+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effectiveness of annual single doses of diethylcarbamazine citrate among bancroftian filariasis infected individuals in an endemic area under mass drug administration in Brazil



Effectiveness of annual single doses of diethylcarbamazine citrate among bancroftian filariasis infected individuals in an endemic area under mass drug administration in Brazil



Pathogens and Global Health 112(5): 274-280



The Global Program to Eliminate Lymphatic Filariasis has achieved extraordinary success in reducing transmission and preventing morbidity through mass drug administration (MDA) to the population at-risk. Brazil is the only currently using diethylcarbamazine citrate (DEC) alone for MDA, so an assessment of its effectiveness is needed. We report the trends of filarial markers in a cohort of 175 individuals infected with Wuchereria bancrofti in areas that underwent MDA in the city of Olinda, Northeastern Brazil. The prospective study was conducted between 2007 and 2012 (corresponding to five annual MDA rounds). The quantification of microfilaraemia (QMFF) was assessed by filtration. Circulating filarial antigen (CFA) was detected through immunochromatographic point-of-care test (POCT-ICT) and Og4C3-ELISA whereas antifilarial antibody titres (IgG4) were assessed through Bm14 assay. The CFA and IgG4 titres were measured by Optical Density (OD). The main characteristics at baseline, MDA coverage and the trend of filarial infection markers during follow up were described. The trend of filarial markers in relation to time (years of MDA), sex and age were analysed through Generalized Estimating Equations (GEE) models. The models demonstrated a significant decrease in all markers during MDA. The probability of remaining positive by QMFF and POCT-ICT diminished 70% and 46%, respectively, after each MDA round. There was a significant annual drop in CFA (-0.290 OD) and IgG4 antibodies titres (-0.303 OD). This study provides evidence that MDA with DEC alone can be effective in the elimination of LF in Brazil.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059558816

Download citation: RISBibTeXText

PMID: 30111259

DOI: 10.1080/20477724.2018.1498821


Related references

Tolerance of diethylcarbamazine by microfilaraemic and amicrofilaraemic individuals in an endemic area of Bancroftian filariasis, Recife, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 88(2): 232-236, 1994

Effectiveness of spaced doses of diethylcarbamazine citrate for the control of bancroftian filariasis. Tropical Medicine and Parasitology 40(2): 111-113, 1989

The efficacy of annual single-dose treatment with diethylcarbamazine citrate against diurnally subperiodic bancroftian filariasis in Samoa. Bulletin of the World Health Organization 63(6): 1097-1106, 1985

Adverse reactions following mass drug administration with diethylcarbamazine in lymphatic filariasis endemic areas in the Northeast of Brazil. Revista Da Sociedade Brasileira de Medicina Tropical 45(6): 745-750, 2012

Adverse reactions following mass drug administration with diethylcarbamazine in lymphatic filariasis endemic areas in the Northeast of Brazil. Revista da Sociedade Brasileira de Medicina Tropical 45(6): 745-750, 2012

Bancroftian filariasis in coastal north Trinidad: the effects of mass chemotherapy using spaced doses of diethylcarbamazine citrate on human microfilaraemias and vector infection rates. Transactions of the Royal Society of Tropical Medicine and Hygiene 81(4): 663-668, 1987

Effect of annual mass administration of diethylcarbamazine and albendazole on bancroftian filariasis in five villages in south India. Transactions of the Royal Society of Tropical Medicine and Hygiene 105(8): 431-437, 2011

The impact of mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt. American Journal of Tropical Medicine & Hygiene 69(3 Suppl.): 270-271, 2003

Studies on the epidemiology and control of filariasis. III. Mass treatment with diethylcarbamazine in endemic areas of bancroftian filariasis.. Endemic Diseases Bulletin of Nagasaki University. 3: 4, 289-298, 1961

Diethylcarbamazine in the control of bancroftian filariasis in the Ok Tedi area of Papua New Guinea: phase 2--annual single-dose treatment. Papua and New Guinea Medical Journal 37(2): 65-81, 1994

Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt: a comprehensive assessment. Lancet 367(9515): 992-999, 2006

Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt: a comprehensive assessment. Yearbook of Dermatology and Dermatologic Surgery 2007: 165-166, 2007

The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea. Plos Neglected Tropical Diseases 2(12): E344-E344, 2008

Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments. Transactions of the Royal Society of Tropical Medicine and Hygiene 90(1): 69-73, 1996

Effectiveness of two annual, single-dose mass drug administrations of diethylcarbamazine alone or in combination with albendazole on soil-transmitted helminthiasis in filariasis elimination programme. Tropical Medicine & International Health 9(9): 1030-1035, 2004