EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

β-Cyclodextrin-based ternary complexes of haloperidol and organic acids: the effect of organic acids on the drug solubility enhancement


β-Cyclodextrin-based ternary complexes of haloperidol and organic acids: the effect of organic acids on the drug solubility enhancement



Pharmaceutical Development and Technology 23(7): 715-722



ISSN/ISBN: 1083-7450

PMID: 28627267

DOI: 10.1080/10837450.2017.1344993

Haloperidol (HALO) is a weak base with very low aqueous solubility that is used as an antipsychotic drug. This study aimed to improve its solubility by forming HALO/β-cyclodextrin (β-CD)-based ternary complexes with organic acids. The solubility of HALO/β-CD binary and HALO/β-CD/organic acid ternary complexes in different media (i.e. citrate buffer pH 3 and 6) was explored. The stoichiometric ratio between the drug and β-CD was 1:1 in all complexes formed. The solubility of HALO/β-CD binary complexes significantly increased in citrate buffer pH 3 compared with citrate buffer pH 6. For the ternary complexes, HALO/β-CD/tartaric acid and HALO/β-CD/lactic acid in citrate buffer pH 3 increased HALO solubility compared with HALO/β-CD/succinic acid due to their higher unionized species. The highest stability constant and complexation efficiency values in citrate buffer pH 3 were shown by the ternary complexes with lactic acid followed by tartaric acid and succinic acid, respectively. Results indicated that lactic acid provided the greatest binding strength and solubilization efficiency for the complex.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059572895

Download citation: RISBibTeXText

Related references

Theoretical and experimental investigations of organic acids/cyclodextrin complexes and their consequences upon the formation of miconazole/cyclodextrin/acid ternary inclusion complexes. International Journal of Pharmaceutics 347(1-2): 62-70, 2008

Cyclodextrin-Based Supramolecular Ternary Complexes: Emerging Role of Ternary Agents on Drug Solubility, Stability, and Bioavailability. Critical Reviews in Therapeutic Drug Carrier Systems 39(5): 1-50, 2022

Drug Solubility Enhancement through the Preparation of Multicomponent Organic Materials: Eutectics of Lovastatin with Carboxylic Acids. Pharmaceutics 11(3), 2019

Gradient elution of organic acids on a beta-cyclodextrin column in the polar organic mode and its application to drug discovery. Journal of Chromatography. a 1052(1-2): 69-75, 2004

The determination of organic acids contained in paddy soil. I. Silica-gel partition chromatography of organic acids and separation of organic acids by extracting with ether.. J. Sci. Soil Tokyo 28: 435-438, 1958

Evaluation of hygienic condition of egg products before pasteurisation by the pattern of organic acids Tricarboxylic acid cycle acids and related acids. I. A gas chromatographic method for simultaneous determination of the organic acids of the hens egg.1. Zeitschrift fur lebensmittel untersuchung und forschung 75(2): 101-105, 1982

The metabolism of organic acids in soils of paddy fields and their inhibitory effects on plant growth. 3. Absorption of organic acids by soils and the quantitative method of determining soil organic acids.. Soil Sci. & Plant Nutr, 7: 80, 1961

Ternary Inclusion Complexes of Rifaximin with β-Cyclodextrin and Sodium Deoxycholate for Solubility Enhancement. Current Drug Discovery Technologies 12(3): 179-189, 2015

Water solubility enhancement of some organic pollutants and pesticides by dissolved humic and fulvic acids. Environmental Science and Technology 20(5): 502-508, 1986

Formation of ternary organic acids-Fe-P complexes on the growth of wheat (Triticum aestivum). Revista Brasileira de Engenharia Agrícola e Ambiental 22(10): 702-706, 2018

Influence of pasture-based feeding systems on fatty acids, organic acids and volatile organic flavour compounds in yoghurt. Journal of Dairy Research 82(3): 279-286, 2015

Impact of different organic acids on solubility enhancement of cefpodxime proxetil immediate release tablet and its stability studies. Pakistan Journal of Pharmaceutical Sciences 30(3): 855-866, 2017

Preparation of mebendazole HP- beta -cyclodextrin complexes using water-soluble polymers and organic acids. STP Pharma Sciences 11(6): 439-442, 2001

Inclusion Complexes of Daidzein with Cyclodextrin-Based Metal-Organic Framework-1 Enhance its Solubility and Antioxidant Capacity. Aaps Pharmscitech 23(1): 2, 2021

Studies on biologically relevant ternary metal complexes part vi. stability of ternary cobalt ii nickel ii copper ii and zinc ii complexes involving aminopolycarboxylic acids and amino acids. Indian Journal of Chemistry Section A Inorganic Bio Inorganic Physical Theoretical and Analytical Chemistry 31(4): 256-259, 1992