Section 60

EurekaMag Full Text Articles Chapter 59,616


Pennings, G. 2017: Disclosure of donor conception, age of disclosure and the well-being of donor offspring. Human Reproduction 32(5): 969-973
Nielsen, L.Moeldrup.; Maribo, T.; Kirkegaard, H.; Petersen, K.Schultz.; Lisby, M.; Oestergaard, L.Gregersen. 2018: Effectiveness of the "Elderly Activity Performance Intervention" on elderly patients' discharge from a short-stay unit at the emergency department: a quasi-experimental trial. Clinical Interventions in Aging 13: 737-747
Anonymous 2004: Disclosure of errors preferred by patients. Journal of Family Practice 53(7): 525-526
Luce, E.A.; Jackman, C.A. 2017: Disclosure of Financial Conflicts of Interest in Plastic and Reconstructive Surgery. Plastic and Reconstructive Surgery 140(3): 635-639
Lucassen, A.; Gilbar, R. 2018: Disclosure of genetic information to relatives: balancing confidentiality and relatives' interests. Journal of Medical Genetics 55(4): 285-286
Akilimali, P.Zalagile.; Musumari, P.Masika.; Kashala-Abotnes, Eérance.; Kayembe, P.Kalambayi.; Lepira, Fçois.B.; Mutombo, P.Beya.; Tylleskar, T.; Ali, M.Mala. 2017: Disclosure of HIV status and its impact on the loss in the follow-up of HIV-infected patients on potent anti-retroviral therapy programs in a (post-) conflict setting: A retrospective cohort study from Goma, Democratic Republic of Congo. Plos one 12(2): E0171407
Ekstrand, M.L.; Heylen, E.; Mehta, K.; Sanjeeva, G.N.; Shet, A. 2018: Disclosure of HIV Status to Infected Children in South India: Perspectives of Caregivers. Journal of Tropical Pediatrics 64(4): 342-347
Malanca, A.; Foradori, I.; Stankievich, E.; Pandullo, H.; Losso, M. 2017: Disclosure of human immunodeficiency virus diagnosis in children and adolescents affected by it and their caregivers. Archivos Argentinos de Pediatria 115(2): 195-199
Qian, J.; Hansen, R.A.; Surry, D.; Howard, J.; Kiptanui, Z.; Harris, I. 2017: Disclosure of industry payments to prescribers: industry payments might be a factor impacting generic drug prescribing. Pharmacoepidemiology and Drug Safety 26(7): 819-826
Gooderham, P. 2005: Disclosure of medical error. Journal of the Royal Society of Medicine 98(9): 437; Author Reply 437
Crossley, K. 2004: A negative result on the Ottawa knee rules excludes fracture in patients with acute knee injury. Australian Journal of PhysioTherapy 50(2): 116
Anonymous 2017: Disclosure of Medical Errors. Annals of Emergency Medicine 70(1): 121-122
Anonymous 2006: Disclosure of medical errors involving gametes and embryos. Fertility and Sterility 86(3): 513-515
Reavley, N.J.; Morgan, A.J.; Jorm, A.F. 2018: Disclosure of mental health problems: findings from an Australian national survey. Epidemiology and Psychiatric Sciences 27(4): 346-356
Crosby, R.A.; Mena, L.; Arnold, T. 2017: Disclosure of newly diagnosed HIV infection and condom use at first sex after diagnosis: a study of young Black men who have sex with men. Sexual Health 14(4): 325-330
Casla, K.; Roderick, P.; Pollock, A.M. 2017: Disclosure of patients' data to the UK Home Office must stop. Bmj 358: J3613
Sparks, J.A.; Iversen, M.D.; Yu, Z.; Triedman, N.A.; Prado, M.G.; Miller Kroouze, R.; Kalia, S.S.; Atkinson, M.L.; Mody, E.A.; Helfgott, S.M.; Todd, D.J.; Dellaripa, P.F.; Bermas, B.L.; Costenbader, K.H.; Deane, K.D.; Lu, B.; Green, R.C.; Karlson, E.W. 2018: Disclosure of Personalized Rheumatoid Arthritis Risk Using Genetics, Biomarkers, and Lifestyle Factors to Motivate Health Behavior Improvements: a Randomized Controlled Trial. Arthritis Care and Research 70(6): 823-833
Tang, W.; Mao, J.; Tang, S.; Liu, C.; Mollan, K.; Cao, B.; Wong, T.; Zhang, Y.; Hudgens, M.; Qin, Y.; Han, L.; Ma, B.; Yang, B.; Ma, W.; Wei, C.; Tucker, J.D.; Hightow-Weidman, L.; Bayus, B.; Terris-Prestholt, F.; Yang, L.; Peeling, R.; Fenton, K.; Huang, S.; Wang, C.; Zheng, H.; Vickerman, P.; Mitchell, K.M.; Cheng, Z.; Best, J.; Tangthanasup, T.May.; Wong, N.Sze.; Tso, L.Sze.; Zhang, W.; Li, H. 2017: Disclosure of sexual orientation to health professionals in China: results from an online cross-sectional study. Journal of the International Aids Society 20(1): 21416
Johny, A.Kelak.; Cheah, W.Lian.; Razitasham, S. 2017: Disclosure of Traditional and Complementary Medicine Use and Its Associated Factors to Medical Doctor in Primary Care Clinics in Kuching Division, Sarawak, Malaysia. Evidence-BasedComplementaryandAlternativeMedicine:Ecam 2017: 5146478
Broekema, K.; Weber, K.M. 2017: Disclosures of Cystic Fibrosis-Related Information to Romantic Partners. Qualitative Health Research 27(10): 1575-1585
Pollitt, A.M.; Muraco, J.A.; Grossman, A.H.; Russell, S.T. 2017: Disclosure Stress, Social Support, and Depressive Symptoms Among Cisgender Bisexual Youth. Journal of Marriage and the Family 79(5): 1278-1294
Thumati, P.; Kerstein, R.B.; Thumati, R.P. 2017: Disclusion time reduction therapy in treating occluso-muscular pains. Journal of Indian Prosthodontic Society 17(1): 95-98
Nosala, C.; Hagen, K.D.; Dawson, S.C. 2018: 'Disc-o-Fever': Getting down with Giardia's Groovy Microtubule Organelle. Trends in Cell Biology 28(2): 99-112
Rozen, D. 2001: Discogenic low back pain. Pain Practice: the Official Journal of World Institute of Pain 1(3): 278-286; Quiz: 287-288
Vagner, E.A.; Denisov, A.S.; Krivoshchekov, V.D.; Ladeĭshchikov, V.M.; Matveev, A.T. 1994: Discogenic lumbosacral radiculitis. Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 1: 29-30
Dhillon, R.S.; Smith, P.D. 2018: Diskogenic Reactivation of Herpes Zoster. World Neurosurgery 109: 138-139
Fairbank, J.C.; Deans, W. 1990: Discography. Spine 15(8): 839-840
Takano, M.; Hikata, T.; Nishimura, S.; Kamata, M. 2017: Discography aids definitive diagnosis of posterior epidural migration of lumbar disc fragments: case report and literature review. Bmc Musculoskeletal Disorders 18(1): 151
Guarino 1999: Discography: a Review. Current Review of Pain 3(6): 473-480
Thomson, S.A. 1946: Discoid Cartilage of the Knee. Canadian Medical Association Journal 54(6): 596-598
Kikuta, K.; Kubota, D.; Yoshida, A.; Qiao, Z.; Morioka, H.; Nakamura, M.; Matsumoto, M.; Chuman, H.; Kawai, A.; Kondo, T. 2017: Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) is a novel biomarker of myxofibrosarcoma invasion identified by global protein expression profiling. Biochimica et Biophysica Acta. Proteins and Proteomics 1865(9): 1160-1166
Xie, X.; Rui, W.; He, W.; Shao, Y.; Sun, F.; Zhou, W.; Wu, Y.; Zhu, Y. 2017: Discoidin domain receptor 1 activity drives an aggressive phenotype in bladder cancer. American Journal of Translational Research 9(5): 2500-2507
Hur, H.; Ham, I.-H.; Lee, D.; Jin, H.; Aguilera, K.Y.; Oh, H.J.; Han, S.-U.; Kwon, J.E.; Kim, Y.-B.; Ding, K.; Brekken, R.A. 2017: Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma. Bmc Cancer 17(1): 87
Coelho, N.M.; Arora, P.D.; van Putten, S.; Boo, S.; Petrovic, P.; Lin, A.X.; Hinz, B.; McCulloch, C.A. 2017: Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction. Cell Reports 18(7): 1774-1790
Majkowska, I.; Shitomi, Y.; Ito, N.; Gray, N.S.; Itoh, Y. 2017: Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. Journal of Biological Chemistry 292(16): 6633-6643
Hebron, M.; Peyton, M.; Liu, X.; Gao, X.; Wang, R.; Lonskaya, I.; Moussa, C.E.-H. 2017: Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models. Journal of Neuroimmunology 311: 1-9
Sohn, D.-W.; Bin, S.-I.; Kim, J.-M.; Lee, B.-S.; Kim, S.-J. 2018: Discoid lateral meniscus can be overlooked by magnetic resonance imaging in patients with meniscal tears. Knee Surgery Sports Traumatology Arthroscopy: Official Journal of the Esska 26(8): 2317-2323
Kocher, M.S.; Logan, C.A.; Kramer, D.E. 2017: Discoid Lateral Meniscus in Children: Diagnosis, Management, and Outcomes. Journal of the American Academy of Orthopaedic Surgeons 25(11): 736-743
Two, A.; So, J.Kim.; Paravar, T. 2017: Discoid Lupus and Human Immunodeficiency Virus: A Retrospective Chart Review to Determine the Prevalence and Progression of Co-occurrence of these Conditions at a Single Academic Center. Indian Journal of Dermatology 62(2): 226
Sehgal, V.N.; Bharija, S.C. 1981: Discoid Lupus Erythematosus and Adenocarcinoma Palate. Indian Journal of Dermatology Venereology and Leprology 47(2): 123-124
Takada, H.; Kimura, N.; Yoshihashi-Nakazato, Y.; Kawahata, K.; Kohsaka, H. 2017: Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome. Internal Medicine 56(12): 1581-1583
Pavithran, K. 1983: Discoid Lupus Erythematosus in Red Tattoo. Indian Journal of Dermatology Venereology and Leprology 49(2): 82-84
Donzis, P.B.; Insler, M.S.; Buntin, D.M.; Gately, L.E. 1984: Discoid lupus erythematosus involving the eyelids. American Journal of Ophthalmology 98(1): 32-36
Hirbod, T.; Altamura, D.; Arkoumani, E.; Stefanato, C.M.; Verdolini, R. 2017: Discoid lupus erythematosus occurring in an area previously affected by herpes zoster virus: Wolf's isotopic reaction?. European Journal of Dermatology: Ejd 27(2): 186-187
Pavithran, K. 1988: Discoid Lupus Erythematosus on a Pre-exi Patch of Chronic Radiodermatitis. Indian Journal of Dermatology Venereology and Leprology 54(5): 266-267
Darjani, A.; Rafiei, R.; Mesbah, A.; Golmohammadi, R.; Rafiee, B.; Movaseghi, M. 2017: Discoid Lupus Erythematosus Presenting as Upper Eyelid Edema and Erythema. Acta Medica Iranica 55(7): 474-476
Das, K.B.; Mishra, S.; Haque, S.M. 1982: Discoid Lupus Erythematosus Resembling Lupus Vulgaris. Indian Journal of Dermatology Venereology and Leprology 48(5): 274-275
Senderey, E.; Patel, S. 2017: Discoid lupus erythematosus: when a superficial injury is a red herring of underlying disease. BMJ Case Reports
Resnick, D.; Goergen, T.G.; Kaye, J.J.; Ghelman, B.; Woody, P.R. 1976: Discoid medial meniscus. Radiology 121(3 Pt. 1): 575-576
Song, I.Soo.; Kim, J.Bum.; Lee, J.Keun.; Park, B-Seop. 2017: Discoid Medial Meniscus Tear, with a Literature Review of Treatments. Knee Surgery and Related Research 29(3): 237-242
Stuparich, M.A.; Lee, T.T.M. 2018: Discoid Resection of Rectosigmoid Endometriotic Nodules. Journal of Minimally Invasive Gynecology 25(3): 388
Liao, C.-H.; Chen, C.-N. 2017: Discoid Skin Rash in a Preterm Infant. Journal of Pediatrics 183: 199
Nitta, Y.; Sugie, A. 2017: DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body. Biochemical and Biophysical Research Communications 487(1): 116-121
Nakhaei, S.; Agahi, R.H.; Aminian, A.; Rezaeizadeh, M. 2017: Discoloration and force degradation of orthodontic elastomeric ligatures. Dental Press Journal of Orthodontics 22(2): 45-54
Baglar, S.; Keskin, E.; Orun, T.; Es, A. 2017: Discoloration Effects of Traditional Turkish Beverages on different Composite Restoratives. Journal of Contemporary Dental Practice 18(2): 83-93
Ceci, M.; Viola, M.; Rattalino, D.; Beltrami, R.; Colombo, M.; Poggio, C. 2017: Discoloration of different esthetic restorative materials: a spectrophotometric evaluation. European Journal of Dentistry 11(2): 149-156
Wheeler, M.C. 1947: Discoloration of the Eyelids from Prolonged use of Ointments Containing Mercury. Transactions of the American Ophthalmological Society 45: 74-80
Link, J. 1973: Discoloration of the teeth in alkaptonuria (ochronosis) and Parkinsonism. Chronicle 36(5): 130
Lauvahutanon, S.; Shiozawa, M.; Takahashi, H.; Iwasaki, N.; Oki, M.; Finger, W.J.; Arksornnukit, M. 2017: Discoloration of various CAD/CAM blocks after immersion in coffee. Restorative Dentistry and Endodontics 42(1): 9-18
Greval, S.D.S.; Bhattacharji, J.N.; Das, B.C. 1944: Discoloured Cholesterol and Wassermann Antigen: Decreased Fortifying Effect Restored by Recrystallization and Washing in Alcohol. Indian Medical Gazette 79(8): 356-357
Hayes, C.; Arkoumani, E.; Pandya, D.; Verdolini, R. 2017: Discoloured saggy skin in a 57-year-old woman. Clinical and Experimental Dermatology 42(4): 444-447
White, D.W.; Julien, K.C.; Jacob, H.; Campbell, P.M.; Buschang, P.H. 2017: Discomfort associated with Invisalign and traditional brackets: a randomized, prospective trial. Angle Orthodontist 87(6): 801-808
Minami, D.; Takigawa, N.; Kano, H.; Ninomiya, T.; Kubo, T.; Ichihara, E.; Ohashi, K.; Sato, A.; Hotta, K.; Tabata, M.; Tanimoto, M.; Kiura, K. 2017: Discomfort during bronchoscopy performed after endobronchial intubation with fentanyl and midazolam: a prospective study. Japanese Journal of Clinical Oncology 47(5): 434-437
Čirgić, E.; Kjellberg, H.; Hansen, K. 2017: Discomfort, expectations, and experiences during treatment of large overjet with Andresen Activator or Prefabricated Functional Appliance: a questionnaire survey. Acta Odontologica Scandinavica 75(3): 166-172
Stanner, J.; Klum, M.; Parvini, P.; Zuhr, O.; Nickles, K.; Eickholz, P. 2017: Discomfort/pain due to periodontal and peri-implant probing: Implant type and age. Journal of Clinical Periodontology 44(7): 749-755
Da Silva Paiva, T.; Küppers, G.C.; Lahr, D.J.é G.; Schweikert, M.; da Silva-Neto, I.ác.D. 2017: Discomorphella pedroeneasi sp. nov. (Ciliophora, Odontostomatida): An anaerobic ciliate hosting multiple cytoplasmic and macronuclear endocytobionts. European Journal of Protistology 58: 103-134
Wolffenbuttel, E. 1957: Disconnect. Revista Brasileira de Medicina 14(9): 661-662
Veazey, K.J.; Wang, H.; Bedi, Y.S.; Skiles, W.M.; Chang, R.C.-A.; Golding, M.C. 2017: Disconnect between alcohol-induced alterations in chromatin structure and gene transcription in a mouse embryonic stem cell model of exposure. Alcohol 60: 121-133
Quesenberry, P.J.; Stewart, F.M. 1995: Disconnected. Experimental Hematology 23(13): 1329-1330
Levine, K.A.; Proulx, J.; Schwartz, K. 2018: Disconnected lives: Women with intellectual disabilities in conflict with the law. Journal of Applied Research in Intellectual Disabilities: Jarid 31(2): 249-258
Sussman, D.M.; Schoenholz, S.S.; Cubuk, E.D.; Liu, A.J. 2017: Disconnecting structure and dynamics in glassy thin films. Proceedings of the National Academy of Sciences of the United States of America 114(40): 10601-10605
Batista, S.; Alves, C.; d'Almeida, O.íl.C.; Afonso, A.; Félix-Morais, R.; Pereira, J.ão.; Macário, C.; Sousa, L.ív.; Castelo-Branco, M.; Santana, I.; Cunha, L.ís. 2017: Disconnection as a mechanism for social cognition impairment in multiple sclerosis. Neurology 89(1): 38-45
Mennella, R.; Leung, R.C.; Taylor, M.J.; Dunkley, B.T. 2017: Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces. Molecular Autism 8: 7
Alexander-Bloch, A.F. 2017: Disconnectionism in Biological Psychiatry. Biological Psychiatry 82(10): E75-E77
Nasser, H.M.; Lafferty, D.S.; Lesser, E.N.; Bacharach, S.Z.; Calu, D.J. 2018: Disconnection of basolateral amygdala and insular cortex disrupts conditioned approach in Pavlovian lever autoshaping. Neurobiology of Learning and Memory 147: 35-45
Stoub, T.R.; Chicharro, A.V.; Grote, C.L.; Kanner, A.M. 2019: Disconnection of hippocampal networks contributes to memory dysfunction in individuals with temporal lobe epilepsy. Hippocampus 29(5): 451-457
Heimer-McGinn, V.R.; Poeta, D.L.; Aghi, K.; Udawatta, M.; Burwell, R.D. 2017: Disconnection of the Perirhinal and Postrhinal Cortices Impairs Recognition of Objects in Context but not Contextual Fear Conditioning. Journal of Neuroscience: the Official Journal of the Society for Neuroscience 37(18): 4819-4829
Yuan, J.-L.; Wang, S.-K.; Guo, X.-J.; Teng, L.-L.; Jiang, H.; Gu, H.; Hu, W.-L. 2017: Disconnections of Cortico-Subcortical Pathways Related to Cognitive Impairment in Patients with Leukoaraiosis: a Preliminary Diffusion Tensor Imaging Study. European Neurology 78(1-2): 41-47
Danielpour, M.; von Koch, C.S.; Ojemann, S.G.; Peacock, W.J. 2001: Disconnective hemispherectomy. Pediatric Neurosurgery 35(4): 169-172
Ikuta, T.; Matsuo, K.; Harada, K.; Nakashima, M.; Hobara, T.; Higuchi, N.; Higuchi, F.; Otsuki, K.; Shibata, T.; Watanuki, T.; Matsubara, T.; Yamagata, H.; Watanabe, Y. 2017: Disconnectivity between Dorsal Raphe Nucleus and Posterior Cingulate Cortex in Later Life Depression. Frontiers in Aging Neuroscience 9: 236
Roddick, A.J.; Chan, F.T.S.; Stefaniak, J.D.; Zheng, S.L. 2017: Discontinuation and non-publication of clinical trials in cardiovascular medicine. International Journal of Cardiology 244: 309-315
Stefaniak, J.D.; Lam, T.C.H.; Sim, N.E.; Al-Shahi Salman, R.; Breen, D.P. 2017: Discontinuation and non-publication of neurodegenerative disease trials: a cross-sectional analysis. European Journal of Neurology 24(8): 1071-1076
Amstutz, A.; Schandelmaier, S.; Frei, R.; Surina, J.; Agarwal, A.; Olu, K.Kalu.; Alturki, R.; Von Niederhäusern, B.; Von Elm, E.; Briel, M. 2017: Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study. Bmj Open 7(7): E016216
Kane, J.A.; Kim, J.K.; Haidry, S.Abbas.; Salciccioli, L.; Lazar, J. 2017: Discontinuation/Dose Reduction of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers during Acute Decompensated Heart Failure in African-American Patients with Reduced Left-Ventricular Ejection Fraction. Cardiology 137(2): 121-125
Blanco-Silvente, L.íd.; Castells, X.; Saez, M.; Barceló, M.A.òn.; Garre-Olmo, J.; Vilalta-Franch, J.; Capellà, D. 2017: Discontinuation, Efficacy, and Safety of Cholinesterase Inhibitors for Alzheimer's Disease: a Meta-Analysis and Meta-Regression of 43 Randomized Clinical Trials Enrolling 16 106 Patients. International Journal of Neuropsychopharmacology 20(7): 519-528
Gesesew, H.A.; Ward, P.; Hajito, K.W.; Feyissa, G.T.; Mohammadi, L.; Mwanri, L. 2017: Discontinuation from Antiretroviral Therapy: a Continuing Challenge among Adults in HIV Care in Ethiopia: a Systematic Review and Meta-Analysis. Plos one 12(1): E0169651
Wang, J.; Qiao, Y.; Spivey, C.A.; Liu, X.; Phatak, H.; Mardekian, J.; Claflin, A.B.; Kachroo, S.; Abdulsatter, Y.; Parker, R.B. 2014: Discontinuation/Interruption of Warfarin Therapy in Patients with Non-Valvular Atrial Fibrillation. Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research 17(7): A763
Baldwin, K.C.; Ginsberg, P.C.; Harkaway, R.C. 2001: Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin for bladder outlet obstruction. Urologia Internationalis 66(2): 84-88
Lossius, M.I.; Alfstad, K.Å; Aaberg, K.M.; Nakken, K.O. 2017: Discontinuation of antiepileptic drugs in seizure-free patients - when and how?. Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 137(6): 451-454
Uesugi, H. 1990: Discontinuation of antiepileptic drug treatment in controlled seizure patients. Seishin Shinkeigaku Zasshi 92(6): 343-366
Hortwitz, G.J.; Tariot, P.N.; Mead, K.; Cox, C. 1995: Discontinuation of Antipsychotics in Nursing Home Patients with Dementia. American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry 3(4): 290-299
Sim, M. 2004: Discontinuation of benzodiazepines. Cmaj: Canadian Medical Association Journal 170(11): 1645-1646
Wolter, D.K. 2017: Discontinuation of benzodiazepines in old age : when and if so, how?. Zeitschrift für Gerontologie und Geriatrie 50(2): 115-122
Rubbert-Roth, A. 2011: Discontinuation of biologicals in rheumatoid arthritis after acquiring remission? Yes. Deutsche Medizinische Wochenschrift 136(33): 1674
Ben-Horin, S.; Mao, R.; Qiu, Y.; Chen, M. 2018: Discontinuation of Biological Treatments in Inflammatory Bowel Disease: a Concise Pragmatic Review. Journal of Clinical Gastroenterology 52(1): 6-12
Strand, V.; Miller, P.; Williams, S.A.; Saunders, K.; Grant, S.; Kremer, J. 2017: Discontinuation of Biologic Therapy in Rheumatoid Arthritis: Analysis from the Corrona RA Registry. Rheumatology and Therapy 4(2): 489-502
McKinnell, J.A.; Eells, S.J.; Clark, E.; Rand, D.D.; Kiet, G.T.; Macias-Gil, R.; Mendez, J.M.; Huang, S.S.; Milefchik, E.N.; Miller, L.G. 2017: Discontinuation of contact precautions with the introduction of universal daily chlorhexidine bathing. Epidemiology and Infection 145(12): 2575-2581
Park, H.J.; Park, N.C.; Kim, T.N.; Baek, S.R.; Lee, K.M.; Choe, S. 2017: Discontinuation of Dapoxetine Treatment in Patients with Premature Ejaculation: a 2-Year Prospective Observational Study. Sexual Medicine 5(2): E99
Tsourdi, E.; Langdahl, B.; Cohen-Solal, M.; Aubry-Rozier, Bérengere.; Eriksen, E.Fink.; Guañabens, N.; Obermayer-Pietsch, B.; Ralston, S.H.; Eastell, R.; Zillikens, M.Carola. 2017: Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS. Bone 105: 11-17
Fagius, J.; Feresiadou, A.; Larsson, E.-M.; Burman, J. 2017: Discontinuation of disease modifying treatments in middle aged multiple sclerosis patients. first line drugs vs natalizumab. Multiple Sclerosis and Related Disorders 12: 82-87
Ardissino, G.; Testa, S.; Possenti, I.; Tel, F.; Paglialonga, F.; Salardi, S.; Tedeschi, S.; Belingheri, M.; Cugno, M. 2014: Discontinuation of eculizumab maintenance treatment for atypical hemolytic uremic syndrome: a report of 10 cases. American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation 64(4): 633-637
Rogers, S.C.; Garcia, C.A.; Wu, S. 2017: Discontinuation of Everolimus Due to Related and Unrelated Adverse Events in Cancer Patients: A Meta-Analysis. Cancer Investigation 35(8): 552-561
Fujigaki, Y.; Morimoto, C.; Iino, R.; Taniguchi, K.; Kawamorita, Y.; Asakawa, S.; Toyoki, D.; Miyano, S.; Fujii, W.; Ota, T.; Shibata, S.; Uchida, S. 2017: Discontinuation of Hemodialysis in a Patient with Anti-GBM Disease by the Treatment with Corticosteroids and Plasmapheresis despite Several Predictors for Dialysis-Dependence. Case Reports in Nephrology 2017: 7143649
Karakaya, F.; Özer, S.; Kalkan, Ça.ğd.ş; Tüzün, E.A.; Çalışkan, A.; Keskin, O.; Kabaçam, G.ök.; Karatayli, S.; Karatayli, E.; Bozdayi, A.M.; Idilman, R.; Yurdaydin, C. 2017: Discontinuation of lamivudine treatment in HBeAg-negative chronic hepatitis B: a pilot study with long-term follow-up. Antiviral Therapy 22(7): 559-570
Kang, P.; Swarbrick, H. 2017: Discontinuation of long term orthokeratology lens wear and subsequent refractive surgery outcome. Contact Lens and Anterior Eye: the Journal of the British Contact Lens Association 40(6): 436-439
Baker, H. 2017: Discontinuation of melanoma combination immunotherapy. LANCET. Oncology 18(10): E565
Dinkova, A.S.; Atanasov, D.T.; Vladimirova-Kitova, L.G. 2017: Discontinuation of Oral Antiplatelet Agents before Dental Extraction - Necessity or Myth?. Folia Medica 59(3): 336-343
Cho, P.; Cheung, S.W. 2017: Discontinuation of orthokeratology on eyeball elongation (DOEE). Contact Lens and Anterior Eye: the Journal of the British Contact Lens Association 40(2): 82-87
Ferrero, F. 2017: Discontinuation of pediatric trials. Archivos Argentinos de Pediatria 115(4): 308-309
Alonso Valente, R.; García Rodríguez, G.Elena.; García Marcote, Y.; Fidalgo Díaz, M.; Becerra Mosquera, V.; Novoa García, D.; Cordal Martínez, T.; Díaz Rodríguez, Cándido. 2017: Discontinuation of Peritoneal Dialysis after Late Initiation of Eculizumab in a Case of Familial Atypical Hemolytic-Uremic Syndrome: A Case Report. Case Reports in Nephrology and Dialysis 7(1): 18-25
Riera, M.; Castells, X.; Tobias, A.; Cunill, R.; Blanco, L.; Capellà, D. 2017: Discontinuation of pharmacological treatment of children and adolescents with attention deficit hyperactivity disorder: meta-analysis of 63 studies enrolling 11,788 patients. Psychopharmacology 234(17): 2657-2671
Geijteman, E.C.T.; Tempelman, M.M.A.; Dees, M.K.; Huisman, B.A.A.; Perez, R.S.G.M.; van Zuylen, L.; van der Heide, A. 2017: Discontinuation of potentially inappropriate medications at the end of life: perspectives from patients, their relatives, and physicians. Nederlands Tijdschrift Voor Geneeskunde 160: D1084
Narayan, S.W.; Nishtala, P.S. 2017: Discontinuation of Preventive Medicines in Older People with Limited Life Expectancy: A Systematic Review. Drugs and Aging 34(10): 767-776
Hu, H.; Xiang, C.; Qiu, C.; Chen, Z.; Huang, S.; Liang, L.; Wang, X. 2017: Discontinuation of Scheduled Infliximab in Crohn's Patients With Clinical Remission: A Retrospective Single-Center Study. Gastroenterology Research 10(2): 92-99
Zhang, H.; Plutzky, J.; Skentzos, S.; Morrison, F.; Mar, P.; Shubina, M.; Turchin, A. 2013: Discontinuation of statins in routine care settings: a cohort study. Annals of Internal Medicine 158(7): 526-534
Elijovich, F.; Laffer, C.L. 2017: Discontinuation of Therapy in Hypertension Research: Value, Ethics, Risk, and Role in Renal Denervation Trials. Hypertension 69(5): 795-797
Kubo, S.; Yamaoka, K.; Amano, K.; Nagano, S.; Tohma, S.; Suematsu, E.; Nagasawa, H.; Iwata, K.; Tanaka, Y. 2017: Discontinuation of tofacitinib after achieving low disease activity in patients with rheumatoid arthritis: a multicentre, observational study. Rheumatology 56(8): 1293-1301
Bonfanti, P.; Madeddu, G.; Gulminetti, R.; Squillace, N.; Orofino, G.; Vitiello, P.; Rusconi, S.; Celesia, B.M.; Maggi, P.; Ricci, E. 2017: Discontinuation of treatment and adverse events in an Italian cohort of patients on dolutegravir. Aids 31(3): 455-457
Hammond, D.A.; McCain, K.; Painter, J.T.; Clem, O.A.; Cullen, J.; Brotherton, A.L.; Chopra, D.; Meena, N. 2019: Discontinuation of Vasopressin Before Norepinephrine in the Recovery Phase of Septic Shock. Journal of Intensive Care Medicine 34(10): 805-810
Barnes, G.D.; Kaatz, S.; Lopez, A.; Gu, X.; Kozlowski, J.; Krol, G.D.; Froehlich, J.B. 2017: Discontinuation of Warfarin Therapy for Patients with Atrial Fibrillation: the Michigan Anticoagulation Quality Improvement Initiative Experience. JAMA Cardiology 2(3): 341-343
Mallick, A.; Fautrel, B.; Sagez, F.; Sordet, C.; Javier, R.-M.; Petit, H.; Chatelus, E.; Rahal, N.; Gottenberg, J.-E.; Sibilia, J. 2017: Discontinuation or tapering strategies of biologics in rheumatoid arthritis in remission. La Revue de Medecine Interne 38(4): 256-263
Yimphong, T.; Temtanakitpaisan, T.; Buppasiri, P.; Chongsomchai, C.; Kanchaiyaphum, S. 2018: Discontinuation rate and adverse events after 1 year of vaginal pessary use in women with pelvic organ prolapse. International Urogynecology Journal 29(8): 1123-1128
Zhao, H.-p.; Xiang, B.-r. 2015: Discontinued cardiovascular drugs in 2013 and 2014. Expert Opinion on Investigational Drugs 24(8): 1083-1092
Hedrington, M.S.; Davis, S.N. 2017: Discontinued drug therapies to treat diabetes in 2015. Expert Opinion on Investigational Drugs 26(2): 219-225
Rikard, R.V.; Berkowsky, R.W.; Cotten, S.R. 2018: Discontinued Information and Communication Technology Usage among Older Adults in Continuing Care Retirement Communities in the United States. Gerontology 64(2): 188-200
Emsley, R. 2018: Discontinuing antipsychotic treatment after a first-episode of psychosis: Who, when and how?. Schizophrenia Research 197: 59-60
Marra, A.R.; Edmond, M.B.; Schweizer, M.L.; Ryan, G.W.; Diekema, D.J. 2018: Discontinuing contact precautions for multidrug-resistant organisms: A systematic literature review and meta-analysis. American Journal of Infection Control 46(3): 333-340
Wouters, H.; Scheper, J.; Koning, H.; Brouwer, C.; Twisk, J.W.; van der Meer, H.; Boersma, F.; Zuidema, S.U.; Taxis, K. 2017: Discontinuing Inappropriate Medication Use in Nursing Home Residents: A Cluster Randomized Controlled Trial. Annals of internal medicine 167(9): 609-617
Sellares, J.; Ferrer, M.; Anton, A.; Loureiro, H.; Bencosme, C.; Alonso, R.; Martinez-Olondris, P.; Sayas, J.; Peñacoba, P.; Torres, A. 2017: Discontinuing noninvasive ventilation in severe chronic obstructive pulmonary disease exacerbations: a randomised controlled trial. European Respiratory Journal 50(1)
Barrand, K. 2017: Discontinuing of Trimacare 80. Veterinary Record 181(8): 210
Saccone, G.; Ciardulli, A.; Baxter, J.K.; Quiñones, J.N.; Diven, L.C.; Pinar, B.; Maruotti, G.M.; Martinelli, P.; Berghella, V. 2017: Discontinuing Oxytocin Infusion in the Active Phase of Labor: a Systematic Review and Meta-analysis. Obstetrics and Gynecology 130(5): 1090-1096
Ostrow, L.; Jessell, L.; Hurd, M.; Darrow, S.M.; Cohen, D. 2017: Discontinuing Psychiatric Medications: a Survey of Long-Term Users. Psychiatric Services 68(12): 1232-1238
De Velasco, G.; Xie, W.; Donskov, F.; Albiges, L.; Beuselinck, B.; Srinivas, S.; Agarwal, N.; Lee, J.L.; Brugarolas, J.; Wood, L.A.; Rha, S.-Y.; Kollmannsberger, C.; North, S.; Kanesvaran, R.; Rini, B.I.; Broom, R.; Yamamoto, H.; Kaymakcalan, M.D.; Heng, D.Y.C.; Choueiri, T.K. 2017: Discontinuing VEGF-targeted Therapy for Progression Versus Toxicity Affects Outcomes of Second-line Therapies in Metastatic Renal Cell Carcinoma. Clinical Genitourinary Cancer 15(3): 403-410.E2
Cocota, J.é A.N.; Garcia, G.C.; da Costa, A.R.; de Lima, M.S.ér.F.; Rocha, F.A.S.; Freitas, G.M. 2017: Discontinuity Detection in the Shield Metal Arc Welding Process. Sensors 17(5)
Hoffman, D.J.; Fayer, M.D. 2017: Discontinuity in Fast Dynamics at the Glass Transition of ortho-Terphenyl. Journal of Physical Chemistry. B 121(45): 10417-10428
Virmani, R.; Jinnouchi, H.; Finn, A.V. 2017: Discontinuity: Is it a Major Cause of Scaffold Thrombosis?. Journal of the American College of Cardiology 70(19): 2345-2348
Ji, X.; Wilk, A.S.; Druss, B.G.; Lally, C.; Cummings, J.R. 2017: Discontinuity of Medicaid Coverage: Impact on Cost and Utilization Among Adult Medicaid Beneficiaries With Major Depression. Medical care 55(8): 735-743
Mylnikov, S.V.; Oparina, T.I.; Bychkovskaia, I.B. 2016: Discontinuity of the annuity curves. I. Departures from Gompertz law in Drosophila melanogaster Canton-S strain. Advances in Gerontology 28(4): 624-628
Bychkovskaia, I.B.; Mylnikov, S.V.; Mozhaev, G.A. 2016: Discontinuity of the annuity curves. III. two types of vital variability in Drosophila melanogaster. Advances in Gerontology 29(4): 541-547
Bychkovskaia, I.B.; Mylnikov, S.V. 2016: Discontinuity of the annuity curves. II. Variability of annuity curves in Drosophila melanogaster Canton S strain. Advances in Gerontology 29(1): 38-43
Otsuki, M.; Hayakawa, H. 2017: Discontinuous change of shear modulus for frictional jammed granular materials. Physical Review e 95(6-1): 062902
Narayan, R.K.J. 1982: Discontinuous DNA Variation in the Evolution of Plant Species: the Genus Lathyrus. Evolution; International Journal of Organic Evolution 36(5): 877-891
Meng, X.; Ryan, J.K. 2017: Discontinuous Galerkin methods for nonlinear scalar hyperbolic conservation laws: divided difference estimates and accuracy enhancement. Numerische Mathematik 136(1): 27-73
Duncan, F.D.; Byrne, M.J. 2000: Discontinuous gas exchange in dung beetles: patterns and ecological implications. Oecologia 122(4): 452-458
Lighton, J.R. 1996: Discontinuous gas exchange in insects. Annual Review of Entomology 41: 309-324
Tumin, D.; King, A.; Walia, H.; Tobias, J.D.; Raman, V.T. 2017: Discontinuous insurance coverage predicts prolonged hospital stay after pediatric adenotonsillectomy. Journal of Surgical Research 218: 86-91
Liu, X.; Ho, D.W.C.; Cao, J.; Xu, W. 2017: Discontinuous Observers Design for Finite-Time Consensus of Multiagent Systems With External Disturbances. IEEE Transactions on Neural Networks and Learning Systems 28(11): 2826-2830
Terry-McElrath, Y.M.; O'Malley, P.M.; Johnston, L.D. 2017: Discontinuous Patterns of Cigarette Smoking from Ages 18 to 50 in the United States: a Repeated-Measures Latent Class Analysis. Nicotine and Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco 20(1): 108-116
Santonastaso, G.F.; Bortone, I.; Chianese, S.; Di Nardo, A.; Di Natale, M.; Erto, A.; Karatza, D.; Musmarra, D. 2018: Discontinuous permeable adsorptive barrier design and cost analysis: a methodological approach to optimisation. Environmental Science and Pollution Research International 25(27): 26793-26800
