+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Two roads to death - Bax targets mitochondria by distinct routes before or during apoptotic cell death



Two roads to death - Bax targets mitochondria by distinct routes before or during apoptotic cell death



Molecular and Cellular Oncology 2(1): E974460



Recent studies have revolutionized our understanding of how the crucial apoptosis effectors Bax and Bak target mitochondria to kill cells. We recently reported that an important determinant of the localization, oligomerization, and apoptotic function of Bax is an interaction with either mitochondrial voltage-dependent anion channel 2 (VDAC2) (in healthy cells) or Bak (in apoptotic cells).(1).

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059184097

Download citation: RISBibTeXText

PMID: 27308408

DOI: 10.4161/23723556.2014.974460


Related references

Death receptor-induced apoptotic and necrotic cell death: Differential role of caspases and mitochondria. Cell Death & Differentiation 8(8): 829-840, 2001

Death signals from the B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascades in a murine B cell line, WEHI-231. International Immunology 11(6): 933-941, 1999

The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells. European Journal of Medicinal Chemistry 46(7): 2709-2721, 2011

Distinct mathematical behavior of apoptotic versus non-apoptotic tumor cell death. International Journal of Radiation Oncology Biology Physics 43(3): 601-605, 1999

Distinct mathematical behavior of apoptotic vs non-apoptotic tumor cell death. International Journal of Radiation Oncology Biology Physics 39(2 Suppl. ): 180, 1997

Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway. Plos Biology 10(3): E1001281, 2012

Conformational Diseases and Er Stress-Mediated Cell Death: Apoptotic Cell Death and Autophagic Cell Death. Current Molecular Medicine 6(1): 111-118, 2006

Conformational diseases and ER stress-mediated cell death: apoptotic cell death and autophagic cell death. Current Molecular Medicine 6(1): 111-118, 2006

A common apoptotic and necrotic death commitment from CpG-specific cleavage and the death cascade of housekeeping gene expressions Epigenetic regulation of cell death. FASEB Journal 14(4): A195, 2000

Apoptotic potential of Fas-associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells. Journal of Cell Communication and Signaling 6(3): 155-168, 2012

Radiation-induced death pathways in prostate cells Role of apoptotic and non-apoptotic cell death. Proceedings of the American Association for Cancer Research Annual Meeting 43: 687, 2002

Mitochondria at the crossroad of apoptotic cell death. Journal of Bioenergetics & Biomembranes 31(4): 321-326, 1999

Mitochondria at the crossroad of apoptotic cell death. Journal of Bioenergetics and Biomembranes 31(4): 321-326, 1999

The role of mitochondria in cell death Regulation of the pro-apoptotic protein Bak. Biochimica et Biophysica Acta (Bba) - Bioenergetics 1817: S160, 2012

Apoptotic cascades as possible targets for inhibiting cell death in Huntington's disease. Journal of Neurology 253(9): 1137-1142, 2006