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Section 60

EurekaMag Full Text Articles Chapter 59,616



References:

Pennings, G. 2017: Disclosure of donor conception, age of disclosure and the well-being of donor offspring. Human Reproduction 32(5): 969-973
Nielsen, L.Moeldrup.; Maribo, T.; Kirkegaard, H.; Petersen, K.Schultz.; Lisby, M.; Oestergaard, L.Gregersen. 2018: Effectiveness of the "Elderly Activity Performance Intervention" on elderly patients' discharge from a short-stay unit at the emergency department: a quasi-experimental trial. Clinical Interventions in Aging 13: 737-747
Anonymous 2004: Disclosure of errors preferred by patients. Journal of Family Practice 53(7): 525-526
Luce, E.A.; Jackman, C.A. 2017: Disclosure of Financial Conflicts of Interest in Plastic and Reconstructive Surgery. Plastic and Reconstructive Surgery 140(3): 635-639
Lucassen, A.; Gilbar, R. 2018: Disclosure of genetic information to relatives: balancing confidentiality and relatives' interests. Journal of Medical Genetics 55(4): 285-286
Akilimali, P.Zalagile.; Musumari, P.Masika.; Kashala-Abotnes, Eérance.; Kayembe, P.Kalambayi.; Lepira, Fçois.B.; Mutombo, P.Beya.; Tylleskar, T.; Ali, M.Mala. 2017: Disclosure of HIV status and its impact on the loss in the follow-up of HIV-infected patients on potent anti-retroviral therapy programs in a (post-) conflict setting: A retrospective cohort study from Goma, Democratic Republic of Congo. Plos one 12(2): E0171407
Ekstrand, M.L.; Heylen, E.; Mehta, K.; Sanjeeva, G.N.; Shet, A. 2018: Disclosure of HIV Status to Infected Children in South India: Perspectives of Caregivers. Journal of Tropical Pediatrics 64(4): 342-347
Malanca, A.; Foradori, I.; Stankievich, E.; Pandullo, H.; Losso, M. 2017: Disclosure of human immunodeficiency virus diagnosis in children and adolescents affected by it and their caregivers. Archivos Argentinos de Pediatria 115(2): 195-199
Qian, J.; Hansen, R.A.; Surry, D.; Howard, J.; Kiptanui, Z.; Harris, I. 2017: Disclosure of industry payments to prescribers: industry payments might be a factor impacting generic drug prescribing. Pharmacoepidemiology and Drug Safety 26(7): 819-826
Gooderham, P. 2005: Disclosure of medical error. Journal of the Royal Society of Medicine 98(9): 437; Author Reply 437
Crossley, K. 2004: A negative result on the Ottawa knee rules excludes fracture in patients with acute knee injury. Australian Journal of PhysioTherapy 50(2): 116
Anonymous 2017: Disclosure of Medical Errors. Annals of Emergency Medicine 70(1): 121-122
Anonymous 2006: Disclosure of medical errors involving gametes and embryos. Fertility and Sterility 86(3): 513-515
Reavley, N.J.; Morgan, A.J.; Jorm, A.F. 2018: Disclosure of mental health problems: findings from an Australian national survey. Epidemiology and Psychiatric Sciences 27(4): 346-356
Crosby, R.A.; Mena, L.; Arnold, T. 2017: Disclosure of newly diagnosed HIV infection and condom use at first sex after diagnosis: a study of young Black men who have sex with men. Sexual Health 14(4): 325-330
Casla, K.; Roderick, P.; Pollock, A.M. 2017: Disclosure of patients' data to the UK Home Office must stop. Bmj 358: J3613
Sparks, J.A.; Iversen, M.D.; Yu, Z.; Triedman, N.A.; Prado, M.G.; Miller Kroouze, R.; Kalia, S.S.; Atkinson, M.L.; Mody, E.A.; Helfgott, S.M.; Todd, D.J.; Dellaripa, P.F.; Bermas, B.L.; Costenbader, K.H.; Deane, K.D.; Lu, B.; Green, R.C.; Karlson, E.W. 2018: Disclosure of Personalized Rheumatoid Arthritis Risk Using Genetics, Biomarkers, and Lifestyle Factors to Motivate Health Behavior Improvements: a Randomized Controlled Trial. Arthritis Care and Research 70(6): 823-833
Tang, W.; Mao, J.; Tang, S.; Liu, C.; Mollan, K.; Cao, B.; Wong, T.; Zhang, Y.; Hudgens, M.; Qin, Y.; Han, L.; Ma, B.; Yang, B.; Ma, W.; Wei, C.; Tucker, J.D.; Hightow-Weidman, L.; Bayus, B.; Terris-Prestholt, F.; Yang, L.; Peeling, R.; Fenton, K.; Huang, S.; Wang, C.; Zheng, H.; Vickerman, P.; Mitchell, K.M.; Cheng, Z.; Best, J.; Tangthanasup, T.May.; Wong, N.Sze.; Tso, L.Sze.; Zhang, W.; Li, H. 2017: Disclosure of sexual orientation to health professionals in China: results from an online cross-sectional study. Journal of the International Aids Society 20(1): 21416
Johny, A.Kelak.; Cheah, W.Lian.; Razitasham, S. 2017: Disclosure of Traditional and Complementary Medicine Use and Its Associated Factors to Medical Doctor in Primary Care Clinics in Kuching Division, Sarawak, Malaysia. Evidence-BasedComplementaryandAlternativeMedicine:Ecam 2017: 5146478
Broekema, K.; Weber, K.M. 2017: Disclosures of Cystic Fibrosis-Related Information to Romantic Partners. Qualitative Health Research 27(10): 1575-1585
Pollitt, A.M.; Muraco, J.A.; Grossman, A.H.; Russell, S.T. 2017: Disclosure Stress, Social Support, and Depressive Symptoms Among Cisgender Bisexual Youth. Journal of Marriage and the Family 79(5): 1278-1294
Thumati, P.; Kerstein, R.B.; Thumati, R.P. 2017: Disclusion time reduction therapy in treating occluso-muscular pains. Journal of Indian Prosthodontic Society 17(1): 95-98
Nosala, C.; Hagen, K.D.; Dawson, S.C. 2018: 'Disc-o-Fever': Getting down with Giardia's Groovy Microtubule Organelle. Trends in Cell Biology 28(2): 99-112
Rozen, D. 2001: Discogenic low back pain. Pain Practice: the Official Journal of World Institute of Pain 1(3): 278-286; Quiz: 287-288
Vagner, E.A.; Denisov, A.S.; Krivoshchekov, V.D.; Ladeĭshchikov, V.M.; Matveev, A.T. 1994: Discogenic lumbosacral radiculitis. Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 1: 29-30
Dhillon, R.S.; Smith, P.D. 2018: Diskogenic Reactivation of Herpes Zoster. World Neurosurgery 109: 138-139
Fairbank, J.C.; Deans, W. 1990: Discography. Spine 15(8): 839-840
Takano, M.; Hikata, T.; Nishimura, S.; Kamata, M. 2017: Discography aids definitive diagnosis of posterior epidural migration of lumbar disc fragments: case report and literature review. Bmc Musculoskeletal Disorders 18(1): 151
Guarino 1999: Discography: a Review. Current Review of Pain 3(6): 473-480
Thomson, S.A. 1946: Discoid Cartilage of the Knee. Canadian Medical Association Journal 54(6): 596-598
Kikuta, K.; Kubota, D.; Yoshida, A.; Qiao, Z.; Morioka, H.; Nakamura, M.; Matsumoto, M.; Chuman, H.; Kawai, A.; Kondo, T. 2017: Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) is a novel biomarker of myxofibrosarcoma invasion identified by global protein expression profiling. Biochimica et Biophysica Acta. Proteins and Proteomics 1865(9): 1160-1166
Xie, X.; Rui, W.; He, W.; Shao, Y.; Sun, F.; Zhou, W.; Wu, Y.; Zhu, Y. 2017: Discoidin domain receptor 1 activity drives an aggressive phenotype in bladder cancer. American Journal of Translational Research 9(5): 2500-2507
Hur, H.; Ham, I.-H.; Lee, D.; Jin, H.; Aguilera, K.Y.; Oh, H.J.; Han, S.-U.; Kwon, J.E.; Kim, Y.-B.; Ding, K.; Brekken, R.A. 2017: Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma. Bmc Cancer 17(1): 87
Coelho, N.M.; Arora, P.D.; van Putten, S.; Boo, S.; Petrovic, P.; Lin, A.X.; Hinz, B.; McCulloch, C.A. 2017: Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction. Cell Reports 18(7): 1774-1790
Majkowska, I.; Shitomi, Y.; Ito, N.; Gray, N.S.; Itoh, Y. 2017: Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. Journal of Biological Chemistry 292(16): 6633-6643
Hebron, M.; Peyton, M.; Liu, X.; Gao, X.; Wang, R.; Lonskaya, I.; Moussa, C.E.-H. 2017: Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models. Journal of Neuroimmunology 311: 1-9
Sohn, D.-W.; Bin, S.-I.; Kim, J.-M.; Lee, B.-S.; Kim, S.-J. 2018: Discoid lateral meniscus can be overlooked by magnetic resonance imaging in patients with meniscal tears. Knee Surgery Sports Traumatology Arthroscopy: Official Journal of the Esska 26(8): 2317-2323
Kocher, M.S.; Logan, C.A.; Kramer, D.E. 2017: Discoid Lateral Meniscus in Children: Diagnosis, Management, and Outcomes. Journal of the American Academy of Orthopaedic Surgeons 25(11): 736-743
Two, A.; So, J.Kim.; Paravar, T. 2017: Discoid Lupus and Human Immunodeficiency Virus: A Retrospective Chart Review to Determine the Prevalence and Progression of Co-occurrence of these Conditions at a Single Academic Center. Indian Journal of Dermatology 62(2): 226
Sehgal, V.N.; Bharija, S.C. 1981: Discoid Lupus Erythematosus and Adenocarcinoma Palate. Indian Journal of Dermatology Venereology and Leprology 47(2): 123-124
Takada, H.; Kimura, N.; Yoshihashi-Nakazato, Y.; Kawahata, K.; Kohsaka, H. 2017: Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome. Internal Medicine 56(12): 1581-1583
Pavithran, K. 1983: Discoid Lupus Erythematosus in Red Tattoo. Indian Journal of Dermatology Venereology and Leprology 49(2): 82-84
Donzis, P.B.; Insler, M.S.; Buntin, D.M.; Gately, L.E. 1984: Discoid lupus erythematosus involving the eyelids. American Journal of Ophthalmology 98(1): 32-36
Hirbod, T.; Altamura, D.; Arkoumani, E.; Stefanato, C.M.; Verdolini, R. 2017: Discoid lupus erythematosus occurring in an area previously affected by herpes zoster virus: Wolf's isotopic reaction?. European Journal of Dermatology: Ejd 27(2): 186-187
Pavithran, K. 1988: Discoid Lupus Erythematosus on a Pre-exi Patch of Chronic Radiodermatitis. Indian Journal of Dermatology Venereology and Leprology 54(5): 266-267
Darjani, A.; Rafiei, R.; Mesbah, A.; Golmohammadi, R.; Rafiee, B.; Movaseghi, M. 2017: Discoid Lupus Erythematosus Presenting as Upper Eyelid Edema and Erythema. Acta Medica Iranica 55(7): 474-476
Das, K.B.; Mishra, S.; Haque, S.M. 1982: Discoid Lupus Erythematosus Resembling Lupus Vulgaris. Indian Journal of Dermatology Venereology and Leprology 48(5): 274-275
Senderey, E.; Patel, S. 2017: Discoid lupus erythematosus: when a superficial injury is a red herring of underlying disease. BMJ Case Reports
Resnick, D.; Goergen, T.G.; Kaye, J.J.; Ghelman, B.; Woody, P.R. 1976: Discoid medial meniscus. Radiology 121(3 Pt. 1): 575-576
Song, I.Soo.; Kim, J.Bum.; Lee, J.Keun.; Park, B-Seop. 2017: Discoid Medial Meniscus Tear, with a Literature Review of Treatments. Knee Surgery and Related Research 29(3): 237-242
Stuparich, M.A.; Lee, T.T.M. 2018: Discoid Resection of Rectosigmoid Endometriotic Nodules. Journal of Minimally Invasive Gynecology 25(3): 388
Liao, C.-H.; Chen, C.-N. 2017: Discoid Skin Rash in a Preterm Infant. Journal of Pediatrics 183: 199
Nitta, Y.; Sugie, A. 2017: DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body. Biochemical and Biophysical Research Communications 487(1): 116-121
Nakhaei, S.; Agahi, R.H.; Aminian, A.; Rezaeizadeh, M. 2017: Discoloration and force degradation of orthodontic elastomeric ligatures. Dental Press Journal of Orthodontics 22(2): 45-54
Baglar, S.; Keskin, E.; Orun, T.; Es, A. 2017: Discoloration Effects of Traditional Turkish Beverages on different Composite Restoratives. Journal of Contemporary Dental Practice 18(2): 83-93
Ceci, M.; Viola, M.; Rattalino, D.; Beltrami, R.; Colombo, M.; Poggio, C. 2017: Discoloration of different esthetic restorative materials: a spectrophotometric evaluation. European Journal of Dentistry 11(2): 149-156
Wheeler, M.C. 1947: Discoloration of the Eyelids from Prolonged use of Ointments Containing Mercury. Transactions of the American Ophthalmological Society 45: 74-80
Link, J. 1973: Discoloration of the teeth in alkaptonuria (ochronosis) and Parkinsonism. Chronicle 36(5): 130
Lauvahutanon, S.; Shiozawa, M.; Takahashi, H.; Iwasaki, N.; Oki, M.; Finger, W.J.; Arksornnukit, M. 2017: Discoloration of various CAD/CAM blocks after immersion in coffee. Restorative Dentistry and Endodontics 42(1): 9-18
Greval, S.D.S.; Bhattacharji, J.N.; Das, B.C. 1944: Discoloured Cholesterol and Wassermann Antigen: Decreased Fortifying Effect Restored by Recrystallization and Washing in Alcohol. Indian Medical Gazette 79(8): 356-357
Hayes, C.; Arkoumani, E.; Pandya, D.; Verdolini, R. 2017: Discoloured saggy skin in a 57-year-old woman. Clinical and Experimental Dermatology 42(4): 444-447
White, D.W.; Julien, K.C.; Jacob, H.; Campbell, P.M.; Buschang, P.H. 2017: Discomfort associated with Invisalign and traditional brackets: a randomized, prospective trial. Angle Orthodontist 87(6): 801-808
Minami, D.; Takigawa, N.; Kano, H.; Ninomiya, T.; Kubo, T.; Ichihara, E.; Ohashi, K.; Sato, A.; Hotta, K.; Tabata, M.; Tanimoto, M.; Kiura, K. 2017: Discomfort during bronchoscopy performed after endobronchial intubation with fentanyl and midazolam: a prospective study. Japanese Journal of Clinical Oncology 47(5): 434-437
Čirgić, E.; Kjellberg, H.; Hansen, K. 2017: Discomfort, expectations, and experiences during treatment of large overjet with Andresen Activator or Prefabricated Functional Appliance: a questionnaire survey. Acta Odontologica Scandinavica 75(3): 166-172
Stanner, J.; Klum, M.; Parvini, P.; Zuhr, O.; Nickles, K.; Eickholz, P. 2017: Discomfort/pain due to periodontal and peri-implant probing: Implant type and age. Journal of Clinical Periodontology 44(7): 749-755
Da Silva Paiva, T.; Küppers, G.C.; Lahr, D.J.é G.; Schweikert, M.; da Silva-Neto, I.ác.D. 2017: Discomorphella pedroeneasi sp. nov. (Ciliophora, Odontostomatida): An anaerobic ciliate hosting multiple cytoplasmic and macronuclear endocytobionts. European Journal of Protistology 58: 103-134
Wolffenbuttel, E. 1957: Disconnect. Revista Brasileira de Medicina 14(9): 661-662
Veazey, K.J.; Wang, H.; Bedi, Y.S.; Skiles, W.M.; Chang, R.C.-A.; Golding, M.C. 2017: Disconnect between alcohol-induced alterations in chromatin structure and gene transcription in a mouse embryonic stem cell model of exposure. Alcohol 60: 121-133
Quesenberry, P.J.; Stewart, F.M. 1995: Disconnected. Experimental Hematology 23(13): 1329-1330
Levine, K.A.; Proulx, J.; Schwartz, K. 2018: Disconnected lives: Women with intellectual disabilities in conflict with the law. Journal of Applied Research in Intellectual Disabilities: Jarid 31(2): 249-258
Sussman, D.M.; Schoenholz, S.S.; Cubuk, E.D.; Liu, A.J. 2017: Disconnecting structure and dynamics in glassy thin films. Proceedings of the National Academy of Sciences of the United States of America 114(40): 10601-10605
Batista, S.; Alves, C.; d'Almeida, O.íl.C.; Afonso, A.; Félix-Morais, R.; Pereira, J.ão.; Macário, C.; Sousa, L.ív.; Castelo-Branco, M.; Santana, I.; Cunha, L.ís. 2017: Disconnection as a mechanism for social cognition impairment in multiple sclerosis. Neurology 89(1): 38-45
Mennella, R.; Leung, R.C.; Taylor, M.J.; Dunkley, B.T. 2017: Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces. Molecular Autism 8: 7
Alexander-Bloch, A.F. 2017: Disconnectionism in Biological Psychiatry. Biological Psychiatry 82(10): E75-E77
Nasser, H.M.; Lafferty, D.S.; Lesser, E.N.; Bacharach, S.Z.; Calu, D.J. 2018: Disconnection of basolateral amygdala and insular cortex disrupts conditioned approach in Pavlovian lever autoshaping. Neurobiology of Learning and Memory 147: 35-45
Stoub, T.R.; Chicharro, A.V.; Grote, C.L.; Kanner, A.M. 2019: Disconnection of hippocampal networks contributes to memory dysfunction in individuals with temporal lobe epilepsy. Hippocampus 29(5): 451-457
Heimer-McGinn, V.R.; Poeta, D.L.; Aghi, K.; Udawatta, M.; Burwell, R.D. 2017: Disconnection of the Perirhinal and Postrhinal Cortices Impairs Recognition of Objects in Context but not Contextual Fear Conditioning. Journal of Neuroscience: the Official Journal of the Society for Neuroscience 37(18): 4819-4829
Yuan, J.-L.; Wang, S.-K.; Guo, X.-J.; Teng, L.-L.; Jiang, H.; Gu, H.; Hu, W.-L. 2017: Disconnections of Cortico-Subcortical Pathways Related to Cognitive Impairment in Patients with Leukoaraiosis: a Preliminary Diffusion Tensor Imaging Study. European Neurology 78(1-2): 41-47
Danielpour, M.; von Koch, C.S.; Ojemann, S.G.; Peacock, W.J. 2001: Disconnective hemispherectomy. Pediatric Neurosurgery 35(4): 169-172
Ikuta, T.; Matsuo, K.; Harada, K.; Nakashima, M.; Hobara, T.; Higuchi, N.; Higuchi, F.; Otsuki, K.; Shibata, T.; Watanuki, T.; Matsubara, T.; Yamagata, H.; Watanabe, Y. 2017: Disconnectivity between Dorsal Raphe Nucleus and Posterior Cingulate Cortex in Later Life Depression. Frontiers in Aging Neuroscience 9: 236
Roddick, A.J.; Chan, F.T.S.; Stefaniak, J.D.; Zheng, S.L. 2017: Discontinuation and non-publication of clinical trials in cardiovascular medicine. International Journal of Cardiology 244: 309-315
Stefaniak, J.D.; Lam, T.C.H.; Sim, N.E.; Al-Shahi Salman, R.; Breen, D.P. 2017: Discontinuation and non-publication of neurodegenerative disease trials: a cross-sectional analysis. European Journal of Neurology 24(8): 1071-1076
Amstutz, A.; Schandelmaier, S.; Frei, R.; Surina, J.; Agarwal, A.; Olu, K.Kalu.; Alturki, R.; Von Niederhäusern, B.; Von Elm, E.; Briel, M. 2017: Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study. Bmj Open 7(7): E016216
Kane, J.A.; Kim, J.K.; Haidry, S.Abbas.; Salciccioli, L.; Lazar, J. 2017: Discontinuation/Dose Reduction of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers during Acute Decompensated Heart Failure in African-American Patients with Reduced Left-Ventricular Ejection Fraction. Cardiology 137(2): 121-125
Blanco-Silvente, L.íd.; Castells, X.; Saez, M.; Barceló, M.A.òn.; Garre-Olmo, J.; Vilalta-Franch, J.; Capellà, D. 2017: Discontinuation, Efficacy, and Safety of Cholinesterase Inhibitors for Alzheimer's Disease: a Meta-Analysis and Meta-Regression of 43 Randomized Clinical Trials Enrolling 16 106 Patients. International Journal of Neuropsychopharmacology 20(7): 519-528
Gesesew, H.A.; Ward, P.; Hajito, K.W.; Feyissa, G.T.; Mohammadi, L.; Mwanri, L. 2017: Discontinuation from Antiretroviral Therapy: a Continuing Challenge among Adults in HIV Care in Ethiopia: a Systematic Review and Meta-Analysis. Plos one 12(1): E0169651
Wang, J.; Qiao, Y.; Spivey, C.A.; Liu, X.; Phatak, H.; Mardekian, J.; Claflin, A.B.; Kachroo, S.; Abdulsatter, Y.; Parker, R.B. 2014: Discontinuation/Interruption of Warfarin Therapy in Patients with Non-Valvular Atrial Fibrillation. Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research 17(7): A763
Baldwin, K.C.; Ginsberg, P.C.; Harkaway, R.C. 2001: Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin for bladder outlet obstruction. Urologia Internationalis 66(2): 84-88
Lossius, M.I.; Alfstad, K.Å; Aaberg, K.M.; Nakken, K.O. 2017: Discontinuation of antiepileptic drugs in seizure-free patients - when and how?. Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 137(6): 451-454
Uesugi, H. 1990: Discontinuation of antiepileptic drug treatment in controlled seizure patients. Seishin Shinkeigaku Zasshi 92(6): 343-366
Hortwitz, G.J.; Tariot, P.N.; Mead, K.; Cox, C. 1995: Discontinuation of Antipsychotics in Nursing Home Patients with Dementia. American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry 3(4): 290-299
Sim, M. 2004: Discontinuation of benzodiazepines. Cmaj: Canadian Medical Association Journal 170(11): 1645-1646
Wolter, D.K. 2017: Discontinuation of benzodiazepines in old age : when and if so, how?. Zeitschrift für Gerontologie und Geriatrie 50(2): 115-122
Rubbert-Roth, A. 2011: Discontinuation of biologicals in rheumatoid arthritis after acquiring remission? Yes. Deutsche Medizinische Wochenschrift 136(33): 1674
Ben-Horin, S.; Mao, R.; Qiu, Y.; Chen, M. 2018: Discontinuation of Biological Treatments in Inflammatory Bowel Disease: a Concise Pragmatic Review. Journal of Clinical Gastroenterology 52(1): 6-12
Strand, V.; Miller, P.; Williams, S.A.; Saunders, K.; Grant, S.; Kremer, J. 2017: Discontinuation of Biologic Therapy in Rheumatoid Arthritis: Analysis from the Corrona RA Registry. Rheumatology and Therapy 4(2): 489-502
McKinnell, J.A.; Eells, S.J.; Clark, E.; Rand, D.D.; Kiet, G.T.; Macias-Gil, R.; Mendez, J.M.; Huang, S.S.; Milefchik, E.N.; Miller, L.G. 2017: Discontinuation of contact precautions with the introduction of universal daily chlorhexidine bathing. Epidemiology and Infection 145(12): 2575-2581
Park, H.J.; Park, N.C.; Kim, T.N.; Baek, S.R.; Lee, K.M.; Choe, S. 2017: Discontinuation of Dapoxetine Treatment in Patients with Premature Ejaculation: a 2-Year Prospective Observational Study. Sexual Medicine 5(2): E99
