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The Pd-catalyzed synthesis of benzofused carbo- and heterocycles through carbene migratory insertion/carbopalladation cascades with tosylhydrazones

The Pd-catalyzed synthesis of benzofused carbo- and heterocycles through carbene migratory insertion/carbopalladation cascades with tosylhydrazones

Chemical Communications 51(90): 16241-3

The Pd-catalyzed reaction between o-iodoallylbenzene and tosylhydrazones gives rise to indene derivatives through a process that involves a carbene migratory insertion followed by an intramolecular carbopalladation, with the formation of two C-C bonds on the same carbon atom. The same strategy has also been applied for the synthesis of 2,3-disubstituted benzofurans and indenones by selecting the appropriate o-substituted iodoarene.

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Accession: 059022174

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PMID: 26400071

DOI: 10.1039/c5cc06348e

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