+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibiotic allergy in systemic lupus erythematosus: a case-control study



Antibiotic allergy in systemic lupus erythematosus: a case-control study



Journal of Rheumatology 19(2): 265-269



Antibiotic allergy, especially to sulfonamides, has been reported as both a predisposing factor and as an exacerbating agent in systemic lupus erythematosus (SLE). We surveyed 221 members of The Johns Hopkins Lupus Cohort and 2 control groups, consisting of 178 relatives and 186 best friends, for antibiotic allergy to penicillin/cephalosporins, sulfonamides, tetracyclines, and erythromycin. Antibiotic allergy was common in patients with SLE exposed to the drug: 27% penicillin/cephalosporin, 31% sulfonamide, 7% tetracycline, and 13% erythromycin. In all cases, the most common allergic reaction was rash. Worsening of SLE occurred in 21% of sulfonamide allergic reactions. Allergy to penicillin/cephalosporin (OR 2.3, 95% CI 1.5-3.6), sulfonamides (OR 2.4, 95% CI 1.2-4.7) and to erythromycin (OR 4.8, 95% CI 1.5-14.9) was significantly more common in exposed patients with SLE than in exposed controls. Thus, antibiotic allergy is a frequent finding in patients with SLE and, in the case of sulfonamide allergy, can be associated with lupus exacerbation.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 059376232

Download citation: RISBibTeXText

PMID: 1629825


Related references

Antibiotic allergy in systemic lupus erythematosus sle a case control study. Arthritis & Rheumatism 34(9 SUPPL): S58, 1991

Antibiotic allergy in systemic lupus erythematosus. Journal of Rheumatology 19(12): 1994-1994, 1992

Subclinical hypothyroidism and its association with lupus nephritis: a case control study in a large cohort of Chinese systemic lupus erythematosus patients. Lupus 20(10): 1035-1041, 2012

Prevalence of conventional and lupus-specific risk factors for cardiovascular disease in patients with systemic lupus erythematosus: A case-control study. Arthritis and Rheumatism 55(6): 892-899, 2006

Correlation between systemic lupus erythematosus and anti-convulsants. Case of systemic lupus erythematosus with aggravated lupus and granulocytopenia caused by diphenyl-hydantoin. Naika. Internal Medicine 26(5): 989-994, 1970

AB0598Thyroiditis in Systemic Lupus Erythematosus: A Case-Control Study. Annals of the Rheumatic Diseases 74(Suppl 2): 1099.4-1100, 2015

Onychomycosis in systemic lupus erythematosus: a case control study. Journal of Rheumatology 30(7): 1491-1494, 2003

Thrombophilia in systemic lupus erythematosus: A case-control study. Journal de Medecine Vasculaire 43(6): 347-353, 2018

Progressive systemic sclerosis and localized scleroderma morphea with positive lupus erythematosus cell test and unusual systemic manifestations compatible with systemic lupus erythematosus presentation of 14 cases including 1 set of identical twins 1 with scleroderma and the other with systemic lupus erythematosus review of the literature. Medicine (Baltimore) 50(3): 199-222, 1971

Classification of Systemic Lupus Erythematosus: Systemic Lupus International Collaborating Clinics Versus American College of Rheumatology Criteria. A Comparative Study of 2,055 Patients From a Real-Life, International Systemic Lupus Erythematosus Cohort. Arthritis Care & Research 67(8): 1180-1185, 2015

Systemic lupus erythematosus and reproductive function: a case-control study. American Journal of Obstetrics and Gynecology 153(2): 179-186, 1985

Thyroid cancer in systemic lupus erythematosus: a case-control study. Journal of Clinical Endocrinology and Metabolism 95(1): 314-318, 2010

A case control study of female systemic lupus erythematosus in Japan. European Journal of Public Health 3(3): 172-176, 1993

Factors associated with remission in systemic lupus erythematosus A case-control study. Arthritis & Rheumatism 41(9 SUPPL ): S220, Sept, 1998

Hair product use in systemic lupus erythematosus. A case-control study. Arthritis and Rheumatism 35(6): 625-629, 1992