Jakkani, R.; Alhajri, F.A.; Alteriki, A.; Almuteri, M.F.; Athyal, R.P.; Hashem, K.Z. 2016: Discontinuous splenogonadal fusion diagnosed on computed tomography. Indian Journal of Radiology and Imaging 26(4): 506-509
Wulfert, R.; Seifert, U.; Speck, T. 2016: Discontinuous thinning in active microrheology of soft complex matter. Physical Review e 94(6-1): 062610
Sahoo, G.; Alexakis, A.; Biferale, L. 2017: Discontinuous Transition from Direct to Inverse Cascade in Three-Dimensional Turbulence. Physical Review Letters 118(16): 164501
Kürsten, Rüdiger.; Behn, U. 2016: Discontinuous transitions in globally coupled potential systems with additive noise. Physical Review e 94(6-1): 062135
Jordan, D.S. 1906: Discontinuous Variation and Pedigree Culture. Science 24(613): 399-400
O'Brien, D.; Scudamore, J.; Charlier, J.; Delavergne, M. 2017: DISCONTOOLS: a database to identify research gaps on vaccines, pharmaceuticals and diagnostics for the control of infectious diseases of animals. Bmc Veterinary Research 13(1): 1
Simmons, M.; Ru, G.; Casalone, C.; Iulini, B.; Cassar, C.; Seuberlich, T. 2018: DISCONTOOLS: Identifying gaps in controlling bovine spongiform encephalopathy. Transboundary and Emerging Diseases 65(Suppl 1): 9-21
Kishan, A.U.; Duchesne, G.; Wang, P.-C.; Rwigema, J.-C.M.; Kishan, A.U.; Saigal, C.; Rettig, M.; Steinberg, M.L.; King, C.R. 2018: Discord Among Radiation Oncologists and Urologists in the Postoperative Management of High-Risk Prostate Cancer. American Journal of Clinical Oncology 41(8): 739-746
Timmer, M.; Werner, J-Michael.; Röhn, G.; Ortmann, M.; Blau, T.; Cramer, C.; Stavrinou, P.; Krischek, B.; Mallman, P.; Goldbrunner, R. 2017: Discordance and Conversion Rates of Progesterone-, Estrogen-, and HER2/neu-Receptor Status in Primary Breast Cancer and Brain Metastasis Mainly Triggered by Hormone Therapy. Anticancer Research 37(9): 4859-4865
Gorodeski, E.Z.; Joyce, E.; Gandesbery, B.T.; Blackstone, E.H.; Taylor, D.O.; Tang, W.H.W.; Starling, R.C.; Hachamovitch, R. 2017: Discordance between 'actual' and 'scheduled' check-in times at a heart failure clinic. Plos one 12(11): E0187849
De Vos, G.; Nazari, R.; Ferastraoaru, D.; Parikh, P.; Geliebter, R.; Pichardo, Y.; Wiznia, A.; Rosenstreich, D. 2013: Discordance between aeroallergen specific serum IgE and skin testing in children younger than 4 years. Annals of Allergy Asthma and Immunology: Official Publication of the American College of Allergy Asthma and Immunology 110(6): 438-443
Smiley, M.L.; Bingham, C.Raymond.; Jacobson, P.D.; Macy, M.L. 2018: Discordance between age- and size-based criteria of child passenger restraint appropriateness. Traffic Injury Prevention 19(3): 326-331
Dehesa-López, E.; Martínez-Felix, J.ús.I.; Ruiz-Ramos, A.; Atilano-Carsi, X. 2017: Discordance between bioelectrical impedance vector analysis and the new ESPEN definition of malnutrition for the diagnosis of hospital malnutrition. Clinical Nutrition Espen 18: 44-48
Heiferman, M.J.; Fawzi, A.A. 2016: Discordance Between Blue-Light Autofluorescence and Near-Infrared Autofluorescence in Age-Related Macular Degeneration. Retina 36 Suppl. 1: S137-S146
Lawler, P.R.; Akinkuolie, A.O.; Ridker, P.M.; Sniderman, A.D.; Buring, J.E.; Glynn, R.J.; Chasman, D.I.; Mora, S. 2017: Discordance between Circulating Atherogenic Cholesterol Mass and Lipoprotein Particle Concentration in Relation to Future Coronary Events in Women. Clinical Chemistry 63(4): 870-879
Rondina, R.G.; de Mello, R.A.F.; Valim, V.; Lourenco, R.B.; Batista, E.F.P.; de Oliveira Júnior, R. 2017: Discordance between clinical and imaging criteria: assessment by magnetic resonance imaging of the foot of patients with rheumatoid arthritis. Rheumatology International 37(8): 1357-1364
Celakovsky, P.; Kalfert, D.; Smatanova, K.; Kordac, P.; Laco, J.; Chrobok, V. 2017: Discordance between clinical and pathological TNM classification: influence on results of treatment and prognosis in patients with laryngeal cancer. Neoplasma 64(2): 305-310
Ahn, S.G.; Suh, J.; Hung, O.Y.; Lee, H.S.; Bouchi, Y.H.; Zeng, W.; Gandhi, R.; Eshtehardi, P.; Gogas, B.D.; Samady, H. 2017: Discordance Between Fractional Flow Reserve and Coronary Flow Reserve: Insights from Intracoronary Imaging and Physiological Assessment. JACC. Cardiovascular Interventions 10(10): 999-1007
Ali, R.M.; Alsudani, A.A. 2016: Discordance between GeneXpert assay and conventional drug-susceptibility testing in detecting rifampicin-resistant tuberculosis: A perspective of the line probe assay. International Journal of Mycobacteriology 5 Suppl. 1: S193-S194
Nanba, A.T.; Nanba, K.; Byrd, J.B.; Shields, J.J.; Giordano, T.J.; Miller, B.S.; Rainey, W.E.; Auchus, R.J.; Turcu, A.F. 2017: Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism. Clinical Endocrinology 87(6): 665-672
Najih, H.; Arous, S.; Laarje, A.; Baghdadi, D.; Benouna, M.Ghali.; Azzouzi, L.; Habbal, R. 2016: Discordance between mitral valve area (MVA) and pressure gradient in patients with mitral valve stenosis: mean transmitral valve gradient is a severity index or a tolerance index of severity of mitralss valve stenosis?. Pan African medical journal 25: 75
Soltis, D.E.; Kuzoff, R.K. 1995: Discordance between Nuclear and Chloroplast Phylogenies in the Heuchera Group (Saxifragaceae). Evolution; International Journal of Organic Evolution 49(4): 727-742
Dodson, A.; Okonji, D.; Assersohn, L.; Rigg, A.; Sheri, A.; Turner, N.; Smith, I.; Parton, M.; Dowsett, M. 2018: Discordance between oncotype DX recurrence score and RSPC for predicting residual risk of recurrence in ER-positive breast cancer. Breast Cancer Research and Treatment 168(1): 249-258
Heyland, D.K.; Heyland, R.; Dodek, P.; You, J.J.; Sinuff, T.; Hiebert, T.; Jiang, X.; Day, A.G. 2017: Discordance between patients' stated values and treatment preferences for end-of-life care: results of a multicentre survey. Bmj Supportive and Palliative Care 7(3): 292-299
Wei, W.; Anderson, P.; Gadkari, A.; Blackburn, S.; Moon, R.; Piercy, J.; Shinde, S.; Gomez, J.; Ghorayeb, E. 2017: Discordance Between Physician- and Patient-Reported Disease Severity in Adults with Atopic Dermatitis: A US Cross-Sectional Survey. American Journal of Clinical Dermatology 18(6): 825-835
Lachner, C.; Armstrong, M.J.; Gruber-Baldini, A.L.; Rezvani, Z.; Reich, S.G.; Fishman, P.S.; Salazar, R.; Shulman, L.M. 2017: Discordance Between Physician Assessment and Patient-Reported Depressive Symptoms in Parkinson Disease. Journal of Geriatric Psychiatry and Neurology 30(4): 191-195
Chang, V.; Blackwell, R.H.; Markossian, T.; Yau, R.M.; Blanco, B.A.; Zapf, M.A.C.; Abood, G.J.; Gupta, G.N.; Kuo, P.C.; Kothari, A.N. 2017: Discordance between surgical care improvement project adherence and postoperative outcomes: implications for new Joint Commission standards. Journal of Surgical Research 212: 205-213
Sun, J.; Yang, G.-H.; Liu, J.-X.; Liu, X.-L.; Ma, Y.-Q.; Lu, R.-Y.; Zhang, Y.-Y.; Chen, S.-B.; Zhao, J.-H.; Ji, W.-J.; Zhou, X.; Li, Y.-M. 2018: Discordance Between VASP Phosphorylation and Platelet Aggregation in Defining High On-Clopidogrel Platelet Reactivity After ST-Segment Elevation Myocardial Infarction. Clinical and Applied Thrombosis/Hemostasis: Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 24(1): 47-54
Moayyeri, A.; Soltani, A.; Tabari, N.K.; Sadatsafavi, M.; Hossein-Neghad, A.; Larijani, B. 2005: Discordance in diagnosis of osteoporosis using spine and hip bone densitometry. Bmc Endocrine Disorders 5(1): 3
Agrawal, S.K.; Chatterjee, S.; Arun, I.; Ahmed, R. 2017: Discordance in Immunohistochemical Status of Breast Cancer Post Neoadjuvant Chemotherapy. Indian Journal of Surgical Oncology 8(2): 245-246
Wise, R.A.; Kowey, P.R.; Austen, G.; Mueller, A.; Metzdorf, N.; Fowler, A.; McGarvey, L.P. 2017: Discordance in investigator-reported and adjudicated sudden death in TIOSPIR. Erj Open Research 3(1)
Rice, L.J.; Jefferson, M.; Briggs, V.; Delmoor, E.; Johnson, J.C.; Gattoni-Celli, S.; Savage, S.J.; Lilly, M.; Prasad, S.M.; Kittles, R.; Halbert, C.Hughes. 2017: Discordance in perceived risk and epidemiological outcomes of prostate cancer among African American men. Preventive medicine reports 7: 1-6
De Stefano, A.; Rosanova, M.; Malapelle, U.; Martini, M.; De Falco, S.; Attademo, L.; Fiore, G.; Cenci, T.; Bellevicine, C.; De Placido, S.; Troncone, G.; Carlomagno, C. 2017: Discordance in RAS mutations between primary colon tumor and metastases: a real event or a matter of methodology?. International Journal of Biological Markers 32(4): E474-E477
Goodman, J.L.; Amendola, L.M.; Horike-Pyne, M.; Trinidad, S.B.; Fullerton, S.M.; Burke, W.; Jarvik, G.P. 2017: Discordance in selected designee for return of genomic findings in the event of participant death and estate executor. Molecular Genetics and Genomic Medicine 5(2): 172-176
Dey, A.; Shakya, H.Baker.; Chandurkar, D.; Kumar, S.; Das, A.Kumar.; Anthony, J.; Shetye, M.; Krishnan, S.; Silverman, J.G.; Raj, A. 2017: Discordance in self-report and observation data on mistreatment of women by providers during childbirth in Uttar Pradesh, India. Reproductive Health 14(1): 149
Ho-Pham, L.T.; Nguyen, U.D.T.; Tran, T.X.; Nguyen, T.V. 2017: Discordance in the diagnosis of diabetes: Comparison between HbA1c and fasting plasma glucose. Plos one 12(8): E0182192
Abel, H.; Kephart, G.; Packer, T.; Warner, G. 2017: Discordance in Utility Measurement in Persons with Neurological Conditions: a Comparison of the SF-6D and the HUI3. Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research 20(8): 1157-1165
Cherla, D.V.; Olavarria, O.A.; Holihan, J.L.; Viso, C.P.; Hannon, C.; Kao, L.S.; Ko, T.C.; Liang, M.K. 2017: Discordance of conflict of interest self-disclosure and the Centers of Medicare and Medicaid Services. Journal of Surgical Research 218: 18-22
Fang, Q.; Yang, H.; Ou, W.; Ye, X.; Zhang, B.-B.; Sun, H.-B.; Zhang, L.; Cao, X.; Wang, S.-Y. 2012: Discordance of epidermal growth factor receptor mutations between primary tumors and corresponding mediastinal nodal metastases in patients operated on for stage N2 non-small cell lung cancer. Thoracic Cancer 3(4): 313-319
Kondo, H.; Shimono, Y.; Mukohyama, J.; Tanaka, Y.; Shibuya, N.; Minami, H.; Kakeji, Y.; Suzuki, A. 2017: Discordance of MCM7 mRNA and its Intronic MicroRNA Levels Under Hypoxia. Anticancer Research 37(7): 3885-3890
Herrera-Enriquez, K.; Narvaez-Guerra, O. 2017: Discordance of metabolic syndrome and abdominal obesity prevalence according to different criteria in Andean highlanders: a community-based study. Diabetes and Metabolic Syndrome 11(Suppl 1): S359-S364
Golder, V.; Ooi, J.J.Y.; Antony, A.S.; Ko, T.; Morton, S.; Kandane-Rathnayake, R.; Morand, E.F.; Hoi, A.Y. 2018: Discordance of patient and physician health status concerns in systemic lupus erythematosus. Lupus 27(3): 501-506
Young, K.A.; Wordingham, S.E.; Strand, J.J.; Roger, Vėronique.L.; Dunlay, S.M. 2017: Discordance of Patient-Reported and Clinician-Ordered Resuscitation Status in Patients Hospitalized With Acute Decompensated Heart Failure. Journal of Pain and Symptom Management 53(4): 745-750
Tollefson, M.M.; Chiu, Y.E.; Brandling-Bennett, H.A.; Pope, E. 2018: Discordance of pediatric morphea treatment by pediatric dermatologists. Pediatric Dermatology 35(1): 47-54
Marcos, P.J.; Restrepo, M.I.; González-Barcala, F.J.; Soni, N.J.; Vidal, I.; Sanjuàn, P.; Llinares, D.; Ferreira-Gonzalez, L.ía.; Rábade, C.; Otero-González, I.; Marcos, P.; Verea-Hernando, H.éc. 2017: Discordance of physician clinical judgment vs. pneumonia severity index (PSI) score to admit patients with low risk community-acquired pneumonia: a prospective multicenter study. Journal of Thoracic Disease 9(6): 1538-1546
Jia, F.; Teer, J.K.; Knepper, T.C.; Lee, J.K.; Zhou, H.-H.; He, Y.-J.; McLeod, H.L. 2017: Discordance of Somatic Mutations Between Asian and Caucasian Patient Populations with Gastric Cancer. Molecular Diagnosis and Therapy 21(2): 179-185
Lower, E.E.; Khan, S.; Kennedy, D.; Baughman, R.P. 2017: Discordance of the estrogen receptor and HER-2/neu in breast cancer from primary lesion to first and second metastatic site. Breast Cancer 9: 515-520
Jafri, K.; Ogdie, A.; Qasim, A.; Patterson, S.L.; Gianfrancesco, M.; Izadi, Z.; Katz, P.; Yazdany, J.; Schmajuk, G. 2018: Discordance of the Framingham cardiovascular risk score and the 2013 American College of Cardiology/American Heart Association risk score in systemic lupus erythematosus and rheumatoid arthritis. Clinical rheumatology 37(2): 467-474
Alexovitz, K.A.; Merchant, R.C.; Clark, M.A.; Liu, T.; Rosenberger, J.G.; Bauermeister, J.; Mayer, K.H. 2018: Discordance of voluntary HIV testing with HIV sexual risk-taking and self-perceived HIV infection risk among social media-using black, Hispanic, and white young-men-who-have-sex-with-men (YMSM). Aids Care 30(1): 81-85
Georgescu, R.; Boros, M.; Moncea, D.; Bauer, O.; Coros, M-Florin.; Oprea, A.; Moldovan, C.; Podoleanu, C.; Stolnicu, S. 2018: Discordance Rate in Estrogen Receptor, Progesterone Receptor, HER2 Status, and Ki67 Index Between Primary Unifocal and Multiple Homogenous Breast Carcinomas and Synchronous Axillary Lymph Node Metastases Have an Impact on Therapeutic Decision. Applied Immunohistochemistry and Molecular Morphology: Aimm 26(8): 533-538
Ieni, A.; Angelico, G.; Giuffrè, G.; Tuccari, G. 2018: Discordance Rate of HER2 Status in Primary Gastric Cancer and Synchronous Lymph Node Metastases: its Impact on Therapeutic Decision and Clinical Management. Pathology Oncology Research: Por 24(3): 695-696
Meyer, M. 1901: Discord and Beats. Science 14(348): 328
Stevens, W.le.C. 1901: Discord and Psychology. Science 14(351): 455-456
Ali, M.; Rajapakshe, D.; Cao, L.; Devaraj, S. 2017: Discordant Analytical Results Caused by Biotin Interference on Diagnostic Immunoassays in a Pediatric Hospital. Annals of Clinical and Laboratory Science 47(5): 638-640
Kunapinun, N.; Treetipsatit, J. 2017: Discordant Anomalies with Combined Features of Pentalogy of Cantrell and OEIS Complex: A Case Report in Monochorionic Twins. Fetal and Pediatric Pathology 36(5): 357-363
Linden, V.v.d.; Linden, H.él.v.d.; Leal, M.d.C.; Rolim, E.L.; Linden, A.v.d.; Aragão, M.d.F.át.V.V.; Brainer-Lima, A.M.; Cruz, D.D.C.S.; Ventura, L.O.; Florêncio, T.L.úc.T.; Cordeiro, M.T.ór.; Caudas, S.d.S.; Ramos, R.C. 2017: Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies. Arquivos de Neuro-Psiquiatria 75(6): 381-386
Verhagen, J.H.; Lexmond, P.; Vuong, O.; Schutten, M.; Guldemeester, J.; Osterhaus, A.D.M.E.; Elbers, A.R.W.; Slaterus, R.; Hornman, M.; Koch, G.; Fouchier, R.A.M. 2017: Discordant detection of avian influenza virus subtypes in time and space between poultry and wild birds; Towards improvement of surveillance programs. Plos one 12(3): E0173470
Mustafa, F.; Najam, Y.; Akbar, M.T.; Ahmed, T.A. 2017: Discordant disease expression of neonatal lupus erythematosus in twins. JPMA. Journal of the Pakistan Medical Association 67(6): 939-941
Shtein, R.M.; Harper, D.E.; Pallazola, V.; Harte, S.E.; Hussain, M.; Sugar, A.; Williams, D.A.; Clauw, D.J. 2016: Discordant Dry Eye Disease (An American Ophthalmological Society Thesis). Transactions of the American Ophthalmological Society 114: T4
Buckwalter, C.M.; Currie, E.G.; Tsang, R.S.W.; Gray-Owen, S.D. 2017: Discordant Effects of Licensed Meningococcal Serogroup B Vaccination on Invasive Disease and Nasal Colonization in a Humanized Mouse Model. Journal of Infectious Diseases 215(10): 1590-1598
Ikenoue, S.; Miyakoshi, K.; Ishii, T.; Sato, Y.; Otani, T.; Akiba, Y.; Kasuga, Y.; Ochiai, D.; Matsumoto, T.; Ichihashi, Y.; Matsuzaki, Y.; Tachikawa, K.; Michigami, T.; Nishimura, G.; Ikeda, K.; Hasegawa, T.; Tanaka, M. 2018: Discordant fetal phenotype of hypophosphatasia in two siblings. American Journal of Medical Genetics. Part a 176(1): 171-174
Miljkovic, D.; Ou, J.; Kirana, C.; Hulse, K.E.; Hauben, E.; Psaltis, A.; Wormald, P-John.; Vreugde, S. 2017: Discordant frequencies of tissue-resident and circulating CD180-negative B cells in chronic rhinosinusitis. International Forum of Allergy and Rhinology 7(6): 609-614
Fernández-Cancio, M.ón.; García-García, E.; González-Cejudo, C.; Martínez-Maestre, M.ía.-A.; Mangas-Cruz, M.-A.; Guerra-Junior, G.; Pandi de Mello, M.; Arnhold, I.J.P.; Nishi, M.Y.; Bilharinho Mendonça, B.; García-Arumí, E.; Audí, L.; Tizzano, E.; Carrascosa, A. 2017: Discordant Genotypic Sex and Phenotype Variations in two Spanish Siblings with 17α-Hydroxylase/17,20-Lyase Deficiency Carrying the Most Prevalent Mutated CYP17A1 Alleles of Brazilian Patients. Sexual Development: Genetics Molecular Biology Evolution Endocrinology Embryology and Pathology of Sex Determination and Differentiation 11(2): 70-77
Tetteh, A.K.; Agyarko, E. 2017: Discordant HIV Test Results: Implications on Perinatal and Haemotransfusion Screening for HIV Infection, Cape Coast, Ghana. Journal of Sexually Transmitted Diseases 2017: 2857397
McWilliams, D.F.; Ferguson, E.; Young, A.; Kiely, P.D.W.; Walsh, D.A. 2016: Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data. Arthritis Research and Therapy 18(1): 295
Wu, J.; Huang, L.-H.; Luo, Y.-M.; Fang, Q. 2017: Discordant intrauterine transfusion in dichorionic twin pregnancy with Rh isoimmunization. Transfusion and Apheresis Science: Official Journal of the World Apheresis Association: Official Journal of the European Society for Haemapheresis 56(6): 883-885
Masson, W.; Lobo, M.ín.; Molinero, G.; Siniawski, D. 2017: Discordant Lipid Pattern and Carotid Atherosclerotic Plaque. Importance of Remnant Cholesterol. Arquivos Brasileiros de Cardiologia 108(6): 526-532
Choi, J.Ju.; Chang, Y.Jin.; Jung, W.Seon.; Lee, K.Cheon.; Kim, J.Ho.; Jo, Y.Yi. 2017: Discordant lumbar epidural hematoma after caudal steroid injection: A case report (CARE-compliant). Medicine 96(24): E7127
Kulkantrakorn, K.; Sangruchi, T. 2017: Discordant manifestation in brothers with Miyoshi myopathy. Journal of the Neurological Sciences 373: 86-87
Tang, M.; Yang, Y.; Yu, J.; Wu, N.; Chen, P.; Xu, L.; Wang, Q.; Xu, Z.; Ge, J.; Yu, K.; Zhuang, J. 2017: Discordant mRNA and protein expression of CXCR4 under in vitro CoCl2-induced hypoxic conditions. Biochemical and Biophysical Research Communications 484(2): 285-291
Hartwig, T.S.; Ambye, L.; Sørensen, S.; Jørgensen, F.S. 2017: Discordant non-invasive prenatal testing (NIPT) - a systematic review. Prenatal Diagnosis 37(6): 527-539
Juckett, D.A.; Davis, F.N.; Gostine, M.; Kasten, E.P.; Reed, P.L.; Gardiner, J.; Risko, R. 2016: Discordant patient pain level reporting between questionnaires and physician encounters of the same day. AMIA .. Annual Symposium Proceedings. AMIA Symposium 2016: 667-676
Karpouzas, G.A.; Ramadan, S.N.; Cost, C.E.; Draper, T.L.; Hernandez, E.; Strand, V.; Ormseth, S.R. 2017: Discordant patient-physician assessments of disease activity and its persistence adversely impact quality of life and work productivity in US Hispanics with rheumatoid arthritis. Rmd Open 3(2): E000551
Ambardekar, A.V.; Thibodeau, J.T.; DeVore, A.D.; Kittleson, M.M.; Forde-McLean, R.C.; Palardy, M.; Mountis, M.M.; Cadaret, L.; Teuteberg, J.J.; Pamboukian, S.V.; Xie, R.; Stevenson, L.W.; Stewart, G.C. 2017: Discordant Perceptions of Prognosis and Treatment Options Between Physicians and Patients with Advanced Heart Failure. JACC. Heart Failure 5(9): 663-671
Li, L.; Huang, L.; Lin, S.; Luo, Y.; Fang, Q. 2017: Discordant phenotypes in monozygotic twins with 16p11.2 microdeletions including the SH2B1 gene. American Journal of Medical Genetics. Part a 173(8): 2284-2288
Jirsová, D.; Štefka, J.; Jirků, M. 2017: Discordant population histories of host and its parasite: a role for ecological permeability of extreme environment?. Plos one 12(4): E0175286
Adetunji, A.A.; Kuti, M.A.; Audu, R.A.; Muyibi, S.A.; Imhansoloeva, M.; Mosuro, O.A.; Solanke, E.A.; Akpa, O.M.; Irabor, A.E.; Ladipo, M.; Berzins, B.; Robertson, K.; Ogunniyi, A.; Adewole, I.F.; Taiwo, B.O. 2018: Discordant rapid HIV tests: lessons from a low-resource community. HIV Medicine 19(1): 72-76
Bonadio, W. 2017: Discordant Rates of Surgeon Versus Pathologist Visual Diagnosis of Perforation with Pediatric Appendicitis. Pediatric Emergency Care 33(3): E3
Buob, A.; Jung, J.; Siaplaouras, S.; Neuberger, H.-R.; Mewis, C. 2006: Discordant regulation of CRP and NT-proBNP plasma levels after electrical cardioversion of persistent atrial fibrillation. Pacing and Clinical Electrophysiology: Pace 29(6): 559-563
Assalino, M.; Hadaya, K.; Andres, A.; Berney, T. 2018: Discordant rejection in simultaneous pancreas and kidney transplantation: true discordance or analysis artefact?. Transplant International: Official Journal of the European Society for Organ Transplantation 31(1): 17-19
Nam, J.-H.; Park, K.-H.; Lee, J.-H.; Lee, C.-H.; Son, J.-W.; Kim, U.; Park, J.-S.; Shin, D.-G. 2017: Discordant Relationships between Systemic Inflammatory Markers and Burden of Oxidative Stress in Patients with Atrial Fibrillation. Korean Circulation Journal 47(5): 752-761
Palamar, J.J.; Le, A. 2017: Discordant reporting of nonmedical amphetamine use among Adderall-using high school seniors in the US. Drug and Alcohol Dependence 181: 208-212
Sheales, M.P.; Sheth, S.; Edwards, A.G.; Carden, S.M. 2017: Discordant retinopathy of prematurity in twin anemia-polycythemia sequence. Journal of Aapos: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus 21(2): 173-174
Choi, S.J.; Kang, M.; Sung, M.J.; Joo, E.Y. 2017: Discordant sleep parameters among actigraphy, polysomnography, and perceived sleep in patients with sleep-disordered breathing in comparison with patients with chronic insomnia disorder. Sleep and Breathing 21(4): 837-843
Botić, T.; Defant, A.; Zanini, P.; Žužek, M.C.; Frangež, R.; Janussen, D.; Kersken, D.; Knez, Že.; Mancini, I.; Sepčić, K. 2017: Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors. European Journal of Medicinal Chemistry 136: 294-304
Chen, Y-Chin.; Wu, B-Hen.; Lin, C.Lung.; Yeh, Y-Hang.; Wu, Y-Ching.; Hung, T-Yao. 2017: Disco spotlight sign: A sign that may be useful for diagnosis of pneumomediastinum. American Journal of Emergency Medicine 35(11): 1786.E1-1786.E2
Anonymous 2017: Discounted CPD for eligible members. Veterinary Record 180(9): 233
Hall, S.; Ali, N.; Chater, N.; Oaksford, M. 2016: Discounting and Augmentation in Causal Conditional Reasoning: Causal Models or Shallow Encoding?. Plos one 11(12): E0167741
Cairns, J. 1992: Discounting and health benefits: another perspective. Health Economics 1(1): 76-79
Young, M.E. 2017: Discounting: a practical guide to multilevel analysis of indifference data. Journal of the Experimental Analysis of Behavior 108(1): 97-112
Nurmohamed, M.T.; Rosendaal, F.R.; Büller, H.R.; Dekker, E.; Hommes, D.W.; Vandenbroucke, J.P.; Briët, E. 1992: Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis. Lancet 340(8812): 152-156
Truong, C.; Trück, S. 2017: Discounting the distant future-Data on Australian discount rates estimated by a stochastic interest rate model. Data in Brief 11: 127-130
De Moraes, M.M.; Mediano, M.F.F.; de Souza, R.A.G.; Moura, A.S.; da Veiga, G.V.; Sichieri, R. 2017: Discouraging soft drink consumption reduces blood glucose and cholesterol of Brazilian elementary students: Secondary analysis of a randomized controlled trial. Preventive Medicine 100: 223-228
Shrivastava, S.R.; Shrivastava, P.S.; Ramasamy, J. 2017: Discouraging the Practice of Tobacco Initiation among Children and Adolescents through Promoting of Smoke-free Films. International Journal of Preventive Medicine 8: 34
Fromm, D.; Forbes, M.; Holland, A.; Dalton, S.G.; Richardson, J.; MacWhinney, B. 2017: Discourse Characteristics in Aphasia Beyond the Western Aphasia Battery Cutoff. American Journal of Speech-Language Pathology 26(3): 762-768
Duygan, M.; Stauffacher, M.; Meylan, G.ég. 2018: Discourse coalitions in Swiss waste management: gridlock or winds of change?. Waste Management 72: 25-44
Borovečki, A.; Babić-Bosanac, S. 2017: Discourse, ethics, public health, abortion, and conscientious objection in Croatia. Croatian Medical Journal 58(4): 316-321
Manago, B.; Davis, J.L.; Goar, C. 2017: Discourse in Action: Parents' use of medical and social models to resist disability stigma. Social Science and Medicine 184: 169-177
Song, Y.; Jia, Z.; Liu, S.; Liang, D. 2017: Discourse production of mandarin-speaking children with high-functioning autism: the effect of mental and action verbs' semantic-pragmatic features. Journal of Communication Disorders 70: 12-24
Mitano, F.; Sicsú, Aélia.Nunes.; Sousa, L.de.Oliveira.; Silva, Lís.Mara.Caetano.da.; Palha, P.Fredemir. 2017: Discourses of healthcare professionals about health surveillance actions for Tuberculosis control. Revista da Escola de Enfermagem da U S P 51: E03213
Cameron, A.; Brangan, E.; Gabbay, J.; Klein, J.H.; Pope, C.; Wye, L. 2018: Discourses of joint commissioning. Health and Social Care in the Community 26(1): 65-71
Humphries, T.; Kushalnagar, P.; Mathur, G.; Napoli, D.Jo.; Padden, C.; Rathmann, C.; Smith, S. 2017: Discourses of prejudice in the professions: the case of sign languages. Journal of Medical Ethics 43(9): 648-652
Góes, F.Garcia.Bezerra.; Cabral, I.Evangelista. 2017: Discourses on discharge care for children with special healthcare needs. Revista Brasileira de Enfermagem 70(1): 163-171
Mitano, F.; Sicsú, Aélia.Nunes.; Lima, Mônica.Cristina.Ribeiro.Alexandre.D.Auria.de.; Peruhype, R.Carvalho.; Protti, S.Terezinha.; Palha, P.Fredemir. 2017: Discourses on short-coursetherapy for tuberculosis control. Revista Brasileira de Enfermagem 70(1): 126-132
Tengelin, E.; Dahlborg-Lyckhage, E. 2017: Discourses with potential to disrupt traditional nursing education: Nursing teachers' talk about norm-critical competence. Nursing Inquiry 24(1)
Gallegos, C.A.; Waters, W.F.; Kuhlmann, A.S. 2017: Discourse versus practice: are traditional practices and beliefs in pregnancy and childbirth included or excluded in the Ecuadorian health care system?. International Health 9(2): 105-111
Roach, W.H.; Chernoff, S.N. 1984: Discoverability of peer review committee records: an update. Topics in Health Record Management 4(3): 99-104
Shangguan, L.; Ning, G-Zhi.; Tang, Y.; Wang, Z.; Luo, Z-Jing.; Zhou, Y. 2017: Discover cervical disc arthroplasty versus anterior cervical discectomy and fusion in symptomatic cervical disc diseases: A meta-analysis. Plos one 12(3): E0174822
Thiam, I.; Dial, C.; Doh, K.; Gaye, A.M.; Woto-Gaye, G. 2016: Discoveries about tubercolosis from autopsies: topographical and morphological profiles of lesions in dakar (Senegal). Medecine et Sante Tropicales 26(4): 419-422
Schnaar, R.L.; Lee, Y.C.; Roseman, S. 2017: Discoveries of the structures of sialic acid and CMP-sialic acid (1957-1960): a letter from Saul Roseman. Glycobiology 27(6): 513-517
Lobanenkov, V.V.; Zentner, G.E. 2018: Discovering a binary CTCF code with a little help from BORIS. Nucleus 9(1): 33-41
Wang, L.; Rastegar-Mojarad, M.; Liu, S.; Zhang, H.; Liu, H. 2017: Discovering adverse drug events combining spontaneous reports with electronic medical records: a case study of conventional DMARDs and biologics for rheumatoid arthritis. AMIA Joint Summits on Translational Science Proceedings. AMIA Joint Summits on Translational Science 2017: 95-103
Li, K.; Zhou, X.; Nie, A.; Sun, S.; He, Y-Bing.; Ren, W.; Li, B.; Kang, F.; Kim, J-Kyo.; Zhang, T-Yi. 2017: Discovering a First-Order Phase Transition in the Li-CeO 2 System. Nano Letters 17(2): 1282-1288
Garbayo, L.Sarmento. 2016: Discovering a Pluralistic Medicine While Overcoming Art and Science Analyses: Solomon's Social Epistemology Reveals the Contemporary Untidy Making of Medical Knowledge 1. American Journal of Bioethics 17(1): W7-W9
Personeni, G.; Bresso, E.; Devignes, M-Dominique.; Dumontier, M.; Smaïl-Tabbone, M.; Coulet, A. 2017: Discovering associations between adverse drug events using pattern structures and ontologies. Journal of Biomedical Semantics 8(1): 29
Lin, A.; Nabatian, A.; Halverstam, C.P. 2017: Discovering Black Soap: A Survey on the Attitudes and Practices of Black Soap Users. Journal of Clinical and Aesthetic Dermatology 10(7): 18-22
Nikolic, I.; Elsworth, B.; Dodson, E.; Wu, S.Z.; Gould, C.M.; Mestdagh, P.; Marshall, G.M.; Horvath, L.G.; Simpson, K.J.; Swarbrick, A. 2017: Discovering cancer vulnerabilities using high-throughput micro-RNA screening. Nucleic Acids Research 45(22): 12657-12670
Sarker, A.; Chandrashekar, P.; Magge, A.; Cai, H.; Klein, A.; Gonzalez, G. 2017: Discovering Cohorts of Pregnant Women From Social Media for Safety Surveillance and Analysis. Journal of Medical Internet Research 19(10): E361
Bertels, F.; Gokhale, C.S.; Traulsen, A. 2017: Discovering Complete Quasispecies in Bacterial Genomes. Genetics 206(4): 2149-2157
Sun, D.; Ren, X.; Ari, E.; Korcsmaros, T.; Csermely, P.; Wu, L-Yun. 2019: Discovering cooperative biomarkers for heterogeneous complex disease diagnoses. Briefings in Bioinformatics 20(1): 89-101
Meng, Y.; Li, G.; Wang, L.; Lin, W.; Gilmore, J.H.; Shen, D. 2016: Discovering Cortical Folding Patterns in Neonatal Cortical Surfaces Using Large-Scale Dataset. Medical Image Computing and Computer-Assisted Intervention: Miccai .. International Conference on Medical Image Computing and Computer-Assisted Intervention 9900: 10-18
Chen, C.; Jack, R.E. 2017: Discovering cultural differences (and similarities) in facial expressions of emotion. Current Opinion in Psychology 17: 61-66
Stuckens, C. 2005: Discovering diabetes in the child, and then?. Soins; la Revue de Reference Infirmiere 2005(694 Pt 2): 5-8
Yuan, Y.; Zheng, X.; Lu, X. 2017: Discovering Diverse Subset for Unsupervised Hyperspectral Band Selection. IEEE transactions on image processing: a publication of the IEEE Signal Processing Society 26(1): 51-64
Ma, X.; Yu, L.; Wang, P.; Yang, X. 2017: Discovering DNA methylation patterns for long non-coding RNAs associated with cancer subtypes. Computational Biology and Chemistry 69: 164-170
Bixler, S.L.; Duplantier, A.J.; Bavari, S. 2017: Discovering Drugs for the Treatment of Ebola Virus. Current Treatment Options in Infectious Diseases 9(3): 299-317
Belyanskaya, S.L.; Ding, Y.; Callahan, J.F.; Lazaar, A.L.; Israel, D.I. 2017: Discovering Drugs with DNA-Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase. Chembiochem: a European Journal of Chemical Biology 18(9): 837-842
Vidaurre, D.; Abeysuriya, R.; Becker, R.; Quinn, A.J.; Alfaro-Almagro, F.; Smith, S.M.; Woolrich, M.W. 2018: Discovering dynamic brain networks from big data in rest and task. Neuroimage 180(Pt B): 646-656
Baldassano, C.; Chen, J.; Zadbood, A.; Pillow, J.W.; Hasson, U.; Norman, K.A. 2017: Discovering Event Structure in Continuous Narrative Perception and Memory. Neuron 95(3): 709-721.E5
Muppalla, R.; Miller, M.; Banerjee, T.; Romine, W. 2017: Discovering explanatory models to identify relevant tweets on Zika. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2017: 1194-1197
Rodriguez, N.; Rojas-Galeano, S. 2017: Discovering feature relevancy and dependency by kernel-guided probabilistic model-building evolution. Biodata Mining 10: 12
Sweeting, A.J.; Aughey, R.J.; Cormack, S.J.; Morgan, S. 2017: Discovering frequently recurring movement sequences in team-sport athlete spatiotemporal data. Journal of Sports Sciences 35(24): 2439-2445
