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Super-resolved insights into human immunodeficiency virus biology

Super-resolved insights into human immunodeficiency virus biology

Febs Letters 590(13): 1858-1876

ISSN/ISBN: 0014-5793

PMID: 27117435

DOI: 10.1002/1873-3468.12186

The recent development of fluorescence microscopy approaches overcoming the diffraction limit of light microscopy opened possibilities for studying small-scale cellular processes. The spatial resolution achieved by these novel techniques, together with the possibility to perform live-cell and multicolor imaging, make them ideally suited for visualization of native viruses and subviral structures within the complex environment of a host cell or organ, thus providing fundamentally new possibilities for investigating virus-cell interactions. Here, we review the use of super-resolution microscopy approaches to study virus-cell interactions, and discuss recent insights into human immunodeficiency virus biology obtained by exploiting these novel techniques.

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Accession: 058933910

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