Tsourdi, E.; Langdahl, B.; Cohen-Solal, M.; Aubry-Rozier, Bérengere.; Eriksen, E.Fink.; Guañabens, N.; Obermayer-Pietsch, B.; Ralston, S.H.; Eastell, R.; Zillikens, M.Carola. 2017: Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS. Bone 105: 11-17
Fagius, J.; Feresiadou, A.; Larsson, E.-M.; Burman, J. 2017: Discontinuation of disease modifying treatments in middle aged multiple sclerosis patients. first line drugs vs natalizumab. Multiple Sclerosis and Related Disorders 12: 82-87
Ardissino, G.; Testa, S.; Possenti, I.; Tel, F.; Paglialonga, F.; Salardi, S.; Tedeschi, S.; Belingheri, M.; Cugno, M. 2014: Discontinuation of eculizumab maintenance treatment for atypical hemolytic uremic syndrome: a report of 10 cases. American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation 64(4): 633-637
Rogers, S.C.; Garcia, C.A.; Wu, S. 2017: Discontinuation of Everolimus Due to Related and Unrelated Adverse Events in Cancer Patients: A Meta-Analysis. Cancer Investigation 35(8): 552-561
Fujigaki, Y.; Morimoto, C.; Iino, R.; Taniguchi, K.; Kawamorita, Y.; Asakawa, S.; Toyoki, D.; Miyano, S.; Fujii, W.; Ota, T.; Shibata, S.; Uchida, S. 2017: Discontinuation of Hemodialysis in a Patient with Anti-GBM Disease by the Treatment with Corticosteroids and Plasmapheresis despite Several Predictors for Dialysis-Dependence. Case Reports in Nephrology 2017: 7143649
Karakaya, F.; Özer, S.; Kalkan, Ça.ğd.ş; Tüzün, E.A.; Çalışkan, A.; Keskin, O.; Kabaçam, G.ök.; Karatayli, S.; Karatayli, E.; Bozdayi, A.M.; Idilman, R.; Yurdaydin, C. 2017: Discontinuation of lamivudine treatment in HBeAg-negative chronic hepatitis B: a pilot study with long-term follow-up. Antiviral Therapy 22(7): 559-570
Kang, P.; Swarbrick, H. 2017: Discontinuation of long term orthokeratology lens wear and subsequent refractive surgery outcome. Contact Lens and Anterior Eye: the Journal of the British Contact Lens Association 40(6): 436-439
Baker, H. 2017: Discontinuation of melanoma combination immunotherapy. LANCET. Oncology 18(10): E565
Dinkova, A.S.; Atanasov, D.T.; Vladimirova-Kitova, L.G. 2017: Discontinuation of Oral Antiplatelet Agents before Dental Extraction - Necessity or Myth?. Folia Medica 59(3): 336-343
Cho, P.; Cheung, S.W. 2017: Discontinuation of orthokeratology on eyeball elongation (DOEE). Contact Lens and Anterior Eye: the Journal of the British Contact Lens Association 40(2): 82-87
Ferrero, F. 2017: Discontinuation of pediatric trials. Archivos Argentinos de Pediatria 115(4): 308-309
Alonso Valente, R.; García Rodríguez, G.Elena.; García Marcote, Y.; Fidalgo Díaz, M.; Becerra Mosquera, V.; Novoa García, D.; Cordal Martínez, T.; Díaz Rodríguez, Cándido. 2017: Discontinuation of Peritoneal Dialysis after Late Initiation of Eculizumab in a Case of Familial Atypical Hemolytic-Uremic Syndrome: A Case Report. Case Reports in Nephrology and Dialysis 7(1): 18-25
Riera, M.; Castells, X.; Tobias, A.; Cunill, R.; Blanco, L.; Capellà, D. 2017: Discontinuation of pharmacological treatment of children and adolescents with attention deficit hyperactivity disorder: meta-analysis of 63 studies enrolling 11,788 patients. Psychopharmacology 234(17): 2657-2671
Geijteman, E.C.T.; Tempelman, M.M.A.; Dees, M.K.; Huisman, B.A.A.; Perez, R.S.G.M.; van Zuylen, L.; van der Heide, A. 2017: Discontinuation of potentially inappropriate medications at the end of life: perspectives from patients, their relatives, and physicians. Nederlands Tijdschrift Voor Geneeskunde 160: D1084
Narayan, S.W.; Nishtala, P.S. 2017: Discontinuation of Preventive Medicines in Older People with Limited Life Expectancy: A Systematic Review. Drugs and Aging 34(10): 767-776
Hu, H.; Xiang, C.; Qiu, C.; Chen, Z.; Huang, S.; Liang, L.; Wang, X. 2017: Discontinuation of Scheduled Infliximab in Crohn's Patients With Clinical Remission: A Retrospective Single-Center Study. Gastroenterology Research 10(2): 92-99
Zhang, H.; Plutzky, J.; Skentzos, S.; Morrison, F.; Mar, P.; Shubina, M.; Turchin, A. 2013: Discontinuation of statins in routine care settings: a cohort study. Annals of Internal Medicine 158(7): 526-534
Elijovich, F.; Laffer, C.L. 2017: Discontinuation of Therapy in Hypertension Research: Value, Ethics, Risk, and Role in Renal Denervation Trials. Hypertension 69(5): 795-797
Kubo, S.; Yamaoka, K.; Amano, K.; Nagano, S.; Tohma, S.; Suematsu, E.; Nagasawa, H.; Iwata, K.; Tanaka, Y. 2017: Discontinuation of tofacitinib after achieving low disease activity in patients with rheumatoid arthritis: a multicentre, observational study. Rheumatology 56(8): 1293-1301
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Bouckaert, C.; Zhu, S.; Govers-Riemslag, Jé.W.P.; Depoorter, M.; Diamond, S.L.; Pochet, L. 2017: Discovery and assessment of water soluble coumarins as inhibitors of the coagulation contact pathway. Thrombosis Research 157: 126-133
Awad, F.Nureldin.; Laborda, P.; Wang, M.; Lu, A.Min.; Li, Q.; Cai, Z.Peng.; Liu, L.; Voglmeir, J. 2017: Discovery and biochemical characterization of a mannose phosphorylase catalyzing the synthesis of novel β-1,3-mannosides. Biochimica et Biophysica Acta. General Subjects 1861(12): 3231-3237
Li, Q.; Huang, Y-Ying.; Conway, L.Patrick.; He, M.; Wei, S.; Huang, K.; Duan, X-Chu.; Flitsch, S.L.; Voglmeir, J. 2017: Discovery and Biochemical Characterization of a Thermostable Glucose-1-phosphate Nucleotidyltransferase from Thermodesulfatator indicus. Protein and Peptide Letters 24(8): 729-734
Wei, S.; Zhang, X-Yang.; Sun, Y.; Conway, L.Patrick.; Liu, L. 2017: Discovery and Biochemical Characterization of UDP-Glucose Dehydrogenase from Akkermansia muciniphila. Protein and Peptide Letters 24(8): 735-741
Zhang, Y.; Liu, H.; Zhang, Z.; Wang, R.; Liu, T.; Wang, C.; Ma, Y.; Ai, J.; Zhao, D.; Shen, J.; Xiong, B. 2017: Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors. Molecules 22(4)
Zhang, T-Jian.; Li, S-Ye.; Yuan, W-Yan.; Wu, Q-Xia.; Wang, L.; Yang, S.; Sun, Q.; Meng, F-Hao. 2017: Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors. Bioorganic and Medicinal Chemistry Letters 27(4): 729-732
La Frano, M.R.; Cai, Y.; Burri, B.J.; Thilsted, S.H. 2018: Discovery and biological relevance of 3,4-didehydroretinol (vitamin A 2 ) in small indigenous fish species and its potential as a dietary source for addressing vitamin A deficiency. International Journal of Food Sciences and Nutrition 69(3): 253-261
Liu, M.; Chang, D.; Li, Y. 2017: Discovery and Biosensing Applications of Diverse RNA-Cleaving DNAzymes. Accounts of Chemical Research 50(9): 2273-2283
Song, L.; Jenner, M.; Masschelein, J.; Jones, C.; Bull, M.J.; Harris, S.R.; Hartkoorn, R.C.; Vocat, A.; Romero-Canelon, I.; Coupland, P.; Webster, G.; Dunn, M.; Weiser, R.; Paisey, C.; Cole, S.T.; Parkhill, J.; Mahenthiralingam, E.; Challis, G.L. 2017: Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis. Journal of the American Chemical Society 139(23): 7974-7981
O'Brien, C.A.; McLean, B.J.; Colmant, A.M.G.; Harrison, J.J.; Hall-Mendelin, S.; van den Hurk, A.F.; Johansen, C.A.; Watterson, D.; Bielefeldt-Ohmann, H.; Newton, N.D.; Schulz, B.L.; Hall, R.A.; Hobson-Peters, J. 2017: Discovery and Characterisation of Castlerea Virus, a New Species of Negevirus Isolated in Australia. Evolutionary Bioinformatics Online 13: 1176934317691269
Umina, P.A.; Lord, A.; Micic, S.; Edwards, O. 2017: Discovery and characterisation of field resistance to organophosphorus chemicals in a major mite pest, Halotydeus destructor. Pest Management Science 73(8): 1719-1724
Koh-Stenta, X.; Poulsen, A.; Li, R.; Wee, J.Liang.Kuan.; Kwek, P.Zekui.; Chew, S.Yin.; Peng, J.; Wu, L.; Guccione, E.; Joy, J.; Hill, J. 2017: Discovery and characterisation of the automethylation properties of PRDM9. Biochemical Journal 474(6): 971-982
Wieting, J.M.; Vadukoot, A.K.; Sharma, S.; Abney, K.K.; Bridges, T.M.; Daniels, J.Scott.; Morrison, R.D.; Wickman, K.; Weaver, C.David.; Hopkins, C.R. 2017: Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators. Acs Chemical Neuroscience 8(9): 1873-1879
Iwatani-Yoshihara, M.; Ito, M.; Ishibashi, Y.; Oki, H.; Tanaka, T.; Morishita, D.; Ito, T.; Kimura, H.; Imaeda, Y.; Aparicio, S.; Nakanishi, A.; Kawamoto, T. 2017: Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. Acs Chemical Biology 12(7): 1760-1768
Stepan, A.F.; Claffey, M.M.; Reese, M.R.; Balan, G.; Barreiro, G.; Barricklow, J.; Bohanon, M.J.; Boscoe, B.P.; Cappon, G.D.; Chenard, L.K.; Cianfrogna, J.; Chen, L.; Coffman, K.J.; Drozda, S.E.; Dunetz, J.R.; Ghosh, S.; Hou, X.; Houle, C.; Karki, K.; Lazzaro, J.T.; Mancuso, J.Y.; Marcek, J.M.; Miller, E.L.; Moen, M.A.; O'Neil, S.; Sakurada, I.; Skaddan, M.; Parikh, V.; Smith, D.L.; Trapa, P.; Tuttle, J.B.; Verhoest, P.R.; Walker, D.P.; Won, A.; Wright, A.S.; Whritenour, J.; Zasadny, K.; Zaleska, M.M.; Zhang, L.; Shaffer, C.L. 2017: Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. Journal of Medicinal Chemistry 60(18): 7764-7780
Zheng, B.; Lv, T.; Xu, H.; Yu, X.; Chen, Y.; Li, J.; Huang, C.; Guo, L.; Zhang, J.; Jiang, X.; Xiao, Y.; Li, L. 2018: Discovery and characterisation of an escherichia coli ST206 strain producing NDM-5 and MCR-1 from a patient with acute diarrhoea in China. International Journal of Antimicrobial Agents 51(2): 273-275
Yang, Y-Long.; Zhang, S.; Ma, K.; Xu, Y.; Tao, Q.; Chen, Y.; Chen, J.; Guo, S.; Ren, J.; Wang, W.; Tao, Y.; Yin, W-Bing.; Liu, H. 2017: Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi. Angewandte Chemie 56(17): 4749-4752
Nguyen, Q-Thai.; Trinco, G.; Binda, C.; Mattevi, A.; Fraaije, M.W. 2017: Discovery and characterization of an F 420 -dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1. Applied Microbiology and Biotechnology 101(7): 2831-2842
Wensel, D.; Sun, Y.; Li, Z.; Zhang, S.; Picarillo, C.; McDonagh, T.; Fabrizio, D.; Cockett, M.; Krystal, M.; Davis, J. 2017: Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity. Antimicrobial Agents and ChemoTherapy 61(8)
Vicari, A.P.; Schoepfer, A.M.; Meresse, B.; Goffin, L.; Léger, O.; Josserand, S.; Guégan, N.; Yousefi, S.; Straumann, A.; Cerf-Bensussan, N.; Simon, H-Uwe.; Chvatchko, Y. 2017: Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis. Mabs 9(6): 927-944
Hu, C.; Wang, A.; Wu, H.; Qi, Z.; Li, X.; Yan, X-E.; Chen, C.; Yu, K.; Zou, F.; Wang, W.; Wang, W.; Wu, J.; Liu, J.; Wang, B.; Wang, L.; Ren, T.; Zhang, S.; Yun, C-Hong.; Liu, J.; Liu, Q. 2017: Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode. Oncotarget 8(11): 18359-18372
Shi, H.; Cui, Y.; Qin, Y. 2018: Discovery and characterization of a novel tryptophan hydroxylase 1 inhibitor as a prodrug. Chemical Biology and Drug Design 91(1): 202-212
Corson, A.E.; Armstrong, S.A.; Wright, M.E.; McClelland, E.E.; Bicker, K.L. 2016: Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. Acs Medicinal Chemistry Letters 7(12): 1139-1144
Hao, D.; Xiao, W.; Liu, R.; Kumar, P.; Li, Y.; Zhou, P.; Guo, F.; Farmer, D.L.; Lam, K.S.; Wang, F.; Wang, A. 2017: Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. Acs Chemical Biology 12(4): 1075-1086
Partridge, K.M.; Antonysamy, S.; Bhattachar, S.N.; Chandrasekhar, S.; Fisher, M.J.; Fretland, A.; Gooding, K.; Harvey, A.; Hughes, N.E.; Kuklish, S.L.; Luz, J.G.; Manninen, P.R.; McGee, J.E.; Mudra, D.R.; Navarro, A.; Norman, B.H.; Quimby, S.J.; Schiffler, M.A.; Sloan, A.V.; Warshawsky, A.M.; Weller, J.M.; York, J.S.; Yu, X-Peng. 2017: Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1. Bioorganic and Medicinal Chemistry Letters 27(6): 1478-1483
Hoffmann, A.; Richter, M.; von Grafenstein, S.; Walther, E.; Xu, Z.; Schumann, L.; Grienke, U.; Mair, C.E.; Kramer, C.; Rollinger, J.M.; Liedl, K.R.; Schmidtke, M.; Kirchmair, J. 2017: Discovery and Characterization of Diazenylaryl Sulfonic Acids as Inhibitors of Viral and Bacterial Neuraminidases. Frontiers in Microbiology 8: 205
Echterbille, J.; Gilles, N.; Araóz, R.; Mourier, G.; Amar, M.; Servent, D.; De Pauw, E.; Quinton, L. 2017: Discovery and characterization of EII B, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon: Official Journal of the International Society on Toxinology 130: 1-10
Jones, D.R.; Uddin, M.Salah.; Gruninger, R.J.; Pham, T.Thanh.My.; Thomas, D.; Boraston, A.B.; Briggs, J.; Pluvinage, B.; McAllister, T.A.; Forster, R.J.; Tsang, A.; Selinger, L.Brent.; Abbott, D.Wade. 2017: Discovery and characterization of family 39 glycoside hydrolases from rumen anaerobic fungi with polyspecific activity on rare arabinosyl substrates. Journal of Biological Chemistry 292(30): 12606-12620
Xu, C-Feng.; Chen, Y.; Yi, L.; Brantley, T.; Stanley, B.; Sosic, Z.; Zang, L. 2017: Discovery and Characterization of Histidine Oxidation Initiated Cross-links in an IgG1 Monoclonal Antibody. Analytical Chemistry 89(15): 7915-7923
Richardson, L.S.; Vargas, G.; Brown, T.; Ochoa, L.; Sheller-Miller, S.; Saade, G.R.; Taylor, R.N.; Menon, R. 2017: Discovery and Characterization of Human Amniochorionic Membrane Microfractures. American Journal of Pathology 187(12): 2821-2830
Guimarães, R.A.; Telles, M.P.C.; Antunes, A.M.; Corrêa, K.M.; Ribeiro, C.V.G.; Coelho, A.S.G.; Soares, T.N. 2017: Discovery and characterization of new microsatellite loci in Dipteryx alata Vogel (Fabaceae) using next-generation sequencing data. Genetics and Molecular Research: Gmr 16(2)
Horley, N.J.; Beresford, K.J.M.; Chawla, T.; McCann, G.J.P.; Ruparelia, K.C.; Gatchie, L.; Sonawane, V.R.; Williams, I.S.; Tan, H.L.; Joshi, P.; Bharate, S.S.; Kumar, V.; Bharate, S.B.; Chaudhuri, B. 2017: Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. European Journal of Medicinal Chemistry 129: 159-174
Sreenivasachary, N.; Kroth, H.; Benderitter, P.; Hamel, A.; Varisco, Y.; Hickman, D.T.; Froestl, W.; Pfeifer, A.; Muhs, A. 2017: Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters 27(6): 1405-1411
Wilsbacher, J.L.; Cheng, M.; Cheng, D.; Trammell, S.A.J.; Shi, Y.; Guo, J.; Koeniger, S.L.; Kovar, P.J.; He, Y.; Selvaraju, S.; Heyman, H.Robin.; Sorensen, B.K.; Clark, R.F.; Hansen, T.Matthew.; Longenecker, K.L.; Raich, D.; Korepanova, A.V.; Cepa, S.; Towne, D.L.; Abraham, V.C.; Tang, H.; Richardson, P.L.; McLoughlin, S.M.; Badagnani, I.; Curtin, M.L.; Michaelides, M.R.; Maag, D.; Buchanan, F.Gregory.; Chiang, G.G.; Gao, W.; Rosenberg, S.H.; Brenner, C.; Tse, C. 2017: Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Molecular Cancer Therapeutics 16(7): 1236-1245
Saribas, A.Sami.; DeVoto, J.; Golla, A.; Wollebo, H.S.; White, M.K.; Safak, M. 2018: Discovery and characterization of novel trans-spliced products of human polyoma JC virus late transcripts from PML patients. Journal of Cellular Physiology 233(5): 4137-4155
Schnekenburger, M.; Goffin, E.; Lee, J-Young.; Jang, J.Young.; Mazumder, A.; Ji, S.; Rogister, B.; Bouider, N.; Lefranc, F.; Miklos, W.; Mathieu, Véronique.; de Tullio, P.; Kim, K-Won.; Dicato, M.; Berger, W.; Han, B.Woo.; Kiss, R.; Pirotte, B.; Diederich, M. 2017: Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. Journal of Medicinal Chemistry 60(11): 4714-4733
Adachi, R.; Ogawa, K.; Matsumoto, S-Ichi.; Satou, T.; Tanaka, Y.; Sakamoto, J.; Nakahata, T.; Okamoto, R.; Kamaura, M.; Kawamoto, T. 2017: Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. European Journal of Medicinal Chemistry 136: 283-293
Baetscher, D.S.; Hasselman, D.J.; Reid, K.; Palkovacs, E.P.; Garza, J.Carlos. 2017: Discovery and characterization of single nucleotide polymorphisms in two anadromous alosine fishes of conservation concern. Ecology and Evolution 7(17): 6638-6648
Arnst, J.L.; Hein, A.L.; Taylor, M.A.; Palermo, N.Y.; Contreras, J.I.; Sonawane, Y.A.; Wahl, A.O.; Ouellette, M.M.; Natarajan, A.; Yan, Y. 2017: Discovery and characterization of small molecule Rac1 inhibitors. Oncotarget 8(21): 34586-34600
Butler, M.S.; Roshan-Moniri, M.; Hsing, M.; Lau, D.; Kim, A.; Yen, P.; Mroczek, M.; Nouri, M.; Lien, S.; Axerio-Cilies, P.; Dalal, K.; Yau, C.; Ghaidi, F.; Guo, Y.; Yamazaki, T.; Lawn, S.; Gleave, M.E.; Gregory-Evans, C.Y.; McIntosh, L.P.; Cox, M.E.; Rennie, P.S.; Cherkasov, A. 2017: Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. Oncotarget 8(26): 42438-42454
Guan, X.; Okazaki, Y.; Lithio, A.; Li, L.; Zhao, X.; Jin, H.; Nettleton, D.; Saito, K.; Nikolau, B.J. 2017: Discovery and Characterization of the 3-Hydroxyacyl-ACP Dehydratase Component of the Plant Mitochondrial Fatty Acid Synthase System. Plant Physiology 173(4): 2010-2028
Yu, G.; Champouret, N.; Steuernagel, B.; Olivera, P.D.; Simmons, J.; Williams, C.; Johnson, R.; Moscou, M.J.; Hernández-Pinzón, I.; Green, P.; Sela, H.; Millet, E.; Jones, J.D.G.; Ward, E.R.; Steffenson, B.J.; Wulff, B.B.H. 2017: Discovery and characterization of two new stem rust resistance genes in Aegilops sharonensis. Tag. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik 130(6): 1207-1222
Ruehle, S.; Wager-Miller, J.; Straiker, A.; Farnsworth, J.; Murphy, M.N.; Loch, S.; Monory, K.; Mackie, K.; Lutz, B. 2017: Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse. Journal of Neurochemistry 142(4): 521-533
Yan, W.; Li, F.; Wang, L.; Zhu, Y.; Dong, Z.; Bai, L. 2017: Discovery and characterizaton of a novel lipase with transesterification activity from hot spring metagenomic library. Biotechnology Reports 14: 27-33
Pramono, A.K.; Kuwahara, H.; Itoh, T.; Toyoda, A.; Yamada, A.; Hongoh, Y. 2017: Discovery and Complete Genome Sequence of a Bacteriophage from an Obligate Intracellular Symbiont of a Cellulolytic Protist in the Termite Gut. Microbes and Environments 32(2): 112-117
Anand, S.; Barnes, J.M.; Young, S.A.; Garcia, D.M.; Tolley, H.Dennis.; Kauwe, J.S.K.; Graves, S.W. 2017: Discovery and Confirmation of Diagnostic Serum Lipid Biomarkers for Alzheimer's Disease Using Direct Infusion Mass Spectrometry. Journal of Alzheimer's Disease: Jad 59(1): 277-290
Furuya, T.; Morikawa, S.; Miyazawa, T. 2016: Discovery and current research status of feline morbillivirus. Uirusu 66(2): 147-154
Zhang, S. 2017: Discovery and design of self-assembling peptides. Interface Focus 7(6): 20170028
Nirogi, R.; Shinde, A.; Kambhampati, R.Sastry.; Mohammed, A.Rasheed.; Saraf, S.Keshari.; Badange, R.Kumar.; Bandyala, T.Reddy.; Bhatta, V.; Bojja, K.; Reballi, V.; Subramanian, R.; Benade, V.; Palacharla, R.Choudary.; Bhyrapuneni, G.; Jayarajan, P.; Goyal, V.; Jasti, V. 2017: Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT 6 ) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. Journal of Medicinal Chemistry 60(5): 1843-1859
Noncovich, A.; Priest, C.; Ung, J.; Patron, A.P.; Servant, G.; Brust, P.; Servant, N.; Faber, N.; Liu, H.; Gonsalves, N.S.; Ditschun, T.L. 2017: Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents. Bioorganic and Medicinal Chemistry Letters 27(16): 3931-3938
Godfraind, Téophile. 2017: Discovery and Development of Calcium Channel Blockers. Frontiers in Pharmacology 8: 286
Xiao, Q.; Wu, J.; Pang, X.; Jiang, Y.; Wang, P.; Leung, A.W.; Gao, L.; Jiang, S.; Xu, C. 2018: Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy. Current Medicinal Chemistry 25(7): 839-860
Erakovic Haber, V.; Spaventi, R. 2017: Discovery and Development of Novel Drugs. Progress in Molecular and Subcellular Biology 55: 91-104
Germa, C.; Miller, M.; Mukhopadhyay, P.; Hewes, B.; Caponigro, G.; Scherer, S.J.; Hirawat, S. 2017: Discovery and development of novel therapies in advanced breast cancer: rapid development of ribociclib. Annals of Oncology: Official Journal of the European Society for Medical Oncology 28(8): 2021-2024
Li, X.; Yang, C.; Wan, H.; Zhang, G.; Feng, J.; Zhang, L.; Chen, X.; Zhong, D.; Lou, L.; Tao, W.; Zhang, L. 2017: Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 110: 51-61
Bravo, L.; Mico, J.Antonio.; Berrocoso, E. 2017: Discovery and development of tramadol for the treatment of pain. Expert Opinion on Drug Discovery 12(12): 1281-1291
Iwaki, T.; Oyama, Y.; Tomoo, T.; Tanaka, T.; Okamura, Y.; Sugiyama, M.; Yamaki, A.; Furuya, M. 2017: Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists. Bioorganic and Medicinal Chemistry 25(6): 1762-1769
