+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults

Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults

Journal of Nutritional Science and Vitaminology 63(1): 59-68

Glycation, a non-enzymatic glycosylation of proteins, induces tissue damage in association with various diseases and aging phenomena. Pentosidine, an advanced glycation end product, is involved in aging phenomena such as tissue stiffness. In this study, we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial. From among 681 hot water plant extracts, lemon balm (Melissa officinalis; LB) leaf extract was selected and revealed to have more potent inhibitory activity for pentosidine formation than a representative anti-glycation agent, aminoguanidine. Rosmarinic acid (RA), a typical polyphenol in Lamiaceae plants, was identified as a major active component in LB extract (LBE). Furthermore, LBE or RA dose-dependently suppressed glycation-associated reactions such as increased fluorescence, yellowing of collagen fiber sheets, and degeneration of the fibrous structure of elastin fiber sheets. An open-label, parallel-group comparative trial was conducted in 28 healthy Japanese subjects aged 31-65 y who consumed LB tea (LB group) or barley tea (Control group) for 6 wk. The LB group showed significant reductions in brachial-ankle pulse wave velocity, reflecting arterial stiffness, and b* (yellow) color values in forearm skin compared with the Control group. A gender-stratified analysis revealed that cheek skin elasticity was significantly improved in the LB group compared with the Control group only in female subjects. It is concluded that the hot water extract of LB leaf has the potential to provide health benefits with regard to glycation-associated tissue damage in blood vessels and skin of healthy adults.

(PDF emailed within 0-6 h: $19.90)

Accession: 059438632

Download citation: RISBibTeXText

PMID: 28367927

DOI: 10.3177/jnsv.63.59

Related references

Chemical composition and in vitro antioxidative activity of a lemon balm (Melissa officinalis L.) extract. LWT - Food Science and Technology 41(3): 0-400, 2008

Lemon balm extract (Melissa officinalis, L.) promotes melanogenesis and prevents UVB-induced oxidative stress and DNA damage in a skin cell model. Journal of Dermatological Science 84(2): 169-177, 2016

Lemon balm--Melissa officinalis; also known as lemon balm, bee balm, garden balm, Melissa, melissengeist. Journal of Primary Health Care 3(2): 165-166, 2011

Effects of lemon balm (Melissa officinalis L.) extract on germination and seedling growth of six plants. Acta Physiologiae Plantarum 23(1): 49-53, 2001

Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice. Molecular Nutrition & Food Research 58(4): 903-907, 2015

Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: Influence of administration and gender. Indian Journal of Pharmacology 44(2): 189-192, 2012

Glycation associated skin autofluorescence and skin elasticity are related to chronological age and body mass index of healthy subjects. Experimental Gerontology 43(7): 663-667, 2008

Antioxidant effect of lemon balm extract and oregano extract on poppy seeds and walnuts. Bulletin Potravinarskeho Vyskumu 41(4): 255-267, 2002

Effects of Melissa officinalis L. (lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus. Neurochemical Research 36(2): 250-257, 2011

Effects of age and aerobic capacity and arterial stiffness in healthy adults. Circulation 88(4 PART 1): 1456-1462, 1993

Negative Chronotropic and Antidysrhythmic Effects of Hydroalcoholic Extract of Lemon Balm (Melissa Officinalis L.) on CaCl2-Induced Arrhythmias in Rats. Electronic Physician 7(1): 971-976, 2015

Postprandial effects on arterial stiffness parameters in healthy young adults. Vascular Medicine 20(6): 501-508, 2016

Acute effects of a mixed meal on arterial stiffness and central hemodynamics in healthy adults. American Journal of Hypertension 27(3): 331-337, 2014

Antiviral Activity Of Melissa Officinalis (Lemon Balm) Extract. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 117: 431-434, 1964

Effects of family history of hypertension and CVA on arterial elasticity in healthy European population-the seven European sites study of arterial elasticity. American Journal of Hypertension 16(5 Part 2): 150A, 2003