+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chronic social instability increases anxiety-like behavior and ethanol preference in male Long Evans rats



Chronic social instability increases anxiety-like behavior and ethanol preference in male Long Evans rats



Physiology and Behavior 173: 179-187



Chronic stress during adolescence is related to increased prevalence of anxiety disorders and alcohol use disorders in humans. This phenotype has been consistently recapitulated in animal models with male subjects, but models using female subjects are fewer. The aim of these studies was to test the hypothesis that chronic social instability (CSI) during adolescence engenders increased anxiety-like behavior, increased corticosterone, and greater ethanol intake and/or preference than control groups in male and female rats. A chronic social instability (CSI) procedure was conducted in separate cohorts of female and male adolescent Long Evans rats. CSI included daily social isolation for 1h, and then pair housing with a novel cage mate for 23h until the next 1h isolation period from PND 30-46. Control groups included social stability (SS), chronic isolation (ISO), and acute social instability (aSI). At PND 49-50, anxiety-like behavior was assessed on the elevated plus maze, and on PND 51 tails bloods were obtained for determination of corticosterone (CORT) levels. This was followed by 4weeks of ethanol drinking in a home cage intermittent access ethanol drinking paradigm (PND 55-81 for males, PND 57-83 for females). Planned contrast testing showed that the male CSI group had greater anxiety-like behavior compared controls, but group differences were not apparent for CORT. CSI males had significantly higher levels of ethanol preference during drinking weeks 2-3 compared to all other groups and compared to SS and ISO groups in week 4. For the female cohort, we did not observe consistent group differences in anxiety-like behavior, CORT levels were unexpectedly lower in the ISO group only compared to the other groups, and group differences were not apparent for ethanol intake/preference. In conclusion, chronic stress during adolescence in the form of social instability increases anxiety-like behavior and ethanol preference in male rats, consistent with other models of chronic stress during adolescence. Conversely, and contrary to our hypothesis, female rats' anxiety-like behavior, CORT level, and ethanol intake/preference were not altered by CSI. New paradigms must continue to be explored for study of clinically relevant relationships in female preclinical models.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059500845

Download citation: RISBibTeXText

PMID: 28202350

DOI: 10.1016/j.physbeh.2017.02.010


Related references

Social instability stress in adolescence increases anxiety and reduces social interactions in adulthood in male Long-Evans rats. Developmental Psychobiology 55(8): 849-859, 2013

Adolescent social isolation does not lead to persistent increases in anxiety- like behavior or ethanol intake in female long-evans rats. Alcoholism Clinical and Experimental Research 38(8): 2199-2207, 2014

Ethanol conditioned place preference in male Long Evans rats effect of social stress. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 292 10, 2003

Adolescent social instability stress increases aggression in a food competition task in adult male Long-Evans rats. Developmental Psychobiology 56(7): 1575-1588, 2014

Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Alcoholism Clinical and Experimental Research 37(Suppl. 1): E394-E403, 2013

Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long-Evans rats. Pharmacology Biochemistry and Behavior 139(Pt A): 67-76, 2015

Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment. Psychopharmacology 158(4): 366-373, 2001

Chronic ethanol treatment increases taurine content in striatum of Long Evans rats. Alcoholism Clinical & Experimental Research 23(5 Suppl. ): 97A, 1999

Impulsive choice predicts anxiety-like behavior, but not alcohol or sucrose consumption, in male Long-Evans rats. Alcoholism Clinical and Experimental Research 39(5): 932-940, 2015

Orbital prefrontal cortex dopamine and social agonistic behavior of male long evans rats. Aggressive Behavior 16(3-4): 231-248, 1990

Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration. Alcoholism Clinical and Experimental Research 33(2): 273-282, 2009

Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake. Alcoholism Clinical and Experimental Research 35(8): 1392-1403, 2011

Patterns of Toxoplasma gondii cyst distribution in the forebrain associate with individual variation in predator odor avoidance and anxiety-related behavior in male Long-Evans rats. Brain Behavior and Immunity 37: 122-133, 2014

Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats. Alcoholism Clinical and Experimental Research 32(12): 2088-2099, 2008

Minimal exposure to ethanol increases ethanol preference in Maudsley reactive male rats. Alcohol 29(3): 149-156, 2003