Elmas, A.; Ou Yang, T-Hsien.; Wang, X.; Anastassiou, D. 2016: Discovering Genome-Wide Tag SNPs Based on the Mutual Information of the Variants. Plos one 11(12): E0167994
Botteon, A.; Conti, C.; Realini, M.; Colombo, C.; Matousek, P. 2017: Discovering Hidden Painted Images: Subsurface Imaging Using Microscale Spatially Offset Raman Spectroscopy. Analytical Chemistry 89(1): 792-798
López, J.I.; De Petris, G. 2017: Discovering intratumor heterogeneity: the next frontier for pathologists. Pathologica 109(2): 110-113
Aguilera-Pesantes, D.; Robayo, L.E.; Méndez, P.E.; Mollocana, D.; Marrero-Ponce, Y.; Torres, F.J.; Méndez, M.A. 2017: Discovering key residues of dengue virus NS2b-NS3-protease: New binding sites for antiviral inhibitors design. Biochemical and Biophysical Research Communications 492(4): 631-642
Lømo, T. 2018: Discovering long-term potentiation (LTP) - recollections and reflections on what came after. Acta Physiologica 222(2)
Balasubramanian, A.; Wang, J.; Prabhakaran, B. 2016: Discovering Multidimensional Motifs in Physiological Signals for Personalized Healthcare. IEEE Journal of Selected Topics in Signal Processing 10(5): 832-841
McCutcheon, K.A.; Stalter, A.M. 2017: Discovering my nursing philosophy. Nursing 47(5): 68-69
Macrae, C.A. 2017: Discovering New Diseases to Accelerate Precision Medicine. Transactions of the American Clinical and Climatological Association 128: 83-89
Feneyrolles, Cémence.; Guiet, Léa.; Singer, M.; Van Hijfte, N.; Daydé-Cazals, Bénédicte.; Fauvel, Bénédicte.; Chevé, Génaël.; Yasri, A. 2017: Discovering novel 7-azaindole-based series as potent AXL kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 27(4): 862-866
Basu, A.; Sohn, Y-Sung.; Alyan, M.; Nechushtai, R.; Domb, A.J.; Goldblum, A. 2016: Discovering Novel and Diverse Iron-Chelators in Silico. Journal of Chemical Information and Modeling 56(12): 2476-2485
Hayes, M.N.; Langenau, D.M. 2017: Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma. Methods in Cell Biology 138: 525-561
Ray, S.; Maulik, U. 2018: Discovering Perturbation of Modular Structure in HIV Progression by Integrating Multiple Data Sources Through Non-Negative Matrix Factorization. Ieee/Acm Transactions on Computational Biology and Bioinformatics 15(3): 869-877
Hu, W.; Singh, R.R.P.; Scalettar, R.T. 2017: Discovering phases, phase transitions, and crossovers through unsupervised machine learning: A critical examination. PhysicalReview.e95(6-1): 062122
Schieman, S.; Koltai, J. 2017: Discovering pockets of complexity: Socioeconomic status, stress exposure, and the nuances of the health gradient. Social Science Research 63: 1-18
Xi, J.; Wang, M.; Li, A. 2017: Discovering potential driver genes through an integrated model of somatic mutation profiles and gene functional information. Molecular Biosystems 13(10): 2135-2144
Marmeisse, R.; Kellner, H.; Fraissinet-Tachet, L.; Luis, P. 2017: Discovering Protein-Coding Genes from the Environment: Time for the Eukaryotes?. Trends in Biotechnology 35(9): 824-835
Mitchell, M.O. 2017: Discovering protein-ligand chalcogen bonding in the protein data bank using endocyclic sulfur-containing heterocycles as ligand search subsets. Journal of Molecular Modeling 23(10): 287
Tang, Y.; Qiu, J.; Machner, M.; LaBaer, J. 2017: Discovering Protein-Protein Interactions Using Nucleic Acid Programmable Protein Arrays. Current Protocols in Cell Biology 74: 15.21.1-15.21.14
Becnel, L.B.; Ochsner, S.A.; Darlington, Y.F.; McOwiti, A.; Kankanamge, W.H.; Dehart, M.; Naumov, A.; McKenna, N.J. 2017: Discovering relationships between nuclear receptor signaling pathways, genes, and tissues in Transcriptomine. Science Signaling 10(476)
Born, M.; Curtis, R. 2013: (Re)Discovering Retrospective Miscue Analysis: An Action Research Exploration Using Recorded Readings to Improve Third-Grade Students' Reading Fluency. I.E. 4(2)
Rinaldo, S.; Giardina, G.; Mantoni, F.; Paiardini, A.; Paone, A.; Cutruzzolà, F. 2017: Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases. Methods in Molecular Biology 1657: 431-453
Bailey, T.L. 2007: Discovering sequence motifs. Methods in Molecular Biology 395: 271-292
De Choudhury, M.; Kiciman, E.; Dredze, M.; Coppersmith, G.; Kumar, M. 2016: Discovering Shifts to Suicidal Ideation from Mental Health Content in Social Media. Proceedings of the Sigchi Conference on Human Factors in Computing Systems. Chi Conference 2016: 2098-2110
Pecora, Nò.; Rovira Kaltwasser, P.; Spelta, A. 2016: Discovering SIFIs in Interbank Communities. Plos one 11(12): E0167781
Furchtgott, L.A.; Melton, S.; Menon, V.; Ramanathan, S. 2017: Discovering sparse transcription factor codes for cell states and state transitions during development. Elife 6
Lee, T.H. 2016: Discovering Strategy: a Key Challenge for Academic Health Centers. Transactions of the American Clinical and Climatological Association 127: 300-312
Weller, S.C.; Baer, R.; Nash, A.; Perez, N. 2017: Discovering successful strategies for diabetic self-management: a qualitative comparative study. Bmj Open Diabetes Research and Care 5(1): E000349
Kulkarni, R.A.; Worth, A.J.; Zengeya, T.T.; Shrimp, J.H.; Garlick, J.M.; Roberts, A.M.; Montgomery, D.C.; Sourbier, C.; Gibbs, B.K.; Mesaros, C.; Tsai, Y.Che.; Das, S.; Chan, K.C.; Zhou, M.; Andresson, T.; Weissman, A.M.; Linehan, W.Marston.; Blair, I.A.; Snyder, N.W.; Meier, J.L. 2017: Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. Cell Chemical Biology 24(2): 231-242
Marchese, D.; Botta-Orfila, T.; Cirillo, D.; Rodriguez, J.Antonio.; Livi, C.Maria.; Fernández-Santiago, Rén.; Ezquerra, M.; Martí, M.J.; Bechara, E.; Tartaglia, G.Gaetano.; Ávila, Aón.; Bayés, Àngels.; Botta-Orfila, T.; Caballol, Núria.; Calopa, M.; Campdelacreu, J.; Compta, Y.; Ezquerra, M.; de Fàbregues, O.; Fernández-Santiago, Rén.; Girado, D.; Hernández-Vara, J.; Jaumà, S.; Marchese, D.; Martí, M.J.; Pagonabarraga, J.; Pastor, P.; Planellas, Lís.; Pont-Sunyer, C.; Puente, Víctor.; Pujol, M.; Saura, J.; Tartaglia, G.Gaetano.; Tolosa, E.; Valldeoriola, F. 2017: Discovering the 3' UTR-mediated regulation of alpha-synuclein. Nucleic Acids Research 45(22): 12888-12903
Morretta, E.; Esposito, R.; Festa, C.; Riccio, R.; Casapullo, A.; Monti, M.Chiara. 2017: Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches. Marine Drugs 15(10)
Chang, C-Ming.; Yang, Y-Ping.; Chuang, J-Hua.; Chuang, C-Mu.; Lin, T-Wei.; Wang, P-Hui.; Yu, M-Hsien.; Chang, C-Chang. 2017: Discovering the Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma Using a Data-Driven, Function-Based Analysis. International Journal of Molecular Sciences 18(11)
Forti, L.Carlos.; Protti de Andrade, A.Paula.; Camargo, R.da.Silva.; Caldato, N.; Moreira, A.Alves. 2017: Discovering the Giant Nest Architecture of Grass-Cutting Ants, Atta capiguara (Hymenoptera, Formicidae). Insects 8(2)
Allen, J.G.; Fowler, J.Christopher.; Madan, A.; Ellis, T.E.; Oldham, J.M.; Frueh, B.Christopher. 2017: Discovering the impact of psychotherapeutic hospital treatment for adults with serious mental illness. Bulletin of the Menninger Clinic 81(1): 1-38
Rizzo, M.; Berti, G.; Russo, F.; Fazio, S.; Evangelista, M.; D'Aurizio, R.; Pellegrini, M.; Rainaldi, G. 2017: Discovering the miR-26a-5p Targetome in Prostate Cancer Cells. Journal of Cancer 8(14): 2729-2739
Wagner, N-Frederic.; Chaves, P.; Wolff, A. 2017: Discovering the Neural Nature of Moral Cognition? Empirical, Theoretical, and Practical Challenges in Bioethical Research with Electroencephalography (EEG). Journal of Bioethical Inquiry 14(2): 299-313
Klein, L. 2017: (Re)Discovering the Neurohormonal and Hemodynamic Duality of Heart Failure. Journal of the American College of Cardiology 70(15): 1887-1889
Wang, X-Zhao.; Wang, R.; Xu, C. 2018: Discovering the Relationship Between Generalization and Uncertainty by Incorporating Complexity of Classification. IEEE Transactions on Cybernetics 48(2): 703-715
Zhu, Y.; Zhang, T.; Li, H.; Yang, Y.; Chen, Q.; Kong, L.; Tai, B. 2017: Discovering the Relative Efficacy of Inhaled Medications for Chronic Obstructive Pulmonary Disease: Multiple Treatment Comparisons. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology Biochemistry and Pharmacology 41(4): 1532-1546
Brown, K.; Dyas, J.; Chahal, P.; Khalil, Y.; Riaz, P.; Cummings-Jones, J. 2006: Discovering the research priorities of people with diabetes in a multicultural community: a focus group study. British Journal of General Practice: the Journal of the Royal College of General Practitioners 56(524): 206-213
Lüddecke, T.; Krehenwinkel, H.; Canning, G.; Glaw, F.; Longhorn, S.J.; Tänzler, Ré.; Wendt, I.; Vences, M. 2018: Discovering the silk road: Nuclear and mitochondrial sequence data resolve the phylogenetic relationships among theraphosid spider subfamilies. Molecular Phylogenetics and Evolution 119: 63-70
Sierański, T. 2017: Discovering the stacking landscape of a pyridine-pyridine system. Journal of Molecular Modeling 23(12): 338
Kovač, J.; Klančar, Gšper.; Trebušak Podkrajšek, K.; Battelino, S. 2017: Discovering the Unexpected with the Utilization of NGS in Diagnostics of Non-syndromic Hearing Loss Disorders: The Family Case of ILDR1 -Dependent Hearing Loss Disorder. Frontiers in Genetics 8: 95
Shukla, A.; Bhattacharyya, A.; Kuppusamy, L.; Srivas, M.; Thattai, M. 2017: Discovering vesicle traffic network constraints by model checking. Plos one 12(7): E0180692
Chandler, D.L. 2017: Discovering Ways to Mend Growing Bodies: The Bioengineering of Devices for the Youngest Patients Brings Unique Challenges and Rewards. IEEE Pulse 8(4): 26-29
Li, Y.; Chen, H.; Jiang, X.; Li, X.; Lv, J.; Peng, H.; Tsien, J.Z.; Liu, T. 2017: Discover mouse gene coexpression landscapes using dictionary learning and sparse coding. Brain Structure and Function 222(9): 4253-4270
Louyot, P.; Remy, M.; Wauthier, M.T. 1956: Discovertebral degenerative pathology and trauma. Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale 17(4): 302-310
Shtaya, A.; Hettige, S. 2019: Disco vertebral osteomyelitis causing intradural spinal abscess with cauda equina compression. British Journal of Neurosurgery 33(1): 104-106
Chi, P.; Wang, X.; Guan, G.; Lin, H.; Huang, Y.; Jiang, W. 2017: Discovery, anatomy and clinical significance of the mesorectal finish line of total mesorectal excision. Zhonghua Wei Chang Wai Ke Za Zhi 20(10): 1145-1150
Zhu, Y.; Chai, S.; Cao, M.; Wang, S.; Feng, Z. 2017: Discovery and analysis of Staphylococcus aureus biofilm inhibitors using functional metagenomics approach. Sheng Wu Gong Cheng Xue Bao 33(9): 1525-1532
Karakülah, Gökhan. 2017: Discovery and Annotation of Plant Endogenous Target Mimicry Sequences from Public Transcriptome Libraries: A Case Study of Prunus persica. Journal of Integrative Bioinformatics 14(4)
Zafeiris, D.; Vadakekolathu, J.; Wagner, S.; Pockley, A.Graham.; Ball, G.Roy.; Rutella, S. 2017: Discovery and application of immune biomarkers for hematological malignancies. Expert Review of Molecular Diagnostics 17(11): 983-1000
Wang, J.; Zeng, W.; Li, S.; Shen, L.; Gu, Z.; Zhang, Y.; Li, J.; Chen, S.; Jia, X. 2017: Discovery and Assessment of Atropisomers of (±)-Lesinurad. Acs Medicinal Chemistry Letters 8(3): 299-303
Bouckaert, C.; Zhu, S.; Govers-Riemslag, Jé.W.P.; Depoorter, M.; Diamond, S.L.; Pochet, L. 2017: Discovery and assessment of water soluble coumarins as inhibitors of the coagulation contact pathway. Thrombosis Research 157: 126-133
Awad, F.Nureldin.; Laborda, P.; Wang, M.; Lu, A.Min.; Li, Q.; Cai, Z.Peng.; Liu, L.; Voglmeir, J. 2017: Discovery and biochemical characterization of a mannose phosphorylase catalyzing the synthesis of novel β-1,3-mannosides. Biochimica et Biophysica Acta. General Subjects 1861(12): 3231-3237
Li, Q.; Huang, Y-Ying.; Conway, L.Patrick.; He, M.; Wei, S.; Huang, K.; Duan, X-Chu.; Flitsch, S.L.; Voglmeir, J. 2017: Discovery and Biochemical Characterization of a Thermostable Glucose-1-phosphate Nucleotidyltransferase from Thermodesulfatator indicus. Protein and Peptide Letters 24(8): 729-734
Wei, S.; Zhang, X-Yang.; Sun, Y.; Conway, L.Patrick.; Liu, L. 2017: Discovery and Biochemical Characterization of UDP-Glucose Dehydrogenase from Akkermansia muciniphila. Protein and Peptide Letters 24(8): 735-741
Zhang, Y.; Liu, H.; Zhang, Z.; Wang, R.; Liu, T.; Wang, C.; Ma, Y.; Ai, J.; Zhao, D.; Shen, J.; Xiong, B. 2017: Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors. Molecules 22(4)
Zhang, T-Jian.; Li, S-Ye.; Yuan, W-Yan.; Wu, Q-Xia.; Wang, L.; Yang, S.; Sun, Q.; Meng, F-Hao. 2017: Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors. Bioorganic and Medicinal Chemistry Letters 27(4): 729-732
La Frano, M.R.; Cai, Y.; Burri, B.J.; Thilsted, S.H. 2018: Discovery and biological relevance of 3,4-didehydroretinol (vitamin A 2 ) in small indigenous fish species and its potential as a dietary source for addressing vitamin A deficiency. International Journal of Food Sciences and Nutrition 69(3): 253-261
Liu, M.; Chang, D.; Li, Y. 2017: Discovery and Biosensing Applications of Diverse RNA-Cleaving DNAzymes. Accounts of Chemical Research 50(9): 2273-2283
Song, L.; Jenner, M.; Masschelein, J.; Jones, C.; Bull, M.J.; Harris, S.R.; Hartkoorn, R.C.; Vocat, A.; Romero-Canelon, I.; Coupland, P.; Webster, G.; Dunn, M.; Weiser, R.; Paisey, C.; Cole, S.T.; Parkhill, J.; Mahenthiralingam, E.; Challis, G.L. 2017: Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis. Journal of the American Chemical Society 139(23): 7974-7981
O'Brien, C.A.; McLean, B.J.; Colmant, A.M.G.; Harrison, J.J.; Hall-Mendelin, S.; van den Hurk, A.F.; Johansen, C.A.; Watterson, D.; Bielefeldt-Ohmann, H.; Newton, N.D.; Schulz, B.L.; Hall, R.A.; Hobson-Peters, J. 2017: Discovery and Characterisation of Castlerea Virus, a New Species of Negevirus Isolated in Australia. Evolutionary Bioinformatics Online 13: 1176934317691269
Umina, P.A.; Lord, A.; Micic, S.; Edwards, O. 2017: Discovery and characterisation of field resistance to organophosphorus chemicals in a major mite pest, Halotydeus destructor. Pest Management Science 73(8): 1719-1724
Koh-Stenta, X.; Poulsen, A.; Li, R.; Wee, J.Liang.Kuan.; Kwek, P.Zekui.; Chew, S.Yin.; Peng, J.; Wu, L.; Guccione, E.; Joy, J.; Hill, J. 2017: Discovery and characterisation of the automethylation properties of PRDM9. Biochemical Journal 474(6): 971-982
Wieting, J.M.; Vadukoot, A.K.; Sharma, S.; Abney, K.K.; Bridges, T.M.; Daniels, J.Scott.; Morrison, R.D.; Wickman, K.; Weaver, C.David.; Hopkins, C.R. 2017: Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators. Acs Chemical Neuroscience 8(9): 1873-1879
Iwatani-Yoshihara, M.; Ito, M.; Ishibashi, Y.; Oki, H.; Tanaka, T.; Morishita, D.; Ito, T.; Kimura, H.; Imaeda, Y.; Aparicio, S.; Nakanishi, A.; Kawamoto, T. 2017: Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. Acs Chemical Biology 12(7): 1760-1768
Stepan, A.F.; Claffey, M.M.; Reese, M.R.; Balan, G.; Barreiro, G.; Barricklow, J.; Bohanon, M.J.; Boscoe, B.P.; Cappon, G.D.; Chenard, L.K.; Cianfrogna, J.; Chen, L.; Coffman, K.J.; Drozda, S.E.; Dunetz, J.R.; Ghosh, S.; Hou, X.; Houle, C.; Karki, K.; Lazzaro, J.T.; Mancuso, J.Y.; Marcek, J.M.; Miller, E.L.; Moen, M.A.; O'Neil, S.; Sakurada, I.; Skaddan, M.; Parikh, V.; Smith, D.L.; Trapa, P.; Tuttle, J.B.; Verhoest, P.R.; Walker, D.P.; Won, A.; Wright, A.S.; Whritenour, J.; Zasadny, K.; Zaleska, M.M.; Zhang, L.; Shaffer, C.L. 2017: Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. Journal of Medicinal Chemistry 60(18): 7764-7780
Zheng, B.; Lv, T.; Xu, H.; Yu, X.; Chen, Y.; Li, J.; Huang, C.; Guo, L.; Zhang, J.; Jiang, X.; Xiao, Y.; Li, L. 2018: Discovery and characterisation of an escherichia coli ST206 strain producing NDM-5 and MCR-1 from a patient with acute diarrhoea in China. International Journal of Antimicrobial Agents 51(2): 273-275
Yang, Y-Long.; Zhang, S.; Ma, K.; Xu, Y.; Tao, Q.; Chen, Y.; Chen, J.; Guo, S.; Ren, J.; Wang, W.; Tao, Y.; Yin, W-Bing.; Liu, H. 2017: Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi. Angewandte Chemie 56(17): 4749-4752
Nguyen, Q-Thai.; Trinco, G.; Binda, C.; Mattevi, A.; Fraaije, M.W. 2017: Discovery and characterization of an F 420 -dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1. Applied Microbiology and Biotechnology 101(7): 2831-2842
Wensel, D.; Sun, Y.; Li, Z.; Zhang, S.; Picarillo, C.; McDonagh, T.; Fabrizio, D.; Cockett, M.; Krystal, M.; Davis, J. 2017: Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity. Antimicrobial Agents and ChemoTherapy 61(8)
Vicari, A.P.; Schoepfer, A.M.; Meresse, B.; Goffin, L.; Léger, O.; Josserand, S.; Guégan, N.; Yousefi, S.; Straumann, A.; Cerf-Bensussan, N.; Simon, H-Uwe.; Chvatchko, Y. 2017: Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis. Mabs 9(6): 927-944
Hu, C.; Wang, A.; Wu, H.; Qi, Z.; Li, X.; Yan, X-E.; Chen, C.; Yu, K.; Zou, F.; Wang, W.; Wang, W.; Wu, J.; Liu, J.; Wang, B.; Wang, L.; Ren, T.; Zhang, S.; Yun, C-Hong.; Liu, J.; Liu, Q. 2017: Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode. Oncotarget 8(11): 18359-18372
Shi, H.; Cui, Y.; Qin, Y. 2018: Discovery and characterization of a novel tryptophan hydroxylase 1 inhibitor as a prodrug. Chemical Biology and Drug Design 91(1): 202-212
Corson, A.E.; Armstrong, S.A.; Wright, M.E.; McClelland, E.E.; Bicker, K.L. 2016: Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. Acs Medicinal Chemistry Letters 7(12): 1139-1144
Hao, D.; Xiao, W.; Liu, R.; Kumar, P.; Li, Y.; Zhou, P.; Guo, F.; Farmer, D.L.; Lam, K.S.; Wang, F.; Wang, A. 2017: Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. Acs Chemical Biology 12(4): 1075-1086
Partridge, K.M.; Antonysamy, S.; Bhattachar, S.N.; Chandrasekhar, S.; Fisher, M.J.; Fretland, A.; Gooding, K.; Harvey, A.; Hughes, N.E.; Kuklish, S.L.; Luz, J.G.; Manninen, P.R.; McGee, J.E.; Mudra, D.R.; Navarro, A.; Norman, B.H.; Quimby, S.J.; Schiffler, M.A.; Sloan, A.V.; Warshawsky, A.M.; Weller, J.M.; York, J.S.; Yu, X-Peng. 2017: Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1. Bioorganic and Medicinal Chemistry Letters 27(6): 1478-1483
Hoffmann, A.; Richter, M.; von Grafenstein, S.; Walther, E.; Xu, Z.; Schumann, L.; Grienke, U.; Mair, C.E.; Kramer, C.; Rollinger, J.M.; Liedl, K.R.; Schmidtke, M.; Kirchmair, J. 2017: Discovery and Characterization of Diazenylaryl Sulfonic Acids as Inhibitors of Viral and Bacterial Neuraminidases. Frontiers in Microbiology 8: 205
Echterbille, J.; Gilles, N.; Araóz, R.; Mourier, G.; Amar, M.; Servent, D.; De Pauw, E.; Quinton, L. 2017: Discovery and characterization of EII B, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon: Official Journal of the International Society on Toxinology 130: 1-10
Jones, D.R.; Uddin, M.Salah.; Gruninger, R.J.; Pham, T.Thanh.My.; Thomas, D.; Boraston, A.B.; Briggs, J.; Pluvinage, B.; McAllister, T.A.; Forster, R.J.; Tsang, A.; Selinger, L.Brent.; Abbott, D.Wade. 2017: Discovery and characterization of family 39 glycoside hydrolases from rumen anaerobic fungi with polyspecific activity on rare arabinosyl substrates. Journal of Biological Chemistry 292(30): 12606-12620
Xu, C-Feng.; Chen, Y.; Yi, L.; Brantley, T.; Stanley, B.; Sosic, Z.; Zang, L. 2017: Discovery and Characterization of Histidine Oxidation Initiated Cross-links in an IgG1 Monoclonal Antibody. Analytical Chemistry 89(15): 7915-7923
Richardson, L.S.; Vargas, G.; Brown, T.; Ochoa, L.; Sheller-Miller, S.; Saade, G.R.; Taylor, R.N.; Menon, R. 2017: Discovery and Characterization of Human Amniochorionic Membrane Microfractures. American Journal of Pathology 187(12): 2821-2830
Guimarães, R.A.; Telles, M.P.C.; Antunes, A.M.; Corrêa, K.M.; Ribeiro, C.V.G.; Coelho, A.S.G.; Soares, T.N. 2017: Discovery and characterization of new microsatellite loci in Dipteryx alata Vogel (Fabaceae) using next-generation sequencing data. Genetics and Molecular Research: Gmr 16(2)
Horley, N.J.; Beresford, K.J.M.; Chawla, T.; McCann, G.J.P.; Ruparelia, K.C.; Gatchie, L.; Sonawane, V.R.; Williams, I.S.; Tan, H.L.; Joshi, P.; Bharate, S.S.; Kumar, V.; Bharate, S.B.; Chaudhuri, B. 2017: Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. European Journal of Medicinal Chemistry 129: 159-174
Sreenivasachary, N.; Kroth, H.; Benderitter, P.; Hamel, A.; Varisco, Y.; Hickman, D.T.; Froestl, W.; Pfeifer, A.; Muhs, A. 2017: Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters 27(6): 1405-1411
Wilsbacher, J.L.; Cheng, M.; Cheng, D.; Trammell, S.A.J.; Shi, Y.; Guo, J.; Koeniger, S.L.; Kovar, P.J.; He, Y.; Selvaraju, S.; Heyman, H.Robin.; Sorensen, B.K.; Clark, R.F.; Hansen, T.Matthew.; Longenecker, K.L.; Raich, D.; Korepanova, A.V.; Cepa, S.; Towne, D.L.; Abraham, V.C.; Tang, H.; Richardson, P.L.; McLoughlin, S.M.; Badagnani, I.; Curtin, M.L.; Michaelides, M.R.; Maag, D.; Buchanan, F.Gregory.; Chiang, G.G.; Gao, W.; Rosenberg, S.H.; Brenner, C.; Tse, C. 2017: Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Molecular Cancer Therapeutics 16(7): 1236-1245
Saribas, A.Sami.; DeVoto, J.; Golla, A.; Wollebo, H.S.; White, M.K.; Safak, M. 2018: Discovery and characterization of novel trans-spliced products of human polyoma JC virus late transcripts from PML patients. Journal of Cellular Physiology 233(5): 4137-4155
Schnekenburger, M.; Goffin, E.; Lee, J-Young.; Jang, J.Young.; Mazumder, A.; Ji, S.; Rogister, B.; Bouider, N.; Lefranc, F.; Miklos, W.; Mathieu, Véronique.; de Tullio, P.; Kim, K-Won.; Dicato, M.; Berger, W.; Han, B.Woo.; Kiss, R.; Pirotte, B.; Diederich, M. 2017: Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. Journal of Medicinal Chemistry 60(11): 4714-4733
Adachi, R.; Ogawa, K.; Matsumoto, S-Ichi.; Satou, T.; Tanaka, Y.; Sakamoto, J.; Nakahata, T.; Okamoto, R.; Kamaura, M.; Kawamoto, T. 2017: Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. European Journal of Medicinal Chemistry 136: 283-293
Baetscher, D.S.; Hasselman, D.J.; Reid, K.; Palkovacs, E.P.; Garza, J.Carlos. 2017: Discovery and characterization of single nucleotide polymorphisms in two anadromous alosine fishes of conservation concern. Ecology and Evolution 7(17): 6638-6648
Arnst, J.L.; Hein, A.L.; Taylor, M.A.; Palermo, N.Y.; Contreras, J.I.; Sonawane, Y.A.; Wahl, A.O.; Ouellette, M.M.; Natarajan, A.; Yan, Y. 2017: Discovery and characterization of small molecule Rac1 inhibitors. Oncotarget 8(21): 34586-34600
Butler, M.S.; Roshan-Moniri, M.; Hsing, M.; Lau, D.; Kim, A.; Yen, P.; Mroczek, M.; Nouri, M.; Lien, S.; Axerio-Cilies, P.; Dalal, K.; Yau, C.; Ghaidi, F.; Guo, Y.; Yamazaki, T.; Lawn, S.; Gleave, M.E.; Gregory-Evans, C.Y.; McIntosh, L.P.; Cox, M.E.; Rennie, P.S.; Cherkasov, A. 2017: Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. Oncotarget 8(26): 42438-42454
Guan, X.; Okazaki, Y.; Lithio, A.; Li, L.; Zhao, X.; Jin, H.; Nettleton, D.; Saito, K.; Nikolau, B.J. 2017: Discovery and Characterization of the 3-Hydroxyacyl-ACP Dehydratase Component of the Plant Mitochondrial Fatty Acid Synthase System. Plant Physiology 173(4): 2010-2028
Yu, G.; Champouret, N.; Steuernagel, B.; Olivera, P.D.; Simmons, J.; Williams, C.; Johnson, R.; Moscou, M.J.; Hernández-Pinzón, I.; Green, P.; Sela, H.; Millet, E.; Jones, J.D.G.; Ward, E.R.; Steffenson, B.J.; Wulff, B.B.H. 2017: Discovery and characterization of two new stem rust resistance genes in Aegilops sharonensis. Tag. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik 130(6): 1207-1222
Ruehle, S.; Wager-Miller, J.; Straiker, A.; Farnsworth, J.; Murphy, M.N.; Loch, S.; Monory, K.; Mackie, K.; Lutz, B. 2017: Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse. Journal of Neurochemistry 142(4): 521-533
Yan, W.; Li, F.; Wang, L.; Zhu, Y.; Dong, Z.; Bai, L. 2017: Discovery and characterizaton of a novel lipase with transesterification activity from hot spring metagenomic library. Biotechnology Reports 14: 27-33
Pramono, A.K.; Kuwahara, H.; Itoh, T.; Toyoda, A.; Yamada, A.; Hongoh, Y. 2017: Discovery and Complete Genome Sequence of a Bacteriophage from an Obligate Intracellular Symbiont of a Cellulolytic Protist in the Termite Gut. Microbes and Environments 32(2): 112-117
Anand, S.; Barnes, J.M.; Young, S.A.; Garcia, D.M.; Tolley, H.Dennis.; Kauwe, J.S.K.; Graves, S.W. 2017: Discovery and Confirmation of Diagnostic Serum Lipid Biomarkers for Alzheimer's Disease Using Direct Infusion Mass Spectrometry. Journal of Alzheimer's Disease: Jad 59(1): 277-290
Furuya, T.; Morikawa, S.; Miyazawa, T. 2016: Discovery and current research status of feline morbillivirus. Uirusu 66(2): 147-154
Zhang, S. 2017: Discovery and design of self-assembling peptides. Interface Focus 7(6): 20170028
Nirogi, R.; Shinde, A.; Kambhampati, R.Sastry.; Mohammed, A.Rasheed.; Saraf, S.Keshari.; Badange, R.Kumar.; Bandyala, T.Reddy.; Bhatta, V.; Bojja, K.; Reballi, V.; Subramanian, R.; Benade, V.; Palacharla, R.Choudary.; Bhyrapuneni, G.; Jayarajan, P.; Goyal, V.; Jasti, V. 2017: Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT 6 ) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. Journal of Medicinal Chemistry 60(5): 1843-1859
Noncovich, A.; Priest, C.; Ung, J.; Patron, A.P.; Servant, G.; Brust, P.; Servant, N.; Faber, N.; Liu, H.; Gonsalves, N.S.; Ditschun, T.L. 2017: Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents. Bioorganic and Medicinal Chemistry Letters 27(16): 3931-3938
Godfraind, Téophile. 2017: Discovery and Development of Calcium Channel Blockers. Frontiers in Pharmacology 8: 286
Xiao, Q.; Wu, J.; Pang, X.; Jiang, Y.; Wang, P.; Leung, A.W.; Gao, L.; Jiang, S.; Xu, C. 2018: Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy. Current Medicinal Chemistry 25(7): 839-860
Erakovic Haber, V.; Spaventi, R. 2017: Discovery and Development of Novel Drugs. Progress in Molecular and Subcellular Biology 55: 91-104
Germa, C.; Miller, M.; Mukhopadhyay, P.; Hewes, B.; Caponigro, G.; Scherer, S.J.; Hirawat, S. 2017: Discovery and development of novel therapies in advanced breast cancer: rapid development of ribociclib. Annals of Oncology: Official Journal of the European Society for Medical Oncology 28(8): 2021-2024
Li, X.; Yang, C.; Wan, H.; Zhang, G.; Feng, J.; Zhang, L.; Chen, X.; Zhong, D.; Lou, L.; Tao, W.; Zhang, L. 2017: Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 110: 51-61
Bravo, L.; Mico, J.Antonio.; Berrocoso, E. 2017: Discovery and development of tramadol for the treatment of pain. Expert Opinion on Drug Discovery 12(12): 1281-1291
Iwaki, T.; Oyama, Y.; Tomoo, T.; Tanaka, T.; Okamura, Y.; Sugiyama, M.; Yamaki, A.; Furuya, M. 2017: Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists. Bioorganic and Medicinal Chemistry 25(6): 1762-1769
Donovan, B.T.; Bandyopadhyay, D.; Duraiswami, C.; Nixon, C.J.; Townsend, C.Y.; Martens, S.F. 2018: Discovery and electrophysiological characterization of SKF-32802: A novel hERG agonist found through a large-scale structural similarity search. European Journal of Pharmacology 818: 306-327
Shi, S.; Choi, Y.Wah.; Zhao, H.; Tan, M.How.; Ang, E.Lui. 2017: Discovery and engineering of a 1-butanol biosensor in Saccharomyces cerevisiae. Bioresource Technology 245(Pt B): 1343-1351
Blaisse, M.R.; Dong, H.; Fu, B.; Chang, M.C.Y. 2017: Discovery and Engineering of Pathways for Production of α-Branched Organic Acids. Journal of the American Chemical Society 139(41): 14526-14532
Thakkar, M.; Bhuniya, D.; Kaduskar, R.; Mengawade, T.; Naik, K.; Salunkhe, V.; Bhalerao, A.; Kurhade, S.; Mavinahalli, J.; Jain, V.; Petla, R.; Avaragolla, S.; Ray, S.; Rouduri, S.; Dhanave, A.; De, S.; Pathade, V.; Tambe, A.; Raje, A.A.; Madgula, V.; Joshi, S.; Nadeem, A.; Bala, M.; Umrani, D.; Hariharan, N.; Kulkarni, B.; Mookhtiar, K.A. 2017: Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis. Bioorganic and Medicinal Chemistry Letters 27(8): 1867-1873
Schmidt, T.C.; Eriksson, P-Olof.; Gustafsson, D.; Cosgrove, D.; Frølund, B.; Boström, J. 2017: Discovery and Evaluation of Anti-Fibrinolytic Plasmin Inhibitors Derived from 5-(4-Piperidyl)isoxazol-3-ol (4-PIOL). Journal of Chemical Information and Modeling 57(7): 1703-1714
Bezençon, O.; Remeň, Lš.; Richard, S.; Roch, C.; Kessler, M.; Moon, R.; Mawet, J.; Ertel, E.A.; Pfeifer, T.; Capeleto, B. 2017: Discovery and evaluation of Ca v 3.1-selective T-type calcium channel blockers. Bioorganic and Medicinal Chemistry Letters 27(23): 5322-5325
Bezençon, O.; Remeň, Lš.; Richard, S.; Roch, C.; Kessler, M.; Ertel, E.A.; Moon, R.; Mawet, J.; Pfeifer, T.; Capeleto, B. 2017: Discovery and evaluation of Ca v 3.2-selective T-type calcium channel blockers. Bioorganic and Medicinal Chemistry Letters 27(23): 5326-5331
Cho, Y.Shin.; Levell, J.R.; Liu, G.; Caferro, T.; Sutton, J.; Shafer, C.M.; Costales, A.; Manning, J.R.; Zhao, Q.; Sendzik, M.; Shultz, M.; Chenail, G.; Dooley, J.; Villalba, B.; Farsidjani, A.; Chen, J.; Kulathila, R.; Xie, X.; Dodd, S.; Gould, T.; Liang, G.; Heimbach, T.; Slocum, K.; Firestone, B.; Pu, M.; Pagliarini, R.; Growney, J.D. 2017: Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. Acs Medicinal Chemistry Letters 8(10): 1116-1121
Tomek, P.; Palmer, B.D.; Flanagan, J.U.; Sun, C.; Raven, E.L.; Ching, L-Ming. 2017: Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. European Journal of Medicinal Chemistry 126: 983-996
Zhang, R.; Yu, R.; Xu, Q.; Li, X.; Luo, J.; Jiang, B.; Wang, L.; Guo, S.; Wu, N.; Shi, D. 2017: Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors. European Journal of Medicinal Chemistry 134: 24-33
Costa-Paiva, E.M.; Whelan, N.V.; Waits, D.S.; Santos, S.R.; Schrago, C.G.; Halanych, K.M. 2017: Discovery and evolution of novel hemerythrin genes in annelid worms. Bmc Evolutionary Biology 17(1): 85
Ng, M.C.Y.; Graff, M.; Lu, Y.; Justice, A.E.; Mudgal, P.; Liu, C-Ti.; Young, K.; Yanek, L.R.; Feitosa, M.F.; Wojczynski, M.K.; Rand, K.; Brody, J.A.; Cade, B.E.; Dimitrov, L.; Duan, Q.; Guo, X.; Lange, L.A.; Nalls, M.A.; Okut, H.; Tajuddin, S.M.; Tayo, B.O.; Vedantam, S.; Bradfield, J.P.; Chen, G.; Chen, W-Min.; Chesi, A.; Irvin, M.R.; Padhukasahasram, B.; Smith, J.A.; Zheng, W.; Allison, M.A.; Ambrosone, C.B.; Bandera, E.V.; Bartz, T.M.; Berndt, S.I.; Bernstein, L.; Blot, W.J.; Bottinger, E.P.; Carpten, J.; Chanock, S.J.; Chen, 2017: Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. Plos Genetics 13(4): E1006719
Hu, Y.; Tanaka, T.; Zhu, J.; Guan, W.; Wu, J.H.Y.; Psaty, B.M.; McKnight, B.; King, I.B.; Sun, Q.; Richard, M.; Manichaikul, A.; Frazier-Wood, A.C.; Kabagambe, E.K.; Hopkins, P.N.; Ordovas, J.M.; Ferrucci, L.; Bandinelli, S.; Arnett, D.K.; Chen, Y-Der.I.; Liang, S.; Siscovick, D.S.; Tsai, M.Y.; Rich, S.S.; Fornage, M.; Hu, F.B.; Rimm, E.B.; Jensen, M.K.; Lemaitre, R.N.; Mozaffarian, D.; Steffen, L.M.; Morris, A.P.; Li, H.; Lin, X. 2017: Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations. Journal of Lipid Research 58(5): 974-981
Jansen, I.E.; Ye, H.; Heetveld, S.; Lechler, M.C.; Michels, H.; Seinstra, Rée.I.; Lubbe, S.J.; Drouet, Vérie.; Lesage, S.; Majounie, E.; Gibbs, J.Raphael.; Nalls, M.A.; Ryten, M.; Botia, J.A.; Vandrovcova, J.; Simon-Sanchez, J.; Castillo-Lizardo, M.; Rizzu, P.; Blauwendraat, C.; Chouhan, A.K.; Li, Y.; Yogi, P.; Amin, N.; van Duijn, C.M.; Morris, H.R.; Brice, A.; Singleton, A.B.; David, D.C.; Nollen, E.A.; Jain, S.; Shulman, J.M.; Heutink, P.; Nalls, M.A.; Plagnol, V.; Hernandez, D.G.; Sharma, M.; Sheerin, U-Marie.; Saad, M.; SimónSánchez, J.; Schulte, C.; Lesage, S.; S 2017: Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology 18(1): 22
Soares, A.Raquel.; Santos, M. 2017: Discovery and function of transfer RNA-derived fragments and their role in disease. Wiley Interdisciplinary Reviews. Rna 8(5)
