+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4)

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4)

Plos one 12(8): E0183166

ISSN/ISBN: 1932-6203

PMID: 28806758

DOI: 10.1371/journal.pone.0183166

GPR116 (ADGRF5) and ELTD1 (ADGRL4) belong to different subfamilies of the adhesion G-protein-coupled receptor group but are both expressed in endothelial cells. We therefore analyzed their functions in mice lacking these receptors. While loss of GPR116 or ELTD1 alone had no obvious effect on cardiovascular or kidney function, mice lacking both, GPR116 and ELTD1, showed malformations of the aortic arch arteries and the cardiac outflow tract leading to perinatal lethality in about 50% of the mutants. In addition to cardiovascular malformations, surviving mice developed renal thrombotic microangiopathy as well as hemolysis and splenomegaly, and their lifespan was significantly reduced. Loss of GPR116 and ELTD1 specifically in endothelial cells or neural crest-derived cells did not recapitulate any of the phenotypes observed in GPR116-ELTD1 double deficient mice, indicating that loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 059595863

Download citation: RISBibTeXText

Related references

Evidence for vascular remodeling in mice lacking angiotensin AT2-receptors. Naunyn-Schmiedeberg's Archives of Pharmacology 357(4): R79, 1998

Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase. Journal of Pharmacology and Experimental Therapeutics 293(3): 896-902, 2000

Vascular remodeling in mice lacking the cytoplasmic domain of tissue factor. Circulation Research 97(3): 293-298, 2005

Postnatal growth failure in mice lacking GDNF family receptor GFRalpha2. Society for Neuroscience Abstracts 24(1-2): 296, 1998

Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Molecular and Cellular Biology 22(4): 1233-1245, 2002

Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382(6586): 73-76, 1996

Accentuated vascular proliferation and altered remodeling after injury in mice lacking angiotensin II type 2 receptor. Circulation 96(8): I547-I548, 10-21/97, 1997

Increased arterial blood pressure and vascular remodeling in mice lacking salt-inducible kinase 1 (SIK1). Circulation Research 116(4): 642-652, 2015

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Human Molecular Genetics 8(5): 723-730, 1999

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367(6461): 380-383, 1994

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 377(6551): 695-701, 1995

Kidney failure in mice lacking the tetraspanin CD151. Journal of Cell Biology 175(1): 33-39, 2006

Kidney Failure in Mice Lacking the Tetraspanin Cd151. The Journal of Cell Biology 175(1): 33-39, 2006

Severe Hypomyelination and Developmental Defects Are Caused in Mice Lacking Protein Arginine Methyltransferase 1 (PRMT1) in the Central Nervous System. Journal of Biological Chemistry 291(5): 2237-2245, 2016

Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation 106(7): 873-879, 2002