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Anticancer activity of a series of copper (II) complexes with tripodal ligands

Jopp, M.; Becker, J.; Becker, S.; Miska, A.; Gandin, V.; Marzano, C.; Schindler, S.

European Journal of Medicinal Chemistry 132: 274-281

2017

ISSN/ISBN: 1768-3254
PMID: 28371639
DOI: 10.1016/j.ejmech.2017.03.019
Accession: 059377150
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A series of copper(II) complexes with tripodal polypyridylamine ligands (derived from the parent ligand tris(2-pyridylmethyl)amine, tmpa) has been synthesized. Crystallographic characterization was possible for all complexes obtained. The copper(II) chloride complexes were investigated for their in vitro anticancer potential using human tumor cell lines containing examples of cervical, colon, ovarian cancers and melanoma. Some compounds showed a similar activity compared to that of cisplatin, however no systematic behavior could be observed.

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