Section 60
Chapter 59,491

Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2) -knock out mice: unexpected adaptive changes of fast-twitch muscles only

Valle, G.; Vergani, B.; Sacchetto, R.; Reggiani, C.; De Rosa, E.; Maccatrozzo, L.; Nori, A.; Villa, A.; Volpe, P.

Journal of Muscle Research and Cell Motility 37(6): 225-233


ISSN/ISBN: 1573-2657
PMID: 28130614
DOI: 10.1007/s10974-016-9463-3
Accession: 059490025

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This study investigates the functional role of calsequestrin 2 (CASQ2) in both fast-twitch and slow-twitch skeletal muscles by using CASQ2-/- mice; CASQ2 is expressed throughout life in slow-twitch muscles, but only in the developmental and neonatal stages in fast-twitch muscles. CASQ2-/- causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types. CASQ2-/- mice have ultrastructural changes in fast-twitch muscles only, i.e., formation of pentads and stacks in the sarcoplasmic reticulum.

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