Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2) -knock out mice: unexpected adaptive changes of fast-twitch muscles only
Valle, G.; Vergani, B.; Sacchetto, R.; Reggiani, C.; De Rosa, E.; Maccatrozzo, L.; Nori, A.; Villa, A.; Volpe, P.
Journal of Muscle Research and Cell Motility 37(6): 225-233
ISSN/ISBN: 1573-2657 PMID: 28130614 DOI: 10.1007/s10974-016-9463-3
This study investigates the functional role of calsequestrin 2 (CASQ2) in both fast-twitch and slow-twitch skeletal muscles by using CASQ2-/- mice; CASQ2 is expressed throughout life in slow-twitch muscles, but only in the developmental and neonatal stages in fast-twitch muscles. CASQ2-/- causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types. CASQ2-/- mice have ultrastructural changes in fast-twitch muscles only, i.e., formation of pentads and stacks in the sarcoplasmic reticulum.