+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The mechanics of malaria parasite invasion of the human erythrocyte - towards a reassessment of the host cell contribution



The mechanics of malaria parasite invasion of the human erythrocyte - towards a reassessment of the host cell contribution



Cellular Microbiology 18(3): 319-329



Despite decades of research, we still know little about the mechanics of Plasmodium host cell invasion. Fundamentally, while the essential or non-essential nature of different parasite proteins is becoming clearer, their actual function and how each comes together to govern invasion are poorly understood. Furthermore, in recent years an emerging world view is shifting focus away from the parasite actin-myosin motor being the sole force responsible for entry to an appreciation of host cell dynamics and forces and their contribution to the process. In this review, we discuss merozoite invasion of the erythrocyte, focusing on the complex set of pre-invasion events and how these might prime the red cell to facilitate invasion. While traditionally parasite interactions at this stage have been viewed simplistically as mediating adhesion only, recent work makes it apparent that by interacting with a number of host receptors and signalling pathways, combined with secretion of parasite-derived lipid material, that the merozoite may initiate cytoskeletal re-arrangements and biophysical changes in the erythrocyte that greatly reduce energy barriers for entry. Seen in this light Plasmodium invasion may well turn out to be a balance between host and parasite forces, much like that of other pathogen infection mechanisms.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059085510

Download citation: RISBibTeXText

PMID: 26663815

DOI: 10.1111/cmi.12557


Related references

Human C1-Inhibitor Suppresses Malaria Parasite Invasion and Cytoadhesion via Binding to Parasite Glycosylphosphatidylinositol and Host Cell Receptors. Journal of Infectious Diseases 213(1): 80-89, 2016

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science 298(5600): 2002-2006, 2002

Inhibitory effects of erythrocyte membrane proteins on the in vitro invasion of the human malarial parasite (Plasmodium falciparum) into its host cell. Journal of Cell Biology 903: 563-567, 1981

Reassessing the mechanics of parasite motility and host-cell invasion. Journal of Cell Biology 214(5): 507-515, 2016

A complete molecular understanding of malaria parasite invasion of the human erythrocyte: are we there yet?. Pathogens and Global Health 107(3): 107, 2013

Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte. Biophysical Journal 107(1): 43-54, 2014

Cytoskeletal and membrane remodelling during malaria parasite invasion of the human erythrocyte. British Journal of Haematology 154(6): 680-689, 2011

How the malaria parasite invades its host cell, the erythrocyte. International Review of Cytology 96: 191-238, 1985

Formin regulation of actin polymerisation during malaria parasite invasion of the human erythrocyte.. 2008

Proteases in host cell invasion by the malaria parasite. Cellular Microbiology 6(10): 893-903, 2004

Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte. Cell Host and Microbe 9(1): 9, 2011

Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi. Proceedings of the National Academy of Sciences of the United States of America 113(26): 7231-7236, 2016

The mechanism for erythrocyte to accept malaria parasite invasion and to allow releasing daughter parasite. Membrane 30(2): 84-90, 2005

Host-parasite interactions that guide red blood cell invasion by malaria parasites. Current Opinion in Hematology 22(3): 220-226, 2015

The chemo therapy of rodent malaria ii host parasite relationships ii the relationship between chloroquine anti parasit sensitivity and the age of the host cell plasmodium berghei mouse poly chromatophilic erythrocyte. Annals of Tropical Medicine & Parasitology 62(2): 246-251, 1968