Donovan, B.T.; Bandyopadhyay, D.; Duraiswami, C.; Nixon, C.J.; Townsend, C.Y.; Martens, S.F. 2018: Discovery and electrophysiological characterization of SKF-32802: A novel hERG agonist found through a large-scale structural similarity search. European Journal of Pharmacology 818: 306-327
Shi, S.; Choi, Y.Wah.; Zhao, H.; Tan, M.How.; Ang, E.Lui. 2017: Discovery and engineering of a 1-butanol biosensor in Saccharomyces cerevisiae. Bioresource Technology 245(Pt B): 1343-1351
Blaisse, M.R.; Dong, H.; Fu, B.; Chang, M.C.Y. 2017: Discovery and Engineering of Pathways for Production of α-Branched Organic Acids. Journal of the American Chemical Society 139(41): 14526-14532
Thakkar, M.; Bhuniya, D.; Kaduskar, R.; Mengawade, T.; Naik, K.; Salunkhe, V.; Bhalerao, A.; Kurhade, S.; Mavinahalli, J.; Jain, V.; Petla, R.; Avaragolla, S.; Ray, S.; Rouduri, S.; Dhanave, A.; De, S.; Pathade, V.; Tambe, A.; Raje, A.A.; Madgula, V.; Joshi, S.; Nadeem, A.; Bala, M.; Umrani, D.; Hariharan, N.; Kulkarni, B.; Mookhtiar, K.A. 2017: Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis. Bioorganic and Medicinal Chemistry Letters 27(8): 1867-1873
Schmidt, T.C.; Eriksson, P-Olof.; Gustafsson, D.; Cosgrove, D.; Frølund, B.; Boström, J. 2017: Discovery and Evaluation of Anti-Fibrinolytic Plasmin Inhibitors Derived from 5-(4-Piperidyl)isoxazol-3-ol (4-PIOL). Journal of Chemical Information and Modeling 57(7): 1703-1714
Bezençon, O.; Remeň, Lš.; Richard, S.; Roch, C.; Kessler, M.; Moon, R.; Mawet, J.; Ertel, E.A.; Pfeifer, T.; Capeleto, B. 2017: Discovery and evaluation of Ca v 3.1-selective T-type calcium channel blockers. Bioorganic and Medicinal Chemistry Letters 27(23): 5322-5325
Bezençon, O.; Remeň, Lš.; Richard, S.; Roch, C.; Kessler, M.; Ertel, E.A.; Moon, R.; Mawet, J.; Pfeifer, T.; Capeleto, B. 2017: Discovery and evaluation of Ca v 3.2-selective T-type calcium channel blockers. Bioorganic and Medicinal Chemistry Letters 27(23): 5326-5331
Cho, Y.Shin.; Levell, J.R.; Liu, G.; Caferro, T.; Sutton, J.; Shafer, C.M.; Costales, A.; Manning, J.R.; Zhao, Q.; Sendzik, M.; Shultz, M.; Chenail, G.; Dooley, J.; Villalba, B.; Farsidjani, A.; Chen, J.; Kulathila, R.; Xie, X.; Dodd, S.; Gould, T.; Liang, G.; Heimbach, T.; Slocum, K.; Firestone, B.; Pu, M.; Pagliarini, R.; Growney, J.D. 2017: Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. Acs Medicinal Chemistry Letters 8(10): 1116-1121
Tomek, P.; Palmer, B.D.; Flanagan, J.U.; Sun, C.; Raven, E.L.; Ching, L-Ming. 2017: Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. European Journal of Medicinal Chemistry 126: 983-996
Zhang, R.; Yu, R.; Xu, Q.; Li, X.; Luo, J.; Jiang, B.; Wang, L.; Guo, S.; Wu, N.; Shi, D. 2017: Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors. European Journal of Medicinal Chemistry 134: 24-33
Costa-Paiva, E.M.; Whelan, N.V.; Waits, D.S.; Santos, S.R.; Schrago, C.G.; Halanych, K.M. 2017: Discovery and evolution of novel hemerythrin genes in annelid worms. Bmc Evolutionary Biology 17(1): 85
Ng, M.C.Y.; Graff, M.; Lu, Y.; Justice, A.E.; Mudgal, P.; Liu, C-Ti.; Young, K.; Yanek, L.R.; Feitosa, M.F.; Wojczynski, M.K.; Rand, K.; Brody, J.A.; Cade, B.E.; Dimitrov, L.; Duan, Q.; Guo, X.; Lange, L.A.; Nalls, M.A.; Okut, H.; Tajuddin, S.M.; Tayo, B.O.; Vedantam, S.; Bradfield, J.P.; Chen, G.; Chen, W-Min.; Chesi, A.; Irvin, M.R.; Padhukasahasram, B.; Smith, J.A.; Zheng, W.; Allison, M.A.; Ambrosone, C.B.; Bandera, E.V.; Bartz, T.M.; Berndt, S.I.; Bernstein, L.; Blot, W.J.; Bottinger, E.P.; Carpten, J.; Chanock, S.J.; Chen, 2017: Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. Plos Genetics 13(4): E1006719
Hu, Y.; Tanaka, T.; Zhu, J.; Guan, W.; Wu, J.H.Y.; Psaty, B.M.; McKnight, B.; King, I.B.; Sun, Q.; Richard, M.; Manichaikul, A.; Frazier-Wood, A.C.; Kabagambe, E.K.; Hopkins, P.N.; Ordovas, J.M.; Ferrucci, L.; Bandinelli, S.; Arnett, D.K.; Chen, Y-Der.I.; Liang, S.; Siscovick, D.S.; Tsai, M.Y.; Rich, S.S.; Fornage, M.; Hu, F.B.; Rimm, E.B.; Jensen, M.K.; Lemaitre, R.N.; Mozaffarian, D.; Steffen, L.M.; Morris, A.P.; Li, H.; Lin, X. 2017: Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations. Journal of Lipid Research 58(5): 974-981
Jansen, I.E.; Ye, H.; Heetveld, S.; Lechler, M.C.; Michels, H.; Seinstra, Rée.I.; Lubbe, S.J.; Drouet, Vérie.; Lesage, S.; Majounie, E.; Gibbs, J.Raphael.; Nalls, M.A.; Ryten, M.; Botia, J.A.; Vandrovcova, J.; Simon-Sanchez, J.; Castillo-Lizardo, M.; Rizzu, P.; Blauwendraat, C.; Chouhan, A.K.; Li, Y.; Yogi, P.; Amin, N.; van Duijn, C.M.; Morris, H.R.; Brice, A.; Singleton, A.B.; David, D.C.; Nollen, E.A.; Jain, S.; Shulman, J.M.; Heutink, P.; Nalls, M.A.; Plagnol, V.; Hernandez, D.G.; Sharma, M.; Sheerin, U-Marie.; Saad, M.; SimónSánchez, J.; Schulte, C.; Lesage, S.; S 2017: Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology 18(1): 22
Soares, A.Raquel.; Santos, M. 2017: Discovery and function of transfer RNA-derived fragments and their role in disease. Wiley Interdisciplinary Reviews. Rna 8(5)
Tihon, E.; Imamura, H.; Dujardin, J-Claude.; Van Den Abbeele, J.; Van den Broeck, F. 2017: Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis. Molecular Ecology 26(23): 6524-6538
Kavak, P.; Lin, Y-Yi.; Numanagic, I.; Asghari, H.; Güngör, T.; Alkan, C.; Hach, F. 2017: Discovery and genotyping of novel sequence insertions in many sequenced individuals. Bioinformatics 33(14): I161-I169
Takashima, K.; Takimoto, Y.; Nakazawa, E.; Hayashi, Y.; Tsuchiya, A.; Fujita, M.; Akabayashi, A. 2017: Discovery and informing research participants of incidental findings detected in brain magnetic resonance imaging studies: Review and multi-institutional study. Brain and Behavior 7(5): E00676
Völler, J-Stefan.; Dulic, M.; Gerling-Driessen, U.I.M.; Biava, H.; Baumann, T.; Budisa, N.; Gruic-Sovulj, I.; Koksch, B. 2017: Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation. Acs Central Science 3(1): 73-80
Iwaki, T.; Tanaka, T.; Miyazaki, K.; Suzuki, Y.; Okamura, Y.; Yamaki, A.; Iwanami, M.; Morozumi, N.; Furuya, M.; Oyama, Y. 2017: Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorganic and Medicinal Chemistry 25(24): 6680-6694
Wan, R.; Ma, P.; Han, M.; Zhang, D.; Zhang, C.; Niu, J.; Wang, J. 2017: Discovery and isolation of the trans-isomers of two 1 : 2-type lanthanide-containing monolacunary Dawson-type tungstophosphates: [Ln III (α 2 -P 2 W 17 O 61 ) 2 ] 17- (Ln = La, Ce). Dalton Transactions 46(16): 5398-5405
Doornbos, M.L.J.; Cid, Jé.María.; Haubrich, J.; Nunes, A.; van de Sande, J.W.; Vermond, S.C.; Mulder-Krieger, T.; Trabanco, Aés.A.; Ahnaou, A.; Drinkenburg, W.H.; Lavreysen, H.; Heitman, L.H.; IJzerman, A.P.; Tresadern, G. 2017: Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2. Journal of Medicinal Chemistry 60(15): 6704-6720
Ma, J.; Li, T.; Han, X.; Yuan, H.; Liang, H.; Wang, Y.; Wang, X.; Duan, Y.; Li, A.; Song, H.; Yang, D. 2017: Discovery and mechanism of action of Novel Baicalein modified derivatives as potent antihepatitis agent. Virology 507: 199-205
Wu, S.; Zhao, Q.; Zhang, P.; Kulp, J.; Hu, L.; Hwang, N.; Zhang, J.; Block, T.M.; Xu, X.; Du, Y.; Chang, J.; Guo, J-Tao. 2017: Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly. Journal of Virology 91(16)
Park, H.; Brotto, A.C.; van Loosdrecht, M.C.M.; Chandran, K. 2017: Discovery and metagenomic analysis of an anammox bacterial enrichment related to Candidatus "Brocadia caroliniensis" in a full-scale glycerol-fed nitritation-denitritation separate centrate treatment process. Water Research 111: 265-273
Sousa, S.R.; Wingerd, J.S.; Brust, A.; Bladen, C.; Ragnarsson, L.; Herzig, V.; Deuis, J.R.; Dutertre, S.; Vetter, I.; Zamponi, G.W.; King, G.F.; Alewood, P.F.; Lewis, R.J. 2017: Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. Plos one 12(9): E0182848
Li, L.; Zhang, H.; Zhang, M.; Zhao, M.; Feng, L.; Luo, X.; Gao, Z.; Huang, Y.; Ardayfio, O.; Zhang, J-Hu.; Lin, Y.; Fan, H.; Mi, Y.; Li, G.; Liu, L.; Feng, L.; Luo, F.; Teng, L.; Qi, W.; Ottl, J.; Lingel, A.; Bussiere, D.E.; Yu, Z.; Atadja, P.; Lu, C.; Li, E.; Gu, J.; Zhao, K. 2017: Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED. Plos one 12(1): E0169855
Silva, Jão.Marcos.Fagundes.; Al Rwahnih, M.; Blawid, R.; Nagata, T.; Fajardo, T.Vinícius.Martins. 2017: Discovery and molecular characterization of a novel enamovirus, Grapevine enamovirus-1. Virus Genes 53(4): 667-671
Er, S.Yan.; Cristofori-Armstrong, B.; Escoubas, P.; Rash, L.D. 2017: Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1. Neuropharmacology 127: 185-195
Schreier, J.D.; Embrey, M.W.; Raheem, I.T.; Barbe, G.; Campeau, L-Charles.; Dubost, D.; McCabe Dunn, J.; Grobler, J.; Hartingh, T.J.; Hazuda, D.J.; Klein, D.; Miller, M.D.; Moore, K.P.; Nguyen, N.; Pajkovic, N.; Powell, D.A.; Rada, V.; Sanders, J.M.; Sisko, J.; Steele, T.G.; Wai, J.; Walji, A.; Xu, M.; Coleman, P.J. 2017: Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV. Bioorganic and Medicinal Chemistry Letters 27(9): 2038-2046
Bender, A.M.; Weiner, R.L.; Luscombe, V.B.; Ajmera, S.; Cho, H.P.; Chang, S.; Zhan, X.; Rodriguez, A.L.; Niswender, C.M.; Engers, D.W.; Bridges, T.M.; Conn, P.Jeffrey.; Lindsley, C.W. 2017: Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Bioorganic and Medicinal Chemistry Letters 27(15): 3576-3581
Brand, S.; Ko, E.Jung.; Viayna, E.; Thompson, S.; Spinks, D.; Thomas, M.; Sandberg, L.; Francisco, A.F.; Jayawardhana, S.; Smith, V.C.; Jansen, C.; De Rycker, M.; Thomas, J.; MacLean, L.; Osuna-Cabello, M.; Riley, J.; Scullion, P.; Stojanovski, L.; Simeons, F.R.C.; Epemolu, O.; Shishikura, Y.; Crouch, S.D.; Bakshi, T.S.; Nixon, C.J.; Reid, I.H.; Hill, A.P.; Underwood, T.Z.; Hindley, S.J.; Robinson, S.A.; Kelly, J.M.; Fiandor, J.M.; Wyatt, P.G.; Marco, M.; Miles, T.J.; Read, K.D.; Gilbert, I.H. 2017: Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. Journal of Medicinal Chemistry 60(17): 7284-7299
Jones, S.; Ahmet, J.; Ayton, K.; Ball, M.; Cockerill, M.; Fairweather, E.; Hamilton, N.; Harper, P.; Hitchin, J.; Jordan, A.; Levy, C.; Lopez, R.; McKenzie, E.; Packer, M.; Plant, D.; Simpson, I.; Simpson, P.; Sinclair, I.; Somervaille, T.C.P.; Small, H.; Spencer, G.J.; Thomson, G.; Tonge, M.; Waddell, I.; Walsh, J.; Waszkowycz, B.; Wigglesworth, M.; Wiseman, D.H.; Ogilvie, D. 2016: Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells. Journal of Medicinal Chemistry 59(24): 11120-11137
Guo, L.; Parker, D.L.; Zang, Y.; Sweis, R.F.; Liu, W.; Sherer, E.C.; Buist, N.; Terebetski, J.; Kelly, T.; Bugianesi, R.; Priest, B.T.; Dingley, K.H.; Li, X.; Mitelman, S.; Salituro, G.; Trujillo, M.E.; Pachanski, M.; Kirkland, M.; Powles, M.Ann.; Eiermann, G.J.; Feng, Y.; Shang, J.; Howard, A.D.; Ujjainwalla, F.; Sinz, C.J.; Debenham, J.S.; Edmondson, S.D.; Nargund, R.P.; Hagmann, W.K.; Li, D. 2016: Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes. Acs Medicinal Chemistry Letters 7(12): 1107-1111
Teno, N.; Iguchi, Y.; Yamashita, Y.; Mori, N.; Une, M.; Nishimaki-Mogami, T.; Gohda, K. 2017: Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists. Bioorganic and Medicinal Chemistry 25(6): 1787-1794
Wu, D.; Zhang, T.; Chen, Y.; Huang, Y.; Geng, H.; Yu, Y.; Zhang, C.; Lai, Z.; Wu, Y.; Guo, X.; Chen, J.; Luo, H-Bin. 2017: Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension. Journal of Medicinal Chemistry 60(15): 6622-6637
Bialucha, C.U.; Collins, S.D.; Li, X.; Saxena, P.; Zhang, X.; Dürr, C.; Lafont, B.; Prieur, P.; Shim, Y.; Mosher, R.; Lee, D.; Ostrom, L.; Hu, T.; Bilic, S.; Rajlic, I.Liric.; Capka, V.; Jiang, W.; Wagner, J.P.; Elliott, G.; Veloso, A.; Piel, J.C.; Flaherty, M.M.; Mansfield, K.G.; Meseck, E.K.; Rubic-Schneider, T.; London, A.Serdakowski.; Tschantz, W.R.; Kurz, M.; Nguyen, D.; Bourret, A.; Meyer, M.J.; Faris, J.E.; Janatpour, M.J.; Chan, V.W.; Yoder, N.C.; Catcott, K.C.; McShea, M.A.; Sun, X.; Gao, H.; Williams, J.; Hofmann, F.; Engelman, J.A.; Ettenb 2017: Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discovery 7(9): 1030-1045
Panchaud, P.; Bruyère, T.; Blumstein, A-Catherine.; Bur, D.; Chambovey, A.; Ertel, E.A.; Gude, M.; Hubschwerlen, C.; Jacob, Lïc.; Kimmerlin, T.; Pfeifer, T.; Prade, L.; Seiler, P.; Ritz, D.; Rueedi, G. 2017: Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. Journal of Medicinal Chemistry 60(9): 3755-3775
Bartolozzi, A.; Abeywardane, A.; Bosanac, T.; Broadwater, J.A.; Chen, Z.; Hutzler, J.Matthew.; Huber, J.D.; Nemoto, P.; Olague, A.; Riether, D.; Simpson, T.; Takahashi, H.; Wu, L.; Zhang, Y.; Zindell, R.M. 2017: Discovery and optimization of oxadiazole-based FLAP inhibitors. Bioorganic and Medicinal Chemistry Letters 27(20): 4652-4659
Rai, G.; Brimacombe, K.R.; Mott, B.T.; Urban, D.J.; Hu, X.; Yang, S-Ming.; Lee, T.D.; Cheff, D.M.; Kouznetsova, J.; Benavides, G.A.; Pohida, K.; Kuenstner, E.J.; Luci, D.K.; Lukacs, C.M.; Davies, D.R.; Dranow, D.M.; Zhu, H.; Sulikowski, G.; Moore, W.J.; Stott, G.M.; Flint, A.J.; Hall, M.D.; Darley-Usmar, V.M.; Neckers, L.M.; Dang, C.V.; Waterson, A.G.; Simeonov, A.; Jadhav, A.; Maloney, D.J. 2017: Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of Medicinal Chemistry 60(22): 9184-9204
Wang, Y.; Chen, Z.; Dai, M.; Sun, P.; Wang, C.; Gao, Y.; Zhao, H.; Zeng, W.; Shen, L.; Mao, W.; Wang, T.; Hu, G.; Li, J.; Chen, S.; Long, C.; Chen, X.; Liu, J.; Zhang, Y. 2017: Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping. Bioorganic and Medicinal Chemistry Letters 27(11): 2420-2423
Ye, Y.; Zhang, B.; Mao, R.; Zhang, C.; Wang, Y.; Xing, J.; Liu, Y-Chih.; Luo, X.; Ding, H.; Yang, Y.; Zhou, B.; Jiang, H.; Chen, K.; Luo, C.; Zheng, M. 2017: Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening. Organic and Biomolecular Chemistry 15(17): 3648-3661
Garzan, A.; Willby, M.J.; Green, K.D.; Tsodikov, O.V.; Posey, J.E.; Garneau-Tsodikova, S. 2016: Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis. Acs Medicinal Chemistry Letters 7(12): 1219-1221
Tadesse, S.; Bantie, L.; Tomusange, K.; Yu, M.; Islam, S.; Bykovska, N.; Noll, B.; Zhu, G.; Li, P.; Lam, F.; Kumarasiri, M.; Milne, R.; Wang, S. 2018: Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents. British Journal of Pharmacology 175(12): 2399-2413
Shibata, A.; Kuno, M.; Adachi, R.; Sato, Y.; Hattori, H.; Matsuda, A.; Okuzono, Y.; Igaki, K.; Tominari, Y.; Takagi, T.; Yabuki, M.; Okaniwa, M. 2017: Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy. Plos one 12(10): E0186587
Perera, T.P.S.; Jovcheva, E.; Mevellec, L.; Vialard, J.; De Lange, D.; Verhulst, T.; Paulussen, C.; Van De Ven, K.; King, P.; Freyne, E.; Rees, D.C.; Squires, M.; Saxty, G.; Page, M.; Murray, C.W.; Gilissen, R.; Ward, G.; Thompson, N.T.; Newell, D.R.; Cheng, N.; Xie, L.; Yang, J.; Platero, S.J.; Karkera, J.D.; Moy, C.; Angibaud, P.; Laquerre, S.; Lorenzi, M.V. 2017: Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor. Molecular Cancer Therapeutics 16(6): 1010-1020
O'Brien-Brown, J.; Jackson, A.; Reekie, T.A.; Barron, M.L.; Werry, E.L.; Schiavini, P.; McDonnell, M.; Munoz, L.; Wilkinson, S.; Noll, B.; Wang, S.; Kassiou, M. 2017: Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X 7 receptor antagonists. European Journal of Medicinal Chemistry 130: 433-439
Galambos, János.; Bielik, A.; Krasavin, M.; Orgován, Zán.; Domány, Görgy.; Nógrádi, K.; Wágner, Gábor.; Balogh, Görgy.T.; Béni, Zán.; Kóti, János.; Szakács, Zán.; Bobok, A.; Kolok, Sándor.; Mikó-Bakk, Mónika.L.; Vastag, Mónika.; Sághy, K.; Laszy, J.; Halász, A.Sándor.; Balázs, O.; Gál, K.; Greiner, Ián.; Szombathelyi, Z.; Keserű, Görgy.M. 2017: Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications. Journal of Medicinal Chemistry 60(6): 2470-2484
Ariazi, J.L.; Duffy, K.J.; Adams, D.F.; Fitch, D.M.; Luo, L.; Pappalardi, M.; Biju, M.; DiFilippo, E.Hugger.; Shaw, T.; Wiggall, K.; Erickson-Miller, C. 2017: Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. Journal of Pharmacology and Experimental Therapeutics 363(3): 336-347
Qiu, Z.; Lin, X.; Zhang, W.; Zhou, M.; Guo, L.; Kocer, B.; Wu, G.; Zhang, Z.; Liu, H.; Shi, H.; Kou, B.; Hu, T.; Hu, Y.; Huang, M.; Yan, S.Frank.; Xu, Z.; Zhou, Z.; Qin, N.; Wang, Y.Fen.; Ren, S.; Qiu, H.; Zhang, Y.; Zhang, Y.; Wu, X.; Sun, K.; Zhong, S.; Xie, J.; Ottaviani, G.; Zhou, Y.; Zhu, L.; Tian, X.; Shi, L.; Shen, F.; Mao, Y.; Zhou, X.; Gao, L.; Young, J.A.T.; Wu, J.Zhen.; Yang, G.; Mayweg, A.V.; Shen, H.C.; Tang, G.; Zhu, W. 2017: Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors. Journal of Medicinal Chemistry 60(8): 3352-3371
El Kassas, M.; Elbaz, T.; Hafez, E.; Wifi, M.Naguib.; Esmat, G. 2017: Discovery and preclinical development of dasabuvir for the treatment of hepatitis C infection. Expert Opinion on Drug Discovery 12(6): 635-642
Lin, C-Wen.; Sherman, B.; Moore, L.A.; Laethem, C.L.; Lu, D-Wen.; Pattabiraman, P.P.; Rao, P.Vasantha.; deLong, M.A.; Kopczynski, C.C. 2018: Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. Journal of Ocular Pharmacology and Therapeutics: the Official Journal of the Association for Ocular Pharmacology and Therapeutics 34(1-2): 40-51
Boiteau, J-Guy.; Ouvry, G.; Arlabosse, J-Marie.; Astri, Séphanie.; Beillard, A.; Bhurruth-Alcor, Y.; Bonnary, L.; Bouix-Peter, C.; Bouquet, K.; Bourotte, M.; Cardinaud, I.; Comino, C.; Deprez, Bît.; Duvert, D.; Féret, Aélique.; Hacini-Rachinel, F.; Harris, C.S.; Luzy, A-Pascale.; Mathieu, A.; Millois, C.; Orsini, N.; Pascau, J.; Pinto, A.; Piwnica, D.; Polge, Gëlle.; Reitz, A.; Reversé, K.; Rodeville, N.; Rossio, P.; Spiesse, D.; Tabet, S.; Taquet, N.; Tomas, Lïc.; Vial, E.; Hennequin, L.F. 2018: Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis. Bioorganic and Medicinal Chemistry 26(4): 945-956
Kojima, H.; Ieda, M. 2017: Discovery and progress of direct cardiac reprogramming. Cellular and Molecular Life Sciences: Cmls 74(12): 2203-2215
Zang, Y-Yang.; Li, Y-Mei.; Yin, Y.; Chen, S-Shan.; Kai, Z-Peng. 2017: Discovery and quantitative structure-activity relationship study of lepidopteran HMG-CoA reductase inhibitors as selective insecticides. Pest Management Science 73(9): 1944-1952
Jakubczyk, D.; Caputi, L.; Hatsch, Aëlle.; Nielsen, C.A.F.; Diefenbacher, M.; Klein, J.; Molt, A.; Schröder, H.; Cheng, J.Z.; Naesby, M.; O'Connor, S.E. 2015: Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway-Enzymatic Formation of a Cyclopropyl Group. Angewandte Chemie 127(17): 5206-5210
Holzinger, E.R.; Verma, S.S.; Moore, C.B.; Hall, M.; De, R.; Gilbert-Diamond, D.; Lanktree, M.B.; Pankratz, N.; Amuzu, A.; Burt, A.; Dale, C.; Dudek, S.; Furlong, C.E.; Gaunt, T.R.; Kim, D.Seung.; Riess, H.; Sivapalaratnam, S.; Tragante, V.; van Iperen, E.P.A.; Brautbar, A.; Carrell, D.S.; Crosslin, D.R.; Jarvik, G.P.; Kuivaniemi, H.; Kullo, I.J.; Larson, E.B.; Rasmussen-Torvik, L.J.; Tromp, G.; Baumert, J.; Cruickshanks, K.J.; Farrall, M.; Hingorani, A.D.; Hovingh, G.K.; Kleber, M.E.; Klein, B.E.; Klein, R.; Koenig, W.; Lange, L.A.; Mӓrz, W.; North, K 2017: Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. Biodata Mining 10: 25
Henne, W.Mike. 2017: Discovery and Roles of ER-Endolysosomal Contact Sites in Disease. Advances in Experimental Medicine and Biology 997: 135-147
Iwaki, T.; Nakamura, Y.; Tanaka, T.; Ogawa, Y.; Iwamoto, O.; Okamura, Y.; Kawase, Y.; Furuya, M.; Oyama, Y.; Nagayama, T. 2017: Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. Bioorganic and Medicinal Chemistry Letters 27(21): 4904-4907
Zhou, M.; Wang, M.; Zhong, R-Feng.; Liao, X-Ming.; Deng, L-Li.; Xu, G-Bo.; He, X.; Li, J.; Li, Y-Jun.; Liu, T.; Wang, Y-Lin.; Liao, S-Gao. 2017: Discovery and structure-activity relationship of auriculatone: A potent hepatoprotective agent against acetaminophen-induced liver injury. Bioorganic and Medicinal Chemistry Letters 27(16): 3636-3642
Li, R.; Ning, X.; Zhou, S.; Lin, Z.; Wu, X.; Chen, H.; Bai, X.; Wang, X.; Ge, Z.; Li, R.; Yin, Y. 2018: Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators. European Journal of Medicinal Chemistry 143: 48-65
Osman, K.T.; Ye, J.; Shi, Z.; Toker, C.; Lovato, D.; Jumani, R.S.; Zuercher, W.; Huston, C.D.; Edwards, A.M.; Lautens, M.; Santhakumar, V.; Hui, R. 2017: Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor. Bioorganic and Medicinal Chemistry 25(5): 1672-1680
