+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Use of Statins and the Risk of Incident Diabetes: A Retrospective Cohort Study



Use of Statins and the Risk of Incident Diabetes: A Retrospective Cohort Study



American Journal of Cardiovascular Drugs 16(5): 377-390



Even though several landmark statin trials have demonstrated the beneficial effects of statin therapy in both primary and secondary prevention of cardiovascular disease, several studies have suggested that statins are associated with a moderate increase in risk of new-onset diabetes. These observations prompted the US FDA to revise statin labels to include a warning of an increased risk of incident diabetes mellitus as a result of increases in glycosylated hemoglobin (HbA1c) and fasting plasma glucose. However, few studies have used US-based data to investigate this statin-associated increased risk of diabetes. The primary objective of our study was to examine whether the use of statins increases the risk of incident diabetes mellitus using data from the Thomson Reuters MarketScan (®) Commercial Claims and Encounters Database. This study was a retrospective cohort analysis utilizing data for the period 2003-2004. The study population included new statin users aged 20-63 years at index who did not have a history of diabetes. The proportion (3.4 %) of statin users (N = 53,212) who had incident diabetes was higher than the proportion (1.2 %) of non-statin users (N = 53,212) who had incident diabetes. Compared with no statin use and controlling for demographic and clinical covariates, statin use was significantly associated with increased risk of incident diabetes (hazard ratio 2.01; 99 % confidence interval 1.74-2.33; p < 0.0001). In addition, risk of diabetes was highest among users of lovastatin, atorvastatin, simvastatin, and fluvastatin. Diabetes risk was lowest among pravastatin and rosuvastatin users. Because the potential for diabetogenicity differs among different statin types, healthcare professionals should individualize statin therapy by identifying patients who would benefit more from less diabetogenic statin types.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059213118

Download citation: RISBibTeXText

PMID: 27272032

DOI: 10.1007/s40256-016-0176-1


Related references

Comparative risk of lipophilic and hydrophilic statins on incident depression: A retrospective cohort study. Journal of Affective Disorders 238: 542-546, 2018

Risk of new-onset diabetes mellitus during treatment with low-dose statins in Japan: A retrospective cohort study. Journal of Clinical Pharmacy and Therapeutics 43(4): 536-542, 2018

THU0222Oral Glucocorticoids and the Risk of Incident Type II Diabetes Mellitus in Patients with Rheumatoid Arthritis, a Retrospective Cohort Study. Annals of the Rheumatic Diseases 72(Suppl 3): A239.3-A240, 2013

Incident rate and risk factors for tuberculosis among patients with type 2 diabetes: retrospective cohort study in Shanghai, China. Tropical Medicine and International Health 22(7): 830-838, 2017

Serum creatinine levels and risk of incident type 2 diabetes mellitus or dysglycemia in middle-aged Japanese men: a retrospective cohort study. Veterinary Record 2018:, 2018

Effects of statins on incident dementia in patients with type 2 DM: a population-based retrospective cohort study in Taiwan. Plos one 9(2): E88434, 2014

The long-term effect of statins on the risk of new-onset diabetes mellitus in elderly Taiwanese patients with hypertension and dyslipidaemia: a retrospective longitudinal cohort study. Drugs and Aging 29(1): 45-51, 2012

Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer's Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan. Journal of Diabetes Research 2016: 9027484, 2016

Statins use and risk of new-onset diabetes in hypertensive patients: a population-based retrospective cohort study in Yinzhou district, Ningbo city, People's Republic of China. Therapeutics and Clinical Risk Management 14: 823-832, 2018

Gestational diabetes associated with incident diabetes in childhood and youth: a retrospective cohort study. Cmaj 191(15): E410-E417, 2019

Statins and new-onset diabetes: a retrospective longitudinal cohort study. Clinical Therapeutics 34(9): 1977-1983, 2012

Statin Use and the Risk for Incident Diabetes Mellitus in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: A Population-Based Retrospective Cohort Study in Taiwan. Canadian Journal of Diabetes 40(3): 264-269, 2016

Risk of incident diabetes among patients treated with statins: population based study. BMJ 346: F2610-F2610, 2013

Underutilization of statins in patients with type 2 diabetes in US clinical practice: a retrospective cohort study. Current Medical Research and Opinion 27(5): 1035-1040, 2011

Use of Statins and Risk of Dementia in Heart Failure: A Retrospective Cohort Study. Drugs and Aging 32(9): 743-754, 2015