+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity

Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity

Cancer Letters 368(2): 209-229

Radiotherapy represents an essential treatment option for the majority of cancer patients in different stages of their disease. Physical achievements of the recent years led to the implementation of high precision treatment planning procedures, and image-guided dose delivery is current state of the art. Yet, radiotherapy still faces several limitations with cancer intrinsic radioresistance being a key driver of therapeutic failure. Accordingly, the mechanisms orchestrating radioresistance and their therapeutic targeting by combined modality approaches are in the center of attention of numerous radiation oncologists. In the present review, we summarize and discuss therapeutic approaches that exploit the heat shock response, either by hyperthermia or by pharmacological heat shock protein inhibition, in combination with radiotherapy. These strategies appear particularly promising, since they sensitize cancer cells to irradiation-induced cell death and at the same time have proven the potential to promote systemic anti-tumor immune mechanisms, which may target not only locally surviving tumor cells, but also distant out-of-field metastases.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058975195

Download citation: RISBibTeXText

PMID: 25754814

DOI: 10.1016/j.canlet.2015.02.047

Related references

Sensitizing tumor cells to radiation by targeting the heat shock response. Cancer Letters 360(2): 294-301, 2015

Protective role of heat shock and heat shock protein 70 in lactacystin-induced cell death both in the rat substantia nigra and PC12 cells. Brain Research 1087(1): 159-167, 2006

Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin. Cancer Research 63(23): 8241-8247, 2003

Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cells. Plos One 8(7): E69509, 2014

Estrogen protects cardiac myogenic cells against lethal heat shock-induced cell death Modulation of estrogen receptor a, glucocorticoid receptors, heat shock protein 70 and iNOS. FASEB Journal 16(5): A870, March 22, 2002

Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. Journal of Cellular and Molecular Medicine 13(11-12): 4540-4550, 2008

Targeting the heat shock response in cancer: tipping the balance in transformed cells. Surgical Oncology Clinics of North America 22(4): 665-684, 2014

Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells. Febs Open Bio 5: 724-730, 2015

Selectively Sensitizing Malignant Cells to Photothermal Therapy Using a CD44-Targeting Heat Shock Protein 72 Depletion Nanosystem. Acs Nano 10(9): 8578-8590, 2018

Targeting Her2 as an approach for sensitizing breast cancer cells to radiotherapy. Proceedings of the American Association for Cancer Research Annual Meeting 44: 129-130, 2003

Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells. Cancer Letters 378(1): 8-15, 2017

Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Research 66(3): 1783-1791, 2006

Targeting interferon response genes sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death. Breast Cancer Research 17: 6, 2015

Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer. Oncology Reports 31(6): 2482-2492, 2014

Selective killing of cancer cells by small molecules targeting heat shock stress response. Biochemical and Biophysical Research Communications 478(4): 1509-1514, 2017