Kadayat, T.Man.; Banskota, S.; Gurung, P.; Bist, G.; Thapa Magar, T.Bahadur.; Shrestha, A.; Kim, J-Ae.; Lee, E-Seok. 2017: Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. European Journal of Medicinal Chemistry 137: 575-597
Luan, S.; Ge, Q.; Chen, Y.; Dai, M.; Yang, J.; Li, K.; Liu, D.; Zhao, L. 2017: Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(9): 1943-1948
Murafuji, H.; Sakai, H.; Goto, M.; Imajo, S.; Sugawara, H.; Muto, T. 2017: Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(23): 5272-5276
Zheng, Q.; Tang, S.; Fu, X.; Chen, Z.; Ye, Y.; Lan, X.; Jiang, L.; Huang, Y.; Ding, J.; Geng, M.; Huang, M.; Wan, H. 2017: Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors. Bioorganic and Medicinal Chemistry Letters 27(23): 5262-5266
Bhide, R.S.; Keon, A.; Weigelt, C.; Sack, J.S.; Schmidt, R.J.; Lin, S.; Xiao, H-Yun.; Spergel, S.H.; Kempson, J.; Pitts, W.J.; Carman, J.; Poss, M.A. 2017: Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(21): 4908-4913
Matsui, Y.; Yasumatsu, I.; Asahi, T.; Kitamura, T.; Kanai, K.; Ubukata, O.; Hayasaka, H.; Takaishi, S.; Hanzawa, H.; Katakura, S. 2017: Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator. Bioorganic and Medicinal Chemistry 25(13): 3540-3546
Zhao, C.; Zhao, P.; Feng, B.; Hou, X.; Zhao, L. 2017: Discovery and Synthesis of Amino Acids Modified Deoxycholic Acid Derivatives and in Vitro Antiproliferative Evaluation. Chemical and Pharmaceutical Bulletin 65(3): 276-283
Siegel, D.; Hui, H.C.; Doerffler, E.; Clarke, M.O.; Chun, K.; Zhang, L.; Neville, S.; Carra, E.; Lew, W.; Ross, B.; Wang, Q.; Wolfe, L.; Jordan, R.; Soloveva, V.; Knox, J.; Perry, J.; Perron, M.; Stray, K.M.; Barauskas, O.; Feng, J.Y.; Xu, Y.; Lee, G.; Rheingold, A.L.; Ray, A.S.; Bannister, R.; Strickley, R.; Swaminathan, S.; Lee, W.A.; Bavari, S.; Cihlar, T.; Lo, M.K.; Warren, T.K.; Mackman, R.L. 2017: Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Journal of Medicinal Chemistry 60(5): 1648-1661
Naman, C.Benjamin.; Almaliti, J.; Armstrong, L.; Caro-Díaz, E.J.; Pierce, M.L.; Glukhov, E.; Fenner, A.; Spadafora, C.; Debonsi, H.M.; Dorrestein, P.C.; Murray, T.F.; Gerwick, W.H. 2017: Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. Journal of Natural Products 80(8): 2328-2334
Wang, J.; Ge, R.; Qiu, X.; Xu, X.; Wei, L.; Li, Z.; Bian, J. 2017: Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro. European Journal of Medicinal Chemistry 140: 421-434
Hüttel, S.; Testolin, G.; Herrmann, J.; Planke, T.; Gille, F.; Moreno, M.; Stadler, M.; Brönstrup, M.; Kirschning, A.; Müller, R. 2017: Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens. Angewandte Chemie 56(41): 12760-12764
Croner, L.J.; Dillon, R.; Kao, A.; Kairs, S.N.; Benz, R.; Christensen, I.J.; Nielsen, H.J.; Blume, J.E.; Wilcox, B. 2017: Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects. Clinical Proteomics 14: 28
De Groote, M.A.; Sterling, D.G.; Hraha, T.; Russell, T.M.; Green, L.S.; Wall, K.; Kraemer, S.; Ostroff, R.; Janjic, N.; Ochsner, U.A. 2017: Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis. Journal of Clinical Microbiology 55(10): 3057-3071
Clarke, M.A.; Luhn, P.; Gage, J.C.; Bodelon, C.; Dunn, S.Terence.; Walker, J.; Zuna, R.; Hewitt, S.; Killian, J.Keith.; Yan, L.; Miller, A.; Schiffman, M.; Wentzensen, N. 2017: Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer. International Journal of Cancer 141(4): 701-710
Zhou, M.; Zhao, H.; Xu, W.; Bao, S.; Cheng, L.; Sun, J. 2017: Discovery and validation of immune-associated long non-coding RNA biomarkers associated with clinically molecular subtype and prognosis in diffuse large B cell lymphoma. Molecular Cancer 16(1): 16
Zhou, Y.; Song, R.; Ma, C.; Zhou, L.; Liu, X.; Yin, P.; Zhang, Z.; Sun, Y.; Xu, C.; Lu, X.; Xu, G. 2017: Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method. Oncotarget 8(13): 20719-20728
Shen, H.; Nelson, D.M.; Oliveira, R.V.; Zhang, Y.; Mcnaney, C.A.; Gu, X.; Chen, W.; Su, C.; Reily, M.D.; Shipkova, P.A.; Gan, J.; Lai, Y.; Marathe, P.; Humphreys, W.Griffith. 2018: Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys. Drug Metabolism and Disposition: the Biological Fate of Chemicals 46(2): 178-188
Wang, Y.; Zhang, M.; Xu, H.; Wang, Y.; Li, Z.; Chang, Y.; Wang, X.; Fu, X.; Zhou, Z.; Yang, S.; Wang, B.; Shang, Y. 2017: Discovery and validation of the tumor-suppressive function of long noncoding RNA PANDA in human diffuse large B-cell lymphoma through the inactivation of MAPK/ERK signaling pathway. Oncotarget 8(42): 72182-72196
Kundu, S.; Kolouri, S.; Erickson, K.I.; Kramer, A.F.; McAuley, E.; Rohde, G.K. 2018: Discovery and visualization of structural biomarkers from MRI using transport-based morphometry. Neuroimage 167: 256-275
Guidi, A.; Lalli, C.; Gimmelli, R.; Nizi, E.; Andreini, M.; Gennari, N.; Saccoccia, F.; Harper, S.; Bresciani, A.; Ruberti, G. 2017: Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production. Plos Neglected Tropical Diseases 11(10): E0005994
Jeffries, D.E.; Witt, J.O.; McCollum, A.L.; Temple, K.J.; Hurtado, M.A.; Harp, J.M.; Blobaum, A.L.; Lindsley, C.W.; Hopkins, C.R. 2016: Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D 4 R) antagonists. Bioorganic and Medicinal Chemistry Letters 26(23): 5757-5764
Shetty, R.; Vestergaard, M.; Jessen, F.; Hägglund, P.; Knorr, V.; Koehler, P.; Prakash, H.S.; Hobley, T.John. 2017: Discovery, cloning and characterisation of proline specific prolyl endopeptidase, a gluten degrading thermo-stable enzyme from Sphaerobacter thermophiles. Enzyme and Microbial Technology 107: 57-63
Watson, G.M.; Kulkarni, K.; Sang, J.; Ma, X.; Gunzburg, M.J.; Perlmutter, P.; Wilce, M.C.J.; Wilce, J.A. 2017: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. Journal of Medicinal Chemistry 60(22): 9349-9359
Holderman, C.J.; Wood, L.A.; Geden, C.J.; Kaufman, P.E. 2017: Discovery, Development, and Evaluation of a Horn Fly-Isolated (Diptera: Muscidae) Beauveria bassiana (Hypocreales: Cordyciptaceae) Strain From Florida, USA. Journal of Insect Science 17(2)
Schock, E.N.; Brugmann, S.A. 2017: Discovery, Diagnosis, and Etiology of Craniofacial Ciliopathies. Cold Spring Harbor Perspectives in Biology 9(9)
Hänninen, P.; Niinimäki, T.; Flinkkilä, T.; Niinimäki, J.; Ohtonen, P.; Yli-Luukko, S.; Leppilahti, J. 2017: Discovery Elbow System: clinical and radiological results after 2- to 10-year follow-up. European Journal of Orthopaedic Surgery and Traumatology: Orthopedie Traumatologie 27(7): 901-907
Nozaki, T. 2017: Discovery in Japan of the second species of the genus Dolichocentrus Martynov (Trichoptera: Brachycentridae). Zootaxa 4227(4)
Chen, W.; Guo, N.; Qi, M.; Dai, H.; Hong, M.; Guan, L.; Huan, X.; Song, S.; He, J.; Wang, Y.; Xi, Y.; Yang, X.; Shen, Y.; Su, Y.; Sun, Y.; Gao, Y.; Chen, Y.; Ding, J.; Tang, Y.; Ren, G.; Miao, Z.; Li, J. 2017: Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy. European Journal of Medicinal Chemistry 138: 514-531
Gómez-Outes, A.; García-Fuentes, M.; Suárez-Gea, Mª.Luisa. 2017: Discovery methods of coagulation-inhibiting drugs. Expert Opinion on Drug Discovery 12(12): 1195-1205
Wu, C.; Eck, B.; Zhang, S.; Zhu, J.; Tiwari, A.Dev.; Zhang, Y.; Zhu, Y.; Zhang, J.; Wang, B.; Wang, X.; Wang, X.; You, J.; Wang, J.; Guan, Y.; Liu, X.; Yu, X.; Trapp, B.D.; Miller, R.; Silver, J.; Wilson, D.; Wang, Y. 2017: Discovery of 1,2,3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System. Journal of Medicinal Chemistry 60(3): 987-999
Wang, S.; Yang, J.; Li, X.; Liu, Z.; Wu, Y.; Si, G.; Tao, Y.; Zhao, N.; Hu, X.; Ma, Y.; Liu, G. 2017: Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo. Journal of Medicinal Chemistry 60(12): 5162-5192
Wang, A.; Li, X.; Chen, C.; Wu, H.; Qi, Z.; Hu, C.; Yu, K.; Wu, J.; Liu, J.; Liu, X.; Hu, Z.; Wang, W.; Wang, W.; Wang, W.; Wang, L.; Wang, B.; Liu, Q.; Li, L.; Ge, J.; Ren, T.; Zhang, S.; Xia, R.; Liu, J.; Liu, Q. 2017: Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML. Journal of Medicinal Chemistry 60(20): 8407-8424
Shin, W.Shik.; Bergstrom, A.; Bonomo, R.A.; Crowder, M.W.; Muthyala, R.; Sham, Y.Yin. 2017: Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor. Chemmedchem 12(11): 845-849
Elkamhawy, A.; Park, J-Eun.; Hassan, A.H.E.; Ra, H.; Pae, A.Nim.; Lee, J.; Park, B-Geon.; Moon, B.; Park, H-Mee.; Roh, E.Joo. 2017: Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction. European Journal of Medicinal Chemistry 128: 56-69
Li, W.; Sun, Q.; Song, L.; Gao, C.; Liu, F.; Chen, Y.; Jiang, Y. 2017: Discovery of 1-(3-aryl-4-chlorophenyl)-3-(p-aryl)urea derivatives against breast cancer by inhibiting PI3K/Akt/mTOR and Hedgehog signalings. European Journal of Medicinal Chemistry 141: 721-733
Desroy, N.; Housseman, C.; Bock, X.; Joncour, Aès.; Bienvenu, N.; Cherel, Lëtitia.; Labeguere, V.; Rondet, E.; Peixoto, C.; Grassot, J-Marie.; Picolet, O.; Annoot, D.; Triballeau, N.; Monjardet, A.; Wakselman, E.; Roncoroni, V.; Le Tallec, S.; Blanque, R.; Cottereaux, C.; Vandervoort, N.; Christophe, T.; Mollat, P.; Lamers, M.; Auberval, M.; Hrvacic, B.; Ralic, J.; Oste, L.; van der Aar, E.; Brys, R.; Heckmann, B. 2017: Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. Journal of Medicinal Chemistry 60(9): 3580-3590
Zhao, H-Yi.; Wang, H-Yan.; Mao, S.; Xin, M.; Zhang, H.; Zhang, S-Qi. 2017: Discovery of 2-(pyridin-2-yl)aniline as a directing group for the sp 2 C-H bond amination mediated by cupric acetate. Organic and Biomolecular Chemistry 15(31): 6622-6631
Tran, T-Anh.; Kramer, B.; Shin, Y-Jun.; Vallar, P.; Boatman, P.Douglas.; Zou, N.; Sage, C.R.; Gharbaoui, T.; Krishnan, A.; Pal, B.; Shakya, S.R.; Garrido Montalban, A.; Adams, J.W.; Ramirez, J.; Behan, D.P.; Shifrina, A.; Blackburn, A.; Leakakos, T.; Shi, Y.; Morgan, M.; Sadeque, A.; Chen, W.; Unett, D.J.; Gaidarov, I.; Chen, X.; Chang, S.; Shu, H-Hui.; Tung, S-Feng.; Semple, G. 2017: Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. Journal of Medicinal Chemistry 60(3): 913-927
Zeng, D.; Zhang, R.; Nie, Q.; Cao, L.; Shang, L.; Yin, Z. 2016: Discovery of 2'-α-C-Methyl-2'-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus. Acs Medicinal Chemistry Letters 7(12): 1197-1201
Feng, B.; Zhang, J.; Ito, S.; Arita, M.; Cheng, C.; Chen, L.; Wu, K.; Komori, F.; Sugino, O.; Miyamoto, K.; Okuda, T.; Meng, S.; Matsuda, I. 2018: Discovery of 2D Anisotropic Dirac Cones. Advanced Materials 30(2)
Wei, L.; Wang, J.; Zhang, X.; Wang, P.; Zhao, Y.; Li, J.; Hou, T.; Qu, L.; Shi, L.; Liang, X.; Fang, Y. 2017: Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists. Journal of Medicinal Chemistry 60(1): 362-372
Liang, X.; Lv, F.; Wang, B.; Yu, K.; Wu, H.; Qi, Z.; Jiang, Z.; Chen, C.; Wang, A.; Miao, W.; Wang, W.; Hu, Z.; Liu, J.; Liu, X.; Zhao, Z.; Wang, L.; Zhang, S.; Ye, Z.; Wang, C.; Ren, T.; Wang, Y.; Liu, Q.; Liu, J. 2017: Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. Journal of Medicinal Chemistry 60(5): 1793-1816
Yang, L.; Ma, X.; Yuan, C.; He, Y.; Li, L.; Fang, S.; Xia, W.; He, T.; Qian, S.; Xu, Z.; Li, G.; Wang, Z. 2017: Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors. European Journal of Medicinal Chemistry 134: 230-241
Kounde, C.S.; Yeo, H-Quan.; Wang, Q-Yin.; Wan, K.Fei.; Dong, H.; Karuna, R.; Dix, I.; Wagner, T.; Zou, B.; Simon, O.; Bonamy, G.M.C.; Yeung, B.K.S.; Yokokawa, F. 2017: Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit. Bioorganic and Medicinal Chemistry Letters 27(6): 1385-1389
Zhou, J.; Ji, M.; Zhu, Z.; Cao, R.; Chen, X.; Xu, B. 2017: Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity. European Journal of Medicinal Chemistry 132: 26-41
Wang, G.; Wang, J.; Xie, Z.; Chen, M.; Li, L.; Peng, Y.; Chen, S.; Li, W.; Deng, B. 2017: Discovery of 3,3-di(indolyl)indolin-2-one as a novel scaffold for α-glucosidase inhibitors: In silico studies and SAR predictions. Bioorganic Chemistry 72: 228-233
Fujimoto, J.; Okamoto, R.; Noguchi, N.; Hara, R.; Masada, S.; Kawamoto, T.; Nagase, H.; Tamura, Y.Okano.; Imanishi, M.; Takagahara, S.; Kubo, K.; Tohyama, K.; Iida, K.; Andou, T.; Miyahisa, I.; Matsui, J.; Hayashi, R.; Maekawa, T.; Matsunaga, N. 2017: Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ-5 Desaturase (D5D) Inhibitors. Journal of Medicinal Chemistry 60(21): 8963-8981
Verhasselt, S.; Roman, B.I.; De Wever, O.; Van Hecke, K.; Van Deun, R.; Bracke, M.E.; Stevens, C.V. 2017: Discovery of (S)-3'-hydroxyblebbistatin and (S)-3'-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties. Organic and Biomolecular Chemistry 15(9): 2104-2118
Boga, S.Babu.; Alhassan, A-Basit.; Liu, J.; Guiadeen, D.; Krikorian, A.; Gao, X.; Wang, J.; Yu, Y.; Anand, R.; Liu, S.; Yang, C.; Wu, H.; Cai, J.; Zhu, H.; Desai, J.; Maloney, K.; Gao, Y-Duo.; Fischmann, T.O.; Presland, J.; Mansueto, M.; Xu, Z.; Leccese, E.; Knemeyer, I.; Garlisi, C.G.; Bays, N.; Stivers, P.; Brandish, P.E.; Hicks, A.; Cooper, A.; Kim, R.M.; Kozlowski, J.A. 2017: Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis. Bioorganic and Medicinal Chemistry Letters 27(16): 3939-3943
Barzen-Hanson, K.A.; Roberts, S.C.; Choyke, S.; Oetjen, K.; McAlees, A.; Riddell, N.; McCrindle, R.; Ferguson, P.Lee.; Higgins, C.P.; Field, J.A. 2017: Discovery of 40 Classes of Per- and Polyfluoroalkyl Substances in Historical Aqueous Film-Forming Foams (AFFFs) and AFFF-Impacted Groundwater. Environmental Science and Technology 51(4): 2047-2057
Galambos, János.; Bielik, A.; Wágner, Gábor.; Domány, Görgy.; Kóti, János.; Béni, Zán.; Szigetvári, Áron.; Sánta, Z.; Orgován, Zán.; Bobok, A.; Kiss, Béla.; Mikó-Bakk, Mónika.L.; Vastag, Mónika.; Sághy, K.; Krasavin, M.; Gál, K.; Greiner, Ián.; Szombathelyi, Z.; Keserű, Görgy.M. 2017: Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu 5 ) receptor negative allosteric modulators. European Journal of Medicinal Chemistry 133: 240-254
Mochizuki, M.; Kojima, T.; Kobayashi, K.; Kotani, E.; Ishichi, Y.; Kanzaki, N.; Nakagawa, H.; Okuda, T.; Kosugi, Y.; Yano, T.; Sako, Y.; Tanaka, M.; Aso, K. 2017: Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF 1 receptor antagonist. Bioorganic and Medicinal Chemistry 25(5): 1556-1570
Aguilar, A.; Lu, J.; Liu, L.; Du, D.; Bernard, D.; McEachern, D.; Przybranowski, S.; Li, X.; Luo, R.; Wen, B.; Sun, D.; Wang, H.; Wen, J.; Wang, G.; Zhai, Y.; Guo, M.; Yang, D.; Wang, S. 2017: Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. Journal of Medicinal Chemistry 60(7): 2819-2839
Wang, Q.; Liu, F.; Wang, B.; Zou, F.; Qi, Z.; Chen, C.; Yu, K.; Hu, C.; Qi, S.; Wang, W.; Hu, Z.; Liu, J.; Wang, W.; Wang, L.; Liang, Q.; Zhang, S.; Ren, T.; Liu, Q.; Liu, J. 2017: Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding. Journal of Medicinal Chemistry 60(1): 273-289
Fu, D-Jun.; Song, J.; Hou, Y-Hui.; Zhao, R-Han.; Li, J-Huan.; Mao, R-Wang.; Yang, J-Jia.; Li, P.; Zi, X-Lin.; Li, Z-Hua.; Zhang, Q-Qing.; Wang, F-Yan.; Zhang, S-Yang.; Zhang, Y-Bing.; Liu, H-Min. 2017: Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers. European Journal of Medicinal Chemistry 138: 1076-1088
Wang, X.; Kolesnikov, A.; Tay, S.; Chan, G.; Chao, Q.; Do, S.; Drummond, J.; Ebens, A.J.; Liu, N.; Ly, J.; Harstad, E.; Hu, H.; Moffat, J.; Munugalavadla, V.; Murray, J.; Slaga, D.; Tsui, V.; Volgraf, M.; Wallweber, H.; Chang, J.H. 2017: Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. Journal of Medicinal Chemistry 60(10): 4458-4473
Chen, J.; Sang, Z.; Li, L.; He, L.; Ma, L. 2017: Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity. Molecular Diversity 21(3): 637-654
Ding, X.; Dai, X.; Long, K.; Peng, C.; Andreotti, D.; Bamborough, P.; Eatherton, A.J.; Edge, C.; Jandu, K.S.; Nichols, P.L.; Philps, O.J.; Stasi, L.Piero.; Wan, Z.; Xiang, J-Ning.; Dong, K.; Dossang, P.; Ho, M-Hsun.; Li, Y.; Mensah, L.; Guan, X.; Reith, A.D.; Ren, F. 2017: Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(17): 4034-4038
Zlatopolskiy, B.D.; Zischler, J.; Schäfer, D.; Urusova, E.A.; Guliyev, M.; Bannykh, O.; Endepols, H.; Neumaier, B. 2018: Discovery of 7-[ 18 F]Fluorotryptophan as a Novel Positron Emission Tomography (PET) Probe for the Visualization of Tryptophan Metabolism in Vivo. Journal of Medicinal Chemistry 61(1): 189-206
Qin, L-Ying.; Ruan, Z.; Cherney, R.J.; Dhar, T.G.Murali.; Neels, J.; Weigelt, C.A.; Sack, J.S.; Srivastava, A.S.; Cornelius, L.A.M.; Tino, J.A.; Stefanski, K.; Gu, X.; Xie, J.; Susulic, V.; Yang, X.; Yarde-Chinn, M.; Skala, S.; Bosnius, R.; Goldstein, C.; Davies, P.; Ruepp, S.; Salter-Cid, L.; Bhide, R.S.; Poss, M.A. 2017: Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors. Bioorganic and Medicinal Chemistry Letters 27(4): 855-861
Zhou, Z-Zhen.; Shi, X-Dong.; Feng, H-Fang.; Cheng, Y-Fang.; Wang, H-Tao.; Xu, J-Ping. 2017: Discovery of 9H-purins as potential tubulin polymerization inhibitors: Synthesis, biological evaluation and structure-activity relationships. European Journal of Medicinal Chemistry 138: 1126-1134
Kurata, H.; Kusumi, K.; Otsuki, K.; Suzuki, R.; Kurono, M.; Komiya, T.; Hagiya, H.; Mizuno, H.; Shioya, H.; Ono, T.; Takada, Y.; Maeda, T.; Matsunaga, N.; Kondo, T.; Tominaga, S.; Nunoya, K-Ici.; Kiyoshi, H.; Komeno, M.; Nakade, S.; Habashita, H. 2017: Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P 1 and S1P 5 Selective Agonist for the Treatment of Autoimmune Diseases. Journal of Medicinal Chemistry 60(23): 9508-9530
Kirschberg, T.A.; Metobo, S.; Clarke, M.O.; Aktoudianakis, V.; Babusis, D.; Barauskas, O.; Birkus, G.; Butler, T.; Byun, D.; Chin, G.; Doerffler, E.; Edwards, T.E.; Fenaux, M.; Lee, R.; Lew, W.; Mish, M.R.; Murakami, E.; Park, Y.; Squires, N.H.; Tirunagari, N.; Wang, T.; Whitcomb, M.; Xu, J.; Yang, H.; Ye, H.; Zhang, L.; Appleby, T.C.; Feng, J.Y.; Ray, A.S.; Cho, A.; Kim, C.U. 2017: Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties. Bioorganic and Medicinal Chemistry Letters 27(8): 1840-1847
Scott, J.D.; DeMong, D.E.; Greshock, T.J.; Basu, K.; Dai, X.; Harris, J.; Hruza, A.; Li, S.W.; Lin, S-Ing.; Liu, H.; Macala, M.K.; Hu, Z.; Mei, H.; Zhang, H.; Walsh, P.; Poirier, M.; Shi, Z-Cai.; Xiao, L.; Agnihotri, G.; Baptista, M.A.S.; Columbus, J.; Fell, M.J.; Hyde, L.A.; Kuvelkar, R.; Lin, Y.; Mirescu, C.; Morrow, J.A.; Yin, Z.; Zhang, X.; Zhou, X.; Chang, R.K.; Embrey, M.W.; Sanders, J.M.; Tiscia, H.E.; Drolet, R.E.; Kern, J.T.; Sur, S.M.; Renger, J.J.; Bilodeau, M.T.; Kennedy, M.E.; Parker, E.M.; Stamford, A.W.; Nargund, R.; McCauley, J.A.; Miller, M 2017: Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. Journal of Medicinal Chemistry 60(7): 2983-2992
Okumura, Y.; Yamagishi, T.; Nukui, S.; Nakao, K. 2017: Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorganic and Medicinal Chemistry Letters 27(5): 1186-1192
Kamada, Y.; Sakai, N.; Sogabe, S.; Ida, K.; Oki, H.; Sakamoto, K.; Lane, W.; Snell, G.; Iida, M.; Imaeda, Y.; Sakamoto, J.; Matsui, J. 2017: Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach. Journal of Medicinal Chemistry 60(10): 4358-4368
Duan, H.; Li, Y.; Arora, D.; Xu, D.; Lim, H-Ying.; Wang, W. 2017: Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress. Journal of Medicinal Chemistry 60(14): 6191-6204
Schenkel, L.B.; DiMauro, E.F.; Nguyen, H.N.; Chakka, N.; Du, B.; Foti, R.S.; Guzman-Perez, A.; Jarosh, M.; La, D.S.; Ligutti, J.; Milgram, B.C.; Moyer, B.D.; Peterson, E.A.; Roberts, J.; Yu, V.L.; Weiss, M.M. 2017: Discovery of a biarylamide series of potent, state-dependent Na V 1.7 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(16): 3817-3824
Yang, S-Hou.; Sun, Q.; Xiong, H.; Liu, S-Yu.; Moosavi, B.; Yang, W-Chao.; Yang, G-Fu. 2017: Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy. Chemical Communications 53(28): 3952-3955
Zhu, Q.; Liu, X. 2017: Discovery of a Calcium-Dependent Enzymatic Cascade for the Selective Assembly of Hapalindole-Type Alkaloids: On the Biosynthetic Origin of Hapalindole U. Angewandte Chemie 56(31): 9062-9066
Cheeseman, M.D.; Chessum, N.E.A.; Rye, C.S.; Pasqua, A.Elisa.; Tucker, M.J.; Wilding, B.; Evans, L.E.; Lepri, S.; Richards, M.; Sharp, S.Y.; Ali, S.; Rowlands, M.; O'Fee, L.; Miah, A.; Hayes, A.; Henley, A.T.; Powers, M.; Te Poele, R.; De Billy, E.; Pellegrino, L.; Raynaud, F.; Burke, R.; van Montfort, R.L.M.; Eccles, S.A.; Workman, P.; Jones, K. 2017: Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. Journal of Medicinal Chemistry 60(1): 180-201
