+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

A systematic review and meta-analysis of the prevalence of norovirus in cases of gastroenteritis in developing countries



A systematic review and meta-analysis of the prevalence of norovirus in cases of gastroenteritis in developing countries



Medicine 96(40): E8139



While norovirus (NoV) is well known as a leading causal pathogen for acute gastroenteritis in developed countries,structured data on prevalence in developing countries are not available thus far. This review aims to estimate the prevalence of NoV in cases of gastroenteritis in developing countries based on recently published reports. Relevant studies were identified by searching PubMed and Web of Science for the period January 1, 1990 through March 31, 2016. We included studies performed in developing countries with a study period of at least 12 months and which provided information on polymerase chain reaction (PCR)-confirmed NoV prevalence in patients diagnosed with acute gastroenteritis. A metaanalysis was conducted on NoV prevalence, focused on viral genogroups GI and GII, in cases of acute gastroenteritis. Using evidence from 178 articles, the estimated NoV prevalence among 148,867 patients with acute gastroenteritis was 17% (95% confidence interval [CI]: 15-18%). The prevalence decreased from 18% (95% CI: 16-20%) for upper middle-income countries to 15% (13-18%) and 6% (3-10%) for lower middle- and low-income countries, respectively. There were no significant differences in NoV prevalence by age group (under 5 years, 5 years and over, and mixed ages) or severity of symptoms as defined by community, outpatient, or inpatient setting. The pooled prevalence of NoV GII (15%, 95% CI: 13-17%) was significantly higher than that of NoV GI (1%, 95% CI: 1-1%) in patients with acute gastroenteritis. From the evidence considered in this review, the estimated prevalence of NoV in patients with acute gastroenteritis in developing countries was 17%. This estimate can be used to evaluate the burden of NoV-associated acute gastroenteritis in developing countries, which is currently unclear due to poor diagnosis and surveillance systems, and the estimation may enhance the development of human NoV vaccines.

(PDF emailed within 0-6 h: $19.90)

Accession: 059421122

Download citation: RISBibTeXText

PMID: 28984764

DOI: 10.1097/MD.0000000000008139


Related references

Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis. Lancet. Infectious Diseases 14(8): 725-730, 2014

Prevalence of gastrointestinal pathogens in developed and developing countries: systematic review and meta-analysis. Journal of Public Health Research 2(1): 42-53, 2013

Gastroenteritis Therapies in Developed Countries: Systematic Review and Meta-Analysis. Plos One 10(6): E0128754, 2016

Economic and Health Predictors of National Postpartum Depression Prevalence: A Systematic Review, Meta-analysis, and Meta-Regression of 291 Studies from 56 Countries. Frontiers in Psychiatry 8: 248, 2018

Prevalence of TB/HIV co-infection in countries except China: a systematic review and meta-analysis. Plos One 8(5): E64915, 2014

Income and child mortality in developing countries: a systematic review and meta-analysis. Journal of the Royal Society of Medicine 106(10): 408-414, 2013

Clostridium difficile-associated Diarrhea in Developing Countries: A Systematic Review and Meta-Analysis. Infectious Diseases and Therapy 2019, 2019

Prevalence of Barrett's Esophagus in Asian Countries: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology 13(11): 1907-1918, 2016

Prevalence of Hypertension in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis. Medicine 94(50): E1959, 2016

Causes of Child and Youth Homelessness in Developed and Developing Countries: A Systematic Review and Meta-analysis. JAMA Pediatrics 170(5): 435-444, 2017

Behavioural interventions for HIV positive prevention in developing countries: a systematic review and meta-analysis. Bulletin of the World Health Organization 88(8): 615-623, 2010

The prevalence of chronic pain with an analysis of countries with a Human Development Index less than 0.9: a systematic review without meta-analysis. Current Medical Research and Opinion 28(7): 1221-1229, 2013

Clinical and economic impact of antibiotic resistance in developing countries: A systematic review and meta-analysis. Plos One 12(12): E0189621, 2018

Perioperative and anaesthetic-related mortality in developed and developing countries: a systematic review and meta-analysis. Lancet 380(9847): 1075-1081, 2012

Effectiveness of peer education interventions for HIV prevention in developing countries: a systematic review and meta-analysis. Aids Education and Prevention 21(3): 181-206, 2009