+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The Role of the Microbiota in Shaping Infectious Immunity

The Role of the Microbiota in Shaping Infectious Immunity

Trends in Immunology 37(10): 647-658

Humans are meta-organisms that maintain a diverse population of microorganisms on their barrier surfaces, collectively named the microbiota. Since most pathogens either cross or inhabit barrier surfaces, the microbiota plays a critical and often protective role during infections, both by modulating immune system responses and by mediating colonization resistance. However, the microbiota can also act as a reservoir for opportunistic microorganisms that can 'bloom', significantly complicating diseases of barrier surfaces by contributing to inflammatory immune responses. This review discusses our current understanding of the complex interactions between the host, its microbiota, and pathogenic organisms, focusing in particular on the intestinal mucosa.

(PDF emailed within 0-6 h: $19.90)

Accession: 059030412

Download citation: RISBibTeXText

PMID: 27616558

DOI: 10.1016/j.it.2016.08.007

Related references

Gut-liver axis: gut microbiota in shaping hepatic innate immunity. Science China. Life Sciences 60(11): 1191-1196, 2017

The role of biogeography in shaping diversity of the intestinal microbiota in house mice. Molecular Ecology 22(7): 1904-1916, 2013

The Role of Gut Microbiota in Shaping the Host Energy Metabolism and Exercise Performance. Medicine & Science in Sports & Exercise 46: 630-631, 2014

Critical Role for a Subset of Intestinal Macrophages in Shaping Gut Microbiota in Adult Zebrafish. Cell Reports 25(2): 424-436, 2018

Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota. Free Radical Biology and Medicine 55: 130-140, 2014

From sensing to shaping microbiota: insights into the role of NOD2 in intestinal homeostasis and progression of Crohn's disease. American Journal of Physiology. Gastrointestinal and Liver Physiology 313(1): G7-G13, 2017

The role of NOD-like Receptors in shaping adaptive immunity. Current Opinion in Immunology 22(1): 34-40, 2010

The mechanism of antiviral immunity; the role of leukocytes in immunity to the viruses of infectious ectromelia and herpes. American Review of Soviet Medicine 3: 217-228, 2018

The role of neutrophilokines in shaping up the humoral antiplague immunity. Immunologiya 24(4): 219-221, July-August, 2003

The lymphatic vasculature: development and role in shaping immunity. Immunological Reviews 271(1): 276-292, 2016

Role of the microbiota in immunity and inflammation. Cell 157(1): 121-141, 2014

The role of microbiota in infectious disease. Trends in Microbiology 16(3): 107-114, 2008

Eco-immunology in the cold: the role of immunity in shaping the overwintering survival of ectotherms. Journal of Experimental Biology 221(Pt 13), 2018

The role of human immunity and social behavior in shaping influenza evolution. Plos Pathogens 13(8): E1006432, 2018

Role of Microbiota in Sexually Dimorphic Immunity. Frontiers in Immunology 9: 1018, 2018