Tihon, E.; Imamura, H.; Dujardin, J-Claude.; Van Den Abbeele, J.; Van den Broeck, F. 2017: Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis. Molecular Ecology 26(23): 6524-6538
Kavak, P.; Lin, Y-Yi.; Numanagic, I.; Asghari, H.; Güngör, T.; Alkan, C.; Hach, F. 2017: Discovery and genotyping of novel sequence insertions in many sequenced individuals. Bioinformatics 33(14): I161-I169
Takashima, K.; Takimoto, Y.; Nakazawa, E.; Hayashi, Y.; Tsuchiya, A.; Fujita, M.; Akabayashi, A. 2017: Discovery and informing research participants of incidental findings detected in brain magnetic resonance imaging studies: Review and multi-institutional study. Brain and Behavior 7(5): E00676
Völler, J-Stefan.; Dulic, M.; Gerling-Driessen, U.I.M.; Biava, H.; Baumann, T.; Budisa, N.; Gruic-Sovulj, I.; Koksch, B. 2017: Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation. Acs Central Science 3(1): 73-80
Iwaki, T.; Tanaka, T.; Miyazaki, K.; Suzuki, Y.; Okamura, Y.; Yamaki, A.; Iwanami, M.; Morozumi, N.; Furuya, M.; Oyama, Y. 2017: Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorganic and Medicinal Chemistry 25(24): 6680-6694
Wan, R.; Ma, P.; Han, M.; Zhang, D.; Zhang, C.; Niu, J.; Wang, J. 2017: Discovery and isolation of the trans-isomers of two 1 : 2-type lanthanide-containing monolacunary Dawson-type tungstophosphates: [Ln III (α 2 -P 2 W 17 O 61 ) 2 ] 17- (Ln = La, Ce). Dalton Transactions 46(16): 5398-5405
Doornbos, M.L.J.; Cid, Jé.María.; Haubrich, J.; Nunes, A.; van de Sande, J.W.; Vermond, S.C.; Mulder-Krieger, T.; Trabanco, Aés.A.; Ahnaou, A.; Drinkenburg, W.H.; Lavreysen, H.; Heitman, L.H.; IJzerman, A.P.; Tresadern, G. 2017: Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2. Journal of Medicinal Chemistry 60(15): 6704-6720
Ma, J.; Li, T.; Han, X.; Yuan, H.; Liang, H.; Wang, Y.; Wang, X.; Duan, Y.; Li, A.; Song, H.; Yang, D. 2017: Discovery and mechanism of action of Novel Baicalein modified derivatives as potent antihepatitis agent. Virology 507: 199-205
Wu, S.; Zhao, Q.; Zhang, P.; Kulp, J.; Hu, L.; Hwang, N.; Zhang, J.; Block, T.M.; Xu, X.; Du, Y.; Chang, J.; Guo, J-Tao. 2017: Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly. Journal of Virology 91(16)
Park, H.; Brotto, A.C.; van Loosdrecht, M.C.M.; Chandran, K. 2017: Discovery and metagenomic analysis of an anammox bacterial enrichment related to Candidatus "Brocadia caroliniensis" in a full-scale glycerol-fed nitritation-denitritation separate centrate treatment process. Water Research 111: 265-273
Sousa, S.R.; Wingerd, J.S.; Brust, A.; Bladen, C.; Ragnarsson, L.; Herzig, V.; Deuis, J.R.; Dutertre, S.; Vetter, I.; Zamponi, G.W.; King, G.F.; Alewood, P.F.; Lewis, R.J. 2017: Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. Plos one 12(9): E0182848
Li, L.; Zhang, H.; Zhang, M.; Zhao, M.; Feng, L.; Luo, X.; Gao, Z.; Huang, Y.; Ardayfio, O.; Zhang, J-Hu.; Lin, Y.; Fan, H.; Mi, Y.; Li, G.; Liu, L.; Feng, L.; Luo, F.; Teng, L.; Qi, W.; Ottl, J.; Lingel, A.; Bussiere, D.E.; Yu, Z.; Atadja, P.; Lu, C.; Li, E.; Gu, J.; Zhao, K. 2017: Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED. Plos one 12(1): E0169855
Silva, Jão.Marcos.Fagundes.; Al Rwahnih, M.; Blawid, R.; Nagata, T.; Fajardo, T.Vinícius.Martins. 2017: Discovery and molecular characterization of a novel enamovirus, Grapevine enamovirus-1. Virus Genes 53(4): 667-671
Er, S.Yan.; Cristofori-Armstrong, B.; Escoubas, P.; Rash, L.D. 2017: Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1. Neuropharmacology 127: 185-195
Schreier, J.D.; Embrey, M.W.; Raheem, I.T.; Barbe, G.; Campeau, L-Charles.; Dubost, D.; McCabe Dunn, J.; Grobler, J.; Hartingh, T.J.; Hazuda, D.J.; Klein, D.; Miller, M.D.; Moore, K.P.; Nguyen, N.; Pajkovic, N.; Powell, D.A.; Rada, V.; Sanders, J.M.; Sisko, J.; Steele, T.G.; Wai, J.; Walji, A.; Xu, M.; Coleman, P.J. 2017: Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV. Bioorganic and Medicinal Chemistry Letters 27(9): 2038-2046
Bender, A.M.; Weiner, R.L.; Luscombe, V.B.; Ajmera, S.; Cho, H.P.; Chang, S.; Zhan, X.; Rodriguez, A.L.; Niswender, C.M.; Engers, D.W.; Bridges, T.M.; Conn, P.Jeffrey.; Lindsley, C.W. 2017: Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Bioorganic and Medicinal Chemistry Letters 27(15): 3576-3581
Brand, S.; Ko, E.Jung.; Viayna, E.; Thompson, S.; Spinks, D.; Thomas, M.; Sandberg, L.; Francisco, A.F.; Jayawardhana, S.; Smith, V.C.; Jansen, C.; De Rycker, M.; Thomas, J.; MacLean, L.; Osuna-Cabello, M.; Riley, J.; Scullion, P.; Stojanovski, L.; Simeons, F.R.C.; Epemolu, O.; Shishikura, Y.; Crouch, S.D.; Bakshi, T.S.; Nixon, C.J.; Reid, I.H.; Hill, A.P.; Underwood, T.Z.; Hindley, S.J.; Robinson, S.A.; Kelly, J.M.; Fiandor, J.M.; Wyatt, P.G.; Marco, M.; Miles, T.J.; Read, K.D.; Gilbert, I.H. 2017: Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. Journal of Medicinal Chemistry 60(17): 7284-7299
Jones, S.; Ahmet, J.; Ayton, K.; Ball, M.; Cockerill, M.; Fairweather, E.; Hamilton, N.; Harper, P.; Hitchin, J.; Jordan, A.; Levy, C.; Lopez, R.; McKenzie, E.; Packer, M.; Plant, D.; Simpson, I.; Simpson, P.; Sinclair, I.; Somervaille, T.C.P.; Small, H.; Spencer, G.J.; Thomson, G.; Tonge, M.; Waddell, I.; Walsh, J.; Waszkowycz, B.; Wigglesworth, M.; Wiseman, D.H.; Ogilvie, D. 2016: Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells. Journal of Medicinal Chemistry 59(24): 11120-11137
Guo, L.; Parker, D.L.; Zang, Y.; Sweis, R.F.; Liu, W.; Sherer, E.C.; Buist, N.; Terebetski, J.; Kelly, T.; Bugianesi, R.; Priest, B.T.; Dingley, K.H.; Li, X.; Mitelman, S.; Salituro, G.; Trujillo, M.E.; Pachanski, M.; Kirkland, M.; Powles, M.Ann.; Eiermann, G.J.; Feng, Y.; Shang, J.; Howard, A.D.; Ujjainwalla, F.; Sinz, C.J.; Debenham, J.S.; Edmondson, S.D.; Nargund, R.P.; Hagmann, W.K.; Li, D. 2016: Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes. Acs Medicinal Chemistry Letters 7(12): 1107-1111
Teno, N.; Iguchi, Y.; Yamashita, Y.; Mori, N.; Une, M.; Nishimaki-Mogami, T.; Gohda, K. 2017: Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists. Bioorganic and Medicinal Chemistry 25(6): 1787-1794
Wu, D.; Zhang, T.; Chen, Y.; Huang, Y.; Geng, H.; Yu, Y.; Zhang, C.; Lai, Z.; Wu, Y.; Guo, X.; Chen, J.; Luo, H-Bin. 2017: Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension. Journal of Medicinal Chemistry 60(15): 6622-6637
Bialucha, C.U.; Collins, S.D.; Li, X.; Saxena, P.; Zhang, X.; Dürr, C.; Lafont, B.; Prieur, P.; Shim, Y.; Mosher, R.; Lee, D.; Ostrom, L.; Hu, T.; Bilic, S.; Rajlic, I.Liric.; Capka, V.; Jiang, W.; Wagner, J.P.; Elliott, G.; Veloso, A.; Piel, J.C.; Flaherty, M.M.; Mansfield, K.G.; Meseck, E.K.; Rubic-Schneider, T.; London, A.Serdakowski.; Tschantz, W.R.; Kurz, M.; Nguyen, D.; Bourret, A.; Meyer, M.J.; Faris, J.E.; Janatpour, M.J.; Chan, V.W.; Yoder, N.C.; Catcott, K.C.; McShea, M.A.; Sun, X.; Gao, H.; Williams, J.; Hofmann, F.; Engelman, J.A.; Ettenb 2017: Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discovery 7(9): 1030-1045
Panchaud, P.; Bruyère, T.; Blumstein, A-Catherine.; Bur, D.; Chambovey, A.; Ertel, E.A.; Gude, M.; Hubschwerlen, C.; Jacob, Lïc.; Kimmerlin, T.; Pfeifer, T.; Prade, L.; Seiler, P.; Ritz, D.; Rueedi, G. 2017: Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. Journal of Medicinal Chemistry 60(9): 3755-3775
Bartolozzi, A.; Abeywardane, A.; Bosanac, T.; Broadwater, J.A.; Chen, Z.; Hutzler, J.Matthew.; Huber, J.D.; Nemoto, P.; Olague, A.; Riether, D.; Simpson, T.; Takahashi, H.; Wu, L.; Zhang, Y.; Zindell, R.M. 2017: Discovery and optimization of oxadiazole-based FLAP inhibitors. Bioorganic and Medicinal Chemistry Letters 27(20): 4652-4659
Rai, G.; Brimacombe, K.R.; Mott, B.T.; Urban, D.J.; Hu, X.; Yang, S-Ming.; Lee, T.D.; Cheff, D.M.; Kouznetsova, J.; Benavides, G.A.; Pohida, K.; Kuenstner, E.J.; Luci, D.K.; Lukacs, C.M.; Davies, D.R.; Dranow, D.M.; Zhu, H.; Sulikowski, G.; Moore, W.J.; Stott, G.M.; Flint, A.J.; Hall, M.D.; Darley-Usmar, V.M.; Neckers, L.M.; Dang, C.V.; Waterson, A.G.; Simeonov, A.; Jadhav, A.; Maloney, D.J. 2017: Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of Medicinal Chemistry 60(22): 9184-9204
Wang, Y.; Chen, Z.; Dai, M.; Sun, P.; Wang, C.; Gao, Y.; Zhao, H.; Zeng, W.; Shen, L.; Mao, W.; Wang, T.; Hu, G.; Li, J.; Chen, S.; Long, C.; Chen, X.; Liu, J.; Zhang, Y. 2017: Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping. Bioorganic and Medicinal Chemistry Letters 27(11): 2420-2423
Ye, Y.; Zhang, B.; Mao, R.; Zhang, C.; Wang, Y.; Xing, J.; Liu, Y-Chih.; Luo, X.; Ding, H.; Yang, Y.; Zhou, B.; Jiang, H.; Chen, K.; Luo, C.; Zheng, M. 2017: Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening. Organic and Biomolecular Chemistry 15(17): 3648-3661
Garzan, A.; Willby, M.J.; Green, K.D.; Tsodikov, O.V.; Posey, J.E.; Garneau-Tsodikova, S. 2016: Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis. Acs Medicinal Chemistry Letters 7(12): 1219-1221
Tadesse, S.; Bantie, L.; Tomusange, K.; Yu, M.; Islam, S.; Bykovska, N.; Noll, B.; Zhu, G.; Li, P.; Lam, F.; Kumarasiri, M.; Milne, R.; Wang, S. 2018: Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents. British Journal of Pharmacology 175(12): 2399-2413
Shibata, A.; Kuno, M.; Adachi, R.; Sato, Y.; Hattori, H.; Matsuda, A.; Okuzono, Y.; Igaki, K.; Tominari, Y.; Takagi, T.; Yabuki, M.; Okaniwa, M. 2017: Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy. Plos one 12(10): E0186587
Perera, T.P.S.; Jovcheva, E.; Mevellec, L.; Vialard, J.; De Lange, D.; Verhulst, T.; Paulussen, C.; Van De Ven, K.; King, P.; Freyne, E.; Rees, D.C.; Squires, M.; Saxty, G.; Page, M.; Murray, C.W.; Gilissen, R.; Ward, G.; Thompson, N.T.; Newell, D.R.; Cheng, N.; Xie, L.; Yang, J.; Platero, S.J.; Karkera, J.D.; Moy, C.; Angibaud, P.; Laquerre, S.; Lorenzi, M.V. 2017: Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor. Molecular Cancer Therapeutics 16(6): 1010-1020
O'Brien-Brown, J.; Jackson, A.; Reekie, T.A.; Barron, M.L.; Werry, E.L.; Schiavini, P.; McDonnell, M.; Munoz, L.; Wilkinson, S.; Noll, B.; Wang, S.; Kassiou, M. 2017: Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X 7 receptor antagonists. European Journal of Medicinal Chemistry 130: 433-439
Galambos, János.; Bielik, A.; Krasavin, M.; Orgován, Zán.; Domány, Görgy.; Nógrádi, K.; Wágner, Gábor.; Balogh, Görgy.T.; Béni, Zán.; Kóti, János.; Szakács, Zán.; Bobok, A.; Kolok, Sándor.; Mikó-Bakk, Mónika.L.; Vastag, Mónika.; Sághy, K.; Laszy, J.; Halász, A.Sándor.; Balázs, O.; Gál, K.; Greiner, Ián.; Szombathelyi, Z.; Keserű, Görgy.M. 2017: Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications. Journal of Medicinal Chemistry 60(6): 2470-2484
Ariazi, J.L.; Duffy, K.J.; Adams, D.F.; Fitch, D.M.; Luo, L.; Pappalardi, M.; Biju, M.; DiFilippo, E.Hugger.; Shaw, T.; Wiggall, K.; Erickson-Miller, C. 2017: Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. Journal of Pharmacology and Experimental Therapeutics 363(3): 336-347
Qiu, Z.; Lin, X.; Zhang, W.; Zhou, M.; Guo, L.; Kocer, B.; Wu, G.; Zhang, Z.; Liu, H.; Shi, H.; Kou, B.; Hu, T.; Hu, Y.; Huang, M.; Yan, S.Frank.; Xu, Z.; Zhou, Z.; Qin, N.; Wang, Y.Fen.; Ren, S.; Qiu, H.; Zhang, Y.; Zhang, Y.; Wu, X.; Sun, K.; Zhong, S.; Xie, J.; Ottaviani, G.; Zhou, Y.; Zhu, L.; Tian, X.; Shi, L.; Shen, F.; Mao, Y.; Zhou, X.; Gao, L.; Young, J.A.T.; Wu, J.Zhen.; Yang, G.; Mayweg, A.V.; Shen, H.C.; Tang, G.; Zhu, W. 2017: Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors. Journal of Medicinal Chemistry 60(8): 3352-3371
El Kassas, M.; Elbaz, T.; Hafez, E.; Wifi, M.Naguib.; Esmat, G. 2017: Discovery and preclinical development of dasabuvir for the treatment of hepatitis C infection. Expert Opinion on Drug Discovery 12(6): 635-642
Lin, C-Wen.; Sherman, B.; Moore, L.A.; Laethem, C.L.; Lu, D-Wen.; Pattabiraman, P.P.; Rao, P.Vasantha.; deLong, M.A.; Kopczynski, C.C. 2018: Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. Journal of Ocular Pharmacology and Therapeutics: the Official Journal of the Association for Ocular Pharmacology and Therapeutics 34(1-2): 40-51
Boiteau, J-Guy.; Ouvry, G.; Arlabosse, J-Marie.; Astri, Séphanie.; Beillard, A.; Bhurruth-Alcor, Y.; Bonnary, L.; Bouix-Peter, C.; Bouquet, K.; Bourotte, M.; Cardinaud, I.; Comino, C.; Deprez, Bît.; Duvert, D.; Féret, Aélique.; Hacini-Rachinel, F.; Harris, C.S.; Luzy, A-Pascale.; Mathieu, A.; Millois, C.; Orsini, N.; Pascau, J.; Pinto, A.; Piwnica, D.; Polge, Gëlle.; Reitz, A.; Reversé, K.; Rodeville, N.; Rossio, P.; Spiesse, D.; Tabet, S.; Taquet, N.; Tomas, Lïc.; Vial, E.; Hennequin, L.F. 2018: Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis. Bioorganic and Medicinal Chemistry 26(4): 945-956
Kojima, H.; Ieda, M. 2017: Discovery and progress of direct cardiac reprogramming. Cellular and Molecular Life Sciences: Cmls 74(12): 2203-2215
Zang, Y-Yang.; Li, Y-Mei.; Yin, Y.; Chen, S-Shan.; Kai, Z-Peng. 2017: Discovery and quantitative structure-activity relationship study of lepidopteran HMG-CoA reductase inhibitors as selective insecticides. Pest Management Science 73(9): 1944-1952
Jakubczyk, D.; Caputi, L.; Hatsch, Aëlle.; Nielsen, C.A.F.; Diefenbacher, M.; Klein, J.; Molt, A.; Schröder, H.; Cheng, J.Z.; Naesby, M.; O'Connor, S.E. 2015: Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway-Enzymatic Formation of a Cyclopropyl Group. Angewandte Chemie 127(17): 5206-5210
Holzinger, E.R.; Verma, S.S.; Moore, C.B.; Hall, M.; De, R.; Gilbert-Diamond, D.; Lanktree, M.B.; Pankratz, N.; Amuzu, A.; Burt, A.; Dale, C.; Dudek, S.; Furlong, C.E.; Gaunt, T.R.; Kim, D.Seung.; Riess, H.; Sivapalaratnam, S.; Tragante, V.; van Iperen, E.P.A.; Brautbar, A.; Carrell, D.S.; Crosslin, D.R.; Jarvik, G.P.; Kuivaniemi, H.; Kullo, I.J.; Larson, E.B.; Rasmussen-Torvik, L.J.; Tromp, G.; Baumert, J.; Cruickshanks, K.J.; Farrall, M.; Hingorani, A.D.; Hovingh, G.K.; Kleber, M.E.; Klein, B.E.; Klein, R.; Koenig, W.; Lange, L.A.; Mӓrz, W.; North, K 2017: Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. Biodata Mining 10: 25
Henne, W.Mike. 2017: Discovery and Roles of ER-Endolysosomal Contact Sites in Disease. Advances in Experimental Medicine and Biology 997: 135-147
Iwaki, T.; Nakamura, Y.; Tanaka, T.; Ogawa, Y.; Iwamoto, O.; Okamura, Y.; Kawase, Y.; Furuya, M.; Oyama, Y.; Nagayama, T. 2017: Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. Bioorganic and Medicinal Chemistry Letters 27(21): 4904-4907
Zhou, M.; Wang, M.; Zhong, R-Feng.; Liao, X-Ming.; Deng, L-Li.; Xu, G-Bo.; He, X.; Li, J.; Li, Y-Jun.; Liu, T.; Wang, Y-Lin.; Liao, S-Gao. 2017: Discovery and structure-activity relationship of auriculatone: A potent hepatoprotective agent against acetaminophen-induced liver injury. Bioorganic and Medicinal Chemistry Letters 27(16): 3636-3642
Li, R.; Ning, X.; Zhou, S.; Lin, Z.; Wu, X.; Chen, H.; Bai, X.; Wang, X.; Ge, Z.; Li, R.; Yin, Y. 2018: Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators. European Journal of Medicinal Chemistry 143: 48-65
Osman, K.T.; Ye, J.; Shi, Z.; Toker, C.; Lovato, D.; Jumani, R.S.; Zuercher, W.; Huston, C.D.; Edwards, A.M.; Lautens, M.; Santhakumar, V.; Hui, R. 2017: Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor. Bioorganic and Medicinal Chemistry 25(5): 1672-1680
Kadayat, T.Man.; Banskota, S.; Gurung, P.; Bist, G.; Thapa Magar, T.Bahadur.; Shrestha, A.; Kim, J-Ae.; Lee, E-Seok. 2017: Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. European Journal of Medicinal Chemistry 137: 575-597
Luan, S.; Ge, Q.; Chen, Y.; Dai, M.; Yang, J.; Li, K.; Liu, D.; Zhao, L. 2017: Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(9): 1943-1948
Murafuji, H.; Sakai, H.; Goto, M.; Imajo, S.; Sugawara, H.; Muto, T. 2017: Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(23): 5272-5276
Zheng, Q.; Tang, S.; Fu, X.; Chen, Z.; Ye, Y.; Lan, X.; Jiang, L.; Huang, Y.; Ding, J.; Geng, M.; Huang, M.; Wan, H. 2017: Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors. Bioorganic and Medicinal Chemistry Letters 27(23): 5262-5266
Bhide, R.S.; Keon, A.; Weigelt, C.; Sack, J.S.; Schmidt, R.J.; Lin, S.; Xiao, H-Yun.; Spergel, S.H.; Kempson, J.; Pitts, W.J.; Carman, J.; Poss, M.A. 2017: Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(21): 4908-4913
Matsui, Y.; Yasumatsu, I.; Asahi, T.; Kitamura, T.; Kanai, K.; Ubukata, O.; Hayasaka, H.; Takaishi, S.; Hanzawa, H.; Katakura, S. 2017: Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator. Bioorganic and Medicinal Chemistry 25(13): 3540-3546
Zhao, C.; Zhao, P.; Feng, B.; Hou, X.; Zhao, L. 2017: Discovery and Synthesis of Amino Acids Modified Deoxycholic Acid Derivatives and in Vitro Antiproliferative Evaluation. Chemical and Pharmaceutical Bulletin 65(3): 276-283
Siegel, D.; Hui, H.C.; Doerffler, E.; Clarke, M.O.; Chun, K.; Zhang, L.; Neville, S.; Carra, E.; Lew, W.; Ross, B.; Wang, Q.; Wolfe, L.; Jordan, R.; Soloveva, V.; Knox, J.; Perry, J.; Perron, M.; Stray, K.M.; Barauskas, O.; Feng, J.Y.; Xu, Y.; Lee, G.; Rheingold, A.L.; Ray, A.S.; Bannister, R.; Strickley, R.; Swaminathan, S.; Lee, W.A.; Bavari, S.; Cihlar, T.; Lo, M.K.; Warren, T.K.; Mackman, R.L. 2017: Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Journal of Medicinal Chemistry 60(5): 1648-1661
Naman, C.Benjamin.; Almaliti, J.; Armstrong, L.; Caro-Díaz, E.J.; Pierce, M.L.; Glukhov, E.; Fenner, A.; Spadafora, C.; Debonsi, H.M.; Dorrestein, P.C.; Murray, T.F.; Gerwick, W.H. 2017: Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. Journal of Natural Products 80(8): 2328-2334
Wang, J.; Ge, R.; Qiu, X.; Xu, X.; Wei, L.; Li, Z.; Bian, J. 2017: Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro. European Journal of Medicinal Chemistry 140: 421-434
Hüttel, S.; Testolin, G.; Herrmann, J.; Planke, T.; Gille, F.; Moreno, M.; Stadler, M.; Brönstrup, M.; Kirschning, A.; Müller, R. 2017: Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens. Angewandte Chemie 56(41): 12760-12764
Croner, L.J.; Dillon, R.; Kao, A.; Kairs, S.N.; Benz, R.; Christensen, I.J.; Nielsen, H.J.; Blume, J.E.; Wilcox, B. 2017: Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects. Clinical Proteomics 14: 28
De Groote, M.A.; Sterling, D.G.; Hraha, T.; Russell, T.M.; Green, L.S.; Wall, K.; Kraemer, S.; Ostroff, R.; Janjic, N.; Ochsner, U.A. 2017: Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis. Journal of Clinical Microbiology 55(10): 3057-3071
Clarke, M.A.; Luhn, P.; Gage, J.C.; Bodelon, C.; Dunn, S.Terence.; Walker, J.; Zuna, R.; Hewitt, S.; Killian, J.Keith.; Yan, L.; Miller, A.; Schiffman, M.; Wentzensen, N. 2017: Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer. International Journal of Cancer 141(4): 701-710
Zhou, M.; Zhao, H.; Xu, W.; Bao, S.; Cheng, L.; Sun, J. 2017: Discovery and validation of immune-associated long non-coding RNA biomarkers associated with clinically molecular subtype and prognosis in diffuse large B cell lymphoma. Molecular Cancer 16(1): 16
Zhou, Y.; Song, R.; Ma, C.; Zhou, L.; Liu, X.; Yin, P.; Zhang, Z.; Sun, Y.; Xu, C.; Lu, X.; Xu, G. 2017: Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method. Oncotarget 8(13): 20719-20728
Shen, H.; Nelson, D.M.; Oliveira, R.V.; Zhang, Y.; Mcnaney, C.A.; Gu, X.; Chen, W.; Su, C.; Reily, M.D.; Shipkova, P.A.; Gan, J.; Lai, Y.; Marathe, P.; Humphreys, W.Griffith. 2018: Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys. Drug Metabolism and Disposition: the Biological Fate of Chemicals 46(2): 178-188
Wang, Y.; Zhang, M.; Xu, H.; Wang, Y.; Li, Z.; Chang, Y.; Wang, X.; Fu, X.; Zhou, Z.; Yang, S.; Wang, B.; Shang, Y. 2017: Discovery and validation of the tumor-suppressive function of long noncoding RNA PANDA in human diffuse large B-cell lymphoma through the inactivation of MAPK/ERK signaling pathway. Oncotarget 8(42): 72182-72196
Kundu, S.; Kolouri, S.; Erickson, K.I.; Kramer, A.F.; McAuley, E.; Rohde, G.K. 2018: Discovery and visualization of structural biomarkers from MRI using transport-based morphometry. Neuroimage 167: 256-275
Guidi, A.; Lalli, C.; Gimmelli, R.; Nizi, E.; Andreini, M.; Gennari, N.; Saccoccia, F.; Harper, S.; Bresciani, A.; Ruberti, G. 2017: Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production. Plos Neglected Tropical Diseases 11(10): E0005994
Jeffries, D.E.; Witt, J.O.; McCollum, A.L.; Temple, K.J.; Hurtado, M.A.; Harp, J.M.; Blobaum, A.L.; Lindsley, C.W.; Hopkins, C.R. 2016: Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D 4 R) antagonists. Bioorganic and Medicinal Chemistry Letters 26(23): 5757-5764
Shetty, R.; Vestergaard, M.; Jessen, F.; Hägglund, P.; Knorr, V.; Koehler, P.; Prakash, H.S.; Hobley, T.John. 2017: Discovery, cloning and characterisation of proline specific prolyl endopeptidase, a gluten degrading thermo-stable enzyme from Sphaerobacter thermophiles. Enzyme and Microbial Technology 107: 57-63
Watson, G.M.; Kulkarni, K.; Sang, J.; Ma, X.; Gunzburg, M.J.; Perlmutter, P.; Wilce, M.C.J.; Wilce, J.A. 2017: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. Journal of Medicinal Chemistry 60(22): 9349-9359
Holderman, C.J.; Wood, L.A.; Geden, C.J.; Kaufman, P.E. 2017: Discovery, Development, and Evaluation of a Horn Fly-Isolated (Diptera: Muscidae) Beauveria bassiana (Hypocreales: Cordyciptaceae) Strain From Florida, USA. Journal of Insect Science 17(2)
Schock, E.N.; Brugmann, S.A. 2017: Discovery, Diagnosis, and Etiology of Craniofacial Ciliopathies. Cold Spring Harbor Perspectives in Biology 9(9)
Hänninen, P.; Niinimäki, T.; Flinkkilä, T.; Niinimäki, J.; Ohtonen, P.; Yli-Luukko, S.; Leppilahti, J. 2017: Discovery Elbow System: clinical and radiological results after 2- to 10-year follow-up. European Journal of Orthopaedic Surgery and Traumatology: Orthopedie Traumatologie 27(7): 901-907
Nozaki, T. 2017: Discovery in Japan of the second species of the genus Dolichocentrus Martynov (Trichoptera: Brachycentridae). Zootaxa 4227(4)
Chen, W.; Guo, N.; Qi, M.; Dai, H.; Hong, M.; Guan, L.; Huan, X.; Song, S.; He, J.; Wang, Y.; Xi, Y.; Yang, X.; Shen, Y.; Su, Y.; Sun, Y.; Gao, Y.; Chen, Y.; Ding, J.; Tang, Y.; Ren, G.; Miao, Z.; Li, J. 2017: Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy. European Journal of Medicinal Chemistry 138: 514-531
Gómez-Outes, A.; García-Fuentes, M.; Suárez-Gea, Mª.Luisa. 2017: Discovery methods of coagulation-inhibiting drugs. Expert Opinion on Drug Discovery 12(12): 1195-1205
Wu, C.; Eck, B.; Zhang, S.; Zhu, J.; Tiwari, A.Dev.; Zhang, Y.; Zhu, Y.; Zhang, J.; Wang, B.; Wang, X.; Wang, X.; You, J.; Wang, J.; Guan, Y.; Liu, X.; Yu, X.; Trapp, B.D.; Miller, R.; Silver, J.; Wilson, D.; Wang, Y. 2017: Discovery of 1,2,3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System. Journal of Medicinal Chemistry 60(3): 987-999
Wang, S.; Yang, J.; Li, X.; Liu, Z.; Wu, Y.; Si, G.; Tao, Y.; Zhao, N.; Hu, X.; Ma, Y.; Liu, G. 2017: Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo. Journal of Medicinal Chemistry 60(12): 5162-5192
Wang, A.; Li, X.; Chen, C.; Wu, H.; Qi, Z.; Hu, C.; Yu, K.; Wu, J.; Liu, J.; Liu, X.; Hu, Z.; Wang, W.; Wang, W.; Wang, W.; Wang, L.; Wang, B.; Liu, Q.; Li, L.; Ge, J.; Ren, T.; Zhang, S.; Xia, R.; Liu, J.; Liu, Q. 2017: Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML. Journal of Medicinal Chemistry 60(20): 8407-8424
Shin, W.Shik.; Bergstrom, A.; Bonomo, R.A.; Crowder, M.W.; Muthyala, R.; Sham, Y.Yin. 2017: Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor. Chemmedchem 12(11): 845-849
Elkamhawy, A.; Park, J-Eun.; Hassan, A.H.E.; Ra, H.; Pae, A.Nim.; Lee, J.; Park, B-Geon.; Moon, B.; Park, H-Mee.; Roh, E.Joo. 2017: Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction. European Journal of Medicinal Chemistry 128: 56-69
Li, W.; Sun, Q.; Song, L.; Gao, C.; Liu, F.; Chen, Y.; Jiang, Y. 2017: Discovery of 1-(3-aryl-4-chlorophenyl)-3-(p-aryl)urea derivatives against breast cancer by inhibiting PI3K/Akt/mTOR and Hedgehog signalings. European Journal of Medicinal Chemistry 141: 721-733
Desroy, N.; Housseman, C.; Bock, X.; Joncour, Aès.; Bienvenu, N.; Cherel, Lëtitia.; Labeguere, V.; Rondet, E.; Peixoto, C.; Grassot, J-Marie.; Picolet, O.; Annoot, D.; Triballeau, N.; Monjardet, A.; Wakselman, E.; Roncoroni, V.; Le Tallec, S.; Blanque, R.; Cottereaux, C.; Vandervoort, N.; Christophe, T.; Mollat, P.; Lamers, M.; Auberval, M.; Hrvacic, B.; Ralic, J.; Oste, L.; van der Aar, E.; Brys, R.; Heckmann, B. 2017: Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. Journal of Medicinal Chemistry 60(9): 3580-3590
Zhao, H-Yi.; Wang, H-Yan.; Mao, S.; Xin, M.; Zhang, H.; Zhang, S-Qi. 2017: Discovery of 2-(pyridin-2-yl)aniline as a directing group for the sp 2 C-H bond amination mediated by cupric acetate. Organic and Biomolecular Chemistry 15(31): 6622-6631
Tran, T-Anh.; Kramer, B.; Shin, Y-Jun.; Vallar, P.; Boatman, P.Douglas.; Zou, N.; Sage, C.R.; Gharbaoui, T.; Krishnan, A.; Pal, B.; Shakya, S.R.; Garrido Montalban, A.; Adams, J.W.; Ramirez, J.; Behan, D.P.; Shifrina, A.; Blackburn, A.; Leakakos, T.; Shi, Y.; Morgan, M.; Sadeque, A.; Chen, W.; Unett, D.J.; Gaidarov, I.; Chen, X.; Chang, S.; Shu, H-Hui.; Tung, S-Feng.; Semple, G. 2017: Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. Journal of Medicinal Chemistry 60(3): 913-927
Zeng, D.; Zhang, R.; Nie, Q.; Cao, L.; Shang, L.; Yin, Z. 2016: Discovery of 2'-α-C-Methyl-2'-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus. Acs Medicinal Chemistry Letters 7(12): 1197-1201
Feng, B.; Zhang, J.; Ito, S.; Arita, M.; Cheng, C.; Chen, L.; Wu, K.; Komori, F.; Sugino, O.; Miyamoto, K.; Okuda, T.; Meng, S.; Matsuda, I. 2018: Discovery of 2D Anisotropic Dirac Cones. Advanced Materials 30(2)
Wei, L.; Wang, J.; Zhang, X.; Wang, P.; Zhao, Y.; Li, J.; Hou, T.; Qu, L.; Shi, L.; Liang, X.; Fang, Y. 2017: Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists. Journal of Medicinal Chemistry 60(1): 362-372
Liang, X.; Lv, F.; Wang, B.; Yu, K.; Wu, H.; Qi, Z.; Jiang, Z.; Chen, C.; Wang, A.; Miao, W.; Wang, W.; Hu, Z.; Liu, J.; Liu, X.; Zhao, Z.; Wang, L.; Zhang, S.; Ye, Z.; Wang, C.; Ren, T.; Wang, Y.; Liu, Q.; Liu, J. 2017: Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. Journal of Medicinal Chemistry 60(5): 1793-1816
Yang, L.; Ma, X.; Yuan, C.; He, Y.; Li, L.; Fang, S.; Xia, W.; He, T.; Qian, S.; Xu, Z.; Li, G.; Wang, Z. 2017: Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors. European Journal of Medicinal Chemistry 134: 230-241
Kounde, C.S.; Yeo, H-Quan.; Wang, Q-Yin.; Wan, K.Fei.; Dong, H.; Karuna, R.; Dix, I.; Wagner, T.; Zou, B.; Simon, O.; Bonamy, G.M.C.; Yeung, B.K.S.; Yokokawa, F. 2017: Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit. Bioorganic and Medicinal Chemistry Letters 27(6): 1385-1389
Zhou, J.; Ji, M.; Zhu, Z.; Cao, R.; Chen, X.; Xu, B. 2017: Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity. European Journal of Medicinal Chemistry 132: 26-41
Wang, G.; Wang, J.; Xie, Z.; Chen, M.; Li, L.; Peng, Y.; Chen, S.; Li, W.; Deng, B. 2017: Discovery of 3,3-di(indolyl)indolin-2-one as a novel scaffold for α-glucosidase inhibitors: In silico studies and SAR predictions. Bioorganic Chemistry 72: 228-233
Fujimoto, J.; Okamoto, R.; Noguchi, N.; Hara, R.; Masada, S.; Kawamoto, T.; Nagase, H.; Tamura, Y.Okano.; Imanishi, M.; Takagahara, S.; Kubo, K.; Tohyama, K.; Iida, K.; Andou, T.; Miyahisa, I.; Matsui, J.; Hayashi, R.; Maekawa, T.; Matsunaga, N. 2017: Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ-5 Desaturase (D5D) Inhibitors. Journal of Medicinal Chemistry 60(21): 8963-8981
Verhasselt, S.; Roman, B.I.; De Wever, O.; Van Hecke, K.; Van Deun, R.; Bracke, M.E.; Stevens, C.V. 2017: Discovery of (S)-3'-hydroxyblebbistatin and (S)-3'-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties. Organic and Biomolecular Chemistry 15(9): 2104-2118
Boga, S.Babu.; Alhassan, A-Basit.; Liu, J.; Guiadeen, D.; Krikorian, A.; Gao, X.; Wang, J.; Yu, Y.; Anand, R.; Liu, S.; Yang, C.; Wu, H.; Cai, J.; Zhu, H.; Desai, J.; Maloney, K.; Gao, Y-Duo.; Fischmann, T.O.; Presland, J.; Mansueto, M.; Xu, Z.; Leccese, E.; Knemeyer, I.; Garlisi, C.G.; Bays, N.; Stivers, P.; Brandish, P.E.; Hicks, A.; Cooper, A.; Kim, R.M.; Kozlowski, J.A. 2017: Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis. Bioorganic and Medicinal Chemistry Letters 27(16): 3939-3943
Barzen-Hanson, K.A.; Roberts, S.C.; Choyke, S.; Oetjen, K.; McAlees, A.; Riddell, N.; McCrindle, R.; Ferguson, P.Lee.; Higgins, C.P.; Field, J.A. 2017: Discovery of 40 Classes of Per- and Polyfluoroalkyl Substances in Historical Aqueous Film-Forming Foams (AFFFs) and AFFF-Impacted Groundwater. Environmental Science and Technology 51(4): 2047-2057
Galambos, János.; Bielik, A.; Wágner, Gábor.; Domány, Görgy.; Kóti, János.; Béni, Zán.; Szigetvári, Áron.; Sánta, Z.; Orgován, Zán.; Bobok, A.; Kiss, Béla.; Mikó-Bakk, Mónika.L.; Vastag, Mónika.; Sághy, K.; Krasavin, M.; Gál, K.; Greiner, Ián.; Szombathelyi, Z.; Keserű, Görgy.M. 2017: Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu 5 ) receptor negative allosteric modulators. European Journal of Medicinal Chemistry 133: 240-254
Mochizuki, M.; Kojima, T.; Kobayashi, K.; Kotani, E.; Ishichi, Y.; Kanzaki, N.; Nakagawa, H.; Okuda, T.; Kosugi, Y.; Yano, T.; Sako, Y.; Tanaka, M.; Aso, K. 2017: Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF 1 receptor antagonist. Bioorganic and Medicinal Chemistry 25(5): 1556-1570
Aguilar, A.; Lu, J.; Liu, L.; Du, D.; Bernard, D.; McEachern, D.; Przybranowski, S.; Li, X.; Luo, R.; Wen, B.; Sun, D.; Wang, H.; Wen, J.; Wang, G.; Zhai, Y.; Guo, M.; Yang, D.; Wang, S. 2017: Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. Journal of Medicinal Chemistry 60(7): 2819-2839
Wang, Q.; Liu, F.; Wang, B.; Zou, F.; Qi, Z.; Chen, C.; Yu, K.; Hu, C.; Qi, S.; Wang, W.; Hu, Z.; Liu, J.; Wang, W.; Wang, L.; Liang, Q.; Zhang, S.; Ren, T.; Liu, Q.; Liu, J. 2017: Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding. Journal of Medicinal Chemistry 60(1): 273-289
Fu, D-Jun.; Song, J.; Hou, Y-Hui.; Zhao, R-Han.; Li, J-Huan.; Mao, R-Wang.; Yang, J-Jia.; Li, P.; Zi, X-Lin.; Li, Z-Hua.; Zhang, Q-Qing.; Wang, F-Yan.; Zhang, S-Yang.; Zhang, Y-Bing.; Liu, H-Min. 2017: Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers. European Journal of Medicinal Chemistry 138: 1076-1088
Wang, X.; Kolesnikov, A.; Tay, S.; Chan, G.; Chao, Q.; Do, S.; Drummond, J.; Ebens, A.J.; Liu, N.; Ly, J.; Harstad, E.; Hu, H.; Moffat, J.; Munugalavadla, V.; Murray, J.; Slaga, D.; Tsui, V.; Volgraf, M.; Wallweber, H.; Chang, J.H. 2017: Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. Journal of Medicinal Chemistry 60(10): 4458-4473
Chen, J.; Sang, Z.; Li, L.; He, L.; Ma, L. 2017: Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity. Molecular Diversity 21(3): 637-654
Ding, X.; Dai, X.; Long, K.; Peng, C.; Andreotti, D.; Bamborough, P.; Eatherton, A.J.; Edge, C.; Jandu, K.S.; Nichols, P.L.; Philps, O.J.; Stasi, L.Piero.; Wan, Z.; Xiang, J-Ning.; Dong, K.; Dossang, P.; Ho, M-Hsun.; Li, Y.; Mensah, L.; Guan, X.; Reith, A.D.; Ren, F. 2017: Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(17): 4034-4038
Zlatopolskiy, B.D.; Zischler, J.; Schäfer, D.; Urusova, E.A.; Guliyev, M.; Bannykh, O.; Endepols, H.; Neumaier, B. 2018: Discovery of 7-[ 18 F]Fluorotryptophan as a Novel Positron Emission Tomography (PET) Probe for the Visualization of Tryptophan Metabolism in Vivo. Journal of Medicinal Chemistry 61(1): 189-206
Qin, L-Ying.; Ruan, Z.; Cherney, R.J.; Dhar, T.G.Murali.; Neels, J.; Weigelt, C.A.; Sack, J.S.; Srivastava, A.S.; Cornelius, L.A.M.; Tino, J.A.; Stefanski, K.; Gu, X.; Xie, J.; Susulic, V.; Yang, X.; Yarde-Chinn, M.; Skala, S.; Bosnius, R.; Goldstein, C.; Davies, P.; Ruepp, S.; Salter-Cid, L.; Bhide, R.S.; Poss, M.A. 2017: Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors. Bioorganic and Medicinal Chemistry Letters 27(4): 855-861
