+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The impact of intermittent exercise in a hypoxic environment on redox status and cardiac troponin release in the serum of well-trained marathon runners



The impact of intermittent exercise in a hypoxic environment on redox status and cardiac troponin release in the serum of well-trained marathon runners



European Journal of Applied Physiology 116(10): 2045-2051



To investigate the effects of hypoxic training on redox status and cardiac troponin (cTn) release after intermittent exercise. Nine well-trained male marathon runners (age, 21.7 ± 2.3 year; body mass, 64.7 ± 4.8 kg; height, 177.9 ± 3.8 cm; and VO2max, 64.3 ± 6.7 ml kg(-1) min(-1)) completed intermittent exercise under normoxic [trial N; fraction of inspiration oxygen (FIO2), 21.0 %] and hypoxic (trial H; FIO2, 14.4 %) conditions in random order. Each bout of intermittent exercise included hard run (16.2 ± 0.8 km h(-1)) at 90 % VO2max for 2 min followed by easy run (9.0 ± 0.4 km h(-1)) at 50 % VO2max for 2 min and 23 bouts in 92 min totally. Malondialdehyde, reduced glutathione (GSH), superoxide dismutase, an estimate of total antioxidant capacity (T-AOC), high-sensitivity cardiac troponin T (hs-cTnT), and cardiac troponin I (cTnI) were measured before, immediately after (0 h), and 2, 4, and 24 h after the completion of trials N and H. GSH was increased immediately after trial N. T-AOC was lower 4 h after trial H than trial N. Hs-cTnT was elevated from 0 to 4 h and returned to baseline 24 h after both trials. CTnI was increased after trial H; peaked at 2-4 h and returned to below the detection by 24 h. The overall redox status was balanced under normoxic conditions, and exercise-induced cTn release did not deviate. However, the protective effects of antioxidant were weaker in the hypoxic state than normoxic, and the stress on the myocardium induced by intermittent exercise was transiently aggravated.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059075903

Download citation: RISBibTeXText

PMID: 27572505

DOI: 10.1007/s00421-016-3460-5


Related references

The impact of exercise intensity on the release of cardiac biomarkers in marathon runners. European Journal of Applied Physiology 111(12): 2961-2967, 2012

Effects of acute, intermittent exercise in hypoxic environments on the release of cardiac troponin. Scandinavian Journal of Medicine and Science in Sports 26(4): 397-403, 2016

High-sensitivity cardiac troponin T release after a single bout of high-intensity interval exercise in experienced marathon runners. Journal of Exercise Science and Fitness 15(2): 49-54, 2018

Cardiac troponin increases among marathon runners in the Perth Marathon: the Troponin in Marathons (TRIM) study. Medical Journal of Australia 190(2): 91-93, 2009

Cardiac troponin T release and inflammation demonstrated in marathon runners. Clinical Laboratory 56(1-2): 51-58, 2010

Comparison of serum cardiac specific troponin i with creatine kinase creatine kinase mb isoenzyme tropomyosin myoglobin and c reactive protein release in marathon runners cardiac or skeletal muscle trauma?. European Journal of Clinical Investigation 17(4): 317-324, 1987

High Sensitivity Troponin T in Marathon Runners, Marathon Runners with Heart Disease and Collapsed Marathon Runners. Scandinavian Journal of Medicine & Science in Sports 2019, 2019

The influence of a half-marathon race upon cardiac troponin T release in adolescent runners. Current Medicinal Chemistry 18(23): 3452-3456, 2011

The Influence of a Half-Marathon Race Upon Cardiac Troponin T Release in Adolescent Runners. Current Medicinal Chemistry 18(23): 3452-3456, 2011

Effects of intermittent hypoxic training performed at high hypoxia level on exercise performance in highly trained runners. Journal of Sports Sciences 36(18): 2045-2052, 2018

Measurement of a Plasma Stroke Biomarker Panel and Cardiac Troponin T in Marathon Runners Before and After the 2005 Boston Marathon. American Journal of Clinical Pathology 126(2): 185-189, 2006

Measurement of a Plasma Stroke Biomarker Panel and Cardiac Troponin T in Marathon Runners Before and After the 2005 Boston Marathon. Yearbook of Sports Medicine 2007: 148-149, 2007

Measurement of a plasma stroke biomarker panel and cardiac troponin T in marathon runners before and after the 2005 Boston marathon. American Journal of Clinical Pathology 126(2): 185-189, 2006

Cardiac markers (BNP, NT-pro-BNP, Troponin I, Troponin T, in female amateur runners before and up until three days after a marathon. Clinical Laboratory 54(3-4): 81-87, 2008

Effect of prolonged exercise in a hypoxic environment on cardiac function and cardiac troponin T. British Journal of Sports Medicine 38(1): 86-88, 2004