+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

An early history of CCN2/CTGF research: the road to CCN2 via hcs24, ctgf, ecogenin, and regenerin

An early history of CCN2/CTGF research: the road to CCN2 via hcs24, ctgf, ecogenin, and regenerin

Journal of Cell Communication and Signaling 12(1): 253-264

The principal aim of this historical review is to present the processes by which the different aspects of CCN2/CTGF/Hcs24 were discovered by different groups and how much CCN2/CTGF, by being integrated into CCN family, has contributed to the establishment of the basic concepts regarding the role and functions of this new class of proteins. This review should be particularly useful to new investigators who have recently entered this exciting field of study and also provides a good opportunity to acknowledge the input of those individuals who participated in the development of this scientific field.

(PDF emailed within 0-6 h: $19.90)

Accession: 059359180

Download citation: RISBibTeXText

PMID: 29076115

DOI: 10.1007/s12079-017-0414-6

Related references

Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells. Biorheology 45(3-4): 289-299, 2008

Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line. Dna and Cell Biology 22(10): 641-648, 2003

Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes. Febs Journal 279(19): 3584-3597, 2012

Role of CCN2/CTGF/Hcs24 in bone growth. International Review of Cytology 257: 1-41, 2007

Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage. Osteoarthritis and Cartilage 12(10): 771-778, 2004

Transforming Growth Factor-b1 (TGFb1) Stimulates Connective Tissue Growth Factor (CCN2/CTGF) Expression in Human Gingival Fibroblasts through a RhoMindependent, Rac1/Cdc42-dependent Mechanism. Statins With Forskolin Block TGFb1-Induced CCN2/CTGF Expression. 2008

Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. Journal of Biological Chemistry 283(16): 10835-10847, 2008

Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24/CCN2) during distraction osteogenesis. Journal of Bone and Mineral Metabolism 22(4): 293-302, 2004

Role of CTGF/HCS24/ecogenin in skeletal growth control. Journal of Cellular Physiology 194(3): 256-266, 2003

Novel mode of processing and secretion of connective tissue growth factor/ecogenin (CTGF/Hcs24) in chondrocytic HCS-2/8 cells. Bone (New York) 29(2): 155-161, 2001

Dynamic analysis of the expression of the TGF beta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development. Cells Tissues Organs 187(3): 199-210, 2008

Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development. Cells, Tissues, Organs 187(3): 199-210, 2007

CTGF/CCN2 is an autocrine regulator of cardiac fibrosis. Journal of Molecular and Cellular Cardiology 121: 205-211, 2018

A potential role for CCN2/CTGF in aggressive colorectal cancer. Journal of Cell Communication and Signaling 10(3): 223-227, 2016

Two novel cis-acting elements of human CTGF/CCN2 gene expression. Molecular Pathology 56(2): 65-66, 2003