There is no association between TNF-α gene polymorphisms and the risk of coronary artery heart disease: a meta-analysis
Huangfu, F.; Zhao, X.; Wang, X.; Tang, L.; Jiang, J.
Journal of Cardiovascular Surgery 58(5): 770-778
ISSN/ISBN: 0021-9509 PMID: 27128104 Accession: 059123181
Coronary artery heart disease (CAD) is a group of complex diseases, including coronary atherosclerosis, myocardial infarction and sudden cardiac death. CAD is also widely accepted as a chronic inflammatory disease. Studies show that pro-inflammatory tumor necrosis factor-alpha (TNF-α) is involved in the CAD pathological pathway and is a reliable predictor of cardiovascular disease. However, the association between TNF-α polymorphisms and CAD risk is still unclear. In this meta-analysis, we investigated the relationship between TNF-α polymorphisms and CAD risk. From EMBASE, Web of science, EBSCO, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases 7525 articles were selected in our study. A meta-analysis on the associations between the T-1031C, C-857T and C-863A polymorphisms and CAD risk was carried out by comparing five genetic models. In this systematic review 14 studies from six English articles and 1 Chinese article were analyzed. The pooled population included 16,774 subjects (8351 cases and 8423 controls). Our results showed that three polymorphisms (T-1031C, C-857T and C-863A) have no association with CAD risk. Our results indicated that T-1031C, C-857T and C-863A polymorphisms are not associated with CAD risk.