Fu, Y.; Tang, S.; Su, Y.; Lan, X.; Ye, Y.; Zha, C.; Li, L.; Cao, J.; Chen, Y.; Jiang, L.; Huang, Y.; Ding, J.; Geng, M.; Huang, M.; Wan, H. 2017: Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(23): 5332-5336
Li, H.; Zhou, T.; Liu, H.; Xu, F.; Niu, Y.; Wang, C.; Liang, L.; Xu, P. 2017: Discovery of a cobalt complex with high MEK1 binding affinity. Bioorganic and Medicinal Chemistry Letters 27(10): 2221-2224
Chan, A.I.; McGregor, L.M.; Jain, T.; Liu, D.R. 2017: Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection. Journal of the American Chemical Society 139(30): 10192-10195
Abdelgawad, M.A.; Bakr, R.B.; El-Gendy, A.O.; Kamel, G.M.; Azouz, A.A.; Bukhari, S.Nasir.Abbas. 2017: Discovery of a COX-2 selective inhibitor hit with anti-inflammatory activity and gastric ulcer protective effect. Future Medicinal Chemistry 9(16): 1899-1912
Xu, F.; Nazari, B.; Moon, K.; Bushin, L.B.; Seyedsayamdost, M.R. 2017: Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. Journal of the American Chemical Society 139(27): 9203-9212
Li, Z.; Meng, Y.; Xu, S.; Shen, W.; Meng, Z.; Wang, Z.; Ding, G.; Huang, W.; Xiao, W.; Xu, J. 2017: Discovery of acylguanidine oseltamivir carboxylate derivatives as potent neuraminidase inhibitors. Bioorganic and Medicinal Chemistry 25(10): 2772-2781
Jarusiewicz, J.A.; Jeon, J.Yoon.; Connelly, M.C.; Chen, Y.; Yang, L.; Baker, S.D.; Guy, R.Kiplin. 2017: Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia. Acs Omega 2(5): 1985-2009
Burlein, C.; Wang, C.; Xu, M.; Bhatt, T.; Stahlhut, M.; Ou, Y.; Adam, G.C.; Heath, J.; Klein, D.J.; Sanders, J.; Narayan, K.; Abeywickrema, P.; Heo, M.Ra.; Carroll, S.S.; Grobler, J.A.; Sharma, S.; Diamond, T.L.; Converso, A.; Krosky, D.J. 2017: Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity. Acs Chemical Biology 12(11): 2858-2865
Harris, P.A.; Berger, S.B.; Jeong, J.U.; Nagilla, R.; Bandyopadhyay, D.; Campobasso, N.; Capriotti, C.A.; Cox, J.A.; Dare, L.; Dong, X.; Eidam, P.M.; Finger, J.N.; Hoffman, S.J.; Kang, J.; Kasparcova, V.; King, B.W.; Lehr, R.; Lan, Y.; Leister, L.K.; Lich, J.D.; MacDonald, T.T.; Miller, N.A.; Ouellette, M.T.; Pao, C.S.; Rahman, A.; Reilly, M.A.; Rendina, A.R.; Rivera, E.J.; Schaeffer, M.C.; Sehon, C.A.; Singhaus, R.R.; Sun, H.H.; Swift, B.A.; Totoritis, R.D.; Vossenkämper, A.; Ward, P.; Wisnoski, D.D.; Zhang, D.; Marquis, R.W.; Gough, P.J.; Bertin, J. 2017: Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. Journal of Medicinal Chemistry 60(4): 1247-1261
Zhang, Y.; Yan, J.; Yao, T-Pang. 2017: Discovery of a fluorescent probe with HDAC6 selective inhibition. European Journal of Medicinal Chemistry 141: 596-602
Carr, M.; Gonzalez, G.; Sasaki, M.; Ito, K.; Ishii, A.; Hang'ombe, B.M.; Mweene, A.S.; Orba, Y.; Sawa, H. 2017: Discovery of African bat polyomaviruses and infrequent recombination in the large T antigen in the Polyomaviridae. Journal of General Virology 98(4): 726-738
Taylor, Z.W.; Brown, H.A.; Narindoshvili, T.; Wenzel, C.Q.; Szymanski, C.M.; Holden, H.M.; Raushel, F.M. 2017: Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni. Journal of the American Chemical Society 139(28): 9463-9466
Lu, M-Chen.; Jiao, Q.; Liu, T.; Tan, S-Jie.; Zhou, H-Shan.; You, Q-Dong.; Jiang, Z-Yu. 2018: Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency. European Journal of Medicinal Chemistry 143: 1578-1589
Yeung, K-Sun.; Beno, B.R.; Parcella, K.; Bender, J.A.; Grant-Young, K.A.; Nickel, A.; Gunaga, P.; Anjanappa, P.; Bora, R.Onkardas.; Selvakumar, K.; Rigat, K.; Wang, Y-Kai.; Liu, M.; Lemm, J.; Mosure, K.; Sheriff, S.; Wan, C.; Witmer, M.; Kish, K.; Hanumegowda, U.; Zhuo, X.; Shu, Y-Zhong.; Parker, D.; Haskell, R.; Ng, A.; Gao, Q.; Colston, E.; Raybon, J.; Grasela, D.M.; Santone, K.; Gao, M.; Meanwell, N.A.; Sinz, M.; Soars, M.G.; Knipe, J.O.; Roberts, S.B.; Kadow, J.F. 2017: Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. Journal of Medicinal Chemistry 60(10): 4369-4385
Wang, W.; Lin, X-Dan.; Liao, Y.; Guan, X-Qing.; Guo, W-Ping.; Xing, J-Guang.; Holmes, E.C.; Zhang, Y-Zhen. 2017: Discovery of a Highly Divergent Coronavirus in the Asian House Shrew from China Illuminates the Origin of the Alphacoronaviruses. Journal of Virology 91(17)
Karatas, H.; Li, Y.; Liu, L.; Ji, J.; Lee, S.; Chen, Y.; Yang, J.; Huang, L.; Bernard, D.; Xu, J.; Townsend, E.C.; Cao, F.; Ran, X.; Li, X.; Wen, B.; Sun, D.; Stuckey, J.A.; Lei, M.; Dou, Y.; Wang, S. 2017: Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. Journal of Medicinal Chemistry 60(12): 4818-4839
Li, Y.; Guo, Q.; Zhang, C.; Huang, Z.; Wang, T.; Wang, X.; Wang, X.; Xu, G.; Liu, Y.; Yang, S.; Fan, Y.; Xiang, R. 2017: Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate. Bioorganic and Medicinal Chemistry Letters 27(15): 3231-3237
Gerken, P.A.; Wolstenhulme, J.R.; Tumber, A.; Hatch, S.B.; Zhang, Y.; Müller, S.; Chandler, S.A.; Mair, B.; Li, F.; Nijman, S.M.B.; Konietzny, R.; Szommer, T.; Yapp, C.; Fedorov, O.; Benesch, J.L.P.; Vedadi, M.; Kessler, B.M.; Kawamura, A.; Brennan, P.E.; Smith, M.D. 2017: Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7. Angewandte Chemie 56(49): 15555-15559
Scannevin, R.H.; Alexander, R.; Haarlander, T.Mezzasalma.; Burke, S.L.; Singer, M.; Huo, C.; Zhang, Y-Mei.; Maguire, D.; Spurlino, J.; Deckman, I.; Carroll, K.I.; Lewandowski, F.; Devine, E.; Dzordzorme, K.; Tounge, B.; Milligan, C.; Bayoumy, S.; Williams, R.; Schalk-Hihi, C.; Leonard, K.; Jackson, P.; Todd, M.; Kuo, L.C.; Rhodes, K.J. 2017: Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. Journal of Biological Chemistry 292(43): 17963-17974
Zhao, G.; Green, C.F.; Hui, Y-Hua.; Prieto, L.; Shepard, R.; Dong, S.; Wang, T.; Tan, B.; Gong, X.; Kays, L.; Johnson, R.L.; Wu, W.; Bhattachar, S.; Del Prado, M.; Gillig, J.R.; Fernandez, M-Carmen.; Roth, K.D.; Buchanan, S.; Kuo, M-Shang.; Geeganage, S.; Burkholder, T.P. 2017: Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration. Molecular Cancer Therapeutics 16(12): 2677-2688
Thomson, D.W.; Wagner, A.J.; Bantscheff, M.; Benson, R.Edward.; Dittus, L.; Duempelfeld, B.; Drewes, G.; Krause, J.; Moore, J.T.; Mueller, K.; Poeckel, D.; Rau, C.; Salzer, E.; Shewchuk, L.; Hopf, C.; Emery, J.G.; Muelbaier, M. 2017: Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. Journal of Medicinal Chemistry 60(13): 5455-5471
Kushwah, J.; Kumar, P.; Garg, V.; Somvanshi, V.Singh. 2017: Discovery of a Highly Virulent Strain of Photorhabdus luminescens ssp . akhurstii from Meghalaya, India. Indian Journal of Microbiology 57(1): 125-128
Takayama, K.; Mori, K.; Tanaka, A.; Nomura, E.; Sohma, Y.; Mori, M.; Taguchi, A.; Taniguchi, A.; Sakane, T.; Yamamoto, A.; Minamino, N.; Miyazato, M.; Kangawa, K.; Hayashi, Y. 2017: Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability. Journal of Medicinal Chemistry 60(12): 5228-5234
Sogabe, S.; Sakamoto, K.; Kamada, Y.; Kadotani, A.; Fukuda, Y.; Sakamoto, J-Ichi. 2017: Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization. Biochemical and Biophysical Research Communications 486(3): 620-625
Zhang, W-Yao.; Lu, W-Chao.; Jiang, H.; Lv, Z-Bing.; Xie, Y-Qian.; Lian, F-Lin.; Liang, Z-Jie.; Jiang, Y-Xi.; Wang, D-Jin.; Luo, C.; Jin, J.; Ye, F. 2017: Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors. Chemical Biology and Drug Design 90(6): 1260-1270
Iwatani-Yoshihara, M.; Ito, M.; Klein, M.G.; Yamamoto, T.; Yonemori, K.; Tanaka, T.; Miwa, M.; Morishita, D.; Endo, S.; Tjhen, R.; Qin, L.; Nakanishi, A.; Maezaki, H.; Kawamoto, T. 2017: Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. Journal of Medicinal Chemistry 60(13): 5759-5771
Yan, J.; Wang, G.; Dang, X.; Guo, B.; Chen, W.; Wang, T.; Zeng, L.; Wang, H.; Hu, Y. 2017: Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety. Bioorganic and Medicinal Chemistry 25(17): 4701-4714
Sharma, K.K.; Maurya, I.Kumar.; Khan, S.I.; Jacob, M.R.; Kumar, V.; Tikoo, K.; Jain, R. 2017: Discovery of a Membrane-Active, Ring-Modified Histidine Containing Ultrashort Amphiphilic Peptide That Exhibits Potent Inhibition of Cryptococcus neoformans. Journal of Medicinal Chemistry 60(15): 6607-6621
Steffen, W.; Ko, F.Chong.; Patel, J.; Lyamichev, V.; Albert, T.J.; Benz, Jörg.; Rudolph, M.G.; Bergmann, F.; Streidl, T.; Kratzsch, P.; Boenitz-Dulat, M.; Oelschlaegel, T.; Schraeml, M. 2017: Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins. Journal of Biological Chemistry 292(38): 15622-15635
Teng, M.; Wu, W.; Li, Z.; Yang, G.; Qin, J.; Wang, Y.; Hu, Z.; Dong, H.; Hou, L.; Hu, G.; Shen, L.; Zhang, Y.; Li, J.; Chen, S.; Tian, J.; Ye, L.; Zhang, J.; Wang, H. 2017: Discovery of aminocyclohexene analogues as selective and orally bioavailable hNav1.7 inhibitors for analgesia. Bioorganic and Medicinal Chemistry Letters 27(22): 4979-4984
Dai, Z.; Zhao, Y-Yang. 2017: Discovery of a murine model of clinical PAH: Mission impossible?. Trends in Cardiovascular Medicine 27(4): 229-236
Burks, H.E.; Abrams, T.; Kirby, C.A.; Baird, J.; Fekete, A.; Hamann, L.G.; Kim, S.; Lombardo, F.; Loo, A.; Lubicka, D.; Macchi, K.; McDonnell, D.P.; Mishina, Y.; Norris, J.D.; Nunez, J.; Saran, C.; Sun, Y.; Thomsen, N.M.; Wang, C.; Wang, J.; Peukert, S. 2017: Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer. Journal of Medicinal Chemistry 60(7): 2790-2818
Farkašová, H.; Hron, Táš.; Pačes, J.; Hulva, P.; Benda, P.; Gifford, R.James.; Elleder, D. 2017: Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae). Proceedings of the National Academy of Sciences of the United States of America 114(12): 3145-3150
Qiu, Z-Cheng.; Dong, X-Li.; Dai, Y.; Xiao, G-Keng.; Wang, X-Luan.; Wong, K-Chun.; Wong, M-Sau.; Yao, X-Sheng. 2016: Discovery of a New Class of Cathepsin K Inhibitors in Rhizoma Drynariae as Potential Candidates for the Treatment of Osteoporosis. International Journal of Molecular Sciences 17(12)
Yan, B.; Liu, L.; Huang, S.; Ren, Y.; Wang, H.; Yao, Z.; Li, L.; Chen, S.; Wang, X.; Zhang, Z. 2017: Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein. Chemical Communications 53(26): 3637-3640
Ramachandran, G.; Miguel-Arribas, Aés.; Abia, D.; Singh, P.K.; Crespo, I.; Gago-Córdoba, César.; Hao, J.An.; Luque-Ortega, J.Roman.; Alfonso, C.; Wu, L.J.; Boer, D.Roeland.; Meijer, W.J.J. 2017: Discovery of a new family of relaxases in Firmicutes bacteria. Plos Genetics 13(2): E1006586
Kumar, S.; Bharti, D.; Shazib, S.Uddin.Ahmed.; Shin, M.Kyoon. 2017: Discovery of a new hypotrich ciliate from petroleum contaminated soil. Plos one 12(6): E0178657
Chu, Z-Jian.; Sun, H-Huan.; Zhu, X-Guan.; Ying, S-Hua.; Feng, M-Guang. 2017: Discovery of a new intravacuolar protein required for the autophagy, development and virulence of Beauveria bassiana. Environmental Microbiology 19(7): 2806-2818
Zheng, L.; Shockey, J.; Guo, F.; Shi, L.; Li, X.; Shan, L.; Wan, S.; Peng, Z. 2017: Discovery of a new mechanism for regulation of plant triacylglycerol metabolism: The peanut diacylglycerol acyltransferase-1 gene family transcriptome is highly enriched in alternative splicing variants. Journal of Plant Physiology 219: 62-70
Gualdani, R.; Cavalluzzi, M.Maddalena.; Tadini-Buoninsegni, F.; Lentini, G. 2017: Discovery of a new mexiletine-derived agonist of the hERG K + channel. Biophysical Chemistry 229: 62-67
JurcuŢ, R.Oana.; Bastian, A.Eugenia.; Militaru, S.; Popa, A.; Manole, E.; Popescu, B.Alexandru.; Tallila, J.; Popescu, B.Ovidiu.; Ginghină, C.Doina. 2017: Discovery of a new mutation in the desmin gene in a young patient with cardiomyopathy and muscular weakness. Romanian Journal of Morphology and Embryology 58(1): 225-230
Abu El Asrar, R.; Margamuljana, L.; Klaassen, H.; Nijs, M.; Marchand, A.; Chaltin, P.; Myllykallio, H.; Becker, H.F.; De Jonghe, S.; Herdewijn, P.; Lescrinier, E. 2017: Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile. Biochemical Pharmacology 135: 69-78
Okuda, A.; Uranishi, K.; Suzuki, A. 2017: Discovery of a new role for the p53 family in the onset of mesendodermal differentiation of embryonic stem cells. Stem Cell Investigation 4: 24
Lemaitre, R. 2017: Discovery of a new species of hermit crab of the genus Pylopaguropsis Alcock, 1905 from the Caribbean: "den commensal" or "cleaner"? (Crustacea, Anomura, Paguridae). Zookeys 2017(646): 139-158
Wu, W.; Pang, X.; Lin, J.; Liu, X.; Wang, R.; Lin, J.; Chen, L. 2017: Discovery of a new subgroup of sulfur dioxygenases and characterization of sulfur dioxygenases in the sulfur metabolic network of Acidithiobacillus caldus. Plos one 12(9): E0183668
Valiante, V.; Mattern, D.J.; Schüffler, A.; Horn, F.; Walther, G.; Scherlach, K.; Petzke, L.; Dickhaut, J.; Guthke, R.; Hertweck, C.; Nett, M.; Thines, E.; Brakhage, A.A. 2017: Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. Acs Chemical Biology 12(5): 1227-1234
Perez, C.; Li, J.; Parlati, F.; Rouffet, M.; Ma, Y.; Mackinnon, A.L.; Chou, T-Fen.; Deshaies, R.J.; Cohen, S.M. 2017: Discovery of an Inhibitor of the Proteasome Subunit Rpn11. Journal of Medicinal Chemistry 60(4): 1343-1361
Zhang, X.; Cai, C.; Sui, Z.; Macielag, M.; Wang, Y.; Yan, W.; Suckow, A.; Hua, H.; Bell, A.; Haug, P.; Clapper, W.; Jenkinson, C.; Gunnet, J.; Leonard, J.; Murray, W.V. 2017: Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes. Acs Medicinal Chemistry Letters 8(9): 947-952
Fu, C.; Fu, B.; Peng, X.; Liao, G. 2017: Discovery of an Octahedral Silicon Complex as a Potent Antifungal Agent. Molecules 22(4)
Weinell, J.L.; Brown, R.M. 2018: Discovery of an old, archipelago-wide, endemic radiation of Philippine snakes. Molecular Phylogenetics and Evolution 119: 144-150
Larsen, I.Signe.Bohse.; Narimatsu, Y.; Joshi, H.Jitendra.; Siukstaite, L.; Harrison, O.J.; Brasch, J.; Goodman, K.M.; Hansen, L.; Shapiro, L.; Honig, B.; Vakhrushev, S.Y.; Clausen, H.; Halim, A. 2017: Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Proceedings of the National Academy of Sciences of the United States of America 114(42): 11163-11168
Gou, J.; Hao, F.; Huang, C.; Kwon, M.; Chen, F.; Li, C.; Liu, C.; Ro, D-Kyun.; Tang, H.; Zhang, Y. 2018: Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β-hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis. Plant Journal: for Cell and Molecular Biology 93(1): 92-106
Nakajima, K.; Chatelain, R.; Clairmont, K.B.; Commerford, R.; Coppola, G.M.; Daniels, T.; Forster, C.J.; Gilmore, T.A.; Gong, Y.; Jain, M.; Kanter, A.; Kwak, Y.; Li, J.; Meyers, C.D.; Neubert, A.D.; Szklennik, P.; Tedesco, V.; Thompson, J.; Truong, D.; Yang, Q.; Hubbard, B.K.; Serrano-Wu, M.H. 2017: Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans. Journal of Medicinal Chemistry 60(11): 4657-4664
Ha, H-Jin.; Kang, D.Wook.; Kim, H-Min.; Kang, J-Mi.; Ann, J.; Hyun, H.Jung.; Lee, J.Hwan.; Kim, S.Hee.; Kim, H.; Choi, K.; Hong, H-Seok.; Kim, Y.; Jo, D-Gyu.; Lee, J.; Lee, J. 2018: Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a β-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease. Journal of Medicinal Chemistry 61(1): 396-402
Mikami, S.; Sasaki, S.; Asano, Y.; Ujikawa, O.; Fukumoto, S.; Nakashima, K.; Oki, H.; Kamiguchi, N.; Imada, H.; Iwashita, H.; Taniguchi, T. 2017: Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders. Journal of Medicinal Chemistry 60(18): 7658-7676
Yu, W.; Li, C.; Zhang, W.; Xia, Y.; Li, S.; Lin, J-Yuh.; Yu, K.; Liu, M.; Yang, L.; Luo, J.; Chen, Y.; Sun, H.; Kong, L. 2017: Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking. Journal of Medicinal Chemistry 60(7): 2718-2731
Long, M.F.; Engers, J.L.; Chang, S.; Zhan, X.; Weiner, R.L.; Luscombe, V.B.; Rodriguez, A.L.; Cho, H.P.; Niswender, C.M.; Bridges, T.M.; Conn, P.Jeffrey.; Engers, D.W.; Lindsley, C.W. 2017: Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M 4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorganic and Medicinal Chemistry Letters 27(22): 4999-5001
Fang, P.; Fang, L.; Hong, Y.; Liu, X.; Dong, N.; Ma, P.; Bi, J.; Wang, D.; Xiao, S. 2017: Discovery of a novel accessory protein NS7a encoded by porcine deltacoronavirus. Journal of General Virology 98(2): 173-178
Hermanns, K.; Zirkel, F.; Kopp, A.; Marklewitz, M.; Rwego, I.; Estrada, A.; Gillespie, T.Robert.; Drosten, C.; Junglen, S. 2016: Discovery of a novel alphavirus related to Eilat virus. Journal of General Virology
Barlaam, B.; Cosulich, S.; Fitzek, M.; Germain, Hé.; Green, S.; Hanson, L.L.; Harris, C.S.; Hancox, U.; Hudson, K.; Lambert-van der Brempt, C.; Lamorlette, M.; Magnien, Fçoise.; Ouvry, G.; Page, K.; Ruston, L.; Ward, L.; Delouvrié, Bénédicte. 2017: Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors. Bioorganic and Medicinal Chemistry Letters 27(13): 3030-3035
Tang, J.; Jones, S.A.; Jeffrey, J.L.; Miranda, S.R.; Galardi, C.M.; Irlbeck, D.M.; Brown, K.W.; McDanal, C.B.; Johns, B.A. 2017: Discovery of a novel and potent class of anti-HIV-1 maturation inhibitors with improved virology profile against gag polymorphisms. Bioorganic and Medicinal Chemistry Letters 27(12): 2689-2694
Crosignani, S.; Bingham, P.; Bottemanne, P.; Cannelle, Hélène.; Cauwenberghs, S.; Cordonnier, M.; Dalvie, D.; Deroose, F.; Feng, J.Li.; Gomes, B.; Greasley, S.; Kaiser, S.E.; Kraus, M.; Négrerie, M.; Maegley, K.; Miller, N.; Murray, B.W.; Schneider, M.; Soloweij, J.; Stewart, A.E.; Tumang, J.; Torti, V.R.; Van Den Eynde, B.; Wythes, M. 2017: Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. Journal of Medicinal Chemistry 60(23): 9617-9629
Mayer, Fçois.L.; Kronstad, J.W. 2017: Discovery of a Novel Antifungal Agent in the Pathogen Box. Msphere 2(2)
Wada, Y.; Orba, Y.; Sasaki, M.; Kobayashi, S.; Carr, M.J.; Nobori, H.; Sato, A.; Hall, W.W.; Sawa, H. 2017: Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virus. Virology 505: 102-112
Yasui, T.; Yamamoto, T.; Sakai, N.; Asano, K.; Takai, T.; Yoshitomi, Y.; Davis, M.; Takagi, T.; Sakamoto, K.; Sogabe, S.; Kamada, Y.; Lane, W.; Snell, G.; Iwata, M.; Goto, M.; Inooka, H.; Sakamoto, J-Ichi.; Nakada, Y.; Imaeda, Y. 2017: Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design. Bioorganic and Medicinal Chemistry 25(17): 4876-4886
Lu, S.; Wang, Y.; Chen, Y.; Wu, B.; Qin, K.; Zhao, J.; Lou, Y.; Tan, W. 2017: Discovery of a novel canine respiratory coronavirus support genetic recombination among betacoronavirus1. Virus Research 237: 7-13
Wang, F.; Li, Z.; Zhang, T.; Yan, G.; Hu, M.; Zhao, L.; Zhao, Y.; Chen, Y. 2018: Discovery of a novel class of pyridine derivatives that selectively inhibits mutant isocitrate dehydrogenase 2. Chemical Biology and Drug Design 91(6): 1087-1093
Pinard, E.; Green, L.; Reutlinger, M.; Weetall, M.; Naryshkin, N.A.; Baird, J.; Chen, K.S.; Paushkin, S.V.; Metzger, F.; Ratni, H. 2017: Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy. Journal of Medicinal Chemistry 60(10): 4444-4457
Bewley, B.R.; Spearing, P.K.; Weiner, R.L.; Luscombe, V.B.; Zhan, X.; Chang, S.; Cho, H.P.; Rodriguez, A.L.; Niswender, C.M.; Conn, P.Jeffrey.; Bridges, T.M.; Engers, D.W.; Lindsley, C.W. 2017: Discovery of a novel, CNS penetrant M 4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core. Bioorganic and Medicinal Chemistry Letters 27(18): 4274-4279
Clissold, R.L.; Clarke, H.C.; Spasic-Boskovic, O.; Brugger, K.; Abbs, S.; Bingham, C.; Shaw-Smith, C. 2017: Discovery of a novel dominant mutation in the REN gene after forty years of renal disease: a case report. BMC nephrology 18(1): 234
Wang, Y.; Lin, H-Quan.; Wang, P.; Hu, J-Shu.; Ip, T-Ming.; Yang, L-Meng.; Zheng, Y-Tang.; Chi-Cheong Wan, D. 2017: Discovery of a Novel HIV-1 Integrase/p75 Interacting Inhibitor by Docking Screening, Biochemical Assay, and in Vitro Studies. Journal of Chemical Information and Modeling 57(9): 2336-2343
Yang, K.L.; Lin, P.Y. 2017: Discovery of a novel HLA-A*02 variant, HLA-A*02:684, in a Taiwanese individual. Hla 90(5): 301-302
Liu, B.; Lv, J.; Ma, Z. 2017: Discovery of a novel HLA-B*07 variant, HLA-B*07:294, in a Chinese individual. Hla 90(4): 251-252
