Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors
Strick, R.; Strissel, P.L.; Baylin, S.B.; Chiappinelli, K.B.
Oncoimmunology 5(5): E1122160
2016
ISSN/ISBN: 2162-4011
PMID: 27467919
DOI: 10.1080/2162402x.2015.1122160
Accession: 059202843
Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.
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