.1117/12.646251

Related references

Modeling light fluence rate distribution in optically heterogeneous prostate photodynamic therapy using a kernel method. Proceedings of Spie--the International Society for Optical Engineering 6427(): -, 2007

The effect of light fluence rate in photodynamic therapy of normal rat brain. Radiation Research 132(1): 120-123, 1992

A fast heterogeneous algorithm for light fluence rate for prostate photodynamic therapy. Proceedings of Spie--the International Society for Optical Engineering 7551(): -, 2010

The importance of light fluence rate during photodynamic therapy-creation of a response surface. Photochemistry & Photobiology 63(SPEC ISSUE): 97S, 1996

Influence of light fluence rate on the effects of photodynamic therapy in an orthotopic rat glioma model. Journal of Neurosurgery 104(1): 109-117, 2006

Determination of in vivo light fluence distribution in a heterogeneous prostate during photodynamic therapy. Physics in Medicine and Biology 53(8): 2103-2114, 2008

Photodynamic therapy creates fluence rate-dependent gradients in the intratumoral spatial distribution of oxygen. Cancer Research 62(24): 7273-7279, 2002

Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED). Photodiagnosis and Photodynamic Therapy 12(3): 504-510, 2016

In vivo fluence rate measurements during Foscan-mediated photodynamic therapy of persistent and recurrent nasopharyngeal carcinomas using a dedicated light applicator. Journal of Biomedical Optics 11(4): 041107-041107, 2006

Effects of light beam size on fluence distribution and depth of necrosis in superficially applied photodynamic therapy of normal rat brain. Photochemistry & Photobiology 56(3): 379-384, 1992

Deformable medical image registration of pleural cavity for photodynamic therapy by using finite-element based method. Proceedings of Spie--the International Society for Optical Engineering 9701(): 970106-970106, 2016

Low-fluence-rate photodynamic therapy to treat subfoveal choroidal neovascularization in pathological myopia. A study of efficacy and safety. Graefe's Archive for Clinical and Experimental Ophthalmology 248(4): 497-502, 2010

Effect of irradiation fluence rate on meta tetra chlorin based photodynamic therapy in HT 29 xenografts and in spheroids A comparative study. Proceedings of the American Association for Cancer Research Annual Meeting 43: 651, March, 2002

The importance of fluence rate in photodynamic therapy: Is there a parallel with ionizing radiation dose-rate effects?. Radiotherapy and Oncology 37(2): 131-135, 1995