+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population

Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population

Bmc Cardiovascular Disorders 17(1): 264

Familial hypercholesterolaemia (FH) is a genetic disorder with a high risk of developing premature coronary artery disease that should be diagnosed as early as possible. Several clinical diagnostic criteria for FH are available, with the Dutch Lipid Clinic Criteria (DLCC) being widely used. Information regarding diagnostic performances of the other criteria against the DLCC is scarce. We aimed to examine the diagnostic performance of the Simon-Broom (SB) Register criteria, the US Make Early Diagnosis to Prevent Early Deaths (US MEDPED) and the Japanese FH Management Criteria (JFHMC) compared to the DLCC. Seven hundered fifty five individuals from specialist clinics and community health screenings with LDL-c level ≥ 4.0 mmol/L were selected and diagnosed as FH using the DLCC, the SB Register criteria, the US MEDPED and the JFHMC. The sensitivity, specificity, efficiency, positive and negative predictive values of individuals screened with the SB register criteria, US MEDPED and JFHMC were assessed against the DLCC. We found the SB register criteria identified more individuals with FH compared to the US MEDPED and the JFHMC (212 vs. 105 vs. 195; p < 0.001) when assessed against the DLCC. The SB Register criteria, the US MEDPED and the JFHMC had low sensitivity (51.1% vs. 25.3% vs. 47.0% respectively). The SB Register criteria showed better diagnostic performance than the other criteria with 98.8% specificity, 28.6% efficiency value, 98.1% and 62.3% for positive and negative predictive values respectively. The SB Register criteria appears to be more useful in identifying positive cases leading to genetic testing compared to the JFHMC and US MEDPED in this Asian population. However, further research looking into a suitable diagnosis criterion with high likelihood of positive genetic findings is required in the Asian population including in Malaysia.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 059604761

Download citation: RISBibTeXText

PMID: 29037163

DOI: 10.1186/s12872-017-0694-z

Related references

Diagnostic performance of various familial hypercholesterolaemia criteria compared to the Dutch lipid clinic criteria in an Asian population. Atherosclerosis 252: E27-E28, 2016

Molecular-based diagnostic criteria of familial hypercholesterolaemia in children with dominantly-inherited hypercholesterolaemia. Clinical Nutrition 19(Suppl. 1): 48-49, 2000

Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population. Dementia and Geriatric Cognitive Disorders 25(2): 157-164, 2008

Comparing Symptoms of Autism Spectrum Disorders in a Developmentally Disabled Adult Population Using the Current DSM-IV-TR Diagnostic Criteria and the Proposed DSM-5 Diagnostic Criteria. Journal of Developmental and Physical Disabilities 24(4): 403-414, 2012

Diagnostic performance of the ACR/EULAR 2010 criteria for rheumatoid arthritis and two diagnostic algorithms in an early arthritis clinic (REACH). Annals of the Rheumatic Diseases 70(9): 1645-1647, 2011

Performance of PML diagnostic criteria in natalizumab-associated PML: data from the Dutch-Belgian cohort. Journal of Neurology Neurosurgery and Psychiatry 90(1): 44-46, 2019

The accuracy of new diagnostic criteria for the Eosinophilia Myalgia Syndrome compared to the original CDC surveillance criteria. Arthritis & Rheumatism 40(9 Suppl. ): S147, 1997

Dutch Lipid Clinic Network low-density lipoprotein cholesterol criteria are associated with long-term mortality in the general population. Archives of Cardiovascular Diseases 108(10): 511-518, 2015

Prevalence of undiagnosed diabetes in Asian Indian population Evaluation of the new diagnostic criteria. Diabetes Research & Clinical Practice 50(Suppl 1): S127, 2000

Accuracy of new diagnostic criteria for familial hypertrophic cardiomyopathy in a genotyped population. European Heart Journal 22(Abstract Suppl.): 408, 2001

International Consensus Diagnostic Criteria for Autoimmune Pancreatitis and Its Japanese Amendment Have Improved Diagnostic Ability over Existing Criteria. Gastroenterology Research and Practice 2013: 456965-456965, 2013

Diagnostic criteria as dysfunction indicators: bridging the chasm between the definition of mental disorder and diagnostic criteria for specific disorders. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie 58(12): 663-669, 2013

The diagnostic criteria of pityriasis rosea and Gianotti-Crosti syndrome - a protocol to establish diagnostic criteria of skin diseases. Journal of the Royal College of Physicians of Edinburgh 45(3): 218-225, 2015

External validation of IASP diagnostic criteria for Complex Regional Pain Syndrome and proposed research diagnostic criteria. Pain 81(1-2): 147-154, 1999

Intra-alveolar microlithiasis of the lung. Diagnostic and differential diagnostic criteria in 2 familial cases observed. Revista Brasileira de Biologia 26(4): 1465-1476, 1966