The impact of the Alzheimer's Disease Neuroimaging Initiative 2: what role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's disease?
Jones-Davis, D.M.; Buckholtz, N.
Alzheimer's and Dementia the Journal of the Alzheimer's Association 11(7): 860-864
2015
ISSN/ISBN: 1552-5279
PMID: 26194319
DOI: 10.1016/j.jalz.2015.05.006
Accession: 059077079
In the growing landscape of biomedical public-private-partnerships, particularly for Alzheimer's disease, the question is posed as to their value. What impacts do public-private-partnerships have on clinical and basic science research in Alzheimer's disease? The authors answer the question using the Alzheimer's Disease Neuroimaging Initiative (ADNI) as a test case and example. ADNI is an exemplar of how public-private-partnerships can make an impact not only on clinical and basic science research and practice (including clinical trials), but also of how similar partnerships using ADNI as an example, can be designed to create a maximal impact within their fields.
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Li, W.; Risacher, S.L.; Gao, S.; Boehm, S.L.; Elmendorf, J.S.; Saykin, A.J. 2018: Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants Alzheimer's and Dementia 10: 94-98
Barnes, J.; Carmichael, O.T.; Leung, K.K.; Schwarz, C.; Ridgway, G.R.; Bartlett, J.W.; Malone, I.B.; Schott, J.M.; Rossor, M.N.; Biessels, G.J.; DeCarli, C.; Fox, N.C. 2013: Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls Neurobiology of Aging 34(8): 1996-2002
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Koppel, J.; Sunday, S.; Goldberg, T.E.; Davies, P.; Christen, E.; Greenwald, B.S. 2014: Psychosis in Alzheimer's disease is associated with frontal metabolic impairment and accelerated decline in working memory: findings from the Alzheimer's Disease Neuroimaging Initiative American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry 22(7): 698-707
Ellis, K.A.; Rowe, C.C.; Villemagne, V.L.; Martins, R.N.; Masters, C.L.; Salvado, O.; Szoeke, C.; Ames, D. 2010: Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study: collaboration with the Alzheimer's Disease Neuroimaging Initiative Alzheimer's and Dementia: the Journal of the Alzheimer's Association 6(3): 291-296
Henley, D.B.; Sundell, K.L.; Sethuraman, G.; Siemers, E.R. 2012: Safety profile of Alzheimer's disease populations in Alzheimer's Disease Neuroimaging Initiative and other 18-month studies Alzheimer's and Dementia: the Journal of the Alzheimer's Association 8(5): 407-416
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Veitch, D.P.; Weiner, M.W.; Aisen, P.S.; Beckett, L.A.; DeCarli, C.; Green, R.C.; Harvey, D.; Jack, C.R.; Jagust, W.; Landau, S.M.; Morris, J.C.; Okonkwo, O.; Perrin, R.J.; Petersen, R.C.; Rivera-Mindt, M.; Saykin, A.J.; Shaw, L.M.; Toga, A.W.; Tosun, D.; Trojanowski, J.Q. 2022: Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease Alzheimer's and Dementia: the Journal of the Alzheimer's Association 18(4): 824-857
Buerger, K.; Frisoni, G.; Uspenskaya, O.; Ewers, M.; Zetterberg, H.; Geroldi, C.; Binetti, G.; Johannsen, P.; Rossini, P.M.; Wahlund, L.-O.; Vellas, B.; Blennow, K.; Hampel, H. 2009: Validation of Alzheimer's disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer's Disease Neuroimaging Initiative (E-ADNI) Experimental Gerontology 44(9): 579-585