+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Angiopoietin-2 is expressed in oral Kaposi's sarcoma



Angiopoietin-2 is expressed in oral Kaposi's sarcoma



Journal of Oral Pathology and Medicine 46(10): 1011-1014



Kaposi's sarcoma (KS) persists today as a highly prevalent vascular cancer, often found in HIV patients. Studies have shown that angiopoietin 2 (Ang2), a pro-angiogenic protein, is involved in the pathogenesis of this tumor. However, expression of this protein has not been investigated in oral KS lesions. Thus, we aimed to investigate the expression of Ang2 in samples of oral KS. Immunohistochemistry was used to evaluate Ang2 expression in 14 oral KS cases, with degrees of expression being analyzed in a semi-quantitative manner. In addition, clinical information such as age, gender, race, tumor location, size, color, and appearance, as well as HIV status, was collected and included in the analysis. All patients were white males, mostly HIV-positive, with a mean age of 40 years. Clinically, the lesions were dark red/blue/purple masses, ranging from 1 to 2.5 cm in diameter, found in various locations such as the tongue, palate, and gingiva. Expression of Ang2 was noted in 72% (10/14) of the samples. Of these, 10% showed weak expression, 60% moderate, and 30% strong expression. Our results indicate that Ang2 is expressed in oral KS and, consistent with results from previous studies, show that Ang2 may contribute to the pathogenesis of this lesion.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059365489

Download citation: RISBibTeXText

PMID: 28370338

DOI: 10.1111/jop.12574


Related references

Angiopoietin-like 4: a novel molecular hallmark in oral Kaposi's sarcoma. Oral Oncology 47(5): 371-375, 2011

Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. Journal of Virology 70(11): 8218-8223, 1996

Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) DNA in Kaposi's sarcoma lesions, AIDS Kaposi's sarcoma cell lines, endothelial Kaposi's sarcoma simulators, and the skin of immunosuppressed patients. American Journal of Pathology 148(6): 2009-2016, 1996

Quantification of Kaposi's sarcoma-associated herpesvirus in blood, oral mucosa, and saliva in patients with Kaposi's sarcoma. Aids Research and Human Retroviruses 20(7): 704-708, 2004

Kaposi's sarcoma-associated herpesvirus-like DNA sequences (KSHV/HHV-8) in oral AIDS-Kaposi's sarcoma. A PCR and clinicopathologic study. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 83(2): 259-264, 1997

Kaposi's sarcoma herpesvirus load in biopsies of cutaneous and oral Kaposi's sarcoma lesions. European Journal of Cancer 43(12): 1877-1882, 2007

Treatment of early AIDS-related Kaposi's sarcoma with oral all-trans-retinoic acid: results of a sequential non-randomized phase II trial. Kaposi's Sarcoma ANRS Study Group. Agence Nationale de Recherches sur le SIDA. Aids 12(16): 2169-2176, 1998

Mechanism of angiopoietin-1 upregulation in Kaposi's sarcoma-associated herpesvirus-infected PEL cell lines. Journal of Virology 89(9): 4786-4797, 2015

Kaposi's sarcoma-associated herpesvirus induces rapid release of angiopoietin-2 from endothelial cells. Journal of Virology 87(11): 6326-6335, 2013

Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1. Journal of Virology 81(8): 3980-3991, 2007

Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma. Yearbook of Dermatology and Dermatologic Surgery 2009: 460-461, 2009

Classic Kaposi Sarcoma in the United States over the last two decades A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma. Modern Pathology 21(5): 572-582, 2008

Pseudo-Kaposi Sarcoma or Kaposi Sarcoma? Kaposi-sarcoma-like skin lesions in a patient with AIDS. Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 59(3): 233-236, 2008

Kaposi's sarcoma herpesvirus in oral Kaposi's sarcoma. European Journal of Cancer. Part B Oral Oncology 32b(1): 68-69, 1996

Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. Proceedings of the National Academy of Sciences of the United States of America 107(32): 14363-8, 2010