+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Systemic Acute-phase Response in Laparoscopic and Open Ileal Pouch Anal Anastomosis in Patients With Ulcerative Colitis: A Case-matched Comparative Study



Systemic Acute-phase Response in Laparoscopic and Open Ileal Pouch Anal Anastomosis in Patients With Ulcerative Colitis: A Case-matched Comparative Study



Surgical Laparoscopy Endoscopy and Percutaneous Techniques 25(5): 424-429



The current trial was designed to study and compare the postoperative outcomes and systemic acute responses between patients undergoing laparoscopic-ileal pouch anal anastomosis (LAP-IPAA) and open IPAA for ulcerative colitis. The clinical records of patients who underwent 89 restorative proctocolectomy procedures with IPAA were reviewed. After determining which patients underwent LAP-IPAA versus open IPAA, an equivalent number of controls matched for age and ulcerative colitis severity were selected. Twenty of 22 patients who underwent laparoscopic surgery met the inclusion criteria. Patients who underwent LAP-IPAA had significantly shorter times to first walking (P=0.021) and food intake (P=0.0003). The LAP-IPAA group had significantly lower interleukin-6 and interleukin-1ra levels soon after surgery (P=0.011 and P=0.0076). The LAP-IPAA group had significantly lower C-reactive protein levels on postoperative day 1 (P=0.0027). LAP-IPAA is a less-invasive operative procedure than open IPAA with respect to the postoperative systemic inflammatory response and postoperative recovery.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058962813

Download citation: RISBibTeXText

PMID: 25730740

DOI: 10.1097/sle.0000000000000128


Related references

A case-matched study of laparoscopic proctocolectomy and ileal pouch-anal anastomosis versus open PC-IPAA for ulcerative colitis. Gastroenterology 120(5 Suppl. 1): A 452, 2001

Laparoscopic ileal pouch-anal anastomosis in patients with chronic ulcerative colitis and primary sclerosing cholangitis: a case-matched study. Diseases of the Colon and Rectum 51(5): 549-553, 2008

Functional Outcomes Following Laparoscopic Ileal Pouch-Anal Anastomosis in Patients with Chronic Ulcerative Colitis: Long-Term Follow-up of a Case-Matched Study. Journal of Gastrointestinal Surgery 21(8): 1304-1308, 2017

Benefits of a straight laparoscopic restorative proctocolectomy with ileal pouch anal anastomosis for ulcerative colitis: a retrospective case-matched study. Surgical Laparoscopy Endoscopy and Percutaneous Techniques 22(2): 118-121, 2012

Adhesions after laparoscopic and open ileal pouch-anal anastomosis surgery for ulcerative colitis. British Journal of Surgery 99(2): 270-275, 2012

Effect of systemic steroids on ileal pouch-anal anastomosis in patients with ulcerative colitis. Diseases of the Colon and Rectum 39(5): 504-508, 1996

Laparoscopic-assisted vs. open ileal pouch-anal anastomosis: functional outcome in a case-matched series. Diseases of the Colon and Rectum 48(10): 1845-1850, 2005

Laparoscopic-Assisted Vs Open Ileal Pouch-Anal Anastomosis: Functional Outcome in a Case-Matched Series. Yearbook of Gastroenterology 2006: 157-158, 2006

Mo1203 Clinical Risk Factors for Complications After Laparoscopic Ileal-Pouch-Anal Anastomosis in Patients With Ulcerative Colitis. Gastroenterology 146(5): S-585, 2014

Laparoscopic total proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. Journal of Minimal Access Surgery 11(3): 177-183, 2015

Early experience with laparoscopic ileal pouch-anal anastomosis for ulcerative colitis. Surgical Laparoscopy Endoscopy and Percutaneous Techniques 12(5): 337-341, 2002

Case-Matched Comparison of Long-Term Functional and Quality of Life Outcomes Following Laparoscopic Versus Open Ileal Pouch-Anal Anastomosis. World Journal of Surgery 42(11): 3746-3754, 2018

Comparative clinical results of ileal-pouch anal anastomosis and ileorectal anastomosis in ulcerative colitis. Hepato-Gastroenterology 36(4): 235-239, 1989

Neoplasia of the pouch and anal transitional zone in patients with ulcerative colitis treated by ileal pouch-anal anastomosis: A morphologic study of a rare group of neoplasms. 2008

Tu1584 Case-Matched Comparison of Laparoscopic vs. Open Ileal Pouch-Anal Anastomosis Assessing Small Bowel Obstruction and Incisional Hernia Rates. Gastroenterology 146(5): S-1081, 2014