Kremer, L.; Schultz-Fademrecht, C.; Baumann, M.; Habenberger, P.; Choidas, A.; Klebl, B.; Kordes, S.; Schöler, H.R.; Sterneckert, J.; Ziegler, S.; Schneider, G.; Waldmann, H. 2017: Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction. Angewandte Chemie 56(42): 13021-13025
Sampson, K.; Zaitseva, J.; Stauffer, M.; Vande Berg, B.; Guo, R.; Tomso, D.; McNulty, B.; Desai, N.; Balasubramanian, D. 2017: Discovery of a novel insecticidal protein from Chromobacterium piscinae, with activity against Western Corn Rootworm, Diabrotica virgifera virgifera. Journal of Invertebrate Pathology 142: 34-43
Hatziioanou, D.; Gherghisan-Filip, C.; Saalbach, G.; Horn, N.; Wegmann, U.; Duncan, S.H.; Flint, H.J.; Mayer, M.J.; Narbad, A. 2017: Discovery of a novel lantibiotic nisin O from Blautia obeum A2-162, isolated from the human gastrointestinal tract. Microbiology 163(9): 1292-1305
Healy, A.R.; Houston, D.R.; Remnant, L.; Huart, A-Sophie.; Brychtova, V.; Maslon, M.M.; Meers, O.; Muller, P.; Krejci, A.; Blackburn, E.A.; Vojtesek, B.; Hernychova, L.; Walkinshaw, M.D.; Westwood, N.J.; Hupp, T.R. 2015: Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin. Chemical Science 6(5): 3109-3116
Malmquist, J.; Varnäs, K.; Svedberg, M.; Vallée, Fédéric.; Albert, J.S.; Finnema, S.J.; Schou, M. 2018: Discovery of a Novel Muscarinic Receptor PET Radioligand with Rapid Kinetics in the Monkey Brain. Acs Chemical Neuroscience 9(2): 224-229
Hossain, S.; Boon, E.M. 2017: Discovery of a Novel Nitric Oxide Binding Protein and Nitric-Oxide-Responsive Signaling Pathway in Pseudomonas aeruginosa. Acs Infectious Diseases 3(6): 454-461
Zhang, J.; Su, L.; Ye, Q.; Zhang, S.; Kung, H.; Jiang, F.; Jiang, G.; Miao, J.; Zhao, B. 2017: Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells. Oncotarget 8(5): 7625-7636
Hand, J.M.; Zhang, K.; Wang, L.; Koganti, P.P.; Mastrantoni, K.; Rajput, S.K.; Ashry, M.; Smith, G.W.; Yao, J. 2017: Discovery of a novel oocyte-specific Krüppel-associated box domain-containing zinc finger protein required for early embryogenesis in cattle. Mechanisms of Development 144(Pt B): 103-112
Hong, S.Pyo.; Ahn, S.Kil. 2017: Discovery of a novel pan-RAF inhibitor with potent anti-tumor activity in preclinical models of BRAF V600E mutant cancer. Life Sciences 183: 37-44
Sakuna, K.; Elliman, J.; Owens, L. 2017: Discovery of a novel Picornavirales, Chequa iflavirus, from stressed redclaw crayfish (Cherax quadricarinatus) from farms in northern Queensland, Australia. Virus Research 238: 148-155
Yamada, K.; Brousseau, M.; Honma, W.; Iimura, A.; Imase, H.; Iwaki, Y.; Kawanami, T.; LaSala, D.; Liang, G.; Mitani, H.; Nonomura, K.; Ohmori, O.; Pan, M.; Rigel, D.F.; Umemura, I.; Yasoshima, K.; Zhu, G.; Mogi, M. 2017: Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma. Journal of Medicinal Chemistry 60(20): 8466-8481
Adachi, R.; Okada, K.; Skene, R.; Ogawa, K.; Miwa, M.; Tsuchinaga, K.; Ohkubo, S.; Henta, T.; Kawamoto, T. 2017: Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline. Biochemical and Biophysical Research Communications 488(2): 393-399
Yang, C.; Zhang, X.; Wang, Y.; Yang, Y.; Liu, X.; Deng, M.; Jia, Y.; Ling, Y.; Meng, L-Hua.; Zhou, Y. 2017: Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity. Acs Medicinal Chemistry Letters 8(8): 875-880
Singh, S.; Goo, J-Il.; Noh, H.; Lee, S.Jae.; Kim, M.Woo.; Park, H.; Jalani, H.B.; Lee, K.; Kim, C.; Kim, W-Ki.; Ju, C.; Choi, Y. 2017: Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality. Bioorganic and Medicinal Chemistry 25(4): 1394-1405
Nance, K.D.; Days, E.L.; Weaver, C.David.; Coldren, A.; Farmer, T.D.; Cho, H.P.; Niswender, C.M.; Blobaum, A.L.; Niswender, K.D.; Lindsley, C.W. 2017: Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core. Journal of Medicinal Chemistry 60(4): 1611-1616
Mikami, S.; Kawasaki, M.; Ikeda, S.; Negoro, N.; Nakamura, S.; Nomura, I.; Ashizawa, T.; Kokubo, H.; Hoffman, I.Dylan.; Zou, H.; Oki, H.; Uchiyama, N.; Hiura, Y.; Miyamoto, M.; Itou, Y.; Nakashima, M.; Iwashita, H.; Taniguchi, T. 2017: Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders. Chemical and Pharmaceutical Bulletin 65(11): 1058-1077
Anumala, U.Rao.; Waaler, J.; Nkizinkiko, Y.; Ignatev, A.; Lazarow, K.; Lindemann, P.; Olsen, P.Angell.; Murthy, S.; Obaji, E.; Majouga, A.G.; Leonov, S.; von Kries, J.Peter.; Lehtiö, L.; Krauss, S.; Nazaré, M. 2017: Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. Journal of Medicinal Chemistry 60(24): 10013-10025
Maheshwari, S.; Avula, S.R.; Singh, A.; Singh, L.Ravithej.; Palnati, G.R.; Arya, R.K.; Cheruvu, S.H.; Shahi, S.; Sharma, T.; Meena, S.; Singh, A.K.; Kant, R.; Riyazuddin, M.; Bora, H.K.; Siddiqi, M.I.; Gayen, J.R.; Sashidhara, K.V.; Datta, D. 2017: Discovery of a Novel Small-Molecule Inhibitor that Targets PP2A-β-Catenin Signaling and Restricts Tumor Growth and Metastasis. Molecular cancer therapeutics 16(9): 1791-1805
Hayashi, H.; Katayama, S.; Komura, T.; Hinuma, Y.; Yokoyama, T.; Mibu, K.; Oba, F.; Tanaka, I. 2017: Discovery of a Novel Sn(II)-Based Oxide β-SnMoO 4 for Daylight-Driven Photocatalysis. Advanced Science 4(1): 1600246
Lua, W-Heng.; Ling, W-Li.; Su, C.Tran-To.; Yeo, J.Yi.; Verma, C.Shekhar.; Eisenhaber, B.; Eisenhaber, F.; Gan, S.Ken-En. 2017: Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it. Cell Cycle 16(5): 457-467
Nirmala, J.; Saini, J.; Newcomb, M.; Olivera, P.; Gale, S.; Klindworth, D.; Elias, E.; Talbert, L.; Chao, S.; Faris, J.; Xu, S.; Jin, Y.; Rouse, M.N. 2017: Discovery of a Novel Stem Rust Resistance Allele in Durum Wheat that Exhibits Differential Reactions to Ug99 Isolates. G3 7(10): 3481-3490
Pan, Y.; Tian, X.; Qin, P.; Wang, B.; Zhao, P.; Yang, Y-Le.; Wang, L.; Wang, D.; Song, Y.; Zhang, X.; Huang, Y-Wei. 2017: Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China. Veterinary Microbiology 211: 15-21
Kinghorn, A.Douglas.; Carcache de Blanco, E.J.; Chai, H-Byung.; Orjala, J.; Farnsworth, N.R.; Soejarto, D.Doel.; Oberlies, N.H.; Wani, M.C.; Kroll, D.J.; Pearce, C.J.; Swanson, S.M.; Kramer, R.A.; Rose, W.C.; Fairchild, C.R.; Vite, G.D.; Emanuel, S.; Jarjoura, D.; Cope, F.O. 2009: Discovery of anticancer agents of diverse natural origin. Pure and Applied Chemistry. Chimie Pure et Appliquee 81(6): 1051-1063
Dhungat, J.Pai. 2017: Discovery of Anticoagulant Warfarin. Journal of the Association of Physicians of India 65(7): 115
Qiao, L.; Li, B.; Chen, Y.; Li, L.; Chen, X.; Wang, L.; Lu, F.; Luo, G.; Li, G.; Zhang, Y. 2016: Discovery of Anti-Hypertensive Oligopeptides from Adlay Based on In Silico Proteolysis and Virtual Screening. International Journal of Molecular Sciences 17(12)
Murata, T.; Maehara, T. 2016: Discovery of anti-inflammatory role of prostaglandin D 2. Journal of Veterinary Medical Science 78(11): 1643-1647
Maetani, M.; Kato, N.; Jabor, V.A.P.; Calil, F.A.; Nonato, M.Cristina.; Scherer, C.A.; Schreiber, S.L. 2017: Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. Acs Medicinal Chemistry Letters 8(4): 438-442
Ahmad, S.Junaidah.; Abdul Rahim, M.Badrin.Hanizam.; Baharum, S.Nataqain.; Baba, M.Shukri.; Zin, N.Mohamad. 2017: Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. Journal of Tropical Medicine 2017: 2189814
Shah, A.; Rather, M.A.; Hassan, Q.P.; Aga, M.A.; Mushtaq, S.; Shah, A.M.; Hussain, A.; Baba, S.A.; Ahmad, Z. 2017: Discovery of anti-microbial and anti-tubercular molecules from Fusarium solani: an endophyte of Glycyrrhiza glabra. Journal of Applied Microbiology 122(5): 1168-1176
Muytjens, C.M.J.; Yu, Y.; Diamandis, E.P. 2017: Discovery of Antimicrobial Peptides in Cervical-Vaginal Fluid from Healthy Nonpregnant Women via an Integrated Proteome and Peptidome Analysis. Proteomics 17(21)
Li, H.; Huang, H.; Hou, L.; Ju, J.; Li, W. 2017: Discovery of Antimycin-Type Depsipeptides from a wbl Gene Mutant Strain of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66 and Their Effects on Pro-inflammatory Cytokine Production. Frontiers in Microbiology 8: 678
Rais, R.; Vávra, J.; Tichý, Táš.; Dash, R.P.; Gadiano, A.J.; Tenora, Láš.; Monincová, L.; Bařinka, C.; Alt, J.; Zimmermann, S.C.; Slusher, C.Ethan.; Wu, Y.; Wozniak, K.; Majer, P.; Tsukamoto, T.; Slusher, B.S. 2017: Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain. Journal of Medicinal Chemistry 60(18): 7799-7809
Pinto, D.J.P.; Orwat, M.J.; Smith, L.M.; Quan, M.L.; Lam, P.Y.S.; Rossi, K.A.; Apedo, A.; Bozarth, J.M.; Wu, Y.; Zheng, J.J.; Xin, B.; Toussaint, N.; Stetsko, P.; Gudmundsson, O.; Maxwell, B.; Crain, E.J.; Wong, P.C.; Lou, Z.; Harper, T.W.; Chacko, S.A.; Myers, J.E.; Sheriff, S.; Zhang, H.; Hou, X.; Mathur, A.; Seiffert, D.A.; Wexler, R.R.; Luettgen, J.M.; Ewing, W.R. 2017: Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212). Journal of Medicinal Chemistry 60(23): 9703-9723
Moustakim, M.; Clark, P.G.K.; Trulli, L.; Fuentes de Arriba, A.L.; Ehebauer, M.T.; Chaikuad, A.; Murphy, E.J.; Mendez-Johnson, J.; Daniels, D.; Hou, C-Feng.D.; Lin, Y-Hui.; Walker, J.R.; Hui, R.; Yang, H.; Dorrell, L.; Rogers, C.M.; Monteiro, O.P.; Fedorov, O.; Huber, K.V.M.; Knapp, S.; Heer, J.; Dixon, D.J.; Brennan, P.E. 2017: Discovery of a PCAF Bromodomain Chemical Probe. Angewandte Chemie 56(3): 827-831
Perreault, S.; Chandrasekhar, J.; Cui, Z-Hua.; Evarts, J.; Hao, J.; Kaplan, J.A.; Kashishian, A.; Keegan, K.S.; Kenney, T.; Koditek, D.; Lad, L.; Lepist, E-Irene.; McGrath, M.E.; Patel, L.; Phillips, B.; Therrien, J.; Treiberg, J.; Yahiaoui, A.; Phillips, G. 2017: Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. Journal of Medicinal Chemistry 60(4): 1555-1567
Freestone, T.S.; Ju, K-San.; Wang, B.; Zhao, H. 2017: Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring. Acs Synthetic Biology 6(2): 217-223
Neumann, S.; Eliseeva, E.; Boutin, A.; Barnaeva, E.; Ferrer, M.; Southall, N.; Kim, D.; Hu, X.; Morgan, S.J.; Marugan, J.J.; Gershengorn, M.C. 2018: Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. Journal of Pharmacology and Experimental Therapeutics 364(1): 38-45
Schnute, M.E.; McReynolds, M.D.; Carroll, J.; Chrencik, J.; Highkin, M.K.; Iyanar, K.; Jerome, G.; Rains, J.W.; Saabye, M.; Scholten, J.A.; Yates, M.; Nagiec, M.M. 2017: Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits. Journal of Medicinal Chemistry 60(6): 2562-2572
Li, X.; Hernandez, V.; Rock, F.L.; Choi, W.; Mak, Y.S.L.; Mohan, M.; Mao, W.; Zhou, Y.; Easom, E.E.; Plattner, J.J.; Zou, W.; Pérez-Herrán, E.; Giordano, I.; Mendoza-Losana, A.; Alemparte, C.; Rullas, Jín.; Angulo-Barturen, Iñigo.; Crouch, S.; Ortega, Fátima.; Barros, D.; Alley, M.R.K. 2017: Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). Journal of Medicinal Chemistry 60(19): 8011-8026
Ke, Z.; Su, Z.; Zhang, X.; Cao, Z.; Ding, Y.; Cao, L.; Ding, G.; Wang, Z.; Liu, H.; Xiao, W. 2017: Discovery of a potent angiotensin converting enzyme inhibitor via virtual screening. Bioorganic and Medicinal Chemistry Letters 27(16): 3688-3692
Cuozzo, J.W.; Centrella, P.A.; Gikunju, D.; Habeshian, S.; Hupp, C.D.; Keefe, A.D.; Sigel, E.A.; Soutter, H.H.; Thomson, H.A.; Zhang, Y.; Clark, M.A. 2017: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library. Chembiochem: a European journal of chemical biology 18(9): 864-871
Humphreys, P.G.; Bamborough, P.; Chung, C-Wa.; Craggs, P.D.; Gordon, L.; Grandi, P.; Hayhow, T.G.; Hussain, J.; Jones, K.L.; Lindon, M.; Michon, A-Marie.; Renaux, J.F.; Suckling, C.J.; Tough, D.F.; Prinjha, R.K. 2017: Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. Journal of Medicinal Chemistry 60(2): 695-709
Jang, J.; Son, J.Beom.; To, C.; Bahcall, M.; Kim, S.Young.; Kang, S.Yong.; Mushajiang, M.; Lee, Y.; Jänne, P.A.; Choi, H.Geun.; Gray, N.S. 2017: Discovery of a potent dual ALK and EGFR T790M inhibitor. European Journal of Medicinal Chemistry 136: 497-510
Wu, W.; Zhang, Y.; Huang, J.; Wu, Y.; Liu, D.; Chen, Z. 2018: Discovery of a Potentially New Subfamily of ELFV Dehydrogenases Effective for l-Arginine Deamination by Enzyme Mining. Biotechnology journal 13(2)
Schönauer, E.; Kany, A.M.; Haupenthal, Jörg.; Hüsecken, K.; Hoppe, I.J.; Voos, K.; Yahiaoui, S.; Elsässer, B.; Ducho, C.; Brandstetter, H.; Hartmann, R.W. 2017: Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. Journal of the American Chemical Society 139(36): 12696-12703
Edupuganti, R.; Taliaferro, J.M.; Wang, Q.; Xie, X.; Cho, E.Jeong.; Vidhu, F.; Ren, P.; Anslyn, E.V.; Bartholomeusz, C.; Dalby, K.N. 2017: Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorganic and Medicinal Chemistry 25(9): 2609-2616
Chappell, M.D.; Li, R.; Smith, S.C.; Dressman, B.A.; Tromiczak, E.G.; Tripp, A.E.; Blanco, M-Jesus.; Vetman, T.; Quimby, S.J.; Matt, J.; Britton, T.C.; Fivush, A.M.; Schkeryantz, J.M.; Mayhugh, D.; Erickson, J.A.; Bures, M.G.; Jaramillo, C.; Carpintero, M.; Diego, Jé.Eugenio.de.; Barberis, M.; Garcia-Cerrada, S.; Soriano, Jé.F.; Antonysamy, S.; Atwell, S.; MacEwan, I.; Condon, B.; Sougias, C.; Wang, J.; Zhang, A.; Conners, K.; Groshong, C.; Wasserman, S.R.; Koss, J.W.; Witkin, J.M.; Li, X.; Overshiner, C.; Wafford, K.A.; Seidel, W.; Wang, X-Shan.; Heinz, B.A.; Swanson, S 2016: Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. Journal of Medicinal Chemistry 59(24): 10974-10993
Tamanini, E.; Buck, I.M.; Chessari, G.; Chiarparin, E.; Day, J.E.H.; Frederickson, M.; Griffiths-Jones, C.M.; Hearn, K.; Heightman, T.D.; Iqbal, A.; Johnson, C.N.; Lewis, E.J.; Martins, V.; Peakman, T.; Reader, M.; Rich, S.J.; Ward, G.A.; Williams, P.A.; Wilsher, N.E. 2017: Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). Journal of Medicinal Chemistry 60(11): 4611-4625
Verschueren, K.; Cobbaut, M.; Demaerel, J.; Saadah, L.; Voet, A.R.D.; Van Lint, J.; De Borggraeve, W.M. 2017: Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4- d ]pyrimidine analogues. Medchemcomm 8(3): 640-646
Erra, M.; Taltavull, J.; Gréco, A.; Bernal, F.Javier.; Caturla, J.Francisco.; Gràcia, J.; Domínguez, Mía.; Sabaté, M.; Paris, Séphane.; Soria, Sé.; Hernández, Bña.; Armengol, C.; Cabedo, J.; Bravo, Mónica.; Calama, E.; Miralpeix, M.; Lehner, M.D. 2017: Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. Acs Medicinal Chemistry Letters 8(1): 118-123
Li, Y.; Shi, Z.; Chen, L.; Zheng, S.; Li, S.; Xu, B.; Liu, Z.; Liu, J.; Deng, C.; Ye, F. 2017: Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes. Journal of Medicinal Chemistry 60(10): 4173-4184
Bezençon, O.; Heidmann, B.; Siegrist, R.; Stamm, S.; Richard, S.; Pozzi, D.; Corminboeuf, O.; Roch, C.; Kessler, M.; Ertel, E.A.; Reymond, I.; Pfeifer, T.; de Kanter, R.; Toeroek-Schafroth, M.; Moccia, L.G.; Mawet, J.; Moon, R.; Rey, M.; Capeleto, B.; Fournier, E. 2017: Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies. Journal of Medicinal Chemistry 60(23): 9769-9789
Zhao, M.; Zheng, Z-Zheng.; Chen, M.; Modjarrad, K.; Zhang, W.; Zhan, L-Ting.; Cao, J-Li.; Sun, Y-Peng.; McLellan, J.S.; Graham, B.S.; Xia, N-Shao. 2017: Discovery of a Prefusion Respiratory Syncytial Virus F-Specific Monoclonal Antibody That Provides Greater In Vivo Protection than the Murine Precursor of Palivizumab. Journal of Virology 91(15)
Chen, Z.; Liu, H.; Jain, A.; Zhang, L.; Liu, C.; Cheng, K. 2017: Discovery of Aptamer Ligands for Hepatic Stellate Cells Using SELEX. Theranostics 7(12): 2982-2995
Shepard, M.J.; Padmanaban, V.; Edwards, N.A.; Chittiboina, P.; Ray-Chaudhury, A.; Heiss, J.D. 2017: Discovery of Aquaporin-1 and Aquaporin-4 Expression in an Intramedullary Spinal Cord Ependymal Cyst: Case Report. World Neurosurgery 107: 1046.E1-1046.E7
Kinarivala, N.; Patel, R.; Boustany, R-Mary.; Al-Ahmad, A.; Trippier, P.C. 2017: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2). Journal of Medicinal Chemistry 60(23): 9739-9756
Wang, A.; Li, X.; Wu, H.; Zou, F.; Yan, X-E.; Chen, C.; Hu, C.; Yu, K.; Wang, W.; Zhao, P.; Wu, J.; Qi, Z.; Wang, W.; Wang, B.; Wang, L.; Ren, T.; Zhang, S.; Yun, C-Hong.; Liu, J.; Liu, Q. 2017: Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode. Journal of Medicinal Chemistry 60(7): 2944-2962
He, L.; Li, D.; Zhang, C.; Bai, P.; Chen, L. 2017: Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC. Bioorganic and Medicinal Chemistry Letters 27(17): 4171-4175
Schuller, M.; Riedel, K.; Gibbs-Seymour, I.; Uth, K.; Sieg, C.; Gehring, Aé.P.; Ahel, I.; Bracher, F.; Kessler, B.M.; Elkins, J.M.; Knapp, S. 2017: Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. Acs Chemical Biology 12(11): 2866-2874
Sun, J.; Ren, S-Zhen.; Lu, X-Yuan.; Li, J-Jing.; Shen, F-Qian.; Xu, C.; Zhu, H-Liang. 2017: Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors. Bioorganic and Medicinal Chemistry 25(9): 2593-2600
Barlaam, B.; Cosulich, S.; Degorce, Sébastien.; Ellston, R.; Fitzek, M.; Green, S.; Hancox, U.; Lambert-van der Brempt, C.; Lohmann, J-Jacques.; Maudet, Mël.; Morgentin, Rémy.; Plé, P.; Ward, L.; Warin, N. 2017: Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Bioorganic and Medicinal Chemistry Letters 27(9): 1949-1954
Hu, J.; Wang, Y.; Li, Y.; Xu, L.; Cao, D.; Song, S.; Damaneh, M.Soleimani.; Wang, X.; Meng, T.; Chen, Y-Lei.; Shen, J.; Miao, Z.; Xiong, B. 2017: Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor. European Journal of Medicinal Chemistry 137: 176-195
Pryde, D.C.; Marron, B.E.; West, C.W.; Reister, S.; Amato, G.; Yoger, K.; Antonio, B.; Padilla, K.; Cox, P.J.; Turner, J.; Warmus, J.S.; Swain, N.A.; Omoto, K.; Mahoney, J.H.; Gerlach, A.C. 2017: Discovery of a Series of Indazole TRPA1 Antagonists. Acs Medicinal Chemistry Letters 8(6): 666-671
Zhang, J.; Lv, X.; Ma, X.; Hu, Y. 2017: Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors. European Journal of Medicinal Chemistry 127: 509-520
Childs, S.P.; King, Z.R.; Walker, D.R.; Harris, D.K.; Pedley, K.F.; Buck, J.W.; Boerma, H.Roger.; Li, Z. 2018: Discovery of a seventh Rpp soybean rust resistance locus in soybean accession PI 605823. Tag. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik 131(1): 27-41
Dallimore, T.; Hunter, T.; Medlock, J.M.; Vaux, A.G.C.; Harbach, R.E.; Strode, C. 2017: Discovery of a single male Aedes aegypti (L.) in Merseyside, England. Parasites and Vectors 10(1): 309
Zhou, B.; Hu, J.; Xu, F.; Chen, Z.; Bai, L.; Fernandez-Salas, E.; Lin, M.; Liu, L.; Yang, C-Yie.; Zhao, Y.; McEachern, D.; Przybranowski, S.; Wen, B.; Sun, D.; Wang, S. 2018: Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. Journal of Medicinal Chemistry 61(2): 462-481
Quéméner, Aès.; Maillasson, M.; Arzel, L.; Sicard, B.; Vomiandry, R.; Mortier, E.; Dubreuil, D.; Jacques, Y.; Lebreton, J.; Mathé-Allainmat, M. 2017: Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization. Journal of Medicinal Chemistry 60(14): 6249-6272
Cheung, S.T.; Miller, M.S.; Pacoma, R.; Roland, J.; Liu, J.; Schumacher, A.M.; Hsieh-Wilson, L.C. 2017: Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. Acs Chemical Biology 12(12): 3126-3133
Rietz, A.; Li, H.; Quist, K.M.; Cherry, J.J.; Lorson, C.L.; Burnett, B.G.; Kern, N.L.; Calder, A.N.; Fritsche, M.; Lusic, H.; Boaler, P.J.; Choi, S.; Xing, X.; Glicksman, M.A.; Cuny, G.D.; Androphy, E.J.; Hodgetts, K.J. 2017: Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. Journal of Medicinal Chemistry 60(11): 4594-4610
Zhang, L.; Fu, L.; Zhang, S.; Zhang, J.; Zhao, Y.; Zheng, Y.; He, G.; Yang, S.; Ouyang, L.; Liu, B. 2017: Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chemical Science 8(4): 2687-2701
Talbot, J.J.; Houbraken, J.; Frisvad, J.C.; Samson, R.A.; Kidd, S.E.; Pitt, J.; Lindsay, S.; Beatty, J.A.; Barrs, V.R. 2017: Discovery of Aspergillus frankstonensis sp. nov. during environmental sampling for animal and human fungal pathogens. Plos one 12(8): E0181660
Thakral, D.; Tae, H.Seop. 2017: Discovery of a Structurally Unique Small Molecule that Inhibits Protein Synthesis. Yale Journal of Biology and Medicine 90(1): 35-43
Zhao, Z.; Pissarnitski, D.A.; Huang, X.; Palani, A.; Zhu, Z.; Greenlee, W.J.; Hyde, L.A.; Song, L.; Terracina, G.; Zhang, L.; Parker, E.M. 2017: Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators. Acs Medicinal Chemistry Letters 8(10): 1002-1006
Zhou, N.; Yan, Y.; Liu, C.; Hou, J.; Xu, W.; Zhang, Y. 2017: Discovery of a tetrahydroisoquinoline-based HDAC inhibitor with improved plasma stability. Bioorganic and Medicinal Chemistry 25(17): 4614-4619
