+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Targeting Cellular Signaling Pathways in Breast Cancer Stem Cells and its Implication for Cancer Treatment



Targeting Cellular Signaling Pathways in Breast Cancer Stem Cells and its Implication for Cancer Treatment



Anticancer Research 36(11): 5681-5691



Breast cancer is a public health problem both in developing and developed countries. The breast cancer stem cell (BCSC) hypothesis has grown in the cancer research community. These BCSCs comprise of a small subpopulation of cells within the tumor mass which exhibit stem cell-like characteristics and have emerged as being responsible for tumor development, recurrence and metastasis in BC. The complexity of control of gene expression in BCSC is commonly driven by a myriad of signaling pathways triggered by extracellular signals, mutations and epigenetic control. Thus, some signaling pathways have been highlighted in BC, especially those linked to stem cell phenotype, such as nuclear factor-kappa B, signal transducer and activator of transcription 3, wingless-type MMTV integration site family (Wnt)/β-catenin, Hedgehog and NOTCH. Moreover, these BCSCs can also be influenced by the tumor microenvironment, for instance, hypoxic areas. Given the importance of signaling pathways and tumor microenvironment for breast cancer, this review focuses on the relationship between cellular signaling and BCSCs and its therapeutic implications.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 058973383

Download citation: RISBibTeXText

PMID: 27793889


Related references

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy. Seminars in Cancer Biology 40-41: 192-208, 2016

Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment. Stem Cells International 2017: 2925869, 2017

Targeting notch signaling and estrogen receptor pathways in human breast cancer stem cells. Journal of Clinical Oncology 26(15_Suppl): 22066-22066, 2016

Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling. Oncotarget 6(41): 43375-43394, 2015

Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways. European Journal of Nutrition 58(8): 3207-3219, 2019

Immunobiology and signaling pathways of cancer stem cells: implication for cancer therapy. Cytotechnology 67(5): 749-759, 2015

Monobenzyltin Complex C1 Induces Apoptosis in MCF-7 Breast Cancer Cells through the Intrinsic Signaling Pathway and through the Targeting of MCF-7-Derived Breast Cancer Stem Cells via the Wnt/β-Catenin Signaling Pathway. Plos one 11(8): E0160836, 2016

Cancer stem cells in drug resistant lung cancer: Targeting cell surface markers and signaling pathways. Pharmacology and Therapeutics 158: 71-90, 2016

Immune modulation by a cellular network of mesenchymal stem cells and breast cancer cell subsets: Implication for cancer therapy. Cellular Immunology 326: 33-41, 2018

Regulation of stem cells-related signaling pathways in response to doxorubicin treatment in Hs578T triple-negative breast cancer cells. Molecular and Cellular Biochemistry 409(1-2): 163-176, 2015

Cancer stem cells and targeting embryonic signaling pathways. Journal of Thoracic Oncology 5(12 Suppl 6): S492-S494, 2010

The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways. Oncotarget 6(26): 21865-21877, 2015

Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes and Diseases 5(2): 77, 2018

Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial-to-mesenchymal transition. Breast Cancer Research 13(3): 211, 2011

Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways. Stem Cell Reviews and Reports 13(1): 17-23, 2017