Zhou, Z-Zhen.; Shi, X-Dong.; Feng, H-Fang.; Cheng, Y-Fang.; Wang, H-Tao.; Xu, J-Ping. 2017: Discovery of 9H-purins as potential tubulin polymerization inhibitors: Synthesis, biological evaluation and structure-activity relationships. European Journal of Medicinal Chemistry 138: 1126-1134
Kurata, H.; Kusumi, K.; Otsuki, K.; Suzuki, R.; Kurono, M.; Komiya, T.; Hagiya, H.; Mizuno, H.; Shioya, H.; Ono, T.; Takada, Y.; Maeda, T.; Matsunaga, N.; Kondo, T.; Tominaga, S.; Nunoya, K-Ici.; Kiyoshi, H.; Komeno, M.; Nakade, S.; Habashita, H. 2017: Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P 1 and S1P 5 Selective Agonist for the Treatment of Autoimmune Diseases. Journal of Medicinal Chemistry 60(23): 9508-9530
Kirschberg, T.A.; Metobo, S.; Clarke, M.O.; Aktoudianakis, V.; Babusis, D.; Barauskas, O.; Birkus, G.; Butler, T.; Byun, D.; Chin, G.; Doerffler, E.; Edwards, T.E.; Fenaux, M.; Lee, R.; Lew, W.; Mish, M.R.; Murakami, E.; Park, Y.; Squires, N.H.; Tirunagari, N.; Wang, T.; Whitcomb, M.; Xu, J.; Yang, H.; Ye, H.; Zhang, L.; Appleby, T.C.; Feng, J.Y.; Ray, A.S.; Cho, A.; Kim, C.U. 2017: Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties. Bioorganic and Medicinal Chemistry Letters 27(8): 1840-1847
Scott, J.D.; DeMong, D.E.; Greshock, T.J.; Basu, K.; Dai, X.; Harris, J.; Hruza, A.; Li, S.W.; Lin, S-Ing.; Liu, H.; Macala, M.K.; Hu, Z.; Mei, H.; Zhang, H.; Walsh, P.; Poirier, M.; Shi, Z-Cai.; Xiao, L.; Agnihotri, G.; Baptista, M.A.S.; Columbus, J.; Fell, M.J.; Hyde, L.A.; Kuvelkar, R.; Lin, Y.; Mirescu, C.; Morrow, J.A.; Yin, Z.; Zhang, X.; Zhou, X.; Chang, R.K.; Embrey, M.W.; Sanders, J.M.; Tiscia, H.E.; Drolet, R.E.; Kern, J.T.; Sur, S.M.; Renger, J.J.; Bilodeau, M.T.; Kennedy, M.E.; Parker, E.M.; Stamford, A.W.; Nargund, R.; McCauley, J.A.; Miller, M 2017: Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. Journal of Medicinal Chemistry 60(7): 2983-2992
Okumura, Y.; Yamagishi, T.; Nukui, S.; Nakao, K. 2017: Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorganic and Medicinal Chemistry Letters 27(5): 1186-1192
Kamada, Y.; Sakai, N.; Sogabe, S.; Ida, K.; Oki, H.; Sakamoto, K.; Lane, W.; Snell, G.; Iida, M.; Imaeda, Y.; Sakamoto, J.; Matsui, J. 2017: Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach. Journal of Medicinal Chemistry 60(10): 4358-4368
Duan, H.; Li, Y.; Arora, D.; Xu, D.; Lim, H-Ying.; Wang, W. 2017: Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress. Journal of Medicinal Chemistry 60(14): 6191-6204
Schenkel, L.B.; DiMauro, E.F.; Nguyen, H.N.; Chakka, N.; Du, B.; Foti, R.S.; Guzman-Perez, A.; Jarosh, M.; La, D.S.; Ligutti, J.; Milgram, B.C.; Moyer, B.D.; Peterson, E.A.; Roberts, J.; Yu, V.L.; Weiss, M.M. 2017: Discovery of a biarylamide series of potent, state-dependent Na V 1.7 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(16): 3817-3824
Yang, S-Hou.; Sun, Q.; Xiong, H.; Liu, S-Yu.; Moosavi, B.; Yang, W-Chao.; Yang, G-Fu. 2017: Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy. Chemical Communications 53(28): 3952-3955
Zhu, Q.; Liu, X. 2017: Discovery of a Calcium-Dependent Enzymatic Cascade for the Selective Assembly of Hapalindole-Type Alkaloids: On the Biosynthetic Origin of Hapalindole U. Angewandte Chemie 56(31): 9062-9066
Cheeseman, M.D.; Chessum, N.E.A.; Rye, C.S.; Pasqua, A.Elisa.; Tucker, M.J.; Wilding, B.; Evans, L.E.; Lepri, S.; Richards, M.; Sharp, S.Y.; Ali, S.; Rowlands, M.; O'Fee, L.; Miah, A.; Hayes, A.; Henley, A.T.; Powers, M.; Te Poele, R.; De Billy, E.; Pellegrino, L.; Raynaud, F.; Burke, R.; van Montfort, R.L.M.; Eccles, S.A.; Workman, P.; Jones, K. 2017: Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. Journal of Medicinal Chemistry 60(1): 180-201
Fu, Y.; Tang, S.; Su, Y.; Lan, X.; Ye, Y.; Zha, C.; Li, L.; Cao, J.; Chen, Y.; Jiang, L.; Huang, Y.; Ding, J.; Geng, M.; Huang, M.; Wan, H. 2017: Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(23): 5332-5336
Li, H.; Zhou, T.; Liu, H.; Xu, F.; Niu, Y.; Wang, C.; Liang, L.; Xu, P. 2017: Discovery of a cobalt complex with high MEK1 binding affinity. Bioorganic and Medicinal Chemistry Letters 27(10): 2221-2224
Chan, A.I.; McGregor, L.M.; Jain, T.; Liu, D.R. 2017: Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection. Journal of the American Chemical Society 139(30): 10192-10195
Abdelgawad, M.A.; Bakr, R.B.; El-Gendy, A.O.; Kamel, G.M.; Azouz, A.A.; Bukhari, S.Nasir.Abbas. 2017: Discovery of a COX-2 selective inhibitor hit with anti-inflammatory activity and gastric ulcer protective effect. Future Medicinal Chemistry 9(16): 1899-1912
Xu, F.; Nazari, B.; Moon, K.; Bushin, L.B.; Seyedsayamdost, M.R. 2017: Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. Journal of the American Chemical Society 139(27): 9203-9212
Li, Z.; Meng, Y.; Xu, S.; Shen, W.; Meng, Z.; Wang, Z.; Ding, G.; Huang, W.; Xiao, W.; Xu, J. 2017: Discovery of acylguanidine oseltamivir carboxylate derivatives as potent neuraminidase inhibitors. Bioorganic and Medicinal Chemistry 25(10): 2772-2781
Jarusiewicz, J.A.; Jeon, J.Yoon.; Connelly, M.C.; Chen, Y.; Yang, L.; Baker, S.D.; Guy, R.Kiplin. 2017: Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia. Acs Omega 2(5): 1985-2009
Burlein, C.; Wang, C.; Xu, M.; Bhatt, T.; Stahlhut, M.; Ou, Y.; Adam, G.C.; Heath, J.; Klein, D.J.; Sanders, J.; Narayan, K.; Abeywickrema, P.; Heo, M.Ra.; Carroll, S.S.; Grobler, J.A.; Sharma, S.; Diamond, T.L.; Converso, A.; Krosky, D.J. 2017: Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity. Acs Chemical Biology 12(11): 2858-2865
Harris, P.A.; Berger, S.B.; Jeong, J.U.; Nagilla, R.; Bandyopadhyay, D.; Campobasso, N.; Capriotti, C.A.; Cox, J.A.; Dare, L.; Dong, X.; Eidam, P.M.; Finger, J.N.; Hoffman, S.J.; Kang, J.; Kasparcova, V.; King, B.W.; Lehr, R.; Lan, Y.; Leister, L.K.; Lich, J.D.; MacDonald, T.T.; Miller, N.A.; Ouellette, M.T.; Pao, C.S.; Rahman, A.; Reilly, M.A.; Rendina, A.R.; Rivera, E.J.; Schaeffer, M.C.; Sehon, C.A.; Singhaus, R.R.; Sun, H.H.; Swift, B.A.; Totoritis, R.D.; Vossenkämper, A.; Ward, P.; Wisnoski, D.D.; Zhang, D.; Marquis, R.W.; Gough, P.J.; Bertin, J. 2017: Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. Journal of Medicinal Chemistry 60(4): 1247-1261
Zhang, Y.; Yan, J.; Yao, T-Pang. 2017: Discovery of a fluorescent probe with HDAC6 selective inhibition. European Journal of Medicinal Chemistry 141: 596-602
Carr, M.; Gonzalez, G.; Sasaki, M.; Ito, K.; Ishii, A.; Hang'ombe, B.M.; Mweene, A.S.; Orba, Y.; Sawa, H. 2017: Discovery of African bat polyomaviruses and infrequent recombination in the large T antigen in the Polyomaviridae. Journal of General Virology 98(4): 726-738
Taylor, Z.W.; Brown, H.A.; Narindoshvili, T.; Wenzel, C.Q.; Szymanski, C.M.; Holden, H.M.; Raushel, F.M. 2017: Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni. Journal of the American Chemical Society 139(28): 9463-9466
Lu, M-Chen.; Jiao, Q.; Liu, T.; Tan, S-Jie.; Zhou, H-Shan.; You, Q-Dong.; Jiang, Z-Yu. 2018: Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency. European Journal of Medicinal Chemistry 143: 1578-1589
Yeung, K-Sun.; Beno, B.R.; Parcella, K.; Bender, J.A.; Grant-Young, K.A.; Nickel, A.; Gunaga, P.; Anjanappa, P.; Bora, R.Onkardas.; Selvakumar, K.; Rigat, K.; Wang, Y-Kai.; Liu, M.; Lemm, J.; Mosure, K.; Sheriff, S.; Wan, C.; Witmer, M.; Kish, K.; Hanumegowda, U.; Zhuo, X.; Shu, Y-Zhong.; Parker, D.; Haskell, R.; Ng, A.; Gao, Q.; Colston, E.; Raybon, J.; Grasela, D.M.; Santone, K.; Gao, M.; Meanwell, N.A.; Sinz, M.; Soars, M.G.; Knipe, J.O.; Roberts, S.B.; Kadow, J.F. 2017: Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. Journal of Medicinal Chemistry 60(10): 4369-4385
Wang, W.; Lin, X-Dan.; Liao, Y.; Guan, X-Qing.; Guo, W-Ping.; Xing, J-Guang.; Holmes, E.C.; Zhang, Y-Zhen. 2017: Discovery of a Highly Divergent Coronavirus in the Asian House Shrew from China Illuminates the Origin of the Alphacoronaviruses. Journal of Virology 91(17)
Karatas, H.; Li, Y.; Liu, L.; Ji, J.; Lee, S.; Chen, Y.; Yang, J.; Huang, L.; Bernard, D.; Xu, J.; Townsend, E.C.; Cao, F.; Ran, X.; Li, X.; Wen, B.; Sun, D.; Stuckey, J.A.; Lei, M.; Dou, Y.; Wang, S. 2017: Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. Journal of Medicinal Chemistry 60(12): 4818-4839
Li, Y.; Guo, Q.; Zhang, C.; Huang, Z.; Wang, T.; Wang, X.; Wang, X.; Xu, G.; Liu, Y.; Yang, S.; Fan, Y.; Xiang, R. 2017: Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate. Bioorganic and Medicinal Chemistry Letters 27(15): 3231-3237
Gerken, P.A.; Wolstenhulme, J.R.; Tumber, A.; Hatch, S.B.; Zhang, Y.; Müller, S.; Chandler, S.A.; Mair, B.; Li, F.; Nijman, S.M.B.; Konietzny, R.; Szommer, T.; Yapp, C.; Fedorov, O.; Benesch, J.L.P.; Vedadi, M.; Kessler, B.M.; Kawamura, A.; Brennan, P.E.; Smith, M.D. 2017: Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7. Angewandte Chemie 56(49): 15555-15559
Scannevin, R.H.; Alexander, R.; Haarlander, T.Mezzasalma.; Burke, S.L.; Singer, M.; Huo, C.; Zhang, Y-Mei.; Maguire, D.; Spurlino, J.; Deckman, I.; Carroll, K.I.; Lewandowski, F.; Devine, E.; Dzordzorme, K.; Tounge, B.; Milligan, C.; Bayoumy, S.; Williams, R.; Schalk-Hihi, C.; Leonard, K.; Jackson, P.; Todd, M.; Kuo, L.C.; Rhodes, K.J. 2017: Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. Journal of Biological Chemistry 292(43): 17963-17974
Zhao, G.; Green, C.F.; Hui, Y-Hua.; Prieto, L.; Shepard, R.; Dong, S.; Wang, T.; Tan, B.; Gong, X.; Kays, L.; Johnson, R.L.; Wu, W.; Bhattachar, S.; Del Prado, M.; Gillig, J.R.; Fernandez, M-Carmen.; Roth, K.D.; Buchanan, S.; Kuo, M-Shang.; Geeganage, S.; Burkholder, T.P. 2017: Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration. Molecular Cancer Therapeutics 16(12): 2677-2688
Thomson, D.W.; Wagner, A.J.; Bantscheff, M.; Benson, R.Edward.; Dittus, L.; Duempelfeld, B.; Drewes, G.; Krause, J.; Moore, J.T.; Mueller, K.; Poeckel, D.; Rau, C.; Salzer, E.; Shewchuk, L.; Hopf, C.; Emery, J.G.; Muelbaier, M. 2017: Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. Journal of Medicinal Chemistry 60(13): 5455-5471
Kushwah, J.; Kumar, P.; Garg, V.; Somvanshi, V.Singh. 2017: Discovery of a Highly Virulent Strain of Photorhabdus luminescens ssp . akhurstii from Meghalaya, India. Indian Journal of Microbiology 57(1): 125-128
Takayama, K.; Mori, K.; Tanaka, A.; Nomura, E.; Sohma, Y.; Mori, M.; Taguchi, A.; Taniguchi, A.; Sakane, T.; Yamamoto, A.; Minamino, N.; Miyazato, M.; Kangawa, K.; Hayashi, Y. 2017: Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability. Journal of Medicinal Chemistry 60(12): 5228-5234
Sogabe, S.; Sakamoto, K.; Kamada, Y.; Kadotani, A.; Fukuda, Y.; Sakamoto, J-Ichi. 2017: Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization. Biochemical and Biophysical Research Communications 486(3): 620-625
Zhang, W-Yao.; Lu, W-Chao.; Jiang, H.; Lv, Z-Bing.; Xie, Y-Qian.; Lian, F-Lin.; Liang, Z-Jie.; Jiang, Y-Xi.; Wang, D-Jin.; Luo, C.; Jin, J.; Ye, F. 2017: Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors. Chemical Biology and Drug Design 90(6): 1260-1270
Iwatani-Yoshihara, M.; Ito, M.; Klein, M.G.; Yamamoto, T.; Yonemori, K.; Tanaka, T.; Miwa, M.; Morishita, D.; Endo, S.; Tjhen, R.; Qin, L.; Nakanishi, A.; Maezaki, H.; Kawamoto, T. 2017: Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. Journal of Medicinal Chemistry 60(13): 5759-5771
Yan, J.; Wang, G.; Dang, X.; Guo, B.; Chen, W.; Wang, T.; Zeng, L.; Wang, H.; Hu, Y. 2017: Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety. Bioorganic and Medicinal Chemistry 25(17): 4701-4714
Sharma, K.K.; Maurya, I.Kumar.; Khan, S.I.; Jacob, M.R.; Kumar, V.; Tikoo, K.; Jain, R. 2017: Discovery of a Membrane-Active, Ring-Modified Histidine Containing Ultrashort Amphiphilic Peptide That Exhibits Potent Inhibition of Cryptococcus neoformans. Journal of Medicinal Chemistry 60(15): 6607-6621
Steffen, W.; Ko, F.Chong.; Patel, J.; Lyamichev, V.; Albert, T.J.; Benz, Jörg.; Rudolph, M.G.; Bergmann, F.; Streidl, T.; Kratzsch, P.; Boenitz-Dulat, M.; Oelschlaegel, T.; Schraeml, M. 2017: Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins. Journal of Biological Chemistry 292(38): 15622-15635
Teng, M.; Wu, W.; Li, Z.; Yang, G.; Qin, J.; Wang, Y.; Hu, Z.; Dong, H.; Hou, L.; Hu, G.; Shen, L.; Zhang, Y.; Li, J.; Chen, S.; Tian, J.; Ye, L.; Zhang, J.; Wang, H. 2017: Discovery of aminocyclohexene analogues as selective and orally bioavailable hNav1.7 inhibitors for analgesia. Bioorganic and Medicinal Chemistry Letters 27(22): 4979-4984
Dai, Z.; Zhao, Y-Yang. 2017: Discovery of a murine model of clinical PAH: Mission impossible?. Trends in Cardiovascular Medicine 27(4): 229-236
Burks, H.E.; Abrams, T.; Kirby, C.A.; Baird, J.; Fekete, A.; Hamann, L.G.; Kim, S.; Lombardo, F.; Loo, A.; Lubicka, D.; Macchi, K.; McDonnell, D.P.; Mishina, Y.; Norris, J.D.; Nunez, J.; Saran, C.; Sun, Y.; Thomsen, N.M.; Wang, C.; Wang, J.; Peukert, S. 2017: Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer. Journal of Medicinal Chemistry 60(7): 2790-2818
Farkašová, H.; Hron, Táš.; Pačes, J.; Hulva, P.; Benda, P.; Gifford, R.James.; Elleder, D. 2017: Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae). Proceedings of the National Academy of Sciences of the United States of America 114(12): 3145-3150
Qiu, Z-Cheng.; Dong, X-Li.; Dai, Y.; Xiao, G-Keng.; Wang, X-Luan.; Wong, K-Chun.; Wong, M-Sau.; Yao, X-Sheng. 2016: Discovery of a New Class of Cathepsin K Inhibitors in Rhizoma Drynariae as Potential Candidates for the Treatment of Osteoporosis. International Journal of Molecular Sciences 17(12)
Yan, B.; Liu, L.; Huang, S.; Ren, Y.; Wang, H.; Yao, Z.; Li, L.; Chen, S.; Wang, X.; Zhang, Z. 2017: Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein. Chemical Communications 53(26): 3637-3640
Ramachandran, G.; Miguel-Arribas, Aés.; Abia, D.; Singh, P.K.; Crespo, I.; Gago-Córdoba, César.; Hao, J.An.; Luque-Ortega, J.Roman.; Alfonso, C.; Wu, L.J.; Boer, D.Roeland.; Meijer, W.J.J. 2017: Discovery of a new family of relaxases in Firmicutes bacteria. Plos Genetics 13(2): E1006586
Kumar, S.; Bharti, D.; Shazib, S.Uddin.Ahmed.; Shin, M.Kyoon. 2017: Discovery of a new hypotrich ciliate from petroleum contaminated soil. Plos one 12(6): E0178657
Chu, Z-Jian.; Sun, H-Huan.; Zhu, X-Guan.; Ying, S-Hua.; Feng, M-Guang. 2017: Discovery of a new intravacuolar protein required for the autophagy, development and virulence of Beauveria bassiana. Environmental Microbiology 19(7): 2806-2818
Zheng, L.; Shockey, J.; Guo, F.; Shi, L.; Li, X.; Shan, L.; Wan, S.; Peng, Z. 2017: Discovery of a new mechanism for regulation of plant triacylglycerol metabolism: The peanut diacylglycerol acyltransferase-1 gene family transcriptome is highly enriched in alternative splicing variants. Journal of Plant Physiology 219: 62-70
Gualdani, R.; Cavalluzzi, M.Maddalena.; Tadini-Buoninsegni, F.; Lentini, G. 2017: Discovery of a new mexiletine-derived agonist of the hERG K + channel. Biophysical Chemistry 229: 62-67
JurcuŢ, R.Oana.; Bastian, A.Eugenia.; Militaru, S.; Popa, A.; Manole, E.; Popescu, B.Alexandru.; Tallila, J.; Popescu, B.Ovidiu.; Ginghină, C.Doina. 2017: Discovery of a new mutation in the desmin gene in a young patient with cardiomyopathy and muscular weakness. Romanian Journal of Morphology and Embryology 58(1): 225-230
Abu El Asrar, R.; Margamuljana, L.; Klaassen, H.; Nijs, M.; Marchand, A.; Chaltin, P.; Myllykallio, H.; Becker, H.F.; De Jonghe, S.; Herdewijn, P.; Lescrinier, E. 2017: Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile. Biochemical Pharmacology 135: 69-78
Okuda, A.; Uranishi, K.; Suzuki, A. 2017: Discovery of a new role for the p53 family in the onset of mesendodermal differentiation of embryonic stem cells. Stem Cell Investigation 4: 24
Lemaitre, R. 2017: Discovery of a new species of hermit crab of the genus Pylopaguropsis Alcock, 1905 from the Caribbean: "den commensal" or "cleaner"? (Crustacea, Anomura, Paguridae). Zookeys 2017(646): 139-158
Wu, W.; Pang, X.; Lin, J.; Liu, X.; Wang, R.; Lin, J.; Chen, L. 2017: Discovery of a new subgroup of sulfur dioxygenases and characterization of sulfur dioxygenases in the sulfur metabolic network of Acidithiobacillus caldus. Plos one 12(9): E0183668
Valiante, V.; Mattern, D.J.; Schüffler, A.; Horn, F.; Walther, G.; Scherlach, K.; Petzke, L.; Dickhaut, J.; Guthke, R.; Hertweck, C.; Nett, M.; Thines, E.; Brakhage, A.A. 2017: Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. Acs Chemical Biology 12(5): 1227-1234
Perez, C.; Li, J.; Parlati, F.; Rouffet, M.; Ma, Y.; Mackinnon, A.L.; Chou, T-Fen.; Deshaies, R.J.; Cohen, S.M. 2017: Discovery of an Inhibitor of the Proteasome Subunit Rpn11. Journal of Medicinal Chemistry 60(4): 1343-1361
Zhang, X.; Cai, C.; Sui, Z.; Macielag, M.; Wang, Y.; Yan, W.; Suckow, A.; Hua, H.; Bell, A.; Haug, P.; Clapper, W.; Jenkinson, C.; Gunnet, J.; Leonard, J.; Murray, W.V. 2017: Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes. Acs Medicinal Chemistry Letters 8(9): 947-952
Fu, C.; Fu, B.; Peng, X.; Liao, G. 2017: Discovery of an Octahedral Silicon Complex as a Potent Antifungal Agent. Molecules 22(4)
Weinell, J.L.; Brown, R.M. 2018: Discovery of an old, archipelago-wide, endemic radiation of Philippine snakes. Molecular Phylogenetics and Evolution 119: 144-150
Larsen, I.Signe.Bohse.; Narimatsu, Y.; Joshi, H.Jitendra.; Siukstaite, L.; Harrison, O.J.; Brasch, J.; Goodman, K.M.; Hansen, L.; Shapiro, L.; Honig, B.; Vakhrushev, S.Y.; Clausen, H.; Halim, A. 2017: Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Proceedings of the National Academy of Sciences of the United States of America 114(42): 11163-11168
Gou, J.; Hao, F.; Huang, C.; Kwon, M.; Chen, F.; Li, C.; Liu, C.; Ro, D-Kyun.; Tang, H.; Zhang, Y. 2018: Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β-hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis. Plant Journal: for Cell and Molecular Biology 93(1): 92-106
Nakajima, K.; Chatelain, R.; Clairmont, K.B.; Commerford, R.; Coppola, G.M.; Daniels, T.; Forster, C.J.; Gilmore, T.A.; Gong, Y.; Jain, M.; Kanter, A.; Kwak, Y.; Li, J.; Meyers, C.D.; Neubert, A.D.; Szklennik, P.; Tedesco, V.; Thompson, J.; Truong, D.; Yang, Q.; Hubbard, B.K.; Serrano-Wu, M.H. 2017: Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans. Journal of Medicinal Chemistry 60(11): 4657-4664
Ha, H-Jin.; Kang, D.Wook.; Kim, H-Min.; Kang, J-Mi.; Ann, J.; Hyun, H.Jung.; Lee, J.Hwan.; Kim, S.Hee.; Kim, H.; Choi, K.; Hong, H-Seok.; Kim, Y.; Jo, D-Gyu.; Lee, J.; Lee, J. 2018: Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a β-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease. Journal of Medicinal Chemistry 61(1): 396-402
Mikami, S.; Sasaki, S.; Asano, Y.; Ujikawa, O.; Fukumoto, S.; Nakashima, K.; Oki, H.; Kamiguchi, N.; Imada, H.; Iwashita, H.; Taniguchi, T. 2017: Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders. Journal of Medicinal Chemistry 60(18): 7658-7676
Yu, W.; Li, C.; Zhang, W.; Xia, Y.; Li, S.; Lin, J-Yuh.; Yu, K.; Liu, M.; Yang, L.; Luo, J.; Chen, Y.; Sun, H.; Kong, L. 2017: Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking. Journal of Medicinal Chemistry 60(7): 2718-2731
Long, M.F.; Engers, J.L.; Chang, S.; Zhan, X.; Weiner, R.L.; Luscombe, V.B.; Rodriguez, A.L.; Cho, H.P.; Niswender, C.M.; Bridges, T.M.; Conn, P.Jeffrey.; Engers, D.W.; Lindsley, C.W. 2017: Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M 4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorganic and Medicinal Chemistry Letters 27(22): 4999-5001
Fang, P.; Fang, L.; Hong, Y.; Liu, X.; Dong, N.; Ma, P.; Bi, J.; Wang, D.; Xiao, S. 2017: Discovery of a novel accessory protein NS7a encoded by porcine deltacoronavirus. Journal of General Virology 98(2): 173-178
Hermanns, K.; Zirkel, F.; Kopp, A.; Marklewitz, M.; Rwego, I.; Estrada, A.; Gillespie, T.Robert.; Drosten, C.; Junglen, S. 2016: Discovery of a novel alphavirus related to Eilat virus. Journal of General Virology
Barlaam, B.; Cosulich, S.; Fitzek, M.; Germain, Hé.; Green, S.; Hanson, L.L.; Harris, C.S.; Hancox, U.; Hudson, K.; Lambert-van der Brempt, C.; Lamorlette, M.; Magnien, Fçoise.; Ouvry, G.; Page, K.; Ruston, L.; Ward, L.; Delouvrié, Bénédicte. 2017: Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors. Bioorganic and Medicinal Chemistry Letters 27(13): 3030-3035
Tang, J.; Jones, S.A.; Jeffrey, J.L.; Miranda, S.R.; Galardi, C.M.; Irlbeck, D.M.; Brown, K.W.; McDanal, C.B.; Johns, B.A. 2017: Discovery of a novel and potent class of anti-HIV-1 maturation inhibitors with improved virology profile against gag polymorphisms. Bioorganic and Medicinal Chemistry Letters 27(12): 2689-2694
Crosignani, S.; Bingham, P.; Bottemanne, P.; Cannelle, Hélène.; Cauwenberghs, S.; Cordonnier, M.; Dalvie, D.; Deroose, F.; Feng, J.Li.; Gomes, B.; Greasley, S.; Kaiser, S.E.; Kraus, M.; Négrerie, M.; Maegley, K.; Miller, N.; Murray, B.W.; Schneider, M.; Soloweij, J.; Stewart, A.E.; Tumang, J.; Torti, V.R.; Van Den Eynde, B.; Wythes, M. 2017: Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. Journal of Medicinal Chemistry 60(23): 9617-9629
Mayer, Fçois.L.; Kronstad, J.W. 2017: Discovery of a Novel Antifungal Agent in the Pathogen Box. Msphere 2(2)
Wada, Y.; Orba, Y.; Sasaki, M.; Kobayashi, S.; Carr, M.J.; Nobori, H.; Sato, A.; Hall, W.W.; Sawa, H. 2017: Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virus. Virology 505: 102-112
Yasui, T.; Yamamoto, T.; Sakai, N.; Asano, K.; Takai, T.; Yoshitomi, Y.; Davis, M.; Takagi, T.; Sakamoto, K.; Sogabe, S.; Kamada, Y.; Lane, W.; Snell, G.; Iwata, M.; Goto, M.; Inooka, H.; Sakamoto, J-Ichi.; Nakada, Y.; Imaeda, Y. 2017: Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design. Bioorganic and Medicinal Chemistry 25(17): 4876-4886
Lu, S.; Wang, Y.; Chen, Y.; Wu, B.; Qin, K.; Zhao, J.; Lou, Y.; Tan, W. 2017: Discovery of a novel canine respiratory coronavirus support genetic recombination among betacoronavirus1. Virus Research 237: 7-13
Wang, F.; Li, Z.; Zhang, T.; Yan, G.; Hu, M.; Zhao, L.; Zhao, Y.; Chen, Y. 2018: Discovery of a novel class of pyridine derivatives that selectively inhibits mutant isocitrate dehydrogenase 2. Chemical Biology and Drug Design 91(6): 1087-1093
Pinard, E.; Green, L.; Reutlinger, M.; Weetall, M.; Naryshkin, N.A.; Baird, J.; Chen, K.S.; Paushkin, S.V.; Metzger, F.; Ratni, H. 2017: Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy. Journal of Medicinal Chemistry 60(10): 4444-4457
Bewley, B.R.; Spearing, P.K.; Weiner, R.L.; Luscombe, V.B.; Zhan, X.; Chang, S.; Cho, H.P.; Rodriguez, A.L.; Niswender, C.M.; Conn, P.Jeffrey.; Bridges, T.M.; Engers, D.W.; Lindsley, C.W. 2017: Discovery of a novel, CNS penetrant M 4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core. Bioorganic and Medicinal Chemistry Letters 27(18): 4274-4279
Clissold, R.L.; Clarke, H.C.; Spasic-Boskovic, O.; Brugger, K.; Abbs, S.; Bingham, C.; Shaw-Smith, C. 2017: Discovery of a novel dominant mutation in the REN gene after forty years of renal disease: a case report. BMC nephrology 18(1): 234
Wang, Y.; Lin, H-Quan.; Wang, P.; Hu, J-Shu.; Ip, T-Ming.; Yang, L-Meng.; Zheng, Y-Tang.; Chi-Cheong Wan, D. 2017: Discovery of a Novel HIV-1 Integrase/p75 Interacting Inhibitor by Docking Screening, Biochemical Assay, and in Vitro Studies. Journal of Chemical Information and Modeling 57(9): 2336-2343
Yang, K.L.; Lin, P.Y. 2017: Discovery of a novel HLA-A*02 variant, HLA-A*02:684, in a Taiwanese individual. Hla 90(5): 301-302
Liu, B.; Lv, J.; Ma, Z. 2017: Discovery of a novel HLA-B*07 variant, HLA-B*07:294, in a Chinese individual. Hla 90(4): 251-252
Kremer, L.; Schultz-Fademrecht, C.; Baumann, M.; Habenberger, P.; Choidas, A.; Klebl, B.; Kordes, S.; Schöler, H.R.; Sterneckert, J.; Ziegler, S.; Schneider, G.; Waldmann, H. 2017: Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction. Angewandte Chemie 56(42): 13021-13025
Sampson, K.; Zaitseva, J.; Stauffer, M.; Vande Berg, B.; Guo, R.; Tomso, D.; McNulty, B.; Desai, N.; Balasubramanian, D. 2017: Discovery of a novel insecticidal protein from Chromobacterium piscinae, with activity against Western Corn Rootworm, Diabrotica virgifera virgifera. Journal of Invertebrate Pathology 142: 34-43
Hatziioanou, D.; Gherghisan-Filip, C.; Saalbach, G.; Horn, N.; Wegmann, U.; Duncan, S.H.; Flint, H.J.; Mayer, M.J.; Narbad, A. 2017: Discovery of a novel lantibiotic nisin O from Blautia obeum A2-162, isolated from the human gastrointestinal tract. Microbiology 163(9): 1292-1305
Healy, A.R.; Houston, D.R.; Remnant, L.; Huart, A-Sophie.; Brychtova, V.; Maslon, M.M.; Meers, O.; Muller, P.; Krejci, A.; Blackburn, E.A.; Vojtesek, B.; Hernychova, L.; Walkinshaw, M.D.; Westwood, N.J.; Hupp, T.R. 2015: Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin. Chemical Science 6(5): 3109-3116
Malmquist, J.; Varnäs, K.; Svedberg, M.; Vallée, Fédéric.; Albert, J.S.; Finnema, S.J.; Schou, M. 2018: Discovery of a Novel Muscarinic Receptor PET Radioligand with Rapid Kinetics in the Monkey Brain. Acs Chemical Neuroscience 9(2): 224-229
Hossain, S.; Boon, E.M. 2017: Discovery of a Novel Nitric Oxide Binding Protein and Nitric-Oxide-Responsive Signaling Pathway in Pseudomonas aeruginosa. Acs Infectious Diseases 3(6): 454-461
Zhang, J.; Su, L.; Ye, Q.; Zhang, S.; Kung, H.; Jiang, F.; Jiang, G.; Miao, J.; Zhao, B. 2017: Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells. Oncotarget 8(5): 7625-7636
Hand, J.M.; Zhang, K.; Wang, L.; Koganti, P.P.; Mastrantoni, K.; Rajput, S.K.; Ashry, M.; Smith, G.W.; Yao, J. 2017: Discovery of a novel oocyte-specific Krüppel-associated box domain-containing zinc finger protein required for early embryogenesis in cattle. Mechanisms of Development 144(Pt B): 103-112
Hong, S.Pyo.; Ahn, S.Kil. 2017: Discovery of a novel pan-RAF inhibitor with potent anti-tumor activity in preclinical models of BRAF V600E mutant cancer. Life Sciences 183: 37-44
Sakuna, K.; Elliman, J.; Owens, L. 2017: Discovery of a novel Picornavirales, Chequa iflavirus, from stressed redclaw crayfish (Cherax quadricarinatus) from farms in northern Queensland, Australia. Virus Research 238: 148-155
Yamada, K.; Brousseau, M.; Honma, W.; Iimura, A.; Imase, H.; Iwaki, Y.; Kawanami, T.; LaSala, D.; Liang, G.; Mitani, H.; Nonomura, K.; Ohmori, O.; Pan, M.; Rigel, D.F.; Umemura, I.; Yasoshima, K.; Zhu, G.; Mogi, M. 2017: Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma. Journal of Medicinal Chemistry 60(20): 8466-8481
Adachi, R.; Okada, K.; Skene, R.; Ogawa, K.; Miwa, M.; Tsuchinaga, K.; Ohkubo, S.; Henta, T.; Kawamoto, T. 2017: Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline. Biochemical and Biophysical Research Communications 488(2): 393-399
Yang, C.; Zhang, X.; Wang, Y.; Yang, Y.; Liu, X.; Deng, M.; Jia, Y.; Ling, Y.; Meng, L-Hua.; Zhou, Y. 2017: Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity. Acs Medicinal Chemistry Letters 8(8): 875-880
Singh, S.; Goo, J-Il.; Noh, H.; Lee, S.Jae.; Kim, M.Woo.; Park, H.; Jalani, H.B.; Lee, K.; Kim, C.; Kim, W-Ki.; Ju, C.; Choi, Y. 2017: Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality. Bioorganic and Medicinal Chemistry 25(4): 1394-1405
Nance, K.D.; Days, E.L.; Weaver, C.David.; Coldren, A.; Farmer, T.D.; Cho, H.P.; Niswender, C.M.; Blobaum, A.L.; Niswender, K.D.; Lindsley, C.W. 2017: Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core. Journal of Medicinal Chemistry 60(4): 1611-1616
Mikami, S.; Kawasaki, M.; Ikeda, S.; Negoro, N.; Nakamura, S.; Nomura, I.; Ashizawa, T.; Kokubo, H.; Hoffman, I.Dylan.; Zou, H.; Oki, H.; Uchiyama, N.; Hiura, Y.; Miyamoto, M.; Itou, Y.; Nakashima, M.; Iwashita, H.; Taniguchi, T. 2017: Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders. Chemical and Pharmaceutical Bulletin 65(11): 1058-1077
Anumala, U.Rao.; Waaler, J.; Nkizinkiko, Y.; Ignatev, A.; Lazarow, K.; Lindemann, P.; Olsen, P.Angell.; Murthy, S.; Obaji, E.; Majouga, A.G.; Leonov, S.; von Kries, J.Peter.; Lehtiö, L.; Krauss, S.; Nazaré, M. 2017: Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. Journal of Medicinal Chemistry 60(24): 10013-10025
Maheshwari, S.; Avula, S.R.; Singh, A.; Singh, L.Ravithej.; Palnati, G.R.; Arya, R.K.; Cheruvu, S.H.; Shahi, S.; Sharma, T.; Meena, S.; Singh, A.K.; Kant, R.; Riyazuddin, M.; Bora, H.K.; Siddiqi, M.I.; Gayen, J.R.; Sashidhara, K.V.; Datta, D. 2017: Discovery of a Novel Small-Molecule Inhibitor that Targets PP2A-β-Catenin Signaling and Restricts Tumor Growth and Metastasis. Molecular cancer therapeutics 16(9): 1791-1805
Hayashi, H.; Katayama, S.; Komura, T.; Hinuma, Y.; Yokoyama, T.; Mibu, K.; Oba, F.; Tanaka, I. 2017: Discovery of a Novel Sn(II)-Based Oxide β-SnMoO 4 for Daylight-Driven Photocatalysis. Advanced Science 4(1): 1600246
Lua, W-Heng.; Ling, W-Li.; Su, C.Tran-To.; Yeo, J.Yi.; Verma, C.Shekhar.; Eisenhaber, B.; Eisenhaber, F.; Gan, S.Ken-En. 2017: Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it. Cell Cycle 16(5): 457-467
Nirmala, J.; Saini, J.; Newcomb, M.; Olivera, P.; Gale, S.; Klindworth, D.; Elias, E.; Talbert, L.; Chao, S.; Faris, J.; Xu, S.; Jin, Y.; Rouse, M.N. 2017: Discovery of a Novel Stem Rust Resistance Allele in Durum Wheat that Exhibits Differential Reactions to Ug99 Isolates. G3 7(10): 3481-3490
Pan, Y.; Tian, X.; Qin, P.; Wang, B.; Zhao, P.; Yang, Y-Le.; Wang, L.; Wang, D.; Song, Y.; Zhang, X.; Huang, Y-Wei. 2017: Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China. Veterinary Microbiology 211: 15-21
Kinghorn, A.Douglas.; Carcache de Blanco, E.J.; Chai, H-Byung.; Orjala, J.; Farnsworth, N.R.; Soejarto, D.Doel.; Oberlies, N.H.; Wani, M.C.; Kroll, D.J.; Pearce, C.J.; Swanson, S.M.; Kramer, R.A.; Rose, W.C.; Fairchild, C.R.; Vite, G.D.; Emanuel, S.; Jarjoura, D.; Cope, F.O. 2009: Discovery of anticancer agents of diverse natural origin. Pure and Applied Chemistry. Chimie Pure et Appliquee 81(6): 1051-1063
Dhungat, J.Pai. 2017: Discovery of Anticoagulant Warfarin. Journal of the Association of Physicians of India 65(7): 115
Qiao, L.; Li, B.; Chen, Y.; Li, L.; Chen, X.; Wang, L.; Lu, F.; Luo, G.; Li, G.; Zhang, Y. 2016: Discovery of Anti-Hypertensive Oligopeptides from Adlay Based on In Silico Proteolysis and Virtual Screening. International Journal of Molecular Sciences 17(12)
Murata, T.; Maehara, T. 2016: Discovery of anti-inflammatory role of prostaglandin D 2. Journal of Veterinary Medical Science 78(11): 1643-1647
Maetani, M.; Kato, N.; Jabor, V.A.P.; Calil, F.A.; Nonato, M.Cristina.; Scherer, C.A.; Schreiber, S.L. 2017: Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. Acs Medicinal Chemistry Letters 8(4): 438-442
Ahmad, S.Junaidah.; Abdul Rahim, M.Badrin.Hanizam.; Baharum, S.Nataqain.; Baba, M.Shukri.; Zin, N.Mohamad. 2017: Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. Journal of Tropical Medicine 2017: 2189814
Shah, A.; Rather, M.A.; Hassan, Q.P.; Aga, M.A.; Mushtaq, S.; Shah, A.M.; Hussain, A.; Baba, S.A.; Ahmad, Z. 2017: Discovery of anti-microbial and anti-tubercular molecules from Fusarium solani: an endophyte of Glycyrrhiza glabra. Journal of Applied Microbiology 122(5): 1168-1176
Muytjens, C.M.J.; Yu, Y.; Diamandis, E.P. 2017: Discovery of Antimicrobial Peptides in Cervical-Vaginal Fluid from Healthy Nonpregnant Women via an Integrated Proteome and Peptidome Analysis. Proteomics 17(21)
