EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers


The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers



General and Comparative Endocrinology 238: 61-68



ISSN/ISBN: 0016-6480

PMID: 27131391

DOI: 10.1016/j.ygcen.2016.04.029

Obesity has reached pandemic proportions, and there is mounting evidence that environmental exposures to endocrine disrupting chemicals known as "obesogens" may contribute to obesity and associated medical conditions. The Deepwater Horizon (DWH) oil spill resulted in a massive environmental release of crude oil and remediation efforts applied large quantities of Corexit dispersants to the oil spill. The Corexit-enhanced Water Accommodated Fraction (CWAF) of DWH crude oil contains PPARγ transactivation activity, which is attributed to dioctyl sodium sulfosuccinate (DOSS), a probable obesogen. In addition to its use in oil dispersants, DOSS is commonly used as a stool softener and food additive. Because PPARγ functions as a heterodimer with RXRα to transcriptionally regulate adipogenesis we investigated the potential of CWAF to transactivate RXRα and herein demonstrated that the Corexit component Span 80 has RXRα transactivation activity. Span 80 bound to RXRα in the low micromolar range and promoted adipocyte differentiation of 3T3-L1 preadipocytes. Further, the combination of DOSS and Span 80 increased 3T3-L1 adipocyte differentiation substantially more than treatment with either chemical individually, likely increasing the obesogenic potential of Corexit dispersants. From a public health standpoint, the use of DOSS and Span 80 as food additives heightens concerns regarding their use and mandates further investigations.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059048370

Download citation: RISBibTeXText

Related references

Food Emulsifiers, Effect of Nonionic Emulsifiers on Experimental Dietary Injury of the Liver in Rats. Journal of Agricultural and Food Chemistry 6(2): 139-142, 1958

Evidence for vesicle formation from 1:1 nonionic surfactant span 60 and fatty alcohol mixtures in aqueous ethanol: potential delivery vehicle composition. Colloids and Surfaces. B Biointerfaces 58(2): 305-308, 2007

Study on food-grade vitamin E microemulsions based on nonionic emulsifiers. Colloids and Surfaces A: Physicochemical and Engineering Aspects 339(1-3): 1-6, 2009

Spectrophotometric Determination of Sulfate by Solvent Extraction with Nonionic Surfactant Span 20 and Crystal Violet. Analytical Letters 14(7): 531-534, 1981

Food-grade microemulsions based on nonionic emulsifiers: media to enhance lycopene solubilization. Journal of Agricultural and Food Chemistry 50(23): 6917-6922, 2002

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water. Colloids and Surfaces A: Physicochemical and Engineering Aspects 389(1-3): 82-89, 2011

Interaction of bile salts with a nonionic surfactant and their activation energy for conduction as well as calcium and barium ion tolerance in presence of the nonionic surfactant. Indian Journal of Biochemistry and Biophysics 25(3): 287-291, 1988

One-step formulation of nonionic surfactant bicelles (NSBs) by a double-tailed polyglycerol-type nonionic surfactant. Physical Chemistry Chemical Physics: Pccp 19(35): 23802-23808, 2017

Phase behavior in water nonionic surfactant hydrocarbon and water nonionic surfactant amphiphilic oil systems. Journal of Colloid and Interface Science 133(1): 237-243, 1989

Chemical potential of a nonionic surfactant in solution. Journal of Physical Chemistry. B 110(47): 24015-24020, 2006

Adsorption of mixtures of nonionic sugar-based surfactants with other surfactants at solid/liquid interfaces II. Adsorption of n-dodecyl-beta-D-maltoside with a cationic surfactant and a nonionic ethoxylated surfactant on solids. Journal of Colloid and Interface Science 302(1): 25-31, 2006

Studies of mixed surfactant solutions of cationic dimeric (gemini) surfactant with nonionic surfactant C12E6 in aqueous medium. Journal of Colloid and Interface Science 268(2): 482-488, 2003

Structural studies of mutant glucocorticoid receptor transactivation domains establish a link between transactivation activity in vivo and a-helix-forming potential in vitro. Biochemistry (American Chemical Society) 35: 23-7, 1996

Structural studies of mutant glucocorticoid receptor transactivation domains establish a link between transactivation activity in vivo and alpha-helix-forming potential in vitro. Biochemistry 35(4): 1323-1327, 1996

Molecular Composition of Nonionic Vesicles Prepared from Span 80 or Span 85 by a TwoStep Emulsification Method. Journal of Dispersion Science and Technology 27(8): 1217-1222, 2006