EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse


The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse



Journal of Microbiology 53(9): 661-666



ISSN/ISBN: 1225-8873

PMID: 26310306

DOI: 10.1007/s12275-015-5353-4

Human respiratory syncytial virus (hRSV) is the most common cause of respiratory tract infection among young children because of immature T cell immunity of them against hRSV. CD8 T cells play a pivotal role in clearing hRSV and preventing subsequent infection. We examined the effects of dietary bovine colostrum on virus infection and CD8 T cell responses following hRSV infection in the mouse model. Mice received bovine colostrum for 14 days prior to hRSV challenge, and lung indexes (severity of symptom) and lung virus titers were analyzed. In addition, the activation of CD8 T cells in the bronchoalveolar lavage fluids (BALFs) of mice receiving bovine colostrum were compared with those in the BALFs of mice receiving phosphate-buffered saline (PBS) or ribavirin, post virus challenge. The severity of infection and lung virus titers were reduced in the mice receiving bovine colostrum, compared to those receiving PBS. Moreover CD8 T cell responses were selectively enhanced in the former. Our results suggest that dietary bovine colostrum exerts the effects to inhibit hRSV and ameliorate the symptom by hRSV infection, and enhances the CD8 T cell response during the hRSV infection.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059057202

Download citation: RISBibTeXText

Related references

Cell-mediated immune responses of lambs to experimental infection with bovine respiratory syncytial virus. Veterinary Immunology and Immunopathology 50(1-2): 79-91, 1996

Specific dietary oligosaccharides increase Th1 responses in a mouse respiratory syncytial virus infection model. Journal of Virology 86(21): 11472-11482, 2012

Dynamic Host Immune and Transcriptomic Responses to Respiratory Syncytial Virus Infection in a Vaccination-Challenge Mouse Model. Virologica Sinica 36(6): 1327-1340, 2021

Immune mechanisms of pathogenetic synergy in concurrent bovine pulmonary infection with Haemophilus somnus and bovine respiratory syncytial virus. Veterinary Immunology and Immunopathology 107(1-2): 119-130, 2005

Innate immune responses to respiratory syncytial virus infection. Current Topics in Microbiology and Immunology 372: 139-154, 2013

Respiratory syncytial virus (RSV) immune globulin intravenous therapy for RSV lower respiratory tract infection in infants and young children at high risk for severe RSV infections: Respiratory Syncytial Virus Immune Globulin Study Group. Pediatrics 99(3): 454-461, 1997

Comparison of levels and duration of detection of antibodies to bovine viral diarrhea virus 1, bovine viral diarrhea virus 2, bovine respiratory syncytial virus, bovine herpesvirus 1, and bovine parainfluenza virus 3 in calves fed maternal colostrum or a colostrum-replacement product. Canadian Journal of Veterinary Research 78(2): 81-88, 2014

Defective regulation of immune responses in respiratory syncytial virus infection. Journal of Immunology 133(4): 1925-1930, 1984

Immune responses and disease enhancement during respiratory syncytial virus infection. Clinical Microbiology Reviews 18(3): 541-555, 2005

Defective regulation of immune responses in respiratory syncytial virus infection. The Journal of Immunology (1950) 133(4): 1925-1930, 1984

IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. Journal of Immunology 173(6): 4040-4049, 2004

Antiviral immune responses and lung inflammation after respiratory syncytial virus infection. Proceedings of the American Thoracic Society 2(2): 121-125, 2005

Consequences of immature and senescent immune responses for infection with respiratory syncytial virus. Current Topics in Microbiology and Immunology 372: 211-231, 2013

Characterization of a bovine model for studying the immunological responses to respiratory syncytial virus infection. FASEB Journal 8(4-5): A490, 1994

Bovine respiratory syncytial virus brsv provides protection against human respiratory syncytial virus hrsv infection in cotton rats and owl monkeys. American Review of Respiratory Disease 143(4 Part 2): A808, 1991