Li, H.; Huang, H.; Hou, L.; Ju, J.; Li, W. 2017: Discovery of Antimycin-Type Depsipeptides from a wbl Gene Mutant Strain of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66 and Their Effects on Pro-inflammatory Cytokine Production. Frontiers in Microbiology 8: 678
Rais, R.; Vávra, J.; Tichý, Táš.; Dash, R.P.; Gadiano, A.J.; Tenora, Láš.; Monincová, L.; Bařinka, C.; Alt, J.; Zimmermann, S.C.; Slusher, C.Ethan.; Wu, Y.; Wozniak, K.; Majer, P.; Tsukamoto, T.; Slusher, B.S. 2017: Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain. Journal of Medicinal Chemistry 60(18): 7799-7809
Pinto, D.J.P.; Orwat, M.J.; Smith, L.M.; Quan, M.L.; Lam, P.Y.S.; Rossi, K.A.; Apedo, A.; Bozarth, J.M.; Wu, Y.; Zheng, J.J.; Xin, B.; Toussaint, N.; Stetsko, P.; Gudmundsson, O.; Maxwell, B.; Crain, E.J.; Wong, P.C.; Lou, Z.; Harper, T.W.; Chacko, S.A.; Myers, J.E.; Sheriff, S.; Zhang, H.; Hou, X.; Mathur, A.; Seiffert, D.A.; Wexler, R.R.; Luettgen, J.M.; Ewing, W.R. 2017: Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212). Journal of Medicinal Chemistry 60(23): 9703-9723
Moustakim, M.; Clark, P.G.K.; Trulli, L.; Fuentes de Arriba, A.L.; Ehebauer, M.T.; Chaikuad, A.; Murphy, E.J.; Mendez-Johnson, J.; Daniels, D.; Hou, C-Feng.D.; Lin, Y-Hui.; Walker, J.R.; Hui, R.; Yang, H.; Dorrell, L.; Rogers, C.M.; Monteiro, O.P.; Fedorov, O.; Huber, K.V.M.; Knapp, S.; Heer, J.; Dixon, D.J.; Brennan, P.E. 2017: Discovery of a PCAF Bromodomain Chemical Probe. Angewandte Chemie 56(3): 827-831
Perreault, S.; Chandrasekhar, J.; Cui, Z-Hua.; Evarts, J.; Hao, J.; Kaplan, J.A.; Kashishian, A.; Keegan, K.S.; Kenney, T.; Koditek, D.; Lad, L.; Lepist, E-Irene.; McGrath, M.E.; Patel, L.; Phillips, B.; Therrien, J.; Treiberg, J.; Yahiaoui, A.; Phillips, G. 2017: Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. Journal of Medicinal Chemistry 60(4): 1555-1567
Freestone, T.S.; Ju, K-San.; Wang, B.; Zhao, H. 2017: Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring. Acs Synthetic Biology 6(2): 217-223
Neumann, S.; Eliseeva, E.; Boutin, A.; Barnaeva, E.; Ferrer, M.; Southall, N.; Kim, D.; Hu, X.; Morgan, S.J.; Marugan, J.J.; Gershengorn, M.C. 2018: Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. Journal of Pharmacology and Experimental Therapeutics 364(1): 38-45
Schnute, M.E.; McReynolds, M.D.; Carroll, J.; Chrencik, J.; Highkin, M.K.; Iyanar, K.; Jerome, G.; Rains, J.W.; Saabye, M.; Scholten, J.A.; Yates, M.; Nagiec, M.M. 2017: Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits. Journal of Medicinal Chemistry 60(6): 2562-2572
Li, X.; Hernandez, V.; Rock, F.L.; Choi, W.; Mak, Y.S.L.; Mohan, M.; Mao, W.; Zhou, Y.; Easom, E.E.; Plattner, J.J.; Zou, W.; Pérez-Herrán, E.; Giordano, I.; Mendoza-Losana, A.; Alemparte, C.; Rullas, Jín.; Angulo-Barturen, Iñigo.; Crouch, S.; Ortega, Fátima.; Barros, D.; Alley, M.R.K. 2017: Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). Journal of Medicinal Chemistry 60(19): 8011-8026
Ke, Z.; Su, Z.; Zhang, X.; Cao, Z.; Ding, Y.; Cao, L.; Ding, G.; Wang, Z.; Liu, H.; Xiao, W. 2017: Discovery of a potent angiotensin converting enzyme inhibitor via virtual screening. Bioorganic and Medicinal Chemistry Letters 27(16): 3688-3692
Cuozzo, J.W.; Centrella, P.A.; Gikunju, D.; Habeshian, S.; Hupp, C.D.; Keefe, A.D.; Sigel, E.A.; Soutter, H.H.; Thomson, H.A.; Zhang, Y.; Clark, M.A. 2017: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library. Chembiochem: a European journal of chemical biology 18(9): 864-871
Humphreys, P.G.; Bamborough, P.; Chung, C-Wa.; Craggs, P.D.; Gordon, L.; Grandi, P.; Hayhow, T.G.; Hussain, J.; Jones, K.L.; Lindon, M.; Michon, A-Marie.; Renaux, J.F.; Suckling, C.J.; Tough, D.F.; Prinjha, R.K. 2017: Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. Journal of Medicinal Chemistry 60(2): 695-709
Jang, J.; Son, J.Beom.; To, C.; Bahcall, M.; Kim, S.Young.; Kang, S.Yong.; Mushajiang, M.; Lee, Y.; Jänne, P.A.; Choi, H.Geun.; Gray, N.S. 2017: Discovery of a potent dual ALK and EGFR T790M inhibitor. European Journal of Medicinal Chemistry 136: 497-510
Wu, W.; Zhang, Y.; Huang, J.; Wu, Y.; Liu, D.; Chen, Z. 2018: Discovery of a Potentially New Subfamily of ELFV Dehydrogenases Effective for l-Arginine Deamination by Enzyme Mining. Biotechnology journal 13(2)
Schönauer, E.; Kany, A.M.; Haupenthal, Jörg.; Hüsecken, K.; Hoppe, I.J.; Voos, K.; Yahiaoui, S.; Elsässer, B.; Ducho, C.; Brandstetter, H.; Hartmann, R.W. 2017: Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. Journal of the American Chemical Society 139(36): 12696-12703
Edupuganti, R.; Taliaferro, J.M.; Wang, Q.; Xie, X.; Cho, E.Jeong.; Vidhu, F.; Ren, P.; Anslyn, E.V.; Bartholomeusz, C.; Dalby, K.N. 2017: Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorganic and Medicinal Chemistry 25(9): 2609-2616
Chappell, M.D.; Li, R.; Smith, S.C.; Dressman, B.A.; Tromiczak, E.G.; Tripp, A.E.; Blanco, M-Jesus.; Vetman, T.; Quimby, S.J.; Matt, J.; Britton, T.C.; Fivush, A.M.; Schkeryantz, J.M.; Mayhugh, D.; Erickson, J.A.; Bures, M.G.; Jaramillo, C.; Carpintero, M.; Diego, Jé.Eugenio.de.; Barberis, M.; Garcia-Cerrada, S.; Soriano, Jé.F.; Antonysamy, S.; Atwell, S.; MacEwan, I.; Condon, B.; Sougias, C.; Wang, J.; Zhang, A.; Conners, K.; Groshong, C.; Wasserman, S.R.; Koss, J.W.; Witkin, J.M.; Li, X.; Overshiner, C.; Wafford, K.A.; Seidel, W.; Wang, X-Shan.; Heinz, B.A.; Swanson, S 2016: Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. Journal of Medicinal Chemistry 59(24): 10974-10993
Tamanini, E.; Buck, I.M.; Chessari, G.; Chiarparin, E.; Day, J.E.H.; Frederickson, M.; Griffiths-Jones, C.M.; Hearn, K.; Heightman, T.D.; Iqbal, A.; Johnson, C.N.; Lewis, E.J.; Martins, V.; Peakman, T.; Reader, M.; Rich, S.J.; Ward, G.A.; Williams, P.A.; Wilsher, N.E. 2017: Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). Journal of Medicinal Chemistry 60(11): 4611-4625
Verschueren, K.; Cobbaut, M.; Demaerel, J.; Saadah, L.; Voet, A.R.D.; Van Lint, J.; De Borggraeve, W.M. 2017: Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4- d ]pyrimidine analogues. Medchemcomm 8(3): 640-646
Erra, M.; Taltavull, J.; Gréco, A.; Bernal, F.Javier.; Caturla, J.Francisco.; Gràcia, J.; Domínguez, Mía.; Sabaté, M.; Paris, Séphane.; Soria, Sé.; Hernández, Bña.; Armengol, C.; Cabedo, J.; Bravo, Mónica.; Calama, E.; Miralpeix, M.; Lehner, M.D. 2017: Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. Acs Medicinal Chemistry Letters 8(1): 118-123
Li, Y.; Shi, Z.; Chen, L.; Zheng, S.; Li, S.; Xu, B.; Liu, Z.; Liu, J.; Deng, C.; Ye, F. 2017: Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes. Journal of Medicinal Chemistry 60(10): 4173-4184
Bezençon, O.; Heidmann, B.; Siegrist, R.; Stamm, S.; Richard, S.; Pozzi, D.; Corminboeuf, O.; Roch, C.; Kessler, M.; Ertel, E.A.; Reymond, I.; Pfeifer, T.; de Kanter, R.; Toeroek-Schafroth, M.; Moccia, L.G.; Mawet, J.; Moon, R.; Rey, M.; Capeleto, B.; Fournier, E. 2017: Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies. Journal of Medicinal Chemistry 60(23): 9769-9789
Zhao, M.; Zheng, Z-Zheng.; Chen, M.; Modjarrad, K.; Zhang, W.; Zhan, L-Ting.; Cao, J-Li.; Sun, Y-Peng.; McLellan, J.S.; Graham, B.S.; Xia, N-Shao. 2017: Discovery of a Prefusion Respiratory Syncytial Virus F-Specific Monoclonal Antibody That Provides Greater In Vivo Protection than the Murine Precursor of Palivizumab. Journal of Virology 91(15)
Chen, Z.; Liu, H.; Jain, A.; Zhang, L.; Liu, C.; Cheng, K. 2017: Discovery of Aptamer Ligands for Hepatic Stellate Cells Using SELEX. Theranostics 7(12): 2982-2995
Shepard, M.J.; Padmanaban, V.; Edwards, N.A.; Chittiboina, P.; Ray-Chaudhury, A.; Heiss, J.D. 2017: Discovery of Aquaporin-1 and Aquaporin-4 Expression in an Intramedullary Spinal Cord Ependymal Cyst: Case Report. World Neurosurgery 107: 1046.E1-1046.E7
Kinarivala, N.; Patel, R.; Boustany, R-Mary.; Al-Ahmad, A.; Trippier, P.C. 2017: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2). Journal of Medicinal Chemistry 60(23): 9739-9756
Wang, A.; Li, X.; Wu, H.; Zou, F.; Yan, X-E.; Chen, C.; Hu, C.; Yu, K.; Wang, W.; Zhao, P.; Wu, J.; Qi, Z.; Wang, W.; Wang, B.; Wang, L.; Ren, T.; Zhang, S.; Yun, C-Hong.; Liu, J.; Liu, Q. 2017: Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode. Journal of Medicinal Chemistry 60(7): 2944-2962
He, L.; Li, D.; Zhang, C.; Bai, P.; Chen, L. 2017: Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC. Bioorganic and Medicinal Chemistry Letters 27(17): 4171-4175
Schuller, M.; Riedel, K.; Gibbs-Seymour, I.; Uth, K.; Sieg, C.; Gehring, Aé.P.; Ahel, I.; Bracher, F.; Kessler, B.M.; Elkins, J.M.; Knapp, S. 2017: Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. Acs Chemical Biology 12(11): 2866-2874
Sun, J.; Ren, S-Zhen.; Lu, X-Yuan.; Li, J-Jing.; Shen, F-Qian.; Xu, C.; Zhu, H-Liang. 2017: Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors. Bioorganic and Medicinal Chemistry 25(9): 2593-2600
Barlaam, B.; Cosulich, S.; Degorce, Sébastien.; Ellston, R.; Fitzek, M.; Green, S.; Hancox, U.; Lambert-van der Brempt, C.; Lohmann, J-Jacques.; Maudet, Mël.; Morgentin, Rémy.; Plé, P.; Ward, L.; Warin, N. 2017: Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Bioorganic and Medicinal Chemistry Letters 27(9): 1949-1954
Hu, J.; Wang, Y.; Li, Y.; Xu, L.; Cao, D.; Song, S.; Damaneh, M.Soleimani.; Wang, X.; Meng, T.; Chen, Y-Lei.; Shen, J.; Miao, Z.; Xiong, B. 2017: Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor. European Journal of Medicinal Chemistry 137: 176-195
Pryde, D.C.; Marron, B.E.; West, C.W.; Reister, S.; Amato, G.; Yoger, K.; Antonio, B.; Padilla, K.; Cox, P.J.; Turner, J.; Warmus, J.S.; Swain, N.A.; Omoto, K.; Mahoney, J.H.; Gerlach, A.C. 2017: Discovery of a Series of Indazole TRPA1 Antagonists. Acs Medicinal Chemistry Letters 8(6): 666-671
Zhang, J.; Lv, X.; Ma, X.; Hu, Y. 2017: Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors. European Journal of Medicinal Chemistry 127: 509-520
Childs, S.P.; King, Z.R.; Walker, D.R.; Harris, D.K.; Pedley, K.F.; Buck, J.W.; Boerma, H.Roger.; Li, Z. 2018: Discovery of a seventh Rpp soybean rust resistance locus in soybean accession PI 605823. Tag. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik 131(1): 27-41
Dallimore, T.; Hunter, T.; Medlock, J.M.; Vaux, A.G.C.; Harbach, R.E.; Strode, C. 2017: Discovery of a single male Aedes aegypti (L.) in Merseyside, England. Parasites and Vectors 10(1): 309
Zhou, B.; Hu, J.; Xu, F.; Chen, Z.; Bai, L.; Fernandez-Salas, E.; Lin, M.; Liu, L.; Yang, C-Yie.; Zhao, Y.; McEachern, D.; Przybranowski, S.; Wen, B.; Sun, D.; Wang, S. 2018: Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. Journal of Medicinal Chemistry 61(2): 462-481
Quéméner, Aès.; Maillasson, M.; Arzel, L.; Sicard, B.; Vomiandry, R.; Mortier, E.; Dubreuil, D.; Jacques, Y.; Lebreton, J.; Mathé-Allainmat, M. 2017: Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization. Journal of Medicinal Chemistry 60(14): 6249-6272
Cheung, S.T.; Miller, M.S.; Pacoma, R.; Roland, J.; Liu, J.; Schumacher, A.M.; Hsieh-Wilson, L.C. 2017: Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. Acs Chemical Biology 12(12): 3126-3133
Rietz, A.; Li, H.; Quist, K.M.; Cherry, J.J.; Lorson, C.L.; Burnett, B.G.; Kern, N.L.; Calder, A.N.; Fritsche, M.; Lusic, H.; Boaler, P.J.; Choi, S.; Xing, X.; Glicksman, M.A.; Cuny, G.D.; Androphy, E.J.; Hodgetts, K.J. 2017: Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. Journal of Medicinal Chemistry 60(11): 4594-4610
Zhang, L.; Fu, L.; Zhang, S.; Zhang, J.; Zhao, Y.; Zheng, Y.; He, G.; Yang, S.; Ouyang, L.; Liu, B. 2017: Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chemical Science 8(4): 2687-2701
Talbot, J.J.; Houbraken, J.; Frisvad, J.C.; Samson, R.A.; Kidd, S.E.; Pitt, J.; Lindsay, S.; Beatty, J.A.; Barrs, V.R. 2017: Discovery of Aspergillus frankstonensis sp. nov. during environmental sampling for animal and human fungal pathogens. Plos one 12(8): E0181660
Thakral, D.; Tae, H.Seop. 2017: Discovery of a Structurally Unique Small Molecule that Inhibits Protein Synthesis. Yale Journal of Biology and Medicine 90(1): 35-43
Zhao, Z.; Pissarnitski, D.A.; Huang, X.; Palani, A.; Zhu, Z.; Greenlee, W.J.; Hyde, L.A.; Song, L.; Terracina, G.; Zhang, L.; Parker, E.M. 2017: Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators. Acs Medicinal Chemistry Letters 8(10): 1002-1006
Zhou, N.; Yan, Y.; Liu, C.; Hou, J.; Xu, W.; Zhang, Y. 2017: Discovery of a tetrahydroisoquinoline-based HDAC inhibitor with improved plasma stability. Bioorganic and Medicinal Chemistry 25(17): 4614-4619
Liu, T.; Gao, Y.; Zhang, X.; Wan, Y.; Du, L.; Fang, H.; Li, M. 2017: Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 Protein. Analytical Chemistry 89(21): 11173-11177
Ashrap, P.; Zheng, G.; Wan, Y.; Li, T.; Hu, W.; Li, W.; Zhang, H.; Zhang, Z.; Hu, J. 2017: Discovery of a widespread metabolic pathway within and among phenolic xenobiotics. Proceedings of the National Academy of Sciences of the United States of America 114(23): 6062-6067
Niehaus, T.D.; Elbadawi-Sidhu, M.; de Crécy-Lagard, Vérie.; Fiehn, O.; Hanson, A.D. 2017: Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight. Journal of Biological Chemistry 292(39): 16360-16367
Kindon, N.; Andrews, G.; Baxter, A.; Cheshire, D.; Hemsley, P.; Johnson, T.; Liu, Y-Zhen.; McGinnity, D.; McHale, M.; Mete, A.; Reuberson, J.; Roberts, B.; Steele, J.; Teobald, B.; Unitt, J.; Vaughan, D.; Walters, I.; Stocks, M.J. 2017: Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. Acs Medicinal Chemistry Letters 8(9): 981-986
Spiliotopoulos, D.; Wamhoff, E-Christian.; Lolli, G.; Rademacher, C.; Caflisch, A. 2017: Discovery of BAZ2A bromodomain ligands. European Journal of Medicinal Chemistry 139: 564-572
Mishra, C.Bhushan.; Kumari, S.; Angeli, A.; Monti, S.Maria.; Buonanno, M.; Tiwari, M.; Supuran, C.T. 2017: Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment. Journal of Medicinal Chemistry 60(6): 2456-2469
Wang, S.; Xu, L.; Lu, Y-Ting.; Liu, Y-Fei.; Han, B.; Liu, T.; Tang, J.; Li, J.; Wu, J.; Li, J-Ya.; Yu, L-Fang.; Yang, F. 2017: Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis. European Journal of Medicinal Chemistry 130: 195-208
Yasuda, D.; Yuasa, A.; Obata, R.; Nakajima, M.; Takahashi, K.; Ohe, T.; Ichimura, Y.; Komatsu, M.; Yamamoto, M.; Imamura, R.; Kojima, H.; Okabe, T.; Nagano, T.; Mashino, T. 2017: Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor. Bioorganic and Medicinal Chemistry Letters 27(22): 5006-5009
Paparin, J-Laurent.; Amador, Aès.; Badaroux, E.; Bot, Séphanie.; Caillet, C.; Convard, T.; Da Costa, D.; Dukhan, D.; Griffe, L.; Griffon, J-François.; LaColla, M.; Leroy, Fédéric.; Liuzzi, M.; Giulia Loi, A.; McCarville, J.; Mascia, V.; Milhau, J.; Onidi, L.; Pierra, C.; Rahali, R.; Rosinosky, E.; Sais, E.; Seifer, M.; Surleraux, D.; Standring, D.; Dousson, C.B. 2017: Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor. Bioorganic and Medicinal Chemistry Letters 27(11): 2634-2640
Alsaid, M.S.; Al-Mishari, A.A.; Soliman, A.M.; Ragab, F.A.; Ghorab, M.M. 2017: Discovery of Benzo[g]quinazolin benzenesulfonamide derivatives as dual EGFR/HER2 inhibitors. European Journal of Medicinal Chemistry 141: 84-91
Ma, H.; Zhuang, C.; Xu, X.; Li, J.; Wang, J.; Min, X.; Zhang, W.; Zhang, H.; Miao, Z. 2017: Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. European Journal of Medicinal Chemistry 133: 174-183
Enkhtaivan, G.; Muthuraman, P.; Kim, D.Hwan.; Mistry, B. 2017: Discovery of berberine based derivatives as anti-influenza agent through blocking of neuraminidase. Bioorganic and Medicinal Chemistry 25(20): 5185-5193
Zhuang, L.; Tice, C.M.; Xu, Z.; Zhao, W.; Cacatian, S.; Ye, Y-Jie.; Singh, S.B.; Lindblom, P.; McKeever, B.M.; Krosky, P.M.; Zhao, Y.; Lala, D.; Kruk, B.A.; Meng, S.; Howard, L.; Johnson, J.A.; Bukhtiyarov, Y.; Panemangalore, R.; Guo, J.; Guo, R.; Himmelsbach, F.; Hamilton, B.; Schuler-Metz, A.; Schauerte, H.; Gregg, R.; McGeehan, G.M.; Leftheris, K.; Claremon, D.A. 2017: Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor. Bioorganic and Medicinal Chemistry 25(14): 3649-3657
Gülbakan, B.; Özgül, Rıza.Köksal.; Yüzbaşıoğlu, Aşe.; Kohl, M.; Deigner, H-Peter.; Özgüç, M. 2016: Discovery of biomarkers in rare diseases: innovative approaches by predictive and personalized medicine. Epma Journal 7: 24
Jing, C.; Li, Z.; Jia, K.; Chen, C.; Liu, X.; Wang, B.; Hu, W.; Li, J.; Zhu, T.; Dong, S. 2017: Discovery of Bisindole as a Novel Scaffold for Protein Tyrosine Phosphatase 1B Inhibitors. Archiv der Pharmazie 350(1)
Zheng, B.Zhizhen.; D'Andrea, S.V.; Hanumegowda, U.; Knipe, J.O.; Mosure, K.; Zhuo, X.; Lemm, J.A.; Liu, M.; Rigat, K.L.; Wang, Y-Kai.; Fang, H.; Poronsky, C.; Cutrone, J.; Wu, D-Rurng.; Arunachalam, P.Nayagam.; Balapragalathan, T.J.; Arumugam, A.; Mathur, A.; Meanwell, N.A.; Gao, M.; Roberts, S.B.; Kadow, J.F. 2017: Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase. Bioorganic and Medicinal Chemistry Letters 27(15): 3294-3300
Zhang, J.; Zhang, S. 2017: Discovery of cancer common and specific driver gene sets. Nucleic Acids Research 45(10): E86
Wiktorowicz, J.E.; Soman, K.V. 2016: Discovery of Candidate Biomarkers. Advances in Experimental Medicine and Biology 919: 443-462
Ge, Y-Shu.; Han, Q-Qian.; Duan, W.; Zhang, J-Qi.; Chen, K.; Wan, J-Jia.; Liu, Y.; Liu, D. 2017: Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components. Chemmedchem 12(6): 438-447
Hoegenauer, K.; Soldermann, N.; Zécri, Fédéric.; Strang, R.S.; Graveleau, N.; Wolf, R.M.; Cooke, N.G.; Smith, A.B.; Hollingworth, G.J.; Blanz, J.; Gutmann, S.; Rummel, G.; Littlewood-Evans, A.; Burkhart, C. 2017: Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. Acs Medicinal Chemistry Letters 8(9): 975-980
Wang, Y.; Zhu, J.; Zhang, L. 2017: Discovery of Cell-Permeable O-GlcNAc Transferase Inhibitors via Tethering in Situ Click Chemistry. Journal of Medicinal Chemistry 60(1): 263-272
Onagi, J.; Komatsu, T.; Ichihashi, Y.; Kuriki, Y.; Kamiya, M.; Terai, T.; Ueno, T.; Hanaoka, K.; Matsuzaki, H.; Hata, K.; Watanabe, T.; Nagano, T.; Urano, Y. 2017: Discovery of Cell-Type-Specific and Disease-Related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism. Journal of the American Chemical Society 139(9): 3465-3472
Shi, X.; Li, D.; Wang, Y.; Liu, S.; Qin, J.; Wang, J.; Ran, J.; Zhang, Y.; Huang, Q.; Liu, X.; Zhou, J.; Liu, M. 2017: Discovery of Centrosomal Protein 70 as an Important Player in the Development and Progression of Breast Cancer. American Journal of Pathology 187(3): 679-688
Wu, C.; Du, C.; Ichinose, K.; Choi, Y.Hae.; van Wezel, G.P. 2017: Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow. Journal of Natural Products 80(2): 269-277
Bai, Y-Jia.; Xu, J-Di.; Kong, M.; Gao, Q.; Liu, L-Fang.; Li, S-Lin. 2015: Discovery of characteristic chemical markers for inspecting sulfur-fumigated Radix Angelicae Sinensis by ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry based metabolomics and chemical profiling approach. Food Research International 76(Pt 3): 387-394
Distel, D.L.; Altamia, M.A.; Lin, Z.; Shipway, J.Reuben.; Han, A.; Forteza, I.; Antemano, R.; Limbaco, M.Gwen.J.Peñaflor.; Tebo, A.G.; Dechavez, R.; Albano, J.; Rosenberg, G.; Concepcion, G.P.; Schmidt, E.W.; Haygood, M.G. 2017: Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory. Proceedings of the National Academy of Sciences of the United States of America 114(18): E3652-E3658
Adams, G.L.; Velazquez, F.; Jayne, C.; Shah, U.; Miao, S.; Ashley, E.R.; Madeira, M.; Akiyama, T.E.; Di Salvo, J.; Suzuki, T.; Wang, N.; Truong, Q.; Gilbert, E.; Zhou, D.; Verras, A.; Kirkland, M.; Pachanski, M.; Powles, M.; Yin, W.; Ujjainwalla, F.; Venkatraman, S.; Edmondson, S.D. 2017: Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents. Acs Medicinal Chemistry Letters 8(1): 96-101
Obaidullah, A.J.; Al-Horani, R.A. 2017: Discovery of Chromen-7-yl Furan-2-Carboxylate as a Potent and Selective Factor XIa Inhibitor. Cardiovascular and Hematological Agents in Medicinal Chemistry 15(1): 40-48
Jentsch, T.J. 2015: Discovery of CLC transport proteins: cloning, structure, function and pathophysiology. Journal of Physiology
Lee, K.L.; Ambler, C.M.; Anderson, D.R.; Boscoe, B.P.; Bree, A.G.; Brodfuehrer, J.I.; Chang, J.S.; Choi, C.; Chung, S.; Curran, K.J.; Day, J.E.; Dehnhardt, C.M.; Dower, K.; Drozda, S.E.; Frisbie, R.K.; Gavrin, L.K.; Goldberg, J.A.; Han, S.; Hegen, M.; Hepworth, D.; Hope, H.R.; Kamtekar, S.; Kilty, I.C.; Lee, A.; Lin, L-Ling.; Lovering, F.E.; Lowe, M.D.; Mathias, J.P.; Morgan, H.M.; Murphy, E.A.; Papaioannou, N.; Patny, A.; Pierce, B.S.; Rao, V.R.; Saiah, E.; Samardjiev, I.J.; Samas, B.M.; Shen, M.W.H.; Shin, J.H.; Soutter, H.H.; Strohbach, J.W. 2017: Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. Journal of Medicinal Chemistry 60(13): 5521-5542
Ye, X-Yang.; Chen, S.Y.; Wu, S.; Yoon, D.S.; Wang, H.; Hong, Z.; O'Connor, S.P.; Li, J.; Li, J.J.; Kennedy, L.J.; Walker, S.J.; Nayeem, A.; Sheriff, S.; Camac, D.M.; Ramamurthy, V.; Morin, P.E.; Zebo, R.; Taylor, J.R.; Morgan, N.N.; Ponticiello, R.P.; Harrity, T.; Apedo, A.; Golla, R.; Seethala, R.; Wang, M.; Harper, T.W.; Sleczka, B.G.; He, B.; Kirby, M.; Leahy, D.K.; Li, J.; Hanson, R.L.; Guo, Z.; Li, Y-Xin.; DiMarco, J.D.; Scaringe, R.; Maxwell, B.; Moulin, F.; Barrish, J.C.; Gordon, D.A.; Robl, J.A. 2017: Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. Journal of Medicinal Chemistry 60(12): 4932-4948
Swain, N.A.; Batchelor, D.; Beaudoin, S.; Bechle, B.M.; Bradley, P.A.; Brown, A.D.; Brown, B.; Butcher, K.J.; Butt, R.P.; Chapman, M.L.; Denton, S.; Ellis, D.; Galan, S.R.G.; Gaulier, S.M.; Greener, B.S.; de Groot, M.J.; Glossop, M.S.; Gurrell, I.K.; Hannam, J.; Johnson, M.S.; Lin, Z.; Markworth, C.J.; Marron, B.E.; Millan, D.S.; Nakagawa, S.; Pike, A.; Printzenhoff, D.; Rawson, D.J.; Ransley, S.J.; Reister, S.M.; Sasaki, K.; Storer, R.Ian.; Stupple, P.A.; West, C.W. 2017: Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7. Journal of Medicinal Chemistry 60(16): 7029-7042
Mikami, S.; Nakamura, S.; Ashizawa, T.; Nomura, I.; Kawasaki, M.; Sasaki, S.; Oki, H.; Kokubo, H.; Hoffman, I.D.; Zou, H.; Uchiyama, N.; Nakashima, K.; Kamiguchi, N.; Imada, H.; Suzuki, N.; Iwashita, H.; Taniguchi, T. 2017: Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders. Journal of Medicinal Chemistry 60(18): 7677-7702
Rangappa, P.; Zsigmondy, R.; Svedberg, T.H.E. 2009: Discovery of colloids. Journal of the Association of Physicians of India 57: 664
Chen, E.C.; Khuri, N.; Liang, X.; Stecula, A.; Chien, H-Chieh.; Yee, S.Wah.; Huang, Y.; Sali, A.; Giacomini, K.M. 2017: Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of Medicinal Chemistry 60(7): 2685-2696
Choudhary, P.; Armstrong, E.J.; Jorgensen, C.C.; Piotrowski, M.; Barthmes, M.; Torella, R.; Johnston, S.E.; Maruyama, Y.; Janiszewski, J.S.; Storer, R.Ian.; Skerratt, S.E.; Benn, C.L. 2017: Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter. Frontiers in Molecular Neuroscience 10: 40
Dong, S.; Lei, Y.; Jia, S.; Gao, L.; Li, J.; Zhu, T.; Liu, S.; Hu, W. 2017: Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction. Bioorganic and Medicinal Chemistry Letters 27(4): 1105-1108
Ramya, P.V.Sri.; Angapelly, S.; Angeli, A.; Digwal, C.Singh.; Arifuddin, M.; Babu, B.Nagendra.; Supuran, C.T.; Kamal, A. 2017: Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 32(1): 1274-1281
Wang, Z.; Shi, X.; Zhang, H.; Yu, L.; Cheng, Y.; Zhang, H.; Zhang, H.; Zhou, J.; Chen, J.; Shen, X.; Duan, W. 2017: Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry 139: 128-152
Pinho, P.; Kalayanov, G.; Westerlind, H.; Rosenquist, Åsa.; Wähling, H.; Sund, C.; Almeida, M.; Ayesa, S.; Tejbrant, J.; Targett-Adams, P.; Eneroth, A.; Lindqvist, A. 2017: Discovery of β-d-2'-deoxy-2'-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication. Bioorganic and Medicinal Chemistry Letters 27(15): 3468-3471
Hu, Y.; Zhang, J.; Musharrafieh, R.Ghassan.; Ma, C.; Hau, R.; Wang, J. 2017: Discovery of dapivirine, a nonnucleoside HIV-1 reverse transcriptase inhibitor, as a broad-spectrum antiviral against both influenza A and B viruses. Antiviral Research 145: 103-113
Zhang, J.; Qian, K.; Yan, C.; He, M.; Jassim, B.A.; Ivanov, I.; Zheng, Y.George. 2017: Discovery of Decamidine as a New and Potent PRMT1 Inhibitor. Medchemcomm 8(2): 440-444
Huang, R-Zhen.; Liang, G-Bin.; Huang, X-Chao.; Zhang, B.; Zhou, M-Mei.; Liao, Z-Xin.; Wang, H-Shan. 2017: Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. European Journal of Medicinal Chemistry 138: 979-992
Lévy, P.; Pacot, L.; Bastard, J-Philippe.; Vatier, C. 2017: Discovery of diabetes in the elderly: what diagnosis?. Annales de Biologie Clinique 75(2): 222-224
Wang, F.; Wang, B.; Wang, L.; Xiong, Z-Yue.; Gao, W.; Li, P.; Li, H-Jun. 2017: Discovery of discriminatory quality control markers for Chinese herbal medicines and related processed products by combination of chromatographic analysis and chemometrics methods: Radix Scutellariae as a case study. Journal of Pharmaceutical and Biomedical Analysis 138: 70-79
Xin, L-Ting.; Liu, L.; Shao, C-Lun.; Yu, R-Lei.; Chen, F-Ling.; Yue, S-Jun.; Wang, M.; Guo, Z-Long.; Fan, Y-Chu.; Guan, H-Shi.; Wang, C-Yun. 2017: Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products. Marine Drugs 15(7)
Kalluri, R.; LeBleu, V.S. 2016: Discovery of Double-Stranded Genomic DNA in Circulating Exosomes. Cold Spring Harbor Symposia on Quantitative Biology 81: 275-280
Tomonaga, T. 2017: Discovery of drug targets by quantitative proteomics and their clinical application. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 149(3): 123-127
Fukuda, T.; Goto, R.; Kiho, T.; Ueda, K.; Muramatsu, S.; Hashimoto, M.; Aki, A.; Watanabe, K.; Tanaka, N. 2017: Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorganic and Medicinal Chemistry Letters 27(23): 5252-5257
Fukuda, T.; Goto, R.; Kiho, T.; Ueda, K.; Muramatsu, S.; Hashimoto, M.; Aki, A.; Watanabe, K.; Tanaka, N. 2017: Discovery of DS79182026: A potent orally active hepcidin production inhibitor. Bioorganic and Medicinal Chemistry Letters 27(16): 3716-3722
Goff, D.; Zhang, J.; Heckrodt, T.; Yu, J.; Ding, P.; Singh, R.; Holland, S.; Li, W.; Irving, M. 2017: Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy. Bioorganic and Medicinal Chemistry Letters 27(16): 3766-3771
Izawa, K.; Kuwahara, H.; Sugaya, K.; Lo, N.; Ohkuma, M.; Hongoh, Y. 2017: Discovery of ectosymbiotic Endomicrobium lineages associated with protists in the gut of stolotermitid termites. Environmental Microbiology Reports 9(4): 411-418
Liang, J-Hua.; Yang, L.; Wu, S.; Liu, S-Si.; Cushman, M.; Tian, J.; Li, N-Min.; Yang, Q-Hu.; Zhang, H-Ao.; Qiu, Y-Jie.; Xiang, L.; Ma, C-Xuan.; Li, X-Meng.; Qing, H. 2017: Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood. European Journal of Medicinal Chemistry 136: 382-392
Park, H.; Jung, H-Yun.; Mah, S.; Hong, S. 2017: Discovery of EGF Receptor Inhibitors That Are Selective for the d746-750/T790M/C797S Mutant through Structure-Based de Novo Design. Angewandte Chemie 56(26): 7634-7638
Ballantyne, J.C.; Sullivan, M.D. 2017: Discovery of endogenous opioid systems: what it has meant for the clinician's understanding of pain and its treatment. Pain 158(12): 2290-2300
Xue, X.; Zhou, Z.; Dong, G.; Feng, M.; Zhang, Y.; Zhao, S.; Hu, Z.; Ren, W.; Ye, Z-Guang.; Liu, Y.; Liu, M. 2017: Discovery of Enhanced Magnetoelectric Coupling through Electric Field Control of Two-Magnon Scattering within Distorted Nanostructures. Acs Nano 11(9): 9286-9293
Yan, Y.; Du, S.; Ji, Y.; Su, N.; Wang, Y.; Mei, X.; Zhu, W.; He, D.; Lu, Y.; Zhang, C.; Xing, X-Hui. 2017: Discovery of enzymatically depolymerized heparins capable of treating Bleomycin-induced pulmonary injury and fibrosis in mice. Carbohydrate Polymers 174: 82-88
Wang, S-Rong.; Xu, T.; Deng, K.; Wong, C-Wai.; Liu, J.; Fang, W-Shuo. 2017: Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods. Molecules 22(5)
Sandham, D.A.; Barker, L.; Brown, L.; Brown, Z.; Budd, D.; Charlton, S.J.; Chatterjee, D.; Cox, B.; Dubois, G.; Duggan, N.; Hall, E.; Hatto, J.; Maas, J.; Manini, J.; Profit, R.; Riddy, D.; Ritchie, C.; Sohal, B.; Shaw, D.; Stringer, R.; Sykes, D.A.; Thomas, M.; Turner, K.L.; Watson, S.J.; West, R.; Willard, E.; Williams, G.; Willis, J. 2017: Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP 2 Receptor Antagonist for Treatment of Asthma. Acs Medicinal Chemistry Letters 8(5): 582-586
Huang, Y.; Zhang, J.; Yu, Z.; Zhang, H.; Wang, Y.; Lingel, A.; Qi, W.; Gu, J.; Zhao, K.; Shultz, M.D.; Wang, L.; Fu, X.; Sun, Y.; Zhang, Q.; Jiang, X.; Zhang, J.; Zhang, C.; Li, L.; Zeng, J.; Feng, L.; Zhang, C.; Liu, Y.; Zhang, M.; Zhang, L.; Zhao, M.; Gao, Z.; Liu, X.; Fang, D.; Guo, H.; Mi, Y.; Gabriel, T.; Dillon, M.P.; Atadja, P.; Oyang, C. 2017: Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. Journal of Medicinal Chemistry 60(6): 2215-2226
Lequime, S.; Lambrechts, L. 2017: Discovery of flavivirus-derived endogenous viral elements in Anopheles mosquito genomes supports the existence of Anopheles -associated insect-specific flaviviruses. Virus Evolution 3(1): Vew035
Zhao, H.; Lu, Y.; Sheng, L.; Yuan, Z.; Wang, B.; Wang, W.; Li, Y.; Ma, C.; Wang, X.; Zhang, D.; Huang, H. 2017: Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis. Acs Medicinal Chemistry Letters 8(5): 533-537
Huard, K.; Ahn, K.; Amor, P.; Beebe, D.A.; Borzilleri, K.A.; Chrunyk, B.A.; Coffey, S.B.; Cong, Y.; Conn, E.L.; Culp, J.S.; Dowling, M.S.; Gorgoglione, M.F.; Gutierrez, J.A.; Knafels, J.D.; Lachapelle, E.A.; Pandit, J.; Parris, K.D.; Perez, S.; Pfefferkorn, J.A.; Price, D.A.; Raymer, B.; Ross, T.T.; Shavnya, A.; Smith, A.C.; Subashi, T.A.; Tesz, G.J.; Thuma, B.A.; Tu, M.; Weaver, J.D.; Weng, Y.; Withka, J.M.; Xing, G.; Magee, T.V. 2017: Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). Journal of Medicinal Chemistry 60(18): 7835-7849
Saha, T.Kumar.; Katebi, A.; Dhifli, W.; Al Hasan, M. 2019: Discovery of Functional Motifs from the Interface Region of Oligomeric Proteins Using Frequent Subgraph Mining. Ieee/Acm Transactions on Computational Biology and Bioinformatics 16(5): 1537-1549
Matsuoka, M.; Kumar, A.; Muddassar, M.; Matsuyama, A.; Yoshida, M.; Zhang, K.Y.J. 2017: Discovery of Fungal Denitrification Inhibitors by Targeting Copper Nitrite Reductase from Fusarium oxysporum. Journal of Chemical Information and Modeling 57(2): 203-213
Muthukaman, N.; Tambe, M.; Deshmukh, S.; Pisal, D.; Tondlekar, S.; Shaikh, M.; Sarode, N.; Kattige, V.G.; Pisat, M.; Sawant, P.; Honnegowda, S.; Karande, V.; Kulkarni, A.; Behera, D.; Jadhav, S.B.; Sangana, R.R.; Gudi, G.S.; Khairatkar-Joshi, N.; Gharat, L.A. 2017: Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1. Bioorganic and Medicinal Chemistry Letters 27(23): 5131-5138
Jernigan, F.E.; Hanai, J-Ichi.; Sukhatme, V.P.; Sun, L. 2017: Discovery of furan carboxylate derivatives as novel inhibitors of ATP-citrate lyase via virtual high-throughput screening. Bioorganic and Medicinal Chemistry Letters 27(4): 929-935
Oba, M.; Katayama, Y.; Naoi, Y.; Tsuchiaka, S.; Omatsu, T.; Okumura, A.; Nagai, M.; Mizutani, T. 2017: Discovery of fur seal feces-associated circular DNA virus in swine feces in Japan. Journal of Veterinary Medical Science 79(10): 1664-1666
Chen, Y.; Li, C.; Zheng, Y.; Gao, Y.; Hu, J.; Chen, H. 2017: Discovery of FZU-03,010 as a self-assembling anticancer amphiphile for acute myeloid leukemia. Bioorganic and Medicinal Chemistry Letters 27(4): 1007-1011
Yoo, M-Won.; Park, J.; Han, H-Seung.; Yun, Y-Min.; Kang, J.Won.; Choi, D-Young.; Lee, J.Won.; Jung, J.Hun.; Lee, K-Yung.; Kim, K.Pyo. 2017: Discovery of gastric cancer specific biomarkers by the application of serum proteomics. Proteomics 17(6)