Liu, T.; Gao, Y.; Zhang, X.; Wan, Y.; Du, L.; Fang, H.; Li, M. 2017: Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 Protein. Analytical Chemistry 89(21): 11173-11177
Ashrap, P.; Zheng, G.; Wan, Y.; Li, T.; Hu, W.; Li, W.; Zhang, H.; Zhang, Z.; Hu, J. 2017: Discovery of a widespread metabolic pathway within and among phenolic xenobiotics. Proceedings of the National Academy of Sciences of the United States of America 114(23): 6062-6067
Niehaus, T.D.; Elbadawi-Sidhu, M.; de Crécy-Lagard, Vérie.; Fiehn, O.; Hanson, A.D. 2017: Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight. Journal of Biological Chemistry 292(39): 16360-16367
Kindon, N.; Andrews, G.; Baxter, A.; Cheshire, D.; Hemsley, P.; Johnson, T.; Liu, Y-Zhen.; McGinnity, D.; McHale, M.; Mete, A.; Reuberson, J.; Roberts, B.; Steele, J.; Teobald, B.; Unitt, J.; Vaughan, D.; Walters, I.; Stocks, M.J. 2017: Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. Acs Medicinal Chemistry Letters 8(9): 981-986
Spiliotopoulos, D.; Wamhoff, E-Christian.; Lolli, G.; Rademacher, C.; Caflisch, A. 2017: Discovery of BAZ2A bromodomain ligands. European Journal of Medicinal Chemistry 139: 564-572
Mishra, C.Bhushan.; Kumari, S.; Angeli, A.; Monti, S.Maria.; Buonanno, M.; Tiwari, M.; Supuran, C.T. 2017: Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment. Journal of Medicinal Chemistry 60(6): 2456-2469
Wang, S.; Xu, L.; Lu, Y-Ting.; Liu, Y-Fei.; Han, B.; Liu, T.; Tang, J.; Li, J.; Wu, J.; Li, J-Ya.; Yu, L-Fang.; Yang, F. 2017: Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis. European Journal of Medicinal Chemistry 130: 195-208
Yasuda, D.; Yuasa, A.; Obata, R.; Nakajima, M.; Takahashi, K.; Ohe, T.; Ichimura, Y.; Komatsu, M.; Yamamoto, M.; Imamura, R.; Kojima, H.; Okabe, T.; Nagano, T.; Mashino, T. 2017: Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor. Bioorganic and Medicinal Chemistry Letters 27(22): 5006-5009
Paparin, J-Laurent.; Amador, Aès.; Badaroux, E.; Bot, Séphanie.; Caillet, C.; Convard, T.; Da Costa, D.; Dukhan, D.; Griffe, L.; Griffon, J-François.; LaColla, M.; Leroy, Fédéric.; Liuzzi, M.; Giulia Loi, A.; McCarville, J.; Mascia, V.; Milhau, J.; Onidi, L.; Pierra, C.; Rahali, R.; Rosinosky, E.; Sais, E.; Seifer, M.; Surleraux, D.; Standring, D.; Dousson, C.B. 2017: Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor. Bioorganic and Medicinal Chemistry Letters 27(11): 2634-2640
Alsaid, M.S.; Al-Mishari, A.A.; Soliman, A.M.; Ragab, F.A.; Ghorab, M.M. 2017: Discovery of Benzo[g]quinazolin benzenesulfonamide derivatives as dual EGFR/HER2 inhibitors. European Journal of Medicinal Chemistry 141: 84-91
Ma, H.; Zhuang, C.; Xu, X.; Li, J.; Wang, J.; Min, X.; Zhang, W.; Zhang, H.; Miao, Z. 2017: Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. European Journal of Medicinal Chemistry 133: 174-183
Enkhtaivan, G.; Muthuraman, P.; Kim, D.Hwan.; Mistry, B. 2017: Discovery of berberine based derivatives as anti-influenza agent through blocking of neuraminidase. Bioorganic and Medicinal Chemistry 25(20): 5185-5193
Zhuang, L.; Tice, C.M.; Xu, Z.; Zhao, W.; Cacatian, S.; Ye, Y-Jie.; Singh, S.B.; Lindblom, P.; McKeever, B.M.; Krosky, P.M.; Zhao, Y.; Lala, D.; Kruk, B.A.; Meng, S.; Howard, L.; Johnson, J.A.; Bukhtiyarov, Y.; Panemangalore, R.; Guo, J.; Guo, R.; Himmelsbach, F.; Hamilton, B.; Schuler-Metz, A.; Schauerte, H.; Gregg, R.; McGeehan, G.M.; Leftheris, K.; Claremon, D.A. 2017: Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor. Bioorganic and Medicinal Chemistry 25(14): 3649-3657
Gülbakan, B.; Özgül, Rıza.Köksal.; Yüzbaşıoğlu, Aşe.; Kohl, M.; Deigner, H-Peter.; Özgüç, M. 2016: Discovery of biomarkers in rare diseases: innovative approaches by predictive and personalized medicine. Epma Journal 7: 24
Jing, C.; Li, Z.; Jia, K.; Chen, C.; Liu, X.; Wang, B.; Hu, W.; Li, J.; Zhu, T.; Dong, S. 2017: Discovery of Bisindole as a Novel Scaffold for Protein Tyrosine Phosphatase 1B Inhibitors. Archiv der Pharmazie 350(1)
Zheng, B.Zhizhen.; D'Andrea, S.V.; Hanumegowda, U.; Knipe, J.O.; Mosure, K.; Zhuo, X.; Lemm, J.A.; Liu, M.; Rigat, K.L.; Wang, Y-Kai.; Fang, H.; Poronsky, C.; Cutrone, J.; Wu, D-Rurng.; Arunachalam, P.Nayagam.; Balapragalathan, T.J.; Arumugam, A.; Mathur, A.; Meanwell, N.A.; Gao, M.; Roberts, S.B.; Kadow, J.F. 2017: Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase. Bioorganic and Medicinal Chemistry Letters 27(15): 3294-3300
Zhang, J.; Zhang, S. 2017: Discovery of cancer common and specific driver gene sets. Nucleic Acids Research 45(10): E86
Wiktorowicz, J.E.; Soman, K.V. 2016: Discovery of Candidate Biomarkers. Advances in Experimental Medicine and Biology 919: 443-462
Ge, Y-Shu.; Han, Q-Qian.; Duan, W.; Zhang, J-Qi.; Chen, K.; Wan, J-Jia.; Liu, Y.; Liu, D. 2017: Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components. Chemmedchem 12(6): 438-447
Hoegenauer, K.; Soldermann, N.; Zécri, Fédéric.; Strang, R.S.; Graveleau, N.; Wolf, R.M.; Cooke, N.G.; Smith, A.B.; Hollingworth, G.J.; Blanz, J.; Gutmann, S.; Rummel, G.; Littlewood-Evans, A.; Burkhart, C. 2017: Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. Acs Medicinal Chemistry Letters 8(9): 975-980
Wang, Y.; Zhu, J.; Zhang, L. 2017: Discovery of Cell-Permeable O-GlcNAc Transferase Inhibitors via Tethering in Situ Click Chemistry. Journal of Medicinal Chemistry 60(1): 263-272
Onagi, J.; Komatsu, T.; Ichihashi, Y.; Kuriki, Y.; Kamiya, M.; Terai, T.; Ueno, T.; Hanaoka, K.; Matsuzaki, H.; Hata, K.; Watanabe, T.; Nagano, T.; Urano, Y. 2017: Discovery of Cell-Type-Specific and Disease-Related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism. Journal of the American Chemical Society 139(9): 3465-3472
Shi, X.; Li, D.; Wang, Y.; Liu, S.; Qin, J.; Wang, J.; Ran, J.; Zhang, Y.; Huang, Q.; Liu, X.; Zhou, J.; Liu, M. 2017: Discovery of Centrosomal Protein 70 as an Important Player in the Development and Progression of Breast Cancer. American Journal of Pathology 187(3): 679-688
Wu, C.; Du, C.; Ichinose, K.; Choi, Y.Hae.; van Wezel, G.P. 2017: Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow. Journal of Natural Products 80(2): 269-277
Bai, Y-Jia.; Xu, J-Di.; Kong, M.; Gao, Q.; Liu, L-Fang.; Li, S-Lin. 2015: Discovery of characteristic chemical markers for inspecting sulfur-fumigated Radix Angelicae Sinensis by ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry based metabolomics and chemical profiling approach. Food Research International 76(Pt 3): 387-394
Distel, D.L.; Altamia, M.A.; Lin, Z.; Shipway, J.Reuben.; Han, A.; Forteza, I.; Antemano, R.; Limbaco, M.Gwen.J.Peñaflor.; Tebo, A.G.; Dechavez, R.; Albano, J.; Rosenberg, G.; Concepcion, G.P.; Schmidt, E.W.; Haygood, M.G. 2017: Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory. Proceedings of the National Academy of Sciences of the United States of America 114(18): E3652-E3658
Adams, G.L.; Velazquez, F.; Jayne, C.; Shah, U.; Miao, S.; Ashley, E.R.; Madeira, M.; Akiyama, T.E.; Di Salvo, J.; Suzuki, T.; Wang, N.; Truong, Q.; Gilbert, E.; Zhou, D.; Verras, A.; Kirkland, M.; Pachanski, M.; Powles, M.; Yin, W.; Ujjainwalla, F.; Venkatraman, S.; Edmondson, S.D. 2017: Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents. Acs Medicinal Chemistry Letters 8(1): 96-101
Obaidullah, A.J.; Al-Horani, R.A. 2017: Discovery of Chromen-7-yl Furan-2-Carboxylate as a Potent and Selective Factor XIa Inhibitor. Cardiovascular and Hematological Agents in Medicinal Chemistry 15(1): 40-48
Jentsch, T.J. 2015: Discovery of CLC transport proteins: cloning, structure, function and pathophysiology. Journal of Physiology
Lee, K.L.; Ambler, C.M.; Anderson, D.R.; Boscoe, B.P.; Bree, A.G.; Brodfuehrer, J.I.; Chang, J.S.; Choi, C.; Chung, S.; Curran, K.J.; Day, J.E.; Dehnhardt, C.M.; Dower, K.; Drozda, S.E.; Frisbie, R.K.; Gavrin, L.K.; Goldberg, J.A.; Han, S.; Hegen, M.; Hepworth, D.; Hope, H.R.; Kamtekar, S.; Kilty, I.C.; Lee, A.; Lin, L-Ling.; Lovering, F.E.; Lowe, M.D.; Mathias, J.P.; Morgan, H.M.; Murphy, E.A.; Papaioannou, N.; Patny, A.; Pierce, B.S.; Rao, V.R.; Saiah, E.; Samardjiev, I.J.; Samas, B.M.; Shen, M.W.H.; Shin, J.H.; Soutter, H.H.; Strohbach, J.W. 2017: Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. Journal of Medicinal Chemistry 60(13): 5521-5542
Ye, X-Yang.; Chen, S.Y.; Wu, S.; Yoon, D.S.; Wang, H.; Hong, Z.; O'Connor, S.P.; Li, J.; Li, J.J.; Kennedy, L.J.; Walker, S.J.; Nayeem, A.; Sheriff, S.; Camac, D.M.; Ramamurthy, V.; Morin, P.E.; Zebo, R.; Taylor, J.R.; Morgan, N.N.; Ponticiello, R.P.; Harrity, T.; Apedo, A.; Golla, R.; Seethala, R.; Wang, M.; Harper, T.W.; Sleczka, B.G.; He, B.; Kirby, M.; Leahy, D.K.; Li, J.; Hanson, R.L.; Guo, Z.; Li, Y-Xin.; DiMarco, J.D.; Scaringe, R.; Maxwell, B.; Moulin, F.; Barrish, J.C.; Gordon, D.A.; Robl, J.A. 2017: Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. Journal of Medicinal Chemistry 60(12): 4932-4948
Swain, N.A.; Batchelor, D.; Beaudoin, S.; Bechle, B.M.; Bradley, P.A.; Brown, A.D.; Brown, B.; Butcher, K.J.; Butt, R.P.; Chapman, M.L.; Denton, S.; Ellis, D.; Galan, S.R.G.; Gaulier, S.M.; Greener, B.S.; de Groot, M.J.; Glossop, M.S.; Gurrell, I.K.; Hannam, J.; Johnson, M.S.; Lin, Z.; Markworth, C.J.; Marron, B.E.; Millan, D.S.; Nakagawa, S.; Pike, A.; Printzenhoff, D.; Rawson, D.J.; Ransley, S.J.; Reister, S.M.; Sasaki, K.; Storer, R.Ian.; Stupple, P.A.; West, C.W. 2017: Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7. Journal of Medicinal Chemistry 60(16): 7029-7042
Mikami, S.; Nakamura, S.; Ashizawa, T.; Nomura, I.; Kawasaki, M.; Sasaki, S.; Oki, H.; Kokubo, H.; Hoffman, I.D.; Zou, H.; Uchiyama, N.; Nakashima, K.; Kamiguchi, N.; Imada, H.; Suzuki, N.; Iwashita, H.; Taniguchi, T. 2017: Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders. Journal of Medicinal Chemistry 60(18): 7677-7702
Rangappa, P.; Zsigmondy, R.; Svedberg, T.H.E. 2009: Discovery of colloids. Journal of the Association of Physicians of India 57: 664
Chen, E.C.; Khuri, N.; Liang, X.; Stecula, A.; Chien, H-Chieh.; Yee, S.Wah.; Huang, Y.; Sali, A.; Giacomini, K.M. 2017: Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of Medicinal Chemistry 60(7): 2685-2696
Choudhary, P.; Armstrong, E.J.; Jorgensen, C.C.; Piotrowski, M.; Barthmes, M.; Torella, R.; Johnston, S.E.; Maruyama, Y.; Janiszewski, J.S.; Storer, R.Ian.; Skerratt, S.E.; Benn, C.L. 2017: Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter. Frontiers in Molecular Neuroscience 10: 40
Dong, S.; Lei, Y.; Jia, S.; Gao, L.; Li, J.; Zhu, T.; Liu, S.; Hu, W. 2017: Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction. Bioorganic and Medicinal Chemistry Letters 27(4): 1105-1108
Ramya, P.V.Sri.; Angapelly, S.; Angeli, A.; Digwal, C.Singh.; Arifuddin, M.; Babu, B.Nagendra.; Supuran, C.T.; Kamal, A. 2017: Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 32(1): 1274-1281
Wang, Z.; Shi, X.; Zhang, H.; Yu, L.; Cheng, Y.; Zhang, H.; Zhang, H.; Zhou, J.; Chen, J.; Shen, X.; Duan, W. 2017: Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry 139: 128-152
Pinho, P.; Kalayanov, G.; Westerlind, H.; Rosenquist, Åsa.; Wähling, H.; Sund, C.; Almeida, M.; Ayesa, S.; Tejbrant, J.; Targett-Adams, P.; Eneroth, A.; Lindqvist, A. 2017: Discovery of β-d-2'-deoxy-2'-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication. Bioorganic and Medicinal Chemistry Letters 27(15): 3468-3471
Hu, Y.; Zhang, J.; Musharrafieh, R.Ghassan.; Ma, C.; Hau, R.; Wang, J. 2017: Discovery of dapivirine, a nonnucleoside HIV-1 reverse transcriptase inhibitor, as a broad-spectrum antiviral against both influenza A and B viruses. Antiviral Research 145: 103-113
Zhang, J.; Qian, K.; Yan, C.; He, M.; Jassim, B.A.; Ivanov, I.; Zheng, Y.George. 2017: Discovery of Decamidine as a New and Potent PRMT1 Inhibitor. Medchemcomm 8(2): 440-444
Huang, R-Zhen.; Liang, G-Bin.; Huang, X-Chao.; Zhang, B.; Zhou, M-Mei.; Liao, Z-Xin.; Wang, H-Shan. 2017: Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. European Journal of Medicinal Chemistry 138: 979-992
Lévy, P.; Pacot, L.; Bastard, J-Philippe.; Vatier, C. 2017: Discovery of diabetes in the elderly: what diagnosis?. Annales de Biologie Clinique 75(2): 222-224
Wang, F.; Wang, B.; Wang, L.; Xiong, Z-Yue.; Gao, W.; Li, P.; Li, H-Jun. 2017: Discovery of discriminatory quality control markers for Chinese herbal medicines and related processed products by combination of chromatographic analysis and chemometrics methods: Radix Scutellariae as a case study. Journal of Pharmaceutical and Biomedical Analysis 138: 70-79
Xin, L-Ting.; Liu, L.; Shao, C-Lun.; Yu, R-Lei.; Chen, F-Ling.; Yue, S-Jun.; Wang, M.; Guo, Z-Long.; Fan, Y-Chu.; Guan, H-Shi.; Wang, C-Yun. 2017: Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products. Marine Drugs 15(7)
Kalluri, R.; LeBleu, V.S. 2016: Discovery of Double-Stranded Genomic DNA in Circulating Exosomes. Cold Spring Harbor Symposia on Quantitative Biology 81: 275-280
Tomonaga, T. 2017: Discovery of drug targets by quantitative proteomics and their clinical application. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 149(3): 123-127
Fukuda, T.; Goto, R.; Kiho, T.; Ueda, K.; Muramatsu, S.; Hashimoto, M.; Aki, A.; Watanabe, K.; Tanaka, N. 2017: Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorganic and Medicinal Chemistry Letters 27(23): 5252-5257
Fukuda, T.; Goto, R.; Kiho, T.; Ueda, K.; Muramatsu, S.; Hashimoto, M.; Aki, A.; Watanabe, K.; Tanaka, N. 2017: Discovery of DS79182026: A potent orally active hepcidin production inhibitor. Bioorganic and Medicinal Chemistry Letters 27(16): 3716-3722
Goff, D.; Zhang, J.; Heckrodt, T.; Yu, J.; Ding, P.; Singh, R.; Holland, S.; Li, W.; Irving, M. 2017: Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy. Bioorganic and Medicinal Chemistry Letters 27(16): 3766-3771
Izawa, K.; Kuwahara, H.; Sugaya, K.; Lo, N.; Ohkuma, M.; Hongoh, Y. 2017: Discovery of ectosymbiotic Endomicrobium lineages associated with protists in the gut of stolotermitid termites. Environmental Microbiology Reports 9(4): 411-418
Liang, J-Hua.; Yang, L.; Wu, S.; Liu, S-Si.; Cushman, M.; Tian, J.; Li, N-Min.; Yang, Q-Hu.; Zhang, H-Ao.; Qiu, Y-Jie.; Xiang, L.; Ma, C-Xuan.; Li, X-Meng.; Qing, H. 2017: Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood. European Journal of Medicinal Chemistry 136: 382-392
Park, H.; Jung, H-Yun.; Mah, S.; Hong, S. 2017: Discovery of EGF Receptor Inhibitors That Are Selective for the d746-750/T790M/C797S Mutant through Structure-Based de Novo Design. Angewandte Chemie 56(26): 7634-7638
Ballantyne, J.C.; Sullivan, M.D. 2017: Discovery of endogenous opioid systems: what it has meant for the clinician's understanding of pain and its treatment. Pain 158(12): 2290-2300
Xue, X.; Zhou, Z.; Dong, G.; Feng, M.; Zhang, Y.; Zhao, S.; Hu, Z.; Ren, W.; Ye, Z-Guang.; Liu, Y.; Liu, M. 2017: Discovery of Enhanced Magnetoelectric Coupling through Electric Field Control of Two-Magnon Scattering within Distorted Nanostructures. Acs Nano 11(9): 9286-9293
Yan, Y.; Du, S.; Ji, Y.; Su, N.; Wang, Y.; Mei, X.; Zhu, W.; He, D.; Lu, Y.; Zhang, C.; Xing, X-Hui. 2017: Discovery of enzymatically depolymerized heparins capable of treating Bleomycin-induced pulmonary injury and fibrosis in mice. Carbohydrate Polymers 174: 82-88
Wang, S-Rong.; Xu, T.; Deng, K.; Wong, C-Wai.; Liu, J.; Fang, W-Shuo. 2017: Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods. Molecules 22(5)
Sandham, D.A.; Barker, L.; Brown, L.; Brown, Z.; Budd, D.; Charlton, S.J.; Chatterjee, D.; Cox, B.; Dubois, G.; Duggan, N.; Hall, E.; Hatto, J.; Maas, J.; Manini, J.; Profit, R.; Riddy, D.; Ritchie, C.; Sohal, B.; Shaw, D.; Stringer, R.; Sykes, D.A.; Thomas, M.; Turner, K.L.; Watson, S.J.; West, R.; Willard, E.; Williams, G.; Willis, J. 2017: Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP 2 Receptor Antagonist for Treatment of Asthma. Acs Medicinal Chemistry Letters 8(5): 582-586
Huang, Y.; Zhang, J.; Yu, Z.; Zhang, H.; Wang, Y.; Lingel, A.; Qi, W.; Gu, J.; Zhao, K.; Shultz, M.D.; Wang, L.; Fu, X.; Sun, Y.; Zhang, Q.; Jiang, X.; Zhang, J.; Zhang, C.; Li, L.; Zeng, J.; Feng, L.; Zhang, C.; Liu, Y.; Zhang, M.; Zhang, L.; Zhao, M.; Gao, Z.; Liu, X.; Fang, D.; Guo, H.; Mi, Y.; Gabriel, T.; Dillon, M.P.; Atadja, P.; Oyang, C. 2017: Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. Journal of Medicinal Chemistry 60(6): 2215-2226
Lequime, S.; Lambrechts, L. 2017: Discovery of flavivirus-derived endogenous viral elements in Anopheles mosquito genomes supports the existence of Anopheles -associated insect-specific flaviviruses. Virus Evolution 3(1): Vew035
Zhao, H.; Lu, Y.; Sheng, L.; Yuan, Z.; Wang, B.; Wang, W.; Li, Y.; Ma, C.; Wang, X.; Zhang, D.; Huang, H. 2017: Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis. Acs Medicinal Chemistry Letters 8(5): 533-537
Huard, K.; Ahn, K.; Amor, P.; Beebe, D.A.; Borzilleri, K.A.; Chrunyk, B.A.; Coffey, S.B.; Cong, Y.; Conn, E.L.; Culp, J.S.; Dowling, M.S.; Gorgoglione, M.F.; Gutierrez, J.A.; Knafels, J.D.; Lachapelle, E.A.; Pandit, J.; Parris, K.D.; Perez, S.; Pfefferkorn, J.A.; Price, D.A.; Raymer, B.; Ross, T.T.; Shavnya, A.; Smith, A.C.; Subashi, T.A.; Tesz, G.J.; Thuma, B.A.; Tu, M.; Weaver, J.D.; Weng, Y.; Withka, J.M.; Xing, G.; Magee, T.V. 2017: Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). Journal of Medicinal Chemistry 60(18): 7835-7849
Saha, T.Kumar.; Katebi, A.; Dhifli, W.; Al Hasan, M. 2019: Discovery of Functional Motifs from the Interface Region of Oligomeric Proteins Using Frequent Subgraph Mining. Ieee/Acm Transactions on Computational Biology and Bioinformatics 16(5): 1537-1549
Matsuoka, M.; Kumar, A.; Muddassar, M.; Matsuyama, A.; Yoshida, M.; Zhang, K.Y.J. 2017: Discovery of Fungal Denitrification Inhibitors by Targeting Copper Nitrite Reductase from Fusarium oxysporum. Journal of Chemical Information and Modeling 57(2): 203-213
Muthukaman, N.; Tambe, M.; Deshmukh, S.; Pisal, D.; Tondlekar, S.; Shaikh, M.; Sarode, N.; Kattige, V.G.; Pisat, M.; Sawant, P.; Honnegowda, S.; Karande, V.; Kulkarni, A.; Behera, D.; Jadhav, S.B.; Sangana, R.R.; Gudi, G.S.; Khairatkar-Joshi, N.; Gharat, L.A. 2017: Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1. Bioorganic and Medicinal Chemistry Letters 27(23): 5131-5138
Jernigan, F.E.; Hanai, J-Ichi.; Sukhatme, V.P.; Sun, L. 2017: Discovery of furan carboxylate derivatives as novel inhibitors of ATP-citrate lyase via virtual high-throughput screening. Bioorganic and Medicinal Chemistry Letters 27(4): 929-935
Oba, M.; Katayama, Y.; Naoi, Y.; Tsuchiaka, S.; Omatsu, T.; Okumura, A.; Nagai, M.; Mizutani, T. 2017: Discovery of fur seal feces-associated circular DNA virus in swine feces in Japan. Journal of Veterinary Medical Science 79(10): 1664-1666
Chen, Y.; Li, C.; Zheng, Y.; Gao, Y.; Hu, J.; Chen, H. 2017: Discovery of FZU-03,010 as a self-assembling anticancer amphiphile for acute myeloid leukemia. Bioorganic and Medicinal Chemistry Letters 27(4): 1007-1011
Yoo, M-Won.; Park, J.; Han, H-Seung.; Yun, Y-Min.; Kang, J.Won.; Choi, D-Young.; Lee, J.Won.; Jung, J.Hun.; Lee, K-Yung.; Kim, K.Pyo. 2017: Discovery of gastric cancer specific biomarkers by the application of serum proteomics. Proteomics 17(6)
Metcalf, B.; Chuang, C.; Dufu, K.; Patel, M.P.; Silva-Garcia, A.; Johnson, C.; Lu, Q.; Partridge, J.R.; Patskovska, L.; Patskovsky, Y.; Almo, S.C.; Jacobson, M.P.; Hua, L.; Xu, Q.; Gwaltney, S.L.; Yee, C.; Harris, J.; Morgan, B.P.; James, J.; Xu, D.; Hutchaleelaha, A.; Paulvannan, K.; Oksenberg, D.; Li, Z. 2017: Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. Acs Medicinal Chemistry Letters 8(3): 321-326
Wang, W.; Yan, H.; Yu, J.; Yi, J.; Qu, Y.; Fu, M.; Chen, A.; Tang, H.; Niu, L. 2017: Discovery of genome-wideSNPs by RAD-seqand the genetic diversity of captive hog deer (Axis porcinus). Plos one 12(3): E0174299
Hans, Jörg.B.; Vigilant, L. 2018: Discovery of gorilla MHC-C expressing C1 ligand for KIR. Immunogenetics 70(5): 293-304
