+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease

Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease

Basic and Clinical Pharmacology and Toxicology 122(1): 65-73

Chronic kidney disease (CKD) is known to involve inflammation, oxidative stress and apoptosis. Here, we investigated the impact of curcumin (diferuloyl methane, a phenolic turmeric pigment), which has strong antioxidant, anti-inflammatory and anti-apoptotic activities on kidney structure and function in rats with adenine-induced CKD. Rats were treated for 5 weeks with adenine to induce CKD-like renal damage and combined with three doses of curcumin. Markers of kidney function and oxidative stress were quantified in plasma, urine, renal homogenates and on kidney tissue. Curcumin was found to significantly abate adenine-induced toxic effects such as reduced creatinine clearance, elevated neutrophil gelatinase-associated lipocalin levels and raised urinary N-acetyl-β-D-glucosaminidase activities. Curcumin markedly reduced renal morphological damage and histopathological markers of inflammation, fibrosis and apoptosis. Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1β, IL-6 and TNF-α, cystatin C and adiponectin. It restored plasma sclerostin concentrations and lowered oxidative stress in renal homogenates. In animals treated with the two higher curcumin concentrations, alone or in combination with adenine, an increased expression of the antioxidative transcription factor Nrf2 was found as well as up-regulation of the activity of its direct target glutathione reductase, and of an indirect target, the glutathione level. In conclusion, curcumin exhibits salutary effects against adenine-induced CKD in rats by reducing inflammation and oxidative stress via up-regulation of the transcription factor Nrf2.

(PDF emailed within 0-6 h: $19.90)

Accession: 059569146

Download citation: RISBibTeXText

PMID: 28561324

DOI: 10.1111/bcpt.12817

Related references

High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease. Clinical and Experimental Nephrology 14(6): 536-547, 2011

Indoxyl sulfate-lowering capacity of oral sorbents affects the prognosis of kidney function and oxidative stress in chronic kidney disease. Journal of Renal Nutrition 17(1): 48-52, 2007

Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats with Adenine-Induced Chronic Kidney Disease. Cellular Physiology and Biochemistry 45(6): 2293-2304, 2018

High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease. Plos One 9(12): E114881, 2015

AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress. Nephrology, Dialysis, Transplantation 30(6): 934-942, 2015

Endothelial function, CRP and oxidative stress in chronic kidney disease. Journal of Nephrology 18(6): 721-726, 2005

Phyllanthus niruri leaves aqueous extract improves kidney functions, ameliorates kidney oxidative stress, inflammation, fibrosis and apoptosis and enhances kidney cell proliferation in adult male rats with diabetes mellitus. Journal of Ethnopharmacology 205: 123-137, 2017

Chronic kidney disease influences multiple systems: describing the relationship between oxidative stress, inflammation, kidney damage, and concomitant disease. Oxidative Medicine and Cellular Longevity 2015: 806358, 2015

Chronic kidney disease, kidney transplantation and oxidative stress: a new look to successful kidney transplantation. Clinical Kidney Journal 11(1): 130-135, 2018

The antioxidant tempol ameliorates arterial medial calcification in uremic rats: important role of oxidative stress in the pathogenesis of vascular calcification in chronic kidney disease. Journal of Bone and Mineral Research 27(2): 474-485, 2012

Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury-Mediated Chronic Kidney Disease: Role of Oxidative Stress. Hypertension 69(5): 870-878, 2017

Endothelial function and oxidative stress in chronic kidney disease of varying severity and the effect of acute hemodialysis. Renal Failure 33(4): 411-417, 2011

Dioclea violacea lectin ameliorates oxidative stress and renal dysfunction in an experimental model of acute kidney injury. American Journal of Translational Research 7(12): 2573-2588, 2016

ACEI ramipril ameliorates circulating AGEs and oxidative stress in patients with non-diabetic kidney disease. Nephrology Dialysis Transplantation 17(Abstracts Supplement 1): 100, 2002

Better recovery of kidney function in patients with de novo chronic kidney disease after partial nephrectomy compared with those with pre-existing chronic kidney disease. International Journal of Urology 21(6): 613-616, 2015