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Chapter 59,513

Clonal deletion of T cell repertoires with specific T cell receptor Vβ chains by two endogenous superantigens in NC/Nga mice

Ohkusu-Tsukada, K.; Tsukada, T.; Takahashi, K.

Bioscience Biotechnology and Biochemistry 81(11): 2160-2163

2017

ISSN/ISBN: 0916-8451
PMID: 28934904
DOI: 10.1080/09168451.2017.1374829
Accession: 059512771
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Superantigens (SAgs) are powerful T-cell stimulatory proteins. Because an atopic dermatitis (AD) model NC/Nga mice had two endogenous SAgs, namely minor lymphocyte-stimulating locus-1a (Mls-1a) and mouse mammary tumor virus (MMTV)(SHN), SAg-responsive T-cells bearing Vβ5.1, Vβ6, Vβ8.1, Vβ8.2, Vβ8.3, Vβ9, and Vβ11 should be endogenously deleted. Here, we discuss that the endogenous SAgs-expression may be involved in AD-sensitivity in NC/Nga mice.

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