+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The establishment of a porcine rheumatoid arthritis model: Collagen induced arthritis minipig model



The establishment of a porcine rheumatoid arthritis model: Collagen induced arthritis minipig model



Journal of Pharmacological Sciences 132(1): 41-47



Rheumatoid arthritis (RA) research has been largely dependent on collagen induced arthritis (CIA) rodent models, however, they may not translate well to humans due to innate differences in the size, physiology and lifespan. The present study aimed to establish a CIA porcine model with the physical, hematological, histopathological and etiological properties closer to their human equivalent in an attempt to better meet the needs of RA research. Three month old minipigs were administered of bovine type II collagen (CII) emulsified with complete Freund's adjuvants on Day 1 and incomplete Freund's adjuvants on Day 22, via an intradermal or intra-articular route. The clinical, radiological and hematological assessments of immunized animals were made periodically until Day 43, during which period the onset and progression of arthritis was recorded and characterized. In addition, the histopathological and micro-tomographic assessments of the cartilage degradation with regard to mononuclear cell infiltration, and joint deformity indicated a higher severity in the intradermal injection group over the intra-articular group. With confirmation of the susceptibility to heterogeneous CII for arthritis induction in minipig, the potential suitability of this test system as a large animal model for RA has been demonstrated.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059066839

Download citation: RISBibTeXText

PMID: 27156927

DOI: 10.1016/j.jphs.2016.04.012


Related references

Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats. Journal of Pharmacology and Experimental Therapeutics 326(2): 532-545, 2008

Characteristics of synovial fluid effusion in collagen-induced arthritis (CIA) in the DA rat; a comparison of histology and antibody reactivities in an experimental chronic arthritis model and rheumatoid arthritis (RA). Clinical and Experimental Immunology 107(3): 480-484, 1997

Characteristics of synovial fluid effusion in collagen-induced arthritis in the DA rat; a comparison of histology and antibody reactivities in an experimental chronic arthritis model and rheumatoid arthritis. Clinical & Experimental Immunology 107(3): 480-484, 1997

Modeling corticosteroid effects in a rat model of rheumatoid arthritis II: mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen-induced arthritis. Journal of Pharmacology and Experimental Therapeutics 326(2): 546-554, 2008

Collagen-induced arthritis as an animal model for rheumatoid arthritis: focus on interferon-γ. Journal of Interferon and Cytokine Research 31(12): 917-926, 2011

The molecular pathogenesis of collagen-induced arthritis in mice--a model for rheumatoid arthritis. Ageing Research Reviews 1(1): 135-147, 2002

Collagen-induced arthritis in mice: A model for human rheumatoid arthritis?. Clinical Immunology Newsletter 10(9): 131-136, 1990

Type ii collagen induced arthritis as an experimental model of rheumatoid arthritis. Strauch, G And P L Morselli (Ed ) Colloque Inserm (Institut National De La Sante Et De Recherche Medicale), Vol 168 Pharmacologie Clinique: Actualites Et Perspectives Ii; (Inserm (National Institute Of Health And Medical Research) Colloquium, Vol 168 Recent Trends in Clinical Pharmacology Ii); Fourth National Meeting on Clinical Pharmacology, Giens, France, October 7-9, 1987 X+263p Editions Inserm: Paris, France Illus Paper 227-234, 1988

Hyperimmune colostrum alleviates rheumatoid arthritis in a collagen-induced arthritis murine model. Journal of Dairy Science 101(5): 3778-3787, 2018

Collagen-induced arthritis in mice: an animal model to study the pathogenesis of rheumatoid arthritis. Clinical and Experimental Rheumatology 17(2): 240-244, 1999

Torilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritis. International Immunopharmacology 16(2): 232-242, 2013

Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogenetics, pathogenesis and autoimmunity. Apmis 97(7): 575-584, 1989

Genetics of collagen type ii induced arthritis in mice an experimental model for human rheumatoid arthritis. Arthritis & Rheumatism 24(4 Suppl.): S59, 1981

Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis and Rheumatism 62(11): 3289-3299, 2010

Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis. European Journal of Immunology 30(6): 1568-1575, 2000