Möller, D.; Banerjee, A.; Uzuneser, T.C.; Skultety, M.; Huth, T.; Plouffe, B.; Hübner, H.; Alzheimer, C.; Friedland, K.; Müller, C.P.; Bouvier, M.; Gmeiner, P. 2017: Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure. Journal of Medicinal Chemistry 60(7): 2908-2929
Cheung, M.; Bao, W.; Behm, D.J.; Brooks, C.A.; Bury, M.J.; Dowdell, S.E.; Eidam, H.S.; Fox, R.M.; Goodman, K.B.; Holt, D.A.; Lee, D.; Roethke, T.J.; Willette, R.N.; Xu, X.; Ye, G.; Thorneloe, K.S. 2017: Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4. Acs Medicinal Chemistry Letters 8(5): 549-554
Khatra, H.; Bose, C.; Sinha, S. 2017: Discovery of Hedgehog Antagonists for Cancer Therapy. Current Medicinal Chemistry 24(19): 2033-2058
Ren, Q.; Liu, X.; Luo, Z.; Li, J.; Wang, C.; Goldmann, S.; Zhang, J.; Zhang, Y. 2017: Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4). Bioorganic and Medicinal Chemistry 25(3): 1042-1056
Larochelle, J. 2017: Discovery of Hereditary Tyrosinemia in Saguenay- Lac St-Jean. Advances in Experimental Medicine and Biology 959: 3-8
Chen, X.; Wu, H.; Park, C-Min.; Poole, T.H.; Keceli, G.; Devarie-Baez, N.O.; Tsang, A.W.; Lowther, W.Todd.; Poole, L.B.; King, S.Bruce.; Xian, M.; Furdui, C.M. 2017: Discovery of Heteroaromatic Sulfones As a New Class of Biologically Compatible Thiol-Selective Reagents. Acs Chemical Biology 12(8): 2201-2208
Zhang, D.; Liang, Z.; Liu, S.; Li, L.; Ma, P.; Zhao, S.; Wang, H.; Wang, J.; Niu, J. 2017: Discovery of Heteropolytantalate: Synthesis and Structure of Two 6-Peroxotantalo-4-phosphate Clusters. Inorganic Chemistry 56(10): 5537-5543
Kobayashi, K.; Kobayashi, H.; Maesato, M.; Hayashi, M.; Yamamoto, T.; Yoshioka, S.; Matsumura, S.; Sugiyama, T.; Kawaguchi, S.; Kubota, Y.; Nakanishi, H.; Kitagawa, H. 2017: Discovery of Hexagonal Structured Pd-B Nanocrystals. Angewandte Chemie 56(23): 6578-6582
Lu, S.; Ji, M.; Ni, D.; Zhang, J. 2018: Discovery of hidden allosteric sites as novel targets for allosteric drug design. Drug Discovery Today 23(2): 359-365
Wei, W.; Wu, Z.; Huang, M.; Hsu, C-Hao.; Liu, Y.; Zhang, X.; Xiong, H. 2017: Discovery of hierarchical superstructures in block copolymers by integrating different liquid crystalline interactions. Soft Matter 13(14): 2583-2589
Li, L.; Jiang, X.; Huang, S.; Ying, Z.; Zhang, Z.; Pan, C.; Li, S.; Wang, X.; Zhang, Z. 2017: Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. Acs Medicinal Chemistry Letters 8(4): 407-412
Lorthiois, E.; Anderson, K.; Vulpetti, A.; Rogel, O.; Cumin, F.; Ostermann, N.; Steinbacher, S.; Mac Sweeney, A.; Delgado, O.; Liao, S-Mei.; Randl, S.; Rüdisser, S.; Dussauge, S.; Fettis, K.; Kieffer, L.; de Erkenez, A.; Yang, L.; Hartwieg, C.; Argikar, U.A.; La Bonte, L.R.; Newton, R.; Kansara, V.; Flohr, S.; Hommel, U.; Jaffee, B.; Maibaum, Jürgen. 2017: Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. Journal of Medicinal Chemistry 60(13): 5717-5735
Kick, E.K.; Busch, B.B.; Martin, R.; Stevens, W.C.; Bollu, V.; Xie, Y.; Boren, B.C.; Nyman, M.C.; Nanao, M.H.; Nguyen, L.; Plonowski, A.; Schulman, I.G.; Yan, G.; Zhang, H.; Hou, X.; Valente, M.N.; Narayanan, R.; Behnia, K.; Rodrigues, A.David.; Brock, B.; Smalley, J.; Cantor, G.H.; Lupisella, J.; Sleph, P.; Grimm, D.; Ostrowski, J.; Wexler, R.R.; Kirchgessner, T.; Mohan, R. 2016: Discovery of Highly Potent Liver X Receptor β Agonists. Acs Medicinal Chemistry Letters 7(12): 1207-1212
Kempson, J.; Ovalle, D.; Guo, J.; Wrobleski, S.T.; Lin, S.; Spergel, S.H.; Duan, J.J-W.; Jiang, B.; Lu, Z.; Das, J.; Yang, B.V.; Hynes, J.; Wu, H.; Tokarski, J.; Sack, J.S.; Khan, J.; Schieven, G.; Blatt, Y.; Chaudhry, C.; Salter-Cid, L.M.; Fura, A.; Barrish, J.C.; Carter, P.H.; Pitts, W.J. 2017: Discovery of highly potent, selective, covalent inhibitors of JAK3. Bioorganic and Medicinal Chemistry Letters 27(20): 4622-4625
Kurashige, N.; Fuchida, H.; Tabata, S.; Uchinomiya, S.; Ojida, A. 2017: Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation. Bioorganic and Medicinal Chemistry Letters 27(15): 3486-3489
Lee, J.; Lee, Y.; Park, S.Jung.; Lee, J.; Kim, Y.Shik.; Suh, Y-Ger.; Lee, J. 2017: Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one. European Journal of Medicinal Chemistry 130: 365-378
Johnson, H.W.B.; Anderl, J.L.; Bradley, E.K.; Bui, J.; Jones, J.; Arastu-Kapur, S.; Kelly, L.M.; Lowe, E.; Moebius, D.C.; Muchamuel, T.; Kirk, C.; Wang, Z.; McMinn, D. 2017: Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit. Acs Medicinal Chemistry Letters 8(4): 413-417
Suzuki, S.; Sugawara, Y.; Tsuji, R.; Tanimura, R.; Kaneko, C.; Yuzawa, N.; Yagi, M.; Kawai, K. 2017: Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives. Bioorganic and Medicinal Chemistry Letters 27(16): 3920-3924
Bhaumik, A.; Sachan, R.; Gupta, S.; Narayan, J. 2017: Discovery of High-Temperature Superconductivity (T c = 55 K) in B-Doped Q-Carbon. Acs Nano 11(12): 11915-11922
Yang, K.L.; Lin, P.Y. 2018: Discovery of HLA-C*14:87, a novel HLA-C*14 variant, in a Taiwanese individual. Hla 91(1): 72-73
de Wispelaere, Mélissanne.; Carocci, M.; Liang, Y.; Liu, Q.; Sun, E.; Vetter, M.L.; Wang, J.; Gray, N.S.; Yang, P.L. 2017: Discovery of host-targeted covalent inhibitors of dengue virus. Antiviral Research 139: 171-179
Adachi, R.; Ishii, T.; Matsumoto, S.; Satou, T.; Sakamoto, J.; Kawamoto, T. 2017: Discovery of Human Intestinal MGAT Inhibitors Using High-Throughput Mass Spectrometry. Slas Discovery: Advancing Life Sciences R and D 22(4): 360-365
Silva, L.C.; Pucca, M.B.; Pessenda, G.; Campos, L.B.; Martinez, E.Z.; Cerni, F.A.; Barbosa, Jé.E. 2018: Discovery of human sc Fvs that cross-neutralize the toxic effects of B. jararacussu and C. d. terrificus venoms. Acta Tropica 177: 66-73
Ulvé, R.; Rault, Mélanie.; Bahin, M.; Lagoutte, L.; Abadie, Jérôme.; De Brito, C.; Coindre, J-Michel.; Botherel, N.; Rousseau, A.; Wucher, V.; Cadieu, E.; Thieblemont, C.; Hitte, C.; Cornevin, L.; Cabillic, F.; Bachelot, L.; Gilot, D.; Hennuy, B.; Guillaudeux, T.; Le Goff, A.; Derrien, T.; Hédan, Bît.; André, C. 2017: Discovery of Human-Similar Gene Fusions in Canine Cancers. Cancer Research 77(21): 5721-5727
Tomohara, K.; Ito, T.; Onikata, S.; Kato, A.; Adachi, I. 2017: Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions. Bioorganic and Medicinal Chemistry Letters 27(7): 1620-1623
Zou, Y.; Wang, F.; Wang, Y.; Sun, Q.; Hu, Y.; Li, Y.; Liu, W.; Guo, W.; Huang, Z.; Zhang, Y.; Xu, Q.; Lai, Y. 2017: Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies. European Journal of Medicinal Chemistry 140: 293-304
Felts, A.S.; Rodriguez, A.L.; Morrison, R.D.; Bollinger, K.A.; Venable, D.F.; Blobaum, A.L.; Byers, F.W.; Thompson Gray, A.; Daniels, J.Scott.; Niswender, C.M.; Jones, C.K.; Conn, P.Jeffrey.; Lindsley, C.W.; Emmitte, K.A. 2017: Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorganic and Medicinal Chemistry Letters 27(21): 4858-4866
N'Guessan, J-Paul.Déto.Ursul.; Delaye, P-Olivier.; Pénichon, Mélanie.; Charvet, C.L.; Neveu, Cédric.; Ouattara, M.; Enguehard-Gueiffier, Cécile.; Gueiffier, A.; Allouchi, H. 2017: Discovery of imidazo[1,2-a]pyridine-based anthelmintic targeting cholinergic receptors of Haemonchus contortus. Bioorganic and Medicinal Chemistry 25(24): 6695-6706
Yang, Y.; Zhang, Y.; Yang, L.; Zhao, L.; Si, L.; Zhang, H.; Liu, Q.; Zhou, J. 2017: Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity. Bioorganic Chemistry 70: 126-132
Tantry, S.J.; Markad, S.D.; Shinde, V.; Bhat, J.; Balakrishnan, G.; Gupta, A.K.; Ambady, A.; Raichurkar, A.; Kedari, C.; Sharma, S.; Mudugal, N.V.; Narayan, A.; Naveen Kumar, C.N.; Nanduri, R.; Bharath, S.; Reddy, J.; Panduga, V.; Prabhakar, K.R.; Kandaswamy, K.; Saralaya, R.; Kaur, P.; Dinesh, N.; Guptha, S.; Rich, K.; Murray, D.; Plant, H.; Preston, M.; Ashton, H.; Plant, D.; Walsh, J.; Alcock, P.; Naylor, K.; Collier, M.; Whiteaker, J.; McLaughlin, R.E.; Mallya, M.; Panda, M.; Rudrapatna, S.; Ramachandran, V.; Shan 2017: Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis. Journal of Medicinal Chemistry 60(4): 1379-1399
Azimi, S.; Zonouzi, A.; Firuzi, O.; Iraji, A.; Saeedi, M.; Mahdavi, M.; Edraki, N. 2017: Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis. European Journal of Medicinal Chemistry 138: 729-737
Sigdel, T.K.; Sarwal, M.M. 2018: Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA. Methods in Molecular Biology 1788: 11-21
Schoville, R.R. 2017: Discovery of Implementation Factors That Lead to Technology Adoption in Long-Term Care. Journal of Gerontological Nursing 43(10): 21-26
Wang, W.; Krosky, D.; Ahn, K. 2017: Discovery of Inactive Conformation-Selective Kinase Inhibitors by Utilizing Cascade Assays. Biochemistry 56(34): 4449-4456
Hoyt, S.B.; Taylor, J.; London, C.; Ali, A.; Ujjainwalla, F.; Tata, J.; Struthers, M.; Cully, D.; Wisniewski, T.; Ren, N.; Bopp, C.; Sok, A.; Verras, A.; McMasters, D.; Chen, Q.; Tung, E.; Tang, W.; Salituro, G.; Clemas, J.; Zhou, G.; MacNeil, D.; Duffy, R.; Xiong, Y. 2017: Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension. Bioorganic and Medicinal Chemistry Letters 27(11): 2384-2388
Tseng, C-Hua.; Tung, C-Wei.; Wu, C-Hsin.; Tzeng, C-Chyi.; Chen, Y-Hsu.; Hwang, T-Long.; Chen, Y-Long. 2017: Discovery of Indeno[1,2-c]quinoline Derivatives as Potent Dual Antituberculosis and Anti-Inflammatory Agents. Molecules 22(6)
Guo, J.; Zhu, M.; Wu, T.; Hao, C.; Wang, K.; Yan, Z.; Huang, W.; Wang, J.; Zhao, D.; Cheng, M. 2017: Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study. Bioorganic and Medicinal Chemistry 25(13): 3500-3511
Huang, Z.; Li, H.; Zhang, Q.; Lu, F.; Hong, M.; Zhang, Z.; Guo, X.; Zhu, Y.; Li, S.; Liu, H. 2017: Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis. Acs Medicinal Chemistry Letters 8(11): 1142-1147
Marchand, J-Rémy.; Dalle Vedove, A.; Lolli, G.; Caflisch, A. 2017: Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking. Journal of Chemical Information and Modeling 57(10): 2584-2597
Connelly, C.M.; Boer, R.E.; Moon, M.H.; Gareiss, P.; Schneekloth, J.S. 2017: Discovery of Inhibitors of MicroRNA-21 Processing Using Small Molecule Microarrays. Acs Chemical Biology 12(2): 435-443
Mao, D.; Bushin, L.B.; Moon, K.; Wu, Y.; Seyedsayamdost, M.R. 2017: Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264. Proceedings of the National Academy of Sciences of the United States of America 114(14): E2920-E2928
Morgan, B.S.; Forte, J.E.; Culver, R.N.; Zhang, Y.; Hargrove, A.E. 2017: Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands. Angewandte Chemie 56(43): 13498-13502
Viborg, A.Holm.; Katayama, T.; Arakawa, T.; Abou Hachem, M.; Lo Leggio, L.; Kitaoka, M.; Svensson, B.; Fushinobu, S. 2017: Discovery of α-l-arabinopyranosidases from human gut microbiome expands the diversity within glycoside hydrolase family 42. Journal of Biological Chemistry 292(51): 21092-21101
Eslami Rasekh, M.; Chiatante, G.; Miroballo, M.; Tang, J.; Ventura, M.; Amemiya, C.T.; Eichler, E.E.; Antonacci, F.; Alkan, C. 2017: Discovery of large genomic inversions using long range information. Bmc Genomics 18(1): 65
Dayal, N.B.; Müller, H. 2017: Discovery of left ventricular hypertrophy during adult echocardiography. Revue Medicale Suisse 13(564): 1106-1112
Zhang, G.; Vilim, F.S.; Liu, D-Dan.; Romanova, E.V.; Yu, K.; Yuan, W-Ding.; Xiao, H.; Hummon, A.B.; Chen, T-Ting.; Alexeeva, V.; Yin, S-Yuan.; Chen, S-An.; Cropper, E.C.; Sweedler, J.V.; Weiss, K.R.; Jing, J. 2017: Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model, Aplysia. Journal of Biological Chemistry 292(46): 18775-18789
Schally, A.V.; Block, N.L.; Rick, F.G. 2017: Discovery of LHRH and development of LHRH analogs for prostate cancer treatment. Prostate 77(9): 1036-1054
Deshpande, A.M.; Bhuniya, D.; De, S.; Dave, B.; Vyavahare, V.P.; Kurhade, S.H.; Kandalkar, S.R.; Naik, K.P.; Kobal, B.S.; Kaduskar, R.D.; Basu, S.; Jain, V.; Patil, P.; Chaturvedi Joshi, S.; Bhat, G.; Raje, A.A.; Reddy, S.; Gundu, J.; Madgula, V.; Tambe, S.; Shitole, P.; Umrani, D.; Chugh, A.; Palle, V.P.; Mookhtiar, K.A. 2017: Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia. European Journal of Medicinal Chemistry 133: 268-286
Ronnås, C.; Werth, S.; Ovaskainen, O.; Várkonyi, G.; Scheidegger, C.; Snäll, T. 2017: Discovery of long-distance gamete dispersal in a lichen-forming ascomycete. New Phytologist 216(1): 216-226
Xu, S-Yang.; Alidoust, N.; Chang, G.; Lu, H.; Singh, B.; Belopolski, I.; Sanchez, D.S.; Zhang, X.; Bian, G.; Zheng, H.; Husanu, M-Adrian.; Bian, Y.; Huang, S-Ming.; Hsu, C-Han.; Chang, T-Rong.; Jeng, H-Tay.; Bansil, A.; Neupert, T.; Strocov, V.N.; Lin, H.; Jia, S.; Hasan, M.Zahid. 2017: Discovery of Lorentz-violating type II Weyl fermions in LaAlGe. Science Advances 3(6): E1603266
Carter, T.J.; Heiden, Z.M.; Szymczak, N.K. 2015: Discovery of low energy pathways to metal-mediated B 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 000000000000. Chemical Science 6(12): 7258-7266
Gancia, E.; De Groot, M.; Burton, B.; Clark, D.E. 2017: Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods. Bioorganic and Medicinal Chemistry Letters 27(11): 2520-2527
Wang, M.; Hua, B-Zhen. 2017: Discovery of Neopanorpa chillcotti Byers (Mecoptera: Panorpidae) from Tibet, China, with discussion of its generic status. Zootaxa 4232(2)
Jałoszyński, Pł. 2017: Discovery of Penicillidmus in the Bismarck Archipelago, Papua New Guinea, with description of a new species from Lavongai (New Hanover) Island (Coleoptera, Staphylinidae, Scydmaeninae). Zootaxa 4254(3): 391-395
Goodwin, N.C.; Ding, Z-Ming.; Harrison, B.A.; Strobel, E.D.; Harris, A.L.; Smith, M.; Thompson, A.Y.; Xiong, W.; Mseeh, F.; Bruce, D.J.; Diaz, D.; Gopinathan, S.; Li, L.; O'Neill, E.; Thiel, M.; Wilson, A.G.E.; Carson, K.G.; Powell, D.R.; Rawlins, D.B. 2017: Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes. Journal of Medicinal Chemistry 60(2): 710-721
Hara, R.; Yamagata, K.; Miyake, R.; Kawabata, H.; Uehara, H.; Kino, K. 2017: Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction. Applied and Environmental Microbiology 83(17)
McIver, A.L.; Zhang, W.; Liu, Q.; Jiang, X.; Stashko, M.A.; Nichols, J.; Miley, M.J.; Norris-Drouin, J.; Machius, M.; DeRyckere, D.; Wood, E.; Graham, D.K.; Earp, H.Shelton.; Kireev, D.; Frye, S.V.; Wang, X. 2017: Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. Chemmedchem 12(3): 207-213
Testero, Sán.A.; Granados, C.; Fernández, D.; Gallego, P.; Covaleda, G.; Reverter, D.; Vendrell, J.; Avilés, F.X.; Pallarès, I.; Mobashery, S. 2017: Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. Acs Medicinal Chemistry Letters 8(10): 1122-1127
Feng, W.; Novera, W.; Peh, K.; Neo, D.; Ramanujulu, P.Murugappan.; Moore, P.K.; Deng, L-Wen.; Dymock, B.W. 2017: Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents. Bioorganic and Medicinal Chemistry Letters 27(4): 967-972
Liu, P.; Li, R.; Antonov, A.A.; Wang, L.; Li, W.; Hua, Y.; Guo, H.; Wang, L.; Liu, P.; Chen, L.; Tian, Y.; Xu, F.; Zhang, Z.; Zhu, Y.; Huang, Y. 2017: Discovery of Metabolite Biomarkers for Acute Ischemic Stroke Progression. Journal of Proteome Research 16(2): 773-779
Nabeyama, W.; Ishihara, K.; Ban, H.Seung.; Wada, H.; Nakamura, H. 2017: Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. Bioorganic and Medicinal Chemistry 25(9): 2601-2608
Cernicharo, J.; Agúndez, M.; Velilla Prieto, L.; Guélin, M.; Pardo, J.R.; Kahane, C.; Marka, C.; Kramer, C.; Navarro, S.; Quintana-Lacaci, G.; Fonfría, J.P.; Marcelino, N.; Tercero, B.; Moreno, E.; Massalkhi, S.; Santander-García, M.; McCarthy, M.C.; Gottlieb, C.A.; Alonso, J.L. 2017: Discovery of methyl silane and confirmation of silyl cyanide in IRC +10216. Astronomy and Astrophysics 606
Feng, S.; Li, C.; Chen, D.; Zheng, X.; Yun, H.; Gao, L.; Shen, H.C. 2017: Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors. European Journal of Medicinal Chemistry 138: 1147-1157
Deng, M.; Cao, Y.; Zhao, Z.; Yang, L.; Zhang, Y.; Dong, Y.; Fan, G. 2017: Discovery of MicroRNAs and Their Target Genes Related to Drought in Paulownia "Yuza 1" by High-Throughput Sequencing. International Journal of Genomics 2017: 3674682
Luo, J.; Xiang, G.; Pan, C. 2017: Discovery of micro RNAs and Transcription Factors Co-Regulatory Modules by Integrating Multiple Types of Genomic Data. IEEE Transactions on Nanobioscience 16(1): 51-59
Xu, L.; Guo, Q.; Chang, G.; Qiu, L.; Liu, X.; Bi, Y.; Zhang, Y.; Wang, H.; Lu, W.; Ren, L.; Chen, Y.; Zhang, Y.; Xu, Q.; Chen, G. 2017: Discovery of micro RNAs during early spermatogenesis in chicken. Plos one 12(5): E0177098
Nakamura, Y.; Arakawa, H. 2017: Discovery of Mieap-regulated mitochondrial quality control as a new function of tumor suppressor p53. Cancer Science 108(5): 809-817
Doering, S.R.; Freeman, K.T.; Schnell, S.M.; Haslach, E.M.; Dirain, M.; Debevec, G.; Geer, P.; Santos, R.G.; Giulianotti, M.A.; Pinilla, C.; Appel, J.R.; Speth, R.C.; Houghten, R.A.; Haskell-Luevano, C. 2017: Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa 1 -Arg-(pI)DPhe-Xaa 4 -NH 2. Journal of Medicinal Chemistry 60(10): 4342-4357
Wolkenberg, S.E.; Nolt, M.Brad.; Bilodeau, M.T.; Trotter, B.Wesley.; Manley, P.J.; Kett, N.R.; Nanda, K.K.; Wu, Z.; Cato, M.J.; Kane, S.A.; Kiss, L.; Spencer, R.H.; Wang, J.; Lynch, J.J.; Regan, C.P.; Stump, G.L.; Li, B.; White, R.; Yeh, S.; Dinsmore, C.J.; Lindsley, C.W.; Hartman, G.D. 2017: Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorganic and Medicinal Chemistry Letters 27(4): 1062-1069
Mannel, D.S.; Ahmed, M.S.; Root, T.W.; Stahl, S.S. 2017: Discovery of Multicomponent Heterogeneous Catalysts via Admixture Screening: PdBiTe Catalysts for Aerobic Oxidative Esterification of Primary Alcohols. Journal of the American Chemical Society 139(4): 1690-1698
Tassini, S.; Sun, L.; Lanko, K.; Crespan, E.; Langron, E.; Falchi, F.; Kissova, M.; Armijos-Rivera, J.I.; Delang, L.; Mirabelli, C.; Neyts, J.; Pieroni, M.; Cavalli, A.; Costantino, G.; Maga, G.; Vergani, P.; Leyssen, P.; Radi, M. 2017: Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. Journal of Medicinal Chemistry 60(4): 1400-1416
Ding, Y.Chun.; Adamson, A.W.; Steele, L.; Bailis, A.M.; John, E.M.; Tomlinson, G.; Neuhausen, S.L. 2018: Discovery of mutations in homologous recombination genes in African-American women with breast cancer. Familial cancer 17(2): 187-195
Kim, B.Jik.; Kim, A.Reum.; Han, J.Hee.; Lee, C.; Oh, D.Yi.; Choi, B.Yoon. 2017: Discovery of MYH14 as an important and unique deafness gene causing prelingually severe autosomal dominant nonsyndromic hearing loss. Journal of Gene Medicine 19(4)
Rombouts, F.J.R.; Andrés, Jé-Ignacio.; Ariza, M.; Alonso, Jé.Manuel.; Austin, N.; Bottelbergs, A.; Chen, L.; Chupakhin, V.; Cleiren, E.; Fierens, K.; Fontana, A.; Langlois, X.; Leenaerts, J.E.; Mariën, J.; Martínez Lamenca, C.; Salter, R.; Schmidt, M.E.; Te Riele, P.; Wintmolders, C.; Trabanco, Aés.A.; Zhang, W.; Macdonald, G.; Moechars, D. 2017: Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease. Journal of Medicinal Chemistry 60(4): 1272-1291
Albrecht, W.; Unger, A.; Bauer, S.M.; Laufer, S.A. 2017: Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases. Journal of Medicinal Chemistry 60(13): 5290-5305
Felts, A.S.; Rodriguez, A.L.; Blobaum, A.L.; Morrison, R.D.; Bates, B.S.; Thompson Gray, A.; Rook, J.M.; Tantawy, M.N.; Byers, F.W.; Chang, S.; Venable, D.F.; Luscombe, V.B.; Tamagnan, G.D.; Niswender, C.M.; Daniels, J.Scott.; Jones, C.K.; Conn, P.Jeffrey.; Lindsley, C.W.; Emmitte, K.A. 2017: Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. Journal of Medicinal Chemistry 60(12): 5072-5085
Freitas, R.H.C.N.; Cordeiro, Nália.M.; Carvalho, Pícia.R.; Alves, M.A.; Guedes, I.A.; Valerio, T.S.; Dardenne, L.E.; Lima, Lídia.M.; Barreiro, E.J.; Fernandes, Pícia.D.; Fraga, C.A.M. 2018: Discovery of naphthyl-N-acylhydrazone p38α MAPK inhibitors with in vivo anti-inflammatory and anti-TNF-α activity. Chemical Biology and Drug Design 91(2): 391-397
Chen, Y.; Wu, J.; Wang, A.; Qi, Z.; Jiang, T.; Chen, C.; Zou, F.; Hu, C.; Wang, W.; Wu, H.; Hu, Z.; Wang, W.; Wang, B.; Wang, L.; Ren, T.; Zhang, S.; Liu, Q.; Liu, J. 2017: Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC. European Journal of Medicinal Chemistry 139: 674-697
Debenham, J.S.; Madsen