Metcalf, B.; Chuang, C.; Dufu, K.; Patel, M.P.; Silva-Garcia, A.; Johnson, C.; Lu, Q.; Partridge, J.R.; Patskovska, L.; Patskovsky, Y.; Almo, S.C.; Jacobson, M.P.; Hua, L.; Xu, Q.; Gwaltney, S.L.; Yee, C.; Harris, J.; Morgan, B.P.; James, J.; Xu, D.; Hutchaleelaha, A.; Paulvannan, K.; Oksenberg, D.; Li, Z. 2017: Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. Acs Medicinal Chemistry Letters 8(3): 321-326
Wang, W.; Yan, H.; Yu, J.; Yi, J.; Qu, Y.; Fu, M.; Chen, A.; Tang, H.; Niu, L. 2017: Discovery of genome-wideSNPs by RAD-seqand the genetic diversity of captive hog deer (Axis porcinus). Plos one 12(3): E0174299
Hans, Jörg.B.; Vigilant, L. 2018: Discovery of gorilla MHC-C expressing C1 ligand for KIR. Immunogenetics 70(5): 293-304
Möller, D.; Banerjee, A.; Uzuneser, T.C.; Skultety, M.; Huth, T.; Plouffe, B.; Hübner, H.; Alzheimer, C.; Friedland, K.; Müller, C.P.; Bouvier, M.; Gmeiner, P. 2017: Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure. Journal of Medicinal Chemistry 60(7): 2908-2929
Cheung, M.; Bao, W.; Behm, D.J.; Brooks, C.A.; Bury, M.J.; Dowdell, S.E.; Eidam, H.S.; Fox, R.M.; Goodman, K.B.; Holt, D.A.; Lee, D.; Roethke, T.J.; Willette, R.N.; Xu, X.; Ye, G.; Thorneloe, K.S. 2017: Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4. Acs Medicinal Chemistry Letters 8(5): 549-554
Khatra, H.; Bose, C.; Sinha, S. 2017: Discovery of Hedgehog Antagonists for Cancer Therapy. Current Medicinal Chemistry 24(19): 2033-2058
Ren, Q.; Liu, X.; Luo, Z.; Li, J.; Wang, C.; Goldmann, S.; Zhang, J.; Zhang, Y. 2017: Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4). Bioorganic and Medicinal Chemistry 25(3): 1042-1056
Larochelle, J. 2017: Discovery of Hereditary Tyrosinemia in Saguenay- Lac St-Jean. Advances in Experimental Medicine and Biology 959: 3-8
Chen, X.; Wu, H.; Park, C-Min.; Poole, T.H.; Keceli, G.; Devarie-Baez, N.O.; Tsang, A.W.; Lowther, W.Todd.; Poole, L.B.; King, S.Bruce.; Xian, M.; Furdui, C.M. 2017: Discovery of Heteroaromatic Sulfones As a New Class of Biologically Compatible Thiol-Selective Reagents. Acs Chemical Biology 12(8): 2201-2208
Zhang, D.; Liang, Z.; Liu, S.; Li, L.; Ma, P.; Zhao, S.; Wang, H.; Wang, J.; Niu, J. 2017: Discovery of Heteropolytantalate: Synthesis and Structure of Two 6-Peroxotantalo-4-phosphate Clusters. Inorganic Chemistry 56(10): 5537-5543
Kobayashi, K.; Kobayashi, H.; Maesato, M.; Hayashi, M.; Yamamoto, T.; Yoshioka, S.; Matsumura, S.; Sugiyama, T.; Kawaguchi, S.; Kubota, Y.; Nakanishi, H.; Kitagawa, H. 2017: Discovery of Hexagonal Structured Pd-B Nanocrystals. Angewandte Chemie 56(23): 6578-6582
Lu, S.; Ji, M.; Ni, D.; Zhang, J. 2018: Discovery of hidden allosteric sites as novel targets for allosteric drug design. Drug Discovery Today 23(2): 359-365
Wei, W.; Wu, Z.; Huang, M.; Hsu, C-Hao.; Liu, Y.; Zhang, X.; Xiong, H. 2017: Discovery of hierarchical superstructures in block copolymers by integrating different liquid crystalline interactions. Soft Matter 13(14): 2583-2589
Li, L.; Jiang, X.; Huang, S.; Ying, Z.; Zhang, Z.; Pan, C.; Li, S.; Wang, X.; Zhang, Z. 2017: Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. Acs Medicinal Chemistry Letters 8(4): 407-412
Lorthiois, E.; Anderson, K.; Vulpetti, A.; Rogel, O.; Cumin, F.; Ostermann, N.; Steinbacher, S.; Mac Sweeney, A.; Delgado, O.; Liao, S-Mei.; Randl, S.; Rüdisser, S.; Dussauge, S.; Fettis, K.; Kieffer, L.; de Erkenez, A.; Yang, L.; Hartwieg, C.; Argikar, U.A.; La Bonte, L.R.; Newton, R.; Kansara, V.; Flohr, S.; Hommel, U.; Jaffee, B.; Maibaum, Jürgen. 2017: Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. Journal of Medicinal Chemistry 60(13): 5717-5735
Kick, E.K.; Busch, B.B.; Martin, R.; Stevens, W.C.; Bollu, V.; Xie, Y.; Boren, B.C.; Nyman, M.C.; Nanao, M.H.; Nguyen, L.; Plonowski, A.; Schulman, I.G.; Yan, G.; Zhang, H.; Hou, X.; Valente, M.N.; Narayanan, R.; Behnia, K.; Rodrigues, A.David.; Brock, B.; Smalley, J.; Cantor, G.H.; Lupisella, J.; Sleph, P.; Grimm, D.; Ostrowski, J.; Wexler, R.R.; Kirchgessner, T.; Mohan, R. 2016: Discovery of Highly Potent Liver X Receptor β Agonists. Acs Medicinal Chemistry Letters 7(12): 1207-1212
Kempson, J.; Ovalle, D.; Guo, J.; Wrobleski, S.T.; Lin, S.; Spergel, S.H.; Duan, J.J-W.; Jiang, B.; Lu, Z.; Das, J.; Yang, B.V.; Hynes, J.; Wu, H.; Tokarski, J.; Sack, J.S.; Khan, J.; Schieven, G.; Blatt, Y.; Chaudhry, C.; Salter-Cid, L.M.; Fura, A.; Barrish, J.C.; Carter, P.H.; Pitts, W.J. 2017: Discovery of highly potent, selective, covalent inhibitors of JAK3. Bioorganic and Medicinal Chemistry Letters 27(20): 4622-4625
Kurashige, N.; Fuchida, H.; Tabata, S.; Uchinomiya, S.; Ojida, A. 2017: Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation. Bioorganic and Medicinal Chemistry Letters 27(15): 3486-3489
Lee, J.; Lee, Y.; Park, S.Jung.; Lee, J.; Kim, Y.Shik.; Suh, Y-Ger.; Lee, J. 2017: Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one. European Journal of Medicinal Chemistry 130: 365-378
Johnson, H.W.B.; Anderl, J.L.; Bradley, E.K.; Bui, J.; Jones, J.; Arastu-Kapur, S.; Kelly, L.M.; Lowe, E.; Moebius, D.C.; Muchamuel, T.; Kirk, C.; Wang, Z.; McMinn, D. 2017: Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit. Acs Medicinal Chemistry Letters 8(4): 413-417
Suzuki, S.; Sugawara, Y.; Tsuji, R.; Tanimura, R.; Kaneko, C.; Yuzawa, N.; Yagi, M.; Kawai, K. 2017: Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives. Bioorganic and Medicinal Chemistry Letters 27(16): 3920-3924
Bhaumik, A.; Sachan, R.; Gupta, S.; Narayan, J. 2017: Discovery of High-Temperature Superconductivity (T c = 55 K) in B-Doped Q-Carbon. Acs Nano 11(12): 11915-11922
Yang, K.L.; Lin, P.Y. 2018: Discovery of HLA-C*14:87, a novel HLA-C*14 variant, in a Taiwanese individual. Hla 91(1): 72-73
de Wispelaere, Mélissanne.; Carocci, M.; Liang, Y.; Liu, Q.; Sun, E.; Vetter, M.L.; Wang, J.; Gray, N.S.; Yang, P.L. 2017: Discovery of host-targeted covalent inhibitors of dengue virus. Antiviral Research 139: 171-179
Adachi, R.; Ishii, T.; Matsumoto, S.; Satou, T.; Sakamoto, J.; Kawamoto, T. 2017: Discovery of Human Intestinal MGAT Inhibitors Using High-Throughput Mass Spectrometry. Slas Discovery: Advancing Life Sciences R and D 22(4): 360-365
Silva, L.C.; Pucca, M.B.; Pessenda, G.; Campos, L.B.; Martinez, E.Z.; Cerni, F.A.; Barbosa, Jé.E. 2018: Discovery of human sc Fvs that cross-neutralize the toxic effects of B. jararacussu and C. d. terrificus venoms. Acta Tropica 177: 66-73
Ulvé, R.; Rault, Mélanie.; Bahin, M.; Lagoutte, L.; Abadie, Jérôme.; De Brito, C.; Coindre, J-Michel.; Botherel, N.; Rousseau, A.; Wucher, V.; Cadieu, E.; Thieblemont, C.; Hitte, C.; Cornevin, L.; Cabillic, F.; Bachelot, L.; Gilot, D.; Hennuy, B.; Guillaudeux, T.; Le Goff, A.; Derrien, T.; Hédan, Bît.; André, C. 2017: Discovery of Human-Similar Gene Fusions in Canine Cancers. Cancer Research 77(21): 5721-5727
Tomohara, K.; Ito, T.; Onikata, S.; Kato, A.; Adachi, I. 2017: Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions. Bioorganic and Medicinal Chemistry Letters 27(7): 1620-1623
Zou, Y.; Wang, F.; Wang, Y.; Sun, Q.; Hu, Y.; Li, Y.; Liu, W.; Guo, W.; Huang, Z.; Zhang, Y.; Xu, Q.; Lai, Y. 2017: Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies. European Journal of Medicinal Chemistry 140: 293-304
Felts, A.S.; Rodriguez, A.L.; Morrison, R.D.; Bollinger, K.A.; Venable, D.F.; Blobaum, A.L.; Byers, F.W.; Thompson Gray, A.; Daniels, J.Scott.; Niswender, C.M.; Jones, C.K.; Conn, P.Jeffrey.; Lindsley, C.W.; Emmitte, K.A. 2017: Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorganic and Medicinal Chemistry Letters 27(21): 4858-4866
N'Guessan, J-Paul.Déto.Ursul.; Delaye, P-Olivier.; Pénichon, Mélanie.; Charvet, C.L.; Neveu, Cédric.; Ouattara, M.; Enguehard-Gueiffier, Cécile.; Gueiffier, A.; Allouchi, H. 2017: Discovery of imidazo[1,2-a]pyridine-based anthelmintic targeting cholinergic receptors of Haemonchus contortus. Bioorganic and Medicinal Chemistry 25(24): 6695-6706
Yang, Y.; Zhang, Y.; Yang, L.; Zhao, L.; Si, L.; Zhang, H.; Liu, Q.; Zhou, J. 2017: Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity. Bioorganic Chemistry 70: 126-132
Tantry, S.J.; Markad, S.D.; Shinde, V.; Bhat, J.; Balakrishnan, G.; Gupta, A.K.; Ambady, A.; Raichurkar, A.; Kedari, C.; Sharma, S.; Mudugal, N.V.; Narayan, A.; Naveen Kumar, C.N.; Nanduri, R.; Bharath, S.; Reddy, J.; Panduga, V.; Prabhakar, K.R.; Kandaswamy, K.; Saralaya, R.; Kaur, P.; Dinesh, N.; Guptha, S.; Rich, K.; Murray, D.; Plant, H.; Preston, M.; Ashton, H.; Plant, D.; Walsh, J.; Alcock, P.; Naylor, K.; Collier, M.; Whiteaker, J.; McLaughlin, R.E.; Mallya, M.; Panda, M.; Rudrapatna, S.; Ramachandran, V.; Shan 2017: Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis. Journal of Medicinal Chemistry 60(4): 1379-1399
Azimi, S.; Zonouzi, A.; Firuzi, O.; Iraji, A.; Saeedi, M.; Mahdavi, M.; Edraki, N. 2017: Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis. European Journal of Medicinal Chemistry 138: 729-737
Sigdel, T.K.; Sarwal, M.M. 2018: Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA. Methods in Molecular Biology 1788: 11-21
Schoville, R.R. 2017: Discovery of Implementation Factors That Lead to Technology Adoption in Long-Term Care. Journal of Gerontological Nursing 43(10): 21-26
Wang, W.; Krosky, D.; Ahn, K. 2017: Discovery of Inactive Conformation-Selective Kinase Inhibitors by Utilizing Cascade Assays. Biochemistry 56(34): 4449-4456
Hoyt, S.B.; Taylor, J.; London, C.; Ali, A.; Ujjainwalla, F.; Tata, J.; Struthers, M.; Cully, D.; Wisniewski, T.; Ren, N.; Bopp, C.; Sok, A.; Verras, A.; McMasters, D.; Chen, Q.; Tung, E.; Tang, W.; Salituro, G.; Clemas, J.; Zhou, G.; MacNeil, D.; Duffy, R.; Xiong, Y. 2017: Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension. Bioorganic and Medicinal Chemistry Letters 27(11): 2384-2388
Tseng, C-Hua.; Tung, C-Wei.; Wu, C-Hsin.; Tzeng, C-Chyi.; Chen, Y-Hsu.; Hwang, T-Long.; Chen, Y-Long. 2017: Discovery of Indeno[1,2-c]quinoline Derivatives as Potent Dual Antituberculosis and Anti-Inflammatory Agents. Molecules 22(6)
Guo, J.; Zhu, M.; Wu, T.; Hao, C.; Wang, K.; Yan, Z.; Huang, W.; Wang, J.; Zhao, D.; Cheng, M. 2017: Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study. Bioorganic and Medicinal Chemistry 25(13): 3500-3511
Huang, Z.; Li, H.; Zhang, Q.; Lu, F.; Hong, M.; Zhang, Z.; Guo, X.; Zhu, Y.; Li, S.; Liu, H. 2017: Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis. Acs Medicinal Chemistry Letters 8(11): 1142-1147
Marchand, J-Rémy.; Dalle Vedove, A.; Lolli, G.; Caflisch, A. 2017: Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking. Journal of Chemical Information and Modeling 57(10): 2584-2597
Connelly, C.M.; Boer, R.E.; Moon, M.H.; Gareiss, P.; Schneekloth, J.S. 2017: Discovery of Inhibitors of MicroRNA-21 Processing Using Small Molecule Microarrays. Acs Chemical Biology 12(2): 435-443
Mao, D.; Bushin, L.B.; Moon, K.; Wu, Y.; Seyedsayamdost, M.R. 2017: Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264. Proceedings of the National Academy of Sciences of the United States of America 114(14): E2920-E2928
Morgan, B.S.; Forte, J.E.; Culver, R.N.; Zhang, Y.; Hargrove, A.E. 2017: Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands. Angewandte Chemie 56(43): 13498-13502
Viborg, A.Holm.; Katayama, T.; Arakawa, T.; Abou Hachem, M.; Lo Leggio, L.; Kitaoka, M.; Svensson, B.; Fushinobu, S. 2017: Discovery of α-l-arabinopyranosidases from human gut microbiome expands the diversity within glycoside hydrolase family 42. Journal of Biological Chemistry 292(51): 21092-21101
Eslami Rasekh, M.; Chiatante, G.; Miroballo, M.; Tang, J.; Ventura, M.; Amemiya, C.T.; Eichler, E.E.; Antonacci, F.; Alkan, C. 2017: Discovery of large genomic inversions using long range information. Bmc Genomics 18(1): 65
Dayal, N.B.; Müller, H. 2017: Discovery of left ventricular hypertrophy during adult echocardiography. Revue Medicale Suisse 13(564): 1106-1112
Zhang, G.; Vilim, F.S.; Liu, D-Dan.; Romanova, E.V.; Yu, K.; Yuan, W-Ding.; Xiao, H.; Hummon, A.B.; Chen, T-Ting.; Alexeeva, V.; Yin, S-Yuan.; Chen, S-An.; Cropper, E.C.; Sweedler, J.V.; Weiss, K.R.; Jing, J. 2017: Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model, Aplysia. Journal of Biological Chemistry 292(46): 18775-18789
Schally, A.V.; Block, N.L.; Rick, F.G. 2017: Discovery of LHRH and development of LHRH analogs for prostate cancer treatment. Prostate 77(9): 1036-1054
Deshpande, A.M.; Bhuniya, D.; De, S.; Dave, B.; Vyavahare, V.P.; Kurhade, S.H.; Kandalkar, S.R.; Naik, K.P.; Kobal, B.S.; Kaduskar, R.D.; Basu, S.; Jain, V.; Patil, P.; Chaturvedi Joshi, S.; Bhat, G.; Raje, A.A.; Reddy, S.; Gundu, J.; Madgula, V.; Tambe, S.; Shitole, P.; Umrani, D.; Chugh, A.; Palle, V.P.; Mookhtiar, K.A. 2017: Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia. European Journal of Medicinal Chemistry 133: 268-286
Ronnås, C.; Werth, S.; Ovaskainen, O.; Várkonyi, G.; Scheidegger, C.; Snäll, T. 2017: Discovery of long-distance gamete dispersal in a lichen-forming ascomycete. New Phytologist 216(1): 216-226
Xu, S-Yang.; Alidoust, N.; Chang, G.; Lu, H.; Singh, B.; Belopolski, I.; Sanchez, D.S.; Zhang, X.; Bian, G.; Zheng, H.; Husanu, M-Adrian.; Bian, Y.; Huang, S-Ming.; Hsu, C-Han.; Chang, T-Rong.; Jeng, H-Tay.; Bansil, A.; Neupert, T.; Strocov, V.N.; Lin, H.; Jia, S.; Hasan, M.Zahid. 2017: Discovery of Lorentz-violating type II Weyl fermions in LaAlGe. Science Advances 3(6): E1603266
Carter, T.J.; Heiden, Z.M.; Szymczak, N.K. 2015: Discovery of low energy pathways to metal-mediated B 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 000000000000. Chemical Science 6(12): 7258-7266
Gancia, E.; De Groot, M.; Burton, B.; Clark, D.E. 2017: Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods. Bioorganic and Medicinal Chemistry Letters 27(11): 2520-2527
Wang, M.; Hua, B-Zhen. 2017: Discovery of Neopanorpa chillcotti Byers (Mecoptera: Panorpidae) from Tibet, China, with discussion of its generic status. Zootaxa 4232(2)
Jałoszyński, Pł. 2017: Discovery of Penicillidmus in the Bismarck Archipelago, Papua New Guinea, with description of a new species from Lavongai (New Hanover) Island (Coleoptera, Staphylinidae, Scydmaeninae). Zootaxa 4254(3): 391-395
Goodwin, N.C.; Ding, Z-Ming.; Harrison, B.A.; Strobel, E.D.; Harris, A.L.; Smith, M.; Thompson, A.Y.; Xiong, W.; Mseeh, F.; Bruce, D.J.; Diaz, D.; Gopinathan, S.; Li, L.; O'Neill, E.; Thiel, M.; Wilson, A.G.E.; Carson, K.G.; Powell, D.R.; Rawlins, D.B. 2017: Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes. Journal of Medicinal Chemistry 60(2): 710-721
Hara, R.; Yamagata, K.; Miyake, R.; Kawabata, H.; Uehara, H.; Kino, K. 2017: Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction. Applied and Environmental Microbiology 83(17)
McIver, A.L.; Zhang, W.; Liu, Q.; Jiang, X.; Stashko, M.A.; Nichols, J.; Miley, M.J.; Norris-Drouin, J.; Machius, M.; DeRyckere, D.; Wood, E.; Graham, D.K.; Earp, H.Shelton.; Kireev, D.; Frye, S.V.; Wang, X. 2017: Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. Chemmedchem 12(3): 207-213
Testero, Sán.A.; Granados, C.; Fernández, D.; Gallego, P.; Covaleda, G.; Reverter, D.; Vendrell, J.; Avilés, F.X.; Pallarès, I.; Mobashery, S. 2017: Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. Acs Medicinal Chemistry Letters 8(10): 1122-1127
Feng, W.; Novera, W.; Peh, K.; Neo, D.; Ramanujulu, P.Murugappan.; Moore, P.K.; Deng, L-Wen.; Dymock, B.W. 2017: Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents. Bioorganic and Medicinal Chemistry Letters 27(4): 967-972
Liu, P.; Li, R.; Antonov, A.A.; Wang, L.; Li, W.; Hua, Y.; Guo, H.; Wang, L.; Liu, P.; Chen, L.; Tian, Y.; Xu, F.; Zhang, Z.; Zhu, Y.; Huang, Y. 2017: Discovery of Metabolite Biomarkers for Acute Ischemic Stroke Progression. Journal of Proteome Research 16(2): 773-779
Nabeyama, W.; Ishihara, K.; Ban, H.Seung.; Wada, H.; Nakamura, H. 2017: Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. Bioorganic and Medicinal Chemistry 25(9): 2601-2608
Cernicharo, J.; Agúndez, M.; Velilla Prieto, L.; Guélin, M.; Pardo, J.R.; Kahane, C.; Marka, C.; Kramer, C.; Navarro, S.; Quintana-Lacaci, G.; Fonfría, J.P.; Marcelino, N.; Tercero, B.; Moreno, E.; Massalkhi, S.; Santander-García, M.; McCarthy, M.C.; Gottlieb, C.A.; Alonso, J.L. 2017: Discovery of methyl silane and confirmation of silyl cyanide in IRC +10216. Astronomy and Astrophysics 606
Feng, S.; Li, C.; Chen, D.; Zheng, X.; Yun, H.; Gao, L.; Shen, H.C. 2017: Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors. European Journal of Medicinal Chemistry 138: 1147-1157
Deng, M.; Cao, Y.; Zhao, Z.; Yang, L.; Zhang, Y.; Dong, Y.; Fan, G. 2017: Discovery of MicroRNAs and Their Target Genes Related to Drought in Paulownia "Yuza 1" by High-Throughput Sequencing. International Journal of Genomics 2017: 3674682
Luo, J.; Xiang, G.; Pan, C. 2017: Discovery of micro RNAs and Transcription Factors Co-Regulatory Modules by Integrating Multiple Types of Genomic Data. IEEE Transactions on Nanobioscience 16(1): 51-59
Xu, L.; Guo, Q.; Chang, G.; Qiu, L.; Liu, X.; Bi, Y.; Zhang, Y.; Wang, H.; Lu, W.; Ren, L.; Chen, Y.; Zhang, Y.; Xu, Q.; Chen, G. 2017: Discovery of micro RNAs during early spermatogenesis in chicken. Plos one 12(5): E0177098
Nakamura, Y.; Arakawa, H. 2017: Discovery of Mieap-regulated mitochondrial quality control as a new function of tumor suppressor p53. Cancer Science 108(5): 809-817
Doering, S.R.; Freeman, K.T.; Schnell, S.M.; Haslach, E.M.; Dirain, M.; Debevec, G.; Geer, P.; Santos, R.G.; Giulianotti, M.A.; Pinilla, C.; Appel, J.R.; Speth, R.C.; Houghten, R.A.; Haskell-Luevano, C. 2017: Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa 1 -Arg-(pI)DPhe-Xaa 4 -NH 2. Journal of Medicinal Chemistry 60(10): 4342-4357
Wolkenberg, S.E.; Nolt, M.Brad.; Bilodeau, M.T.; Trotter, B.Wesley.; Manley, P.J.; Kett, N.R.; Nanda, K.K.; Wu, Z.; Cato, M.J.; Kane, S.A.; Kiss, L.; Spencer, R.H.; Wang, J.; Lynch, J.J.; Regan, C.P.; Stump, G.L.; Li, B.; White, R.; Yeh, S.; Dinsmore, C.J.; Lindsley, C.W.; Hartman, G.D. 2017: Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorganic and Medicinal Chemistry Letters 27(4): 1062-1069
Mannel, D.S.; Ahmed, M.S.; Root, T.W.; Stahl, S.S. 2017: Discovery of Multicomponent Heterogeneous Catalysts via Admixture Screening: PdBiTe Catalysts for Aerobic Oxidative Esterification of Primary Alcohols. Journal of the American Chemical Society 139(4): 1690-1698
Tassini, S.; Sun, L.; Lanko, K.; Crespan, E.; Langron, E.; Falchi, F.; Kissova, M.; Armijos-Rivera, J.I.; Delang, L.; Mirabelli, C.; Neyts, J.; Pieroni, M.; Cavalli, A.; Costantino, G.; Maga, G.; Vergani, P.; Leyssen, P.; Radi, M. 2017: Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. Journal of Medicinal Chemistry 60(4): 1400-1416
Ding, Y.Chun.; Adamson, A.W.; Steele, L.; Bailis, A.M.; John, E.M.; Tomlinson, G.; Neuhausen, S.L. 2018: Discovery of mutations in homologous recombination genes in African-American women with breast cancer. Familial cancer 17(2): 187-195
Kim, B.Jik.; Kim, A.Reum.; Han, J.Hee.; Lee, C.; Oh, D.Yi.; Choi, B.Yoon. 2017: Discovery of MYH14 as an important and unique deafness gene causing prelingually severe autosomal dominant nonsyndromic hearing loss. Journal of Gene Medicine 19(4)
Rombouts, F.J.R.; Andrés, Jé-Ignacio.; Ariza, M.; Alonso, Jé.Manuel.; Austin, N.; Bottelbergs, A.; Chen, L.; Chupakhin, V.; Cleiren, E.; Fierens, K.; Fontana, A.; Langlois, X.; Leenaerts, J.E.; Mariën, J.; Martínez Lamenca, C.; Salter, R.; Schmidt, M.E.; Te Riele, P.; Wintmolders, C.; Trabanco, Aés.A.; Zhang, W.; Macdonald, G.; Moechars, D. 2017: Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease. Journal of Medicinal Chemistry 60(4): 1272-1291
Albrecht, W.; Unger, A.; Bauer, S.M.; Laufer, S.A. 2017: Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases. Journal of Medicinal Chemistry 60(13): 5290-5305
Felts, A.S.; Rodriguez, A.L.; Blobaum, A.L.; Morrison, R.D.; Bates, B.S.; Thompson Gray, A.; Rook, J.M.; Tantawy, M.N.; Byers, F.W.; Chang, S.; Venable, D.F.; Luscombe, V.B.; Tamagnan, G.D.; Niswender, C.M.; Daniels, J.Scott.; Jones, C.K.; Conn, P.Jeffrey.; Lindsley, C.W.; Emmitte, K.A. 2017: Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. Journal of Medicinal Chemistry 60(12): 5072-5085
Freitas, R.H.C.N.; Cordeiro, Nália.M.; Carvalho, Pícia.R.; Alves, M.A.; Guedes, I.A.; Valerio, T.S.; Dardenne, L.E.; Lima, Lídia.M.; Barreiro, E.J.; Fernandes, Pícia.D.; Fraga, C.A.M. 2018: Discovery of naphthyl-N-acylhydrazone p38α MAPK inhibitors with in vivo anti-inflammatory and anti-TNF-α activity. Chemical Biology and Drug Design 91(2): 391-397
Chen, Y.; Wu, J.; Wang, A.; Qi, Z.; Jiang, T.; Chen, C.; Zou, F.; Hu, C.; Wang, W.; Wu, H.; Hu, Z.; Wang, W.; Wang, B.; Wang, L.; Ren, T.; Zhang, S.; Liu, Q.; Liu, J. 2017: Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC. European Journal of Medicinal Chemistry 139: 674-697
Debenham, J.S.; Madsen-Duggan, C.; Clements, M.J.; Walsh, T.F.; Kuethe, J.T.; Reibarkh, M.; Salowe, S.P.; Sonatore, L.M.; Hajdu, R.; Milligan, J.A.; Visco, D.M.; Zhou, D.; Lingham, R.B.; Stickens, D.; DeMartino, J.A.; Tong, X.; Wolff, M.; Pang, J.; Miller, R.R.; Sherer, E.C.; Hale, J.J. 2016: Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. Journal of Medicinal Chemistry 59(24): 11039-11049
Van der Plas, S.E.; Kelgtermans, H.; De Munck, T.; Martina, Sébastien.L.X.; Dropsit, Sébastien.; Quinton, E.; De Blieck, A.; Joannesse, C.; Tomaskovic, L.; Jans, M.; Christophe, T.; van der Aar, E.; Borgonovi, M.; Nelles, L.; Gees, M.; Stouten, P.; Van Der Schueren, J.; Mammoliti, O.; Conrath, K.; Andrews, M. 2018: Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. Journal of Medicinal Chemistry 61(4): 1425-1435
Chen, W.; Huang, Z.; Wang, W.; Mao, F.; Guan, L.; Tang, Y.; Jiang, H.; Li, J.; Huang, J.; Jiang, L.; Zhu, J. 2017: Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely. Bioorganic and Medicinal Chemistry 25(24): 6467-6478
Navratilova, I.; Aristotelous, T.; Picaud, S.; Chaikuad, A.; Knapp, S.; Filappakopoulos, P.; Hopkins, A.L. 2016: Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. Acs Medicinal Chemistry Letters 7(12): 1213-1218
Shchetynsky, K.; Diaz-Gallo, L-Marcella.; Folkersen, L.; Hensvold, A.Haj.; Catrina, A.Irinel.; Berg, L.; Klareskog, L.; Padyukov, L. 2017: Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis. Arthritis Research and Therapy 19(1): 19
Pu, Y.; Zhang, S.; Chang, Z.; Zhang, Y.; Wang, D.; Zhang, L.; Li, Y.; Zuo, Z. 2017: Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay. Molecular Biosystems 13(2): 363-370
Hidalgo-Figueroa, S.; Navarrete-Vázquez, G.; Estrada-Soto, S.; Giles-Rivas, D.; Alarcón-Aguilar, F.J.; León-Rivera, I.; Giacoman-Martínez, A.; Miranda Pérez, E.; Almanza-Pérez, J.C. 2017: Discovery of new dual PPARγ-GPR40 agonists with robust antidiabetic activity: Design, synthesis and in combo drug evaluation. Biomedicine and PharmacoTherapy 90: 53-61
Armstrong, Z.; Rahfeld, P.; Withers, S.G. 2017: Discovery of New Glycosidases From Metagenomic Libraries. Methods in Enzymology 597: 3-23
Kassab, S.E.; Khedr, M.A.; Ali, H.I.; Abdalla, M.M. 2017: Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities. European Journal of Medicinal Chemistry 141: 306-321
Spalenka, Jérémy.; Escotte-Binet, S.; Bakiri, A.; Hubert, J.; Renault, J-Hugues.; Velard, Fédéric.; Duchateau, S.; Aubert, D.; Huguenin, A.; Villena, I. 2018: Discovery of New Inhibitors of Toxoplasma gondii via the Pathogen Box. Antimicrobial Agents and ChemoTherapy 62(2)
Wavhale, R.D.; Martis, E.A.F.; Ambre, P.K.; Wan, B.; Franzblau, S.G.; Iyer, K.R.; Raikuvar, K.; Macegoniuk, K.; Berlicki, Łukasz.; Nandan, S.R.; Coutinho, E.C. 2017: Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity. Bioorganic and Medicinal Chemistry 25(17): 4835-4844
Chen, G.; Xiao, B.; Chen, L.; Bai, B.; Zhang, Y.; Xu, Z.; Fu, L.; Liu, Z.; Li, X.; Zhao, Y.; Liang, G. 2017: Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury. European Journal of Medicinal Chemistry 139: 726-740
Rožman, K.; Lešnik, S.; Brus, B.; Hrast, M.; Sova, M.; Patin, D.; Barreteau, Hélène.; Konc, J.; Janežič, Dšanka.; Gobec, S. 2017: Discovery of new MurA inhibitors using induced-fit simulation and docking. Bioorganic and Medicinal Chemistry Letters 27(4): 944-949
Loughlin, W.A.; Jenkins, I.D.; Karis, N.David.; Healy, P.C. 2017: Discovery of new nanomolar inhibitors of GPa: Extension of 2-oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors. European Journal of Medicinal Chemistry 127: 341-356
Colmant, A.M.G.; Etebari, K.; Webb, C.E.; Ritchie, S.A.; Jansen, C.C.; van den Hurk, A.F.; Bielefeldt-Ohmann, H.; Hobson-Peters, J.; Asgari, S.; Hall, R.A. 2017: Discovery of new orbiviruses and totivirus from Anopheles mosquitoes in Eastern Australia. Archives of Virology 162(11): 3529-3534
Di Micco, S.; Terracciano, S.; Cantone, V.; Fischer, K.; Koeberle, A.; Foglia, A.; Riccio, R.; Werz, O.; Bruno, I.; Bifulco, G. 2018: Discovery of new potent molecular entities able to inhibit mPGES-1. European Journal of Medicinal Chemistry 143: 1419-1427
McCormick, S. 2017: Discovery of new QTLs underlying hybrid fertility and reproductive isolation in rice. Plant Journal: for Cell and Molecular Biology 92(3): 347-348
Berger, M.; Rehwinkel, H.; Schmees, N.; Schäcke, H.; Edman, K.; Wissler, L.; Reichel, A.; Jaroch, S. 2017: Discovery of new selective glucocorticoid receptor agonist leads. Bioorganic and Medicinal Chemistry Letters 27(3): 437-442
Angeli, A.; Tanini, D.; Peat, T.S.; Di Cesare Mannelli, L.; Bartolucci, G.; Capperucci, A.; Ghelardini, C.; Supuran, C.T.; Carta, F. 2017: Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. Acs Medicinal Chemistry Letters 8(9): 963-968
Huang, S.; Song, C.; Wang, X.; Zhang, G.; Wang, Y.; Jiang, X.; Sun, Q.; Huang, L.; Xiang, R.; Hu, Y.; Li, L.; Yang, S. 2017: Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis. Journal of Chemical Information and Modeling 57(4): 669-679
Huang, Y.; Zhang, Y.; Fan, K.; Dong, G.; Li, B.; Zhang, W.; Li, J.; Sheng, C. 2017: Discovery of new Syk inhibitors through structure-based virtual screening. Bioorganic and Medicinal Chemistry Letters 27(8): 1776-1779
McDaniel, K.F.; Wang, L.; Soltwedel, T.; Fidanze, S.D.; Hasvold, L.A.; Liu, D.; Mantei, R.A.; Pratt, J.K.; Sheppard, G.S.; Bui, M.H.; Faivre, E.J.; Huang, X.; Li, L.; Lin, X.; Wang, R.; Warder, S.E.; Wilcox, D.; Albert, D.H.; Magoc, T.J.; Rajaraman, G.; Park, C.H.; Hutchins, C.W.; Shen, J.J.; Edalji, R.P.; Sun, C.C.; Martin, R.; Gao, W.; Wong, S.; Fang, G.; Elmore, S.W.; Shen, Y.; Kati, W.M. 2017: Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor. Journal of Medicinal Chemistry 60(20): 8369-8384
Zeng, L.; Shin, W-Hee.; Zhu, X.; Park, S.Hoon.; Park, C.; Tao, W.Andy.; Kihara, D. 2017: Discovery of Nicotinamide Adenine Dinucleotide Binding Proteins in the Escherichia coli Proteome Using a Combined Energetic- and Structural-Bioinformatics-Based Approach. Journal of Proteome Research 16(2): 470-480
Mike, L.A.; Tripathi, A.; Blankenship, C.M.; Saluk, A.; Schultz, P.J.; Tamayo-Castillo, G.; Sherman, D.H.; Mobley, H.L.T. 2017: Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments. Chemical Communications 53(95): 12778-12781
Liang, Q.; Chen, Y.; Yu, K.; Chen, C.; Zhang, S.; Wang, A.; Wang, W.; Wu, H.; Liu, X.; Wang, B.; Wang, L.; Hu, Z.; Wang, W.; Ren, T.; Zhang, S.; Liu, Q.; Yun, C-Hong.; Liu, J. 2017: Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. European Journal of Medicinal Chemistry 131: 107-125
Fales, K.R.; Njoroge, F.George.; Brooks, H.B.; Thibodeaux, S.; Torrado, A.; Si, C.; Toth, J.L.; Mc Cowan, J.R.; Roth, K.D.; Thrasher, K.J.; Frimpong, K.; Lee, M.R.; Dally, R.D.; Shepherd, T.A.; Durham, T.B.; Margolis, B.J.; Wu, Z.; Wang, Y.; Atwell, S.; Wang, J.; Hui, Y-Hua.; Meier, T.I.; Konicek, S.A.; Geeganage, S. 2017: Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. Journal of Medicinal Chemistry 60(23): 9599-9616
Zhou, Y.; Sun, W.; Chen, N.; Xu, C.; Wang, X.; Dong, K.; Zhang, B.; Zhang, J.; Hao, N.; Sun, A.; Wei, H.; He, F.; Jiang, Y. 2017: Discovery of NKCC1 as a potential therapeutic target to inhibit hepatocellular carcinoma cell growth and metastasis. Oncotarget 8(39): 66328-66342
Gao, J.; Bhunia, S.; Wang, K.; Gan, L.; Xia, S.; Ma, D. 2017: Discovery of N-(Naphthalen-1-yl)-N'-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers. Organic Letters 19(11): 2809-2812
Buchynskyy, A.; Gillespie, J.Robert.; Hulverson, M.A.; McQueen, J.; Creason, S.A.; Ranade, R.M.; Duster, N.A.; Gelb, M.H.; Buckner, F.S. 2017: Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors. Bioorganic and Medicinal Chemistry 25(5): 1571-1584
Na, C.Hyun.; Barbhuiya, M.A.; Kim, M-Sik.; Verbruggen, S.; Eacker, S.M.; Pletnikova, O.; Troncoso, J.C.; Halushka, M.K.; Menschaert, G.; Overall, C.M.; Pandey, A. 2018: Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini. Genome Research 28(1): 25-36
Qin, R.; Zhao, J.; Qin, W.; Zhang, Z.; Zhao, R.; Han, J.; Yang, Y.; Li, L.; Wang, X.; Ren, S.; Sun, Y.; Gu, J. 2017: Discovery of Non-invasive Glycan Biomarkers for Detection and Surveillance of Gastric Cancer. Journal of Cancer 8(10): 1908-1916
Park, I.; Londhe, A.M.; Lim, J.Woong.; Park, B-Geon.; Jung, S.Yun.; Lee, J.Yeol.; Lim, S.Min.; No, K.Tai.; Lee, J.; Pae, A.Nim. 2017: Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction. Journal of Computer-Aided Molecular Design 31(10): 929-941
Higaki, S.; Kurihara, Y.; Yoshida, H.; Takahashi, Y.; Shinohara, N. 2017: Discovery of non-spherical heterogeneous radiocesium-bearing particles not derived from Unit 1 of the Fukushima Dai-ichi Nuclear Power Plant, in residences five years after the accident. Journal of Environmental Radioactivity 177: 65-70
Wu, Y-Jin.; Guernon, J.; McClure, A.; Luo, G.; Rajamani, R.; Ng, A.; Easton, A.; Newton, A.; Bourin, C.; Parker, D.; Mosure, K.; Barnaby, O.; Soars, M.G.; Knox, R.J.; Matchett, M.; Pieschl, R.; Herrington, J.; Chen, P.; Sivarao, D.V.; Bristow, L.J.; Meanwell, N.A.; Bronson, J.; Olson, R.; Thompson, L.A.; Dzierba, C. 2017: Discovery of non-zwitterionic aryl sulfonamides as Na v 1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation. Bioorganic and Medicinal Chemistry 25(20): 5490-5505
Zeng, D-Ying.; Kuang, G-Tao.; Wang, S-Ke.; Peng, W.; Lin, S-Ling.; Zhang, Q.; Su, X-Xuan.; Hu, M-Hao.; Wang, H.; Tan, J-Heng.; Huang, Z-Shu.; Gu, L-Quan.; Ou, T-Miao. 2017: Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry. Journal of Medicinal Chemistry 60(13): 5407-5423
Wang, M.; Fang, Y.; Gu, S.; Chen, F.; Zhu, Z.; Sun, X.; Zhu, J. 2017: Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. European Journal of Medicinal Chemistry 132: 157-172
Ito, M.; Tanaka, T.; Cary, D.R.; Iwatani-Yoshihara, M.; Kamada, Y.; Kawamoto, T.; Aparicio, S.; Nakanishi, A.; Imaeda, Y. 2017: Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. Journal of Medicinal Chemistry 60(8): 3335-3351
Raj, V.; Rai, A.; Singh, A.K.; Keshari, A.K.; Trivedi, P.; Ghosh, B.; Kumar, U.; Kumar, D.; Saha, S. 2018: Discovery of Novel 2-Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment. Anti-Cancer Agents in Medicinal Chemistry 18(5): 719-738
Kohara, T.; Nakayama, K.; Watanabe, K.; Kusaka, S-Ichi.; Sakai, D.; Tanaka, H.; Fukunaga, K.; Sunada, S.; Nabeno, M.; Saito, K-Ichi.; Eguchi, J-Ichi.; Mori, A.; Tanaka, S.; Bessho, T.; Takiguchi-Hayashi, K.; Horikawa, T. 2017: Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors. Bioorganic and Medicinal Chemistry Letters 27(16): 3733-3738
