+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Changes of circulating Th22 cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection



Changes of circulating Th22 cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection



Oncotarget 8(17): 29370-29382



Interleukin (IL)-22+CD4+T (Th22) cells play crucial roles in the pathogenesis of autoimmune diseases and infectious diseases, although the role of Th22 cells remains largely unclear in children with hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71). This study aims to explore the role of circulating IL-22+IL-17A-CD4+T (cTh22) cells in children with EV71-associated HFMD. We found that during the acute stage of illness, the frequencies of cTh22 and circulating IL-22+IL-17A+CD4+T (IL-22+cTh17) cells in CD4+T cells infrom affected patients, and especially in severely affected patients, were significantly higher than in healthy controls (HC). The major source of IL-22 production was cTh22 cells, partially from cTh17 cells. Moreover, the protein and mRNA levels of IL-22, IL-17A, IL-23, IL-6, and TNF-α were significantly different among the mild patients, severe patients and HC, as well as AHR and RORγt mRNA levels. A positive correlation was found between plasma IL-22 levels and cTh22 cell frequencies, and cTh17 cell and IL-22+ cTh17 cell frequencies. Furthermore, the frequencies of cTh22 were significantly decreased in the convalescent patients. Our findings indicated that cTh22 cells could play critical roles in the pathogenesis of EV71 infection, and are potential therapeutic targets for patients with EV71-associated HFMD.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 059486858

Download citation: RISBibTeXText

PMID: 28030850


Related references

Increased frequency of circulating follicular helper T cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection. Journal of Immunology Research 2014: 651872, 2015

Fourteen types of co-circulating recombinant enterovirus were associated with hand, foot, and mouth disease in children from Wenzhou, China. Journal of Clinical Virology 70: 29-38, 2016

Thinking about the intervention strategy for critically ill hand-foot-and-mouth disease caused by enterovirus 71 infection. Zhonghua Er Ke Za Zhi 50(4): 244-248, 2013

Association between S100B gene polymorphisms and hand, foot and mouth disease caused by enterovirus 71 infection. Zhongguo Dang Dai Er Ke Za Zhi 19(8): 904-907, 2017

Distinct expression and clinical value of aquaporin 4 in children with hand, foot and mouth disease caused by enterovirus 71. Journal of Medical Virology 2019, 2019

Serum cholinesterase: a potential assistant biomarker for hand, foot, and mouth disease caused by enterovirus 71 infection. Infectious Diseases of Poverty 5: 27, 2016

Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16. Zhongguo Dang Dai Er Ke Za Zhi 13(8): 635-637, 2011

Pulmonary and central nervous system pathology in fatal cases of hand foot and mouth disease caused by enterovirus A71 infection. Pathology 48(3): 267-274, 2018

Polymorphisms of TLR7 rs3853839 and rs179010 are associated with susceptibility to and severity of hand, foot and mouth disease caused by enterovirus 71 in male children. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 33(7): 953-958, 2018

Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. Pediatrics 109(6): E88, 2002

Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia. Clinical Infectious Diseases 32(2): 236-242, 2001

A novel Enterovirus 96 circulating in China causes hand, foot, and mouth disease. Virus Genes 53(3): 352-356, 2017

Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development. Revista do Instituto de Medicina Tropical de Sao Paulo 60: E70, 2018

Enterovirus 71 infection in children with hand, foot, and mouth disease in Shanghai, China: epidemiology, clinical feature and diagnosis. Virology Journal 12: 83, 2016

Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China. Human Vaccines and Immunotherapeutics 2019, 2019