+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The South African Food Sensitisation and Food Allergy population-based study of IgE-mediated food allergy: validity, safety, and acceptability

The South African Food Sensitisation and Food Allergy population-based study of IgE-mediated food allergy: validity, safety, and acceptability

Annals of Allergy Asthma and Immunology 115(2): 113-119

Few studies exist on food sensitization and challenge-proven food allergy in low- and middle-income countries. To describe the study design and methodology to recruit infants from an African population for skin prick testing and oral food challenges and the use of preliminary data to investigate the extent to which the study sample is representative of the target population. Children 12 to 36 months old were recruited from childcare education facilities in Cape Town. Children underwent skin prick testing to foods. Those with a reactive wheal of at least 1 mm larger than the negative control and not clearly tolerant according to history to a full age-appropriate portion to at least 1 food underwent oral food challenges. Parents who chose not to participate completed a nonparticipant questionnaire. Interim analysis of at least 500 respondents was performed. Demographic features of participating children were compared with those of nonparticipants and the population demographics of the most recent Cape Town census data. The response rate was 60.1%, with high participation and completion rates of 96.5% and 97.5%, respectively. Demographics of the completed participant sample were similar to those of the Cape Town census. Use of a nonrespondent questionnaire indicated no selection bias in favor of increased participation of participants with allergy. No ethnic differences in sensitization or food allergy were evident. The study was safe and feasible and the recruitment was effective and representative of the target population. Future studies will aim to increase the precision of the prevalence of food sensitization and allergy, describe environmental risk factors, and include a rural black African cohort.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 059032388

Download citation: RISBibTeXText

PMID: 26105048

DOI: 10.1016/j.anai.2015.06.003

Related references

The HealthNuts population-based study of paediatric food allergy: validity, safety and acceptability. Clinical and Experimental Allergy 40(10): 1516-1522, 2010

Rural and urban food allergy prevalence from the South African Food Allergy (SAFFA) study. Journal of Allergy and Clinical Immunology 143(2): 662-668.E2, 2019

Food allergy knowledge, perception of food allergy labeling, and level of dietary practice: A comparison between children with and without food allergy experience. Nutrition Research and Practice 9(1): 92-98, 2015

Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: Extended phase I study. Journal of Allergy and Clinical Immunology 128(6): 1259-1265.E2, 2011

The natural history of IgE-mediated food allergy: can skin prick tests and serum-specific IgE predict the resolution of food allergy?. International Journal of Environmental Research and Public Health 10(10): 5039-5061, 2013

Final manuscript in the Food Allergy educational series: diagnosis of immunoglobulin E-mediated food allergy. Pediatric Allergy and Immunology 20(4): 307-308, 2009

Impact of food allergy on food insecurity and health literacy in a tertiary care pediatric allergy population. Pediatric Allergy and Immunology 30(3): 363-369, 2019

Clinical and immunological aspects of food allergy in childhood. I. Estimation of IgG, IgA and IgE antibodies to food antigens in children with food allergy and atopic dermatitis. Acta Paediatrica Scandinavica 66(1): 31-37, 1977

Preliminary Development of the Food Allergy Coping and Emotions Questionnaires for Children, Adolescents, and Young People: Qualitative Analysis of Data on IgE-Mediated Food Allergy from Five Countries. Journal of Allergy and Clinical Immunology. in Practice 6(2): 506-513.E11, 2018

IgE mediated food allergy in Korean children: focused on plant food allergy. Asia Pacific Allergy 3(1): 15-22, 2013

Monographs in Allergy, Vol 32 High lights in food allergy; 6th International Symposium on Immunological and Clinical Problems of Food Allergy, Lugano, Switzerland, September 24-26, 1995. Wuethrich, B , Ortolani, C Monographs in Allergy; Highlights in food allergy x+259p, 1996

Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. Journal of Allergy and Clinical Immunology 125(5): 1077-1083.E8, 2010

Food allergy and IgE sensitization caused by spices: CICBAA data (based on 589 cases of food allergy). Allergie et Immunologie 34(4): 135-140, 2002

Evaluation of Food Allergy in Children by Skin Prick Tests with Commercial Extracts and Fresh Foods, Specific IgE and, Open Oral Food Challenge-Our Five Years Experience in Food Allergy Work-up. Iranian Journal of Allergy Asthma and Immunology 16(2): 127-132, 2017

High prevalence of food sensitisation in young children with liver disease: a clue to food allergy pathogenesis?. Pediatric Allergy and Immunology 23(8): 771-778, 2012