Gu, W.; Dai, Y.; Qiang, H.; Shi, W.; Liao, C.; Zhao, F.; Huang, W.; Qian, H. 2017: Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors. Bioorganic Chemistry 72: 116-122
Boggu, P.Reddy.; Venkateswararao, E.; Manickam, M.; Kim, Y.; Jung, S-Hun. 2017: Discovery of novel 3-(hydroxyalkoxy)-2-alkylchromen-4-one analogs as interleukin-5 inhibitors. European Journal of Medicinal Chemistry 139: 290-304
Zhou, P.; Huang, L.; Zhou, J.; Jiang, B.; Zhao, Y.; Deng, X.; Zhao, Q.; Li, F. 2017: Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents. Bioorganic and Medicinal Chemistry Letters 27(17): 4185-4189
Takai, T.; Koike, T.; Nakamura, M.; Kajita, Y.; Yamashita, T.; Taya, N.; Tsukamoto, T.; Watanabe, T.; Murakami, K.; Igari, T.; Kamata, M. 2016: Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2). Bioorganic and Medicinal Chemistry 24(14): 3192-3206
Mizojiri, R.; Nakata, D.; Satoh, Y.; Morishita, D.; Shibata, S.; Iwatani-Yoshihara, M.; Kosugi, Y.; Kosaka, M.; Takeda, J.; Sasaki, S.; Takami, K.; Fukuda, K.; Kamaura, M.; Sasaki, S.; Arai, R.; Cary, D.R.; Imaeda, Y. 2017: Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1 H )-one Derivatives as Orally eIF4A3-Selective Inhibitors. Acs Medicinal Chemistry Letters 8(10): 1077-1082
Hirose, H.; Yamasaki, T.; Ogino, M.; Mizojiri, R.; Tamura-Okano, Y.; Yashiro, H.; Muraki, Y.; Nakano, Y.; Sugama, J.; Hata, A.; Iwasaki, S.; Watanabe, M.; Maekawa, T.; Kasai, S. 2017: Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus. Bioorganic and Medicinal Chemistry 25(15): 4175-4193
Tang, Q.; Wang, L.; Duan, Y.; Wang, W.; Huang, S.; Zhi, J.; Jia, S.; Zhu, W.; Wang, P.; Luo, R.; Zheng, P. 2017: Discovery of novel 7-azaindole derivatives bearing dihydropyridazine moiety as c-Met kinase inhibitors. European Journal of Medicinal Chemistry 133: 97-106
Li, P.; Dorsch, W.; Lauffer, D.J.; Bilimoria, D.; Chauret, N.; Court, J.J.; Das, S.Kumar.; Denis, F.; Mani, N.; Nanthakumar, S.; Nicolas, O.; Rao, B.Govinda.; Ronkin, S.; Selliah, S.; Shawgo, R.S.; Stearns, R.; Tang, Q.; Waal, N.D.; Green, J. 2017: Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates. Acs Medicinal Chemistry Letters 8(2): 251-255
Sakurada, I.; Endo, T.; Hikita, K.; Hirabayashi, T.; Hosaka, Y.; Kato, Y.; Maeda, Y.; Matsumoto, S.; Mizuno, T.; Nagasue, H.; Nishimura, T.; Shimada, S.; Shinozaki, M.; Taguchi, K.; Takeuchi, K.; Yokoyama, T.; Hruza, A.; Reichert, P.; Zhang, T.; Wood, H.B.; Nakao, K.; Furusako, S. 2017: Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors. Bioorganic and Medicinal Chemistry Letters 27(11): 2622-2628
Kling, A.; Jantos, K.; Mack, H.; Hornberger, W.; Drescher, K.; Nimmrich, V.; Relo, A.; Wicke, K.; Hutchins, C.W.; Lao, Y.; Marsh, K.; Moeller, A. 2017: Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. Journal of Medicinal Chemistry 60(16): 7123-7138
Imamura, K.; Tomita, N.; Kawakita, Y.; Ito, Y.; Ono, K.; Nii, N.; Miyazaki, T.; Yonemori, K.; Tawada, M.; Sumi, H.; Satoh, Y.; Yamamoto, Y.; Miyahisa, I.; Sasaki, M.; Satomi, Y.; Hirayama, M.; Nishigaki, R.; Maezaki, H. 2017: Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents. Bioorganic and Medicinal Chemistry 25(14): 3768-3779
Tian, S.; Wang, X.; Li, L.; Zhang, X.; Li, Y.; Zhu, F.; Hou, T.; Zhen, X. 2017: Discovery of Novel and Selective Adenosine A 2A Receptor Antagonists for Treating Parkinson's Disease through Comparative Structure-Based Virtual Screening. Journal of Chemical Information and Modeling 57(6): 1474-1487
de Souza, W.Marciel.; Fumagalli, Mílio.Jorge.; de Araujo, J.; Sabino-Santos, G.; Maia, F.Gonçalves.Motta.; Romeiro, M.Farignoli.; Modha, S.; Nardi, M.Schiavo.; Queiroz, L.Helena.; Durigon, E.Luiz.; Nunes, Márcio.Roberto.Teixeira.; Murcia, P.Ramiro.; Figueiredo, L.Tadeu.Moraes. 2018: Discovery of novel anelloviruses in small mammals expands the host range and diversity of the Anelloviridae. Virology 514: 9-17
Zhang, L.; Shan, Y.; Li, C.; Sun, Y.; Su, P.; Wang, J.; Li, L.; Pan, X.; Zhang, J. 2017: Discovery of novel anti-angiogenesis agents. Part 6: Multi-targeted RTK inhibitors. European Journal of Medicinal Chemistry 127: 275-285
Li, C.; Shan, Y.; Sun, Y.; Si, R.; Liang, L.; Pan, X.; Wang, B.; Zhang, J. 2017: Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4. European Journal of Medicinal Chemistry 141: 506-518
Sun, Y.; Shan, Y.; Li, C.; Si, R.; Pan, X.; Wang, B.; Zhang, J. 2017: Discovery of novel anti-angiogenesis agents. Part 8: Diaryl thiourea bearing 1H-indazole-3-amine as multi-target RTKs inhibitors. European Journal of Medicinal Chemistry 141: 373-385
Miller, J.Richard.; Waldrop, G.L. 2010: Discovery of novel antibacterials. Expert Opinion on Drug Discovery 5(2): 145-154
Bishop, B.M.; Juba, M.L.; Russo, P.S.; Devine, M.; Barksdale, S.M.; Scott, S.; Settlage, R.; Michalak, P.; Gupta, K.; Vliet, K.; Schnur, J.M.; van Hoek, M.L. 2017: Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using Electron-Transfer Dissociation Mass Spectrometry. Journal of Proteome Research 16(4): 1470-1482
Aung, T.Tun.; Chor, W.Hong.Jeff.; Yam, J.Kuok.Hoong.; Givskov, M.; Yang, L.; Beuerman, R.W. 2017: Discovery of novel antimycobacterial drug therapy in biofilm of pathogenic nontuberculous mycobacterial keratitis. Ocular Surface 15(4): 770-783
Chen, J.; Wang, T.; Xu, S.; Zhang, P.; Lin, A.; Wu, L.; Yao, H.; Xie, W.; Zhu, Z.; Xu, J. 2017: Discovery of novel antitumor nitric oxide-donating β-elemene hybrids through inhibiting the PI3K/Akt pathway. European Journal of Medicinal Chemistry 135: 414-423
Fordyce, E.A.F.; Brookes, D.W.; Lise-Ciana, C.; Coates, M.S.; Hunt, S.Fraser.; Ito, K.; King-Underwood, J.; Onions, S.T.; Parra, G.F.; Rapeport, G.; Sherbukhin, V.; Stockwell, J.A.; Strong, P.; Thomas, J.C.; Murray, J. 2017: Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus. Bioorganic and Medicinal Chemistry Letters 27(10): 2201-2206
Jiang, H.; Xing, J.; Wang, C.; Zhang, H.; Yue, L.; Wan, X.; Chen, W.; Ding, H.; Xie, Y.; Tao, H.; Chen, Z.; Jiang, H.; Chen, K.; Chen, S.; Zheng, M.; Zhang, Y.; Luo, C. 2017: Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues. Organic and Biomolecular Chemistry 15(44): 9352-9361
Yi, B.; Jahangir, A.; Evans, A.K.; Briggs, D.; Ravina, K.; Ernest, J.; Farimani, A.B.; Sun, W.; Rajadas, J.; Green, M.; Feinberg, E.N.; Pande, V.S.; Shamloo, M. 2017: Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders. Plos one 12(7): E0180319
Sun, Z.; Zhang, H.; Chen, Z.; Xie, Y.; Jiang, H.; Chen, L.; Ding, H.; Zhang, Y.; Jiang, H.; Zheng, M.; Luo, C. 2017: Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays. Bioorganic and Medicinal Chemistry Letters 27(9): 2003-2009
Wang, L-Jun.; Guo, C-Long.; Li, X-Qian.; Wang, S-Yu.; Jiang, B.; Zhao, Y.; Luo, J.; Xu, K.; Liu, H.; Guo, S-Ju.; Wu, N.; Shi, D-Yong. 2017: Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation. Marine Drugs 15(11)
Ge, Y.; Jin, Y.; Wang, C.; Zhang, J.; Tang, Z.; Peng, J.; Liu, K.; Li, Y.; Zhou, Y.; Ma, X. 2016: Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a N ,9-Diphenyl-9 H -purin-2-amine Scaffold. Acs Medicinal Chemistry Letters 7(12): 1050-1055
Gao, X.; Wang, J.; Liu, J.; Guiadeen, D.; Krikorian, A.; Boga, S.Babu.; Alhassan, A-Basit.; Selyutin, O.; Yu, W.; Yu, Y.; Anand, R.; Liu, S.; Yang, C.; Wu, H.; Cai, J.; Cooper, A.; Zhu, H.; Maloney, K.; Gao, Y-Duo.; Fischmann, T.O.; Presland, J.; Mansueto, M.; Xu, Z.; Leccese, E.; Zhang-Hoover, J.; Knemeyer, I.; Garlisi, C.G.; Bays, N.; Stivers, P.; Brandish, P.E.; Hicks, A.; Kim, R.; Kozlowski, J.A. 2017: Discovery of novel BTK inhibitors with carboxylic acids. Bioorganic and Medicinal Chemistry Letters 27(6): 1471-1477
Wang, T.; Yang, Z.; Zhang, Y.; Yan, W.; Wang, F.; He, L.; Zhou, Y.; Chen, L. 2017: Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening. European Journal of Medicinal Chemistry 129: 275-286
Laraia, L.; Ohsawa, K.; Konstantinidis, G.; Robke, L.; Wu, Y-Wen.; Kumar, K.; Waldmann, H. 2017: Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors. Angewandte Chemie 56(8): 2145-2150
Ying, M.; Kidou, S-Ichiro. 2017: Discovery of novel cold-induced CISP genes encoding small RNA-binding proteins related to cold adaptation in barley. Plant Science: An International Journal of Experimental Plant Biology 260: 129-138
Ao, G-Zhen.; Zhou, M-Ze.; Li, Y-Yao.; Li, S-Ning.; Wang, H-Nian.; Wan, Q-Wen.; Li, H-Qiu.; Hu, Q-Hua. 2017: Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents. Bioorganic and Medicinal Chemistry 25(1): 166-174
Takagi, Y.; Matsui, K.; Nobori, H.; Maeda, H.; Sato, A.; Kurosu, T.; Orba, Y.; Sawa, H.; Hattori, K.; Higashino, K.; Numata, Y.; Yoshida, Y. 2017: Discovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity. Bioorganic and Medicinal Chemistry Letters 27(15): 3586-3590
Huang, B.; Wang, X.; Liu, X.; Chen, Z.; Li, W.; Sun, S.; Liu, H.; Daelemans, D.; De Clercq, E.; Pannecouque, C.; Zhan, P.; Liu, X. 2017: Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays. Bioorganic and Medicinal Chemistry 25(16): 4397-4406
Leal, E.S.; Aucar, M.Gabriela.; Gebhard, L.G.; Iglesias, N.G.; Pascual, Mía.J.; Casal, J.J.; Gamarnik, A.V.; Cavasotto, C.N.; Bollini, M. 2017: Discovery of novel dengue virus entry inhibitors via a structure-based approach. Bioorganic and Medicinal Chemistry Letters 27(16): 3851-3855
Wong, W.Tak.; Matrone, G.; Tian, X.; Tomoiaga, S.Alin.; Au, K.Fai.; Meng, S.; Yamazoe, S.; Sieveking, D.; Chen, K.; Burns, D.M.; Chen, J.K.; Blau, H.M.; Cooke, J.P. 2017: Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. Elife 6
Lee, J-Ching.; Tseng, C-Kai.; Lin, C-Kuang.; Tseng, C-Hua. 2017: Discovery of novel diarylpyrazolylquinoline derivatives as potent anti-dengue virus agents. European Journal of Medicinal Chemistry 141: 282-292
Wang, Y.; Li, L.; Zhang, B.; Xing, J.; Chen, S.; Wan, W.; Song, Y.; Jiang, H.; Jiang, H.; Luo, C.; Zheng, M. 2017: Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family. Journal of Medicinal Chemistry 60(5): 2026-2036
Hempel, C.; Totzke, F.; Schächtele, C.; Najjar, A.; Sippl, W.; Ritter, C.; Hilgeroth, A. 2017: Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R. Journal of Enzyme Inhibition and Medicinal Chemistry 32(1): 271-276
Fischer, T.; Najjar, A.; Totzke, F.; Schächtele, C.; Sippl, W.; Ritter, C.; Hilgeroth, A. 2018: Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance. Journal of Enzyme Inhibition and Medicinal Chemistry 33(1): 1-8
Chen, S.; Qin, C.; Sin, J.En.; Yang, X.; Tao, L.; Zeng, X.; Zhang, P.; Gao, C.Mei.; Jiang, Y.Yang.; Zhang, C.; Chen, Y.Zong.; Chui, W.Keung. 2017: Discovery of novel dual VEGFR2 and Src inhibitors using a multistep virtual screening approach. Future Medicinal Chemistry 9(1): 7-24
Irie, T.; Asami, T.; Sawa, A.; Uno, Y.; Hanada, M.; Taniyama, C.; Funakoshi, Y.; Masai, H.; Sawa, M. 2017: Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. European Journal of Medicinal Chemistry 130: 406-418
Shimizu, Y.; Nakayama, M. 2017: Discovery of Novel Gq-Biased LPA1 Negative Allosteric Modulators. Slas Discovery: Advancing Life Sciences R and D 22(7): 859-866
van den Berg, M.E.; Warren, H.R.; Cabrera, C.P.; Verweij, N.; Mifsud, B.; Haessler, J.; Bihlmeyer, N.A.; Fu, Y-Ping.; Weiss, S.; Lin, H.J.; Grarup, N.; Li-Gao, R.; Pistis, G.; Shah, N.; Brody, J.A.; Müller-Nurasyid, M.; Lin, H.; Mei, H.; Smith, A.V.; Lyytikäinen, L-Pekka.; Hall, L.M.; van Setten, J.; Trompet, S.; Prins, B.P.; Isaacs, A.; Radmanesh, F.; Marten, J.; Entwistle, A.; Kors, J.A.; Silva, C.T.; Alonso, A.; Bis, J.C.; de Boer, R.; de Haan, H.G.; de Mutsert, Rée.; Dedoussis, G.; Dominiczak, A.F.; Doney, A.S.F.; Ellinor, P.T.; Eppinga, R.N.; Felix, S 2017: Discovery of novel heart rate-associated loci using the Exome Chip. Human Molecular Genetics 26(12): 2346-2363
Nara, H.; Kaieda, A.; Sato, K.; Naito, T.; Mototani, H.; Oki, H.; Yamamoto, Y.; Kuno, H.; Santou, T.; Kanzaki, N.; Terauchi, J.; Uchikawa, O.; Kori, M. 2017: Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach. Journal of Medicinal Chemistry 60(2): 608-626
Wada, Y.; Nakano, S.; Morimoto, A.; Kasahara, K-Ichi.; Hayashi, T.; Takada, Y.; Suzuki, H.; Niwa-Sakai, M.; Ohashi, S.; Mori, M.; Hirokawa, T.; Shuto, S. 2017: Discovery of Novel Indazole Derivatives as Orally Available β 3 -Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects. Journal of Medicinal Chemistry 60(8): 3252-3265
Xue, X.; Zhao, N-Yi.; Yu, H-Tao.; Sun, Y.; Kang, C.; Huang, Q-Bin.; Sun, H-Peng.; Wang, X-Long.; Li, N-Guang. 2016: Discovery of novel inhibitors disrupting HIF-1 α /von Hippel-Lindau interaction through shape-based screening and cascade docking. Peerj 4: E2757
Mishra, A.K.; Singh, N.; Agnihotri, P.; Mishra, S.; Singh, S.P.; Kolli, B.K.; Chang, K.Poo.; Sahasrabuddhe, A.A.; Siddiqi, M.I.; Pratap, J.Venkatesh. 2017: Discovery of novel inhibitors for Leishmania nucleoside diphosphatase kinase (NDK) based on its structural and functional characterization. Journal of Computer-Aided Molecular Design 31(6): 547-562
Soojhawon, I.; Pattabiraman, N.; Tsang, A.; Roth, A.L.; Kang, E.; Noble, S.M. 2017: Discovery of novel inhibitors of multidrug-resistant Acinetobacter baumannii. Bioorganic and Medicinal Chemistry 25(20): 5477-5482
Saxena, S.; Abdullah, M.; Sriram, D.; Guruprasad, L. 2018: Discovery of novel inhibitors of Mycobacterium tuberculosis MurG: homology modelling, structure based pharmacophore, molecular docking, and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 36(12): 3184-3198
Chen, Y.; Ma, H.; Zhu, D.; Zhao, G.; Wang, L.; Fu, X.; Chen, W. 2017: Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets. Ppar Research 2017: 8360919
Feng, B.; Li, X.; Xia, J.; Wu, S. 2017: Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling. Journal of Enzyme Inhibition and Medicinal Chemistry 32(1): 968-977
Grassmann, Aé.Alex.; Kremer, F.Schmitt.; Dos Santos, Júlia.Cougo.; Souza, Jéssica.Dias.; Pinto, L.da.Silva.; McBride, A.John.Alexander. 2017: Discovery of Novel Leptospirosis Vaccine Candidates Using Reverse and Structural Vaccinology. Frontiers in Immunology 8: 463
Chen, S.; Feng, Z.; Wang, Y.; Ma, S.; Hu, Z.; Yang, P.; Chai, Y.; Xie, X. 2017: Discovery of Novel Ligands for TNF-α and TNF Receptor-1 through Structure-Based Virtual Screening and Biological Assay. Journal of Chemical Information and Modeling 57(5): 1101-1111
Qiu, L.; Li, Z.; Chang, G.; Bi, Y.; Liu, X.; Xu, L.; Zhang, Y.; Zhao, W.; Xu, Q.; Chen, G. 2017: Discovery of novel long non-coding RNAs induced by subgroup J avian leukosis virus infection in chicken. Developmental and Comparative Immunology 76: 292-302
Liu, G.; Huang, W.; Wang, J.; Liu, X.; Yang, J.; Zhang, Y.; Geng, Y.; Tan, W.; Zhang, A. 2017: Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription. Journal of Medicinal Chemistry 60(19): 8218-8245
Ning, X.; Qi, H.; Li, R.; Li, Y.; Jin, Y.; McNutt, M.A.; Liu, J.; Yin, Y. 2017: Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase. European Journal of Medicinal Chemistry 138: 343-352
Li, Z-Zhen.; Gopala, L.; Tangadanchu, V.Kumar.Reddy.; Gao, W-Wei.; Zhou, C-He. 2017: Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. Bioorganic and Medicinal Chemistry 25(24): 6511-6522
Pascual, I.; Valiente, P.A.; García, G.; Valdés-Tresanco, M.E.; Arrebola, Y.; Díaz, L.; Bounaadja, L.; Uribe, R.María.; Pacheco, M.Chappé.; Florent, I.; Charli, J-Louis. 2017: Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN). Biochimie 142: 216-225
Yao, Y.; Li, R.; Liu, X.; Yang, F.; Yang, Y.; Li, X.; Shi, X.; Yuan, T.; Fang, L.; Du, G.; Jiao, X.; Xie, P. 2017: Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents. Molecules 22(10)
Zhen, L.; Dai, L.; Wen, X.; Yao, L.; Jin, X.; Yang, X-Wen.; Zhao, W.; Yu, S-Qi.; Yuan, H.; Wang, G.; Sun, H. 2017: Discovery of Novel Nucleotide Prodrugs with Improved Potency Against HCV Variants Carrying NS5B S282T Mutation. Journal of Medicinal Chemistry 60(14): 6077-6088
Farmer, L.J.; Clark, M.P.; Boyd, M.J.; Perola, E.; Jones, S.M.; Tsai, A.; Jacobs, M.D.; Bandarage, U.K.; Ledeboer, M.W.; Wang, T.; Deng, H.; Ledford, B.; Gu, W.; Duffy, J.P.; Bethiel, R.S.; Shannon, D.; Byrn, R.A.; Leeman, J.R.; Rijnbrand, R.; Bennett, H.B.; O'Brien, C.; Memmott, C.; Nti-Addae, K.; Bennani, Y.L.; Charifson, P.S. 2017: Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2. Acs Medicinal Chemistry Letters 8(2): 256-260
Baduel, C.; Mueller, J.F.; Rotander, A.; Corfield, J.; Gomez-Ramos, M-José. 2017: Discovery of novel per- and polyfluoroalkyl substances (PFASs) at a fire fighting training ground and preliminary investigation of their fate and mobility. Chemosphere 185: 1030-1038
Zhang, C.; Feng, L-Jun.; Huang, Y.; Wu, D.; Li, Z.; Zhou, Q.; Wu, Y.; Luo, H-Bin. 2017: Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay. Journal of Chemical Information and Modeling 57(2): 355-364
Rateb, H.S.; Ahmed, H.E.A.; Ahmed, S.; Ihmaid, S.; Afifi, T.H. 2016: Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies. Excli Journal 15: 781-796
Geno, K.Aaron.; Saad, J.S.; Nahm, M.H. 2017: Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B. Journal of Clinical Microbiology 55(5): 1416-1425
Zhang, L.; Ren, W.; Wang, X.; Zhang, J.; Liu, J.; Zhao, L.; Zhang, X. 2017: Discovery of novel polycyclic spiro-fused carbocyclicoxindole-based anticancer agents. European Journal of Medicinal Chemistry 126: 1071-1082
Xiang, Z.; Liu, J.; Sun, H.; Wen, X. 2017: Discovery of Novel Potent Muscarinic M 3 Receptor Antagonists with Proper Plasma Stability by Structural Recombination of Marketed M 3 Antagonists. Chemmedchem 12(15): 1173-1182
Al-Sha'er, M.A.; Almazari, I.S.; Taha, M.O. 2017: Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-β) via extensive ligand-based modeling and virtual screening. Journal of Molecular Recognition: Jmr 30(6)
Soubhye, J.; Chikh Alard, I.; Aldib, I.; Prévost, M.; Gelbcke, M.; De Carvalho, A.; Furtmüller, P.G.; Obinger, C.; Flemmig, Jörg.; Tadrent, S.; Meyer, F.; Rousseau, A.; Nève, J.; Mathieu, Véronique.; Zouaoui Boudjeltia, K.; Dufrasne, Fçois.; Van Antwerpen, P. 2017: Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure. Journal of Medicinal Chemistry 60(15): 6563-6586
Nguyen, T.; Decker, A.M.; Langston, T.L.; Mathews, K.M.; Siemian, J.N.; Li, J-Xu.; Harris, D.L.; Runyon, S.P.; Zhang, Y. 2017: Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists. Acs Chemical Neuroscience 8(10): 2290-2308
Xu, Y-Xiang.; Wang, H.; Li, X-Kang.; Dong, S-Nan.; Liu, W-Wen.; Gong, Q.; Wang, T-Duan-Yi.; Tang, Y.; Zhu, J.; Li, J.; Zhang, H-Yan.; Mao, F. 2018: Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 143: 33-47
Nishigaya, Y.; Umei, K.; Saito, Y.; Watanabe, H.; Kondo, T.; Kondo, A.; Kawamura, N.; Tatani, K.; Kohno, Y.; Tanaka, N.; Seto, S. 2017: Discovery of novel pyrazolo[1,5-a]pyridine-based EP 1 receptor antagonists by scaffold hopping: Design, synthesis, and structure-activity relationships. Bioorganic and Medicinal Chemistry Letters 27(17): 4044-4050
Yu, Y-Fa.; Huang, Y-Dan.; Zhang, C.; Wu, X-Nian.; Zhou, Q.; Wu, D.; Wu, Y.; Luo, H-Bin. 2017: Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer's Disease. Acs Chemical Neuroscience 8(11): 2522-2534
Tan, L.; Tao, Y.; Wang, T.; Zou, F.; Zhang, S.; Kou, Q.; Niu, A.; Chen, Q.; Chu, W.; Chen, X.; Wang, H.; Yang, Y. 2017: Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections. Journal of Medicinal Chemistry 60(7): 2669-2684
Wang, L.Xiao.; Liu, X.; Xu, S.; Tang, Q.; Duan, Y.; Xiao, Z.; Zhi, J.; Jiang, L.; Zheng, P.; Zhu, W. 2017: Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors. European Journal of Medicinal Chemistry 141: 538-551
Zhao, H.; Ji, M.; Cui, G.; Zhou, J.; Lai, F.; Chen, X.; Xu, B. 2017: Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors. Bioorganic and Medicinal Chemistry 25(15): 4045-4054
Ali, I.; Lee, J.; Go, A.; Choi, G.; Lee, K. 2017: Discovery of novel [1,2,4]triazolo[4,3-a]quinoxaline aminophenyl derivatives as BET inhibitors for cancer treatment. Bioorganic and Medicinal Chemistry Letters 27(20): 4606-4613
Zandawala, M.; Moghul, I.; Yañez Guerra, L.Alfonso.; Delroisse, Jérôme.; Abylkassimova, N.; Hugall, A.F.; O'Hara, T.D.; Elphick, M.R. 2017: Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms. Open Biology 7(9)
Sugimoto, I.; Kambe, T.; Okino, T.; Obitsu, T.; Ohta, N.; Nishiyama, T.; Kinoshita, A.; Fujimoto, T.; Egashira, H.; Yamane, S.; Shuto, S.; Tani, K.; Maruyama, T. 2017: Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists. Acs Medicinal Chemistry Letters 8(1): 107-112
Kirby, R.Jason.; Divlianska, D.B.; Whig, K.; Bryan, N.; Morfa, C.J.; Koo, A.; Nguyen, K.H.; Maloney, P.; Peddibhotla, S.; Sessions, E.Hampton.; Hershberger, P.M.; Smith, L.H.; Malany, S. 2018: Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress. Journal of Pharmacology and Experimental Therapeutics 364(1): 87-96
Yi, F.; Guo, J.; Dabbagh, D.; Spear, M.; He, S.; Kehn-Hall, K.; Fontenot, J.; Yin, Y.; Bibian, M.; Park, C.Min.; Zheng, K.; Park, H.Jeung.; Soloveva, V.; Gharaibeh, D.; Retterer, C.; Zamani, R.; Pitt, M.L.; Naughton, J.; Jiang, Y.; Shang, H.; Hakami, R.M.; Ling, B.; Young, J.A.T.; Bavari, S.; Xu, X.; Feng, Y.; Wu, Y. 2017: Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. Journal of Virology 91(13)
Cao, L.; Weetall, M.; Bombard, J.; Qi, H.; Arasu, T.; Lennox, W.; Hedrick, J.; Sheedy, J.; Risher, N.; Brooks, P.C.; Trifillis, P.; Trotta, C.; Moon, Y-Choon.; Babiak, J.; Almstead, N.G.; Colacino, J.M.; Davis, T.W.; Peltz, S.W. 2016: Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform. Plos one 11(12): E0168366
Clare, J.J. 2006: Discovery of novel sodium channel inhibitors-A gene family-based approach. Comparative Biochemistry and Physiology. Part D Genomics and Proteomics 1(3): 309-318
Yamasaki, T.; Hirose, H.; Yamashita, T.; Takakura, N.; Morimoto, S.; Nakahata, T.; Kina, A.; Nakano, Y.; Okano Tamura, Y.; Sugama, J.; Odani, T.; Shimizu, Y.; Iwasaki, S.; Watanabe, M.; Maekawa, T.; Kasai, S. 2017: Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition. Bioorganic and Medicinal Chemistry 25(15): 4153-4162
Kikuchi, E.; Mori, T.; Zeniya, M.; Isobe, K.; Ishigami-Yuasa, M.; Fujii, S.; Kagechika, H.; Ishihara, T.; Mizushima, T.; Sasaki, S.; Sohara, E.; Rai, T.; Uchida, S. 2015: Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters. Journal of the American Society of Nephrology: Jasn 26(7): 1525-1536
Xiang, Y.; Hirth, B.; Kane, J.L.; Liao, J.; Noson, K.D.; Yee, C.; Asmussen, G.; Fitzgerald, M.; Klaus, C.; Booker, M. 2010: Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorganic and Medicinal Chemistry Letters 20(15): 4550-4554
Ledneczki, I.; Tapolcsányi, Pál.; Gábor, E.; Éles, János.; Greiner, Ián.; Schmidt, Éva.; Némethy, Z.; Kedves, R.Soukupné.; Balázs, O.; Román, V.; Lévay, Görgy.; Mahó, Sándor. 2017: Discovery of novel steroidal histamine H 3 receptor antagonists/inverse agonists. Bioorganic and Medicinal Chemistry Letters 27(19): 4525-4530
Bhattarai, S.; Pontarelli, F.; Prendergast, E.; Dharap, A. 2017: Discovery of novel stroke-responsive lnc RNAs in the mouse cortex using genome-wide RNA-seq. Neurobiology of Disease 108: 204-212
Fischer, T.; Krüger, T.; Najjar, A.; Totzke, F.; Schächtele, C.; Sippl, W.; Ritter, C.; Hilgeroth, A. 2017: Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(12): 2708-2712
Wu, S.; Sun, Y.; Hu, Y.; Zhang, H.; Hou, L.; Liu, X.; Li, Y.; He, H.; Luo, Z.; Chen, Y.; Wang, Y.; Shi, W.; Shen, L.; Cao, C.; Liang, W.; Xu, Q.; Lv, Q.; Lan, J.; Li, J.; Chen, S. 2017: Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment. Bioorganic and Medicinal Chemistry Letters 27(6): 1458-1462
Yao, T-Ting.; Fang, S-Wei.; Li, Z-Shan.; Xiao, D-Xin.; Cheng, J-Li.; Ying, H-Zhou.; Du, Y-Jun.; Zhao, J-Hao.; Dong, X-Wu. 2017: Discovery of Novel Succinate Dehydrogenase Inhibitors by the Integration of in Silico Library Design and Pharmacophore Mapping. Journal of Agricultural and Food Chemistry 65(15): 3204-3211
Barberis, C.; Moorcroft, N.; Pribish, J.; Tserlin, E.; Gross, A.; Czekaj, M.; Barrague, M.; Erdman, P.; Majid, T.; Batchelor, J.; Levit, M.; Hebert, A.; Shen, L.; Moreno-Mazza, S.; Wang, A. 2017: Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. Bioorganic and Medicinal Chemistry Letters 27(20): 4735-4740
Barberis, C.; Moorcroft, N.; Arendt, C.; Levit, M.; Moreno-Mazza, S.; Batchelor, J.; Mechin, I.; Majid, T. 2017: Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorganic and Medicinal Chemistry Letters 27(20): 4730-4734
Jiang, L.; Beattie, D.T.; Jacobsen, J.R.; Kintz, S.; Obedencio, G.P.; Saito, D.; Stergiades, I.; Vickery, R.G.; Long, D.D. 2017: Discovery of N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of μ-opioid receptor antagonists. Bioorganic and Medicinal Chemistry Letters 27(13): 2926-2930
Zhang, G.; Cheng, J.; McCorvy, J.D.; Lorello, P.J.; Caldarone, B.J.; Roth, B.L.; Kozikowski, A.P. 2017: Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications. Journal of Medicinal Chemistry 60(14): 6273-6288
Planken, S.; Behenna, D.C.; Nair, S.K.; Johnson, T.O.; Nagata, A.; Almaden, C.; Bailey, S.; Ballard, T.Eric.; Bernier, L.; Cheng, H.; Cho-Schultz, S.; Dalvie, D.; Deal, J.G.; Dinh, D.M.; Edwards, M.P.; Ferre, R.Ann.; Gajiwala, K.S.; Hemkens, M.; Kania, R.S.; Kath, J.C.; Matthews, J.; Murray, B.W.; Niessen, S.; Orr, S.T.M.; Pairish, M.; Sach, N.W.; Shen, H.; Shi, M.; Solowiej, J.; Tran, K.; Tseng, E.; Vicini, P.; Wang, Y.; Weinrich, S.L.; Zhou, R.; Zientek, M.; Liu, L.; Luo, Y.; Xin, S.; Zhang, C.; Lafontaine, J. 2017: Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR. Journal of Medicinal Chemistry 60(7): 3002-3019
Hücker, S.M.; Ardern, Z.; Goldberg, T.; Schafferhans, A.; Bernhofer, M.; Vestergaard, G.; Nelson, C.W.; Schloter, M.; Rost, B.; Scherer, S.; Neuhaus, K. 2017: Discovery of numerous novel small genes in the intergenic regions of the Escherichia coli O157:H7 Sakai genome. Plos one 12(9): E0184119
Koonin, E.V.; Makarova, K.S. 2018: Discovery of Oligonucleotide Signaling Mediated by CRISPR-Associated Polymerases Solves Two Puzzles but Leaves an Enigma. Acs Chemical Biology 13(2): 309-312
Schilling, M.; Hodel, F.H.; Luber, S. 2017: Discovery of Open Cubane Core Structures for Biomimetic LnCo 3 (OR) 4 Water Oxidation Catalysts. Chemsuschem 10(22): 4561-4569
Xu, J.; Lin, S.; Myers, R.W.; Trujillo, M.E.; Pachanski, M.J.; Malkani, S.; Chen, H-Shen.; Chen, Z.; Campbell, B.; Eiermann, G.J.; Elowe, N.; Farrer, B.T.; Feng, W.; Fu, Q.; Kats-Kagan, R.; Kavana, M.; McMasters, D.R.; Mitra, K.; Tong, X.; Xu, L.; Zhang, F.; Zhang, R.; Addona, G.H.; Berger, J.P.; Zhang, B.; Parmee, E.R. 2017: Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus. Bioorganic and Medicinal Chemistry Letters 27(9): 2063-2068
Anan, K.; Masui, M.; Hara, S.; Ohara, M.; Kume, M.; Yamamoto, S.; Shinohara, S.; Tsuji, H.; Shimada, S.; Yagi, S.; Hasebe, N.; Kai, H. 2017: Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach. Bioorganic and Medicinal Chemistry Letters 27(17): 4194-4198
Zhang, X.; Wall, M.; Sui, Z.; Kauffman, J.; Hou, C.; Chen, C.; Du, F.; Kirchner, T.; Liang, Y.; Johnson, D.L.; Murray, W.V.; Demarest, K. 2017: Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes. Acs Medicinal Chemistry Letters 8(5): 560-565
Sprau, P.O.; Kostin, A.; Kreisel, A.; Böhmer, A.E.; Taufour, V.; Canfield, P.C.; Mukherjee, S.; Hirschfeld, P.J.; Andersen, B.M.; Davis, J.C.Séamus. 2017: Discovery of orbital-selective Cooper pairing in FeSe. Science 357(6346): 75-80
Mishra, P.; Dauphinee, A.N.; Ward, C.; Sarkar, S.; Gunawardena, A.H.L.A.N.; Manjithaya, R. 2017: Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms. Autophagy 13(9): 1556-1572
Cho, P.Yeon.; Park, J-Min.; Hwang, M-Ki.; Park, S.Hye.; Park, Y-Kyu.; Jeon, B-Young.; Kim, T-Soo.; Lee, H-Woo. 2017: Discovery of Parasite Eggs in Archeological Residence during the 15th Century in Seoul, Korea. Korean Journal of Parasitology 55(3): 357-361
Nakajima, T.; Sawada, K. 2017: Discovery of Pb-Free Perovskite Solar Cells via High-Throughput Simulation on the K Computer. Journal of Physical Chemistry Letters 8(19): 4826-4831
Chen, D.; Huang, X.; Zhou, H.; Luo, H.; Wang, P.; Chang, Y.; He, X.; Ni, S.; Shen, Q.; Cao, G.; Sun, H.; Wen, X.; Liu, J. 2017: Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors. European Journal of Medicinal Chemistry 139: 201-213
Bashari, O.; Redko, B.; Cohen, A.; Luboshits, G.; Gellerman, G.; Firer, M.A. 2017: Discovery of peptide drug carrier candidates for targeted multi-drug delivery into prostate cancer cells. Cancer Letters 408: 164-173
Leffler, A.E.; Kuryatov, A.; Zebroski, H.A.; Powell, S.R.; Filipenko, P.; Hussein, A.K.; Gorson, J.; Heizmann, A.; Lyskov, S.; Tsien, R.W.; Poget, Sébastien.F.; Nicke, A.; Lindstrom, J.; Rudy, B.; Bonneau, R.; Holford, Më. 2017: Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Proceedings of the National Academy of Sciences of the United States of America 114(38): E8100-E8109
Sakamoto, K.; Otake, K.; Umemoto, T. 2017: Discovery of peptidic miR-21 processing inhibitor by mirror image phage display: A novel method to generate RNA binding D-peptides. Bioorganic and Medicinal Chemistry Letters 27(4): 826-828
Barnash, K.D.; The, J.; Norris-Drouin, J.L.; Cholensky, S.H.; Worley, B.M.; Li, F.; Stuckey, J.I.; Brown, P.J.; Vedadi, M.; Arrowsmith, C.H.; Frye, S.V.; James, L.I. 2017: Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. Acs Combinatorial Science 19(3): 161-172
Suzuki, S.; Sugawara, Y.; Inada, H.; Tsuji, R.; Inoue, A.; Tanimura, R.; Shimozono, R.; Konno, M.; Ohyama, T.; Higashi, E.; Sakai, C.; Kawai, K. 2017: Discovery of Peripheral κ-Opioid Receptor Agonists as Novel Analgesics. Chemical and Pharmaceutical Bulletin 65(11): 1085-1088
Hall, J.; Brault, A.; Vincent, F.; Weng, S.; Wang, H.; Dumlao, D.; Aulabaugh, A.; Aivazian, D.; Castro, D.; Chen, M.; Culp, J.; Dower, K.; Gardner, J.; Hawrylik, S.; Golenbock, D.; Hepworth, D.; Horn, M.; Jones, L.; Jones, P.; Latz, E.; Li, J.; Lin, L-Ling.; Lin, W.; Lin, D.; Lovering, F.; Niljanskul, N.; Nistler, R.; Pierce, B.; Plotnikova, O.; Schmitt, D.; Shanker, S.; Smith, J.; Snyder, W.; Subashi, T.; Trujillo, J.; Tyminski, E.; Wang, G.; Wong, J.; Lefker, B.; Dakin, L.; Leach, K. 2017: Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. Plos one 12(9): E0184843
Zhu, C.; Wang, L.; Zhu, Y.; Guo, Z.Zhiqiang.; Liu, P.; Hu, Z.; Szewczyk, J.W.; Kang, L.; Chicchi, G.; Ehrhardt, A.; Woods, A.; Seo, T.; Woods, M.; van Heek, M.; Dingley, K.H.; Pang, J.; Salituro, G.M.; Powell, J.; Terebetski, J.L.; Hornak, V.; Campeau, L-Charles.; Orr, R.K.; Ujjainwalla, F.; Miller, M.; Stamford, A.; Wood, H.B.; Kowalski, T.; Nargund, R.P.; Edmondson, S.D. 2017: Discovery of phenyl acetamides as potent and selective GPR119 agonists. Bioorganic and Medicinal Chemistry Letters 27(5): 1124-1128
Wurtz, N.R.; Parkhurst, B.L.; Jiang, W.; DeLucca, I.; Zhang, X.; Ladziata, V.; Cheney, D.L.; Bozarth, J.R.; Rendina, A.R.; Wei, A.; Luettgen, J.M.; Wu, Y.; Wong, P.C.; Seiffert, D.A.; Wexler, R.R.; Priestley, E.Scott. 2016: Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors. Acs Medicinal Chemistry Letters 7(12): 1077-1081
Li, Z.; Liu, C.; Xu, X.; Qiu, Q.; Su, X.; Dai, Y.; Yang, J.; Li, H.; Shi, W.; Liao, C.; Pan, M.; Huang, W.; Qian, H. 2017: Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. European Journal of Medicinal Chemistry 138: 458-479
Liu, J.; Wu, Q.; Li, L.; Xi, X.; Wu, D.; Zhou, M.; Chen, T.; Shaw, C.; Wang, L. 2017: Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs. Molecules 22(9)