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The developmental switch of visual cortex NMDA receptor NR2 subunits and its implications for visual plasticity

The developmental switch of visual cortex NMDA receptor NR2 subunits and its implications for visual plasticity

Chinese Journal of Ophthalmology 51(6): 470-476

ISSN/ISBN: 0412-4081

PMID: 26310123

Many forms of synaptic plasticity require NMDA-type glutamate receptors (NMDAR). These tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits, usually a combination of NR2A and NR2B. In the neonatal visual cortex NR2B-containing NMDAR predominate, after thatvisual experience facilitates a developmental switch in which NR2A levels increase relative to NR2B. In this review, it puts emphasis on the role and the regulation of this shift as well as the effect on synaptic plasticity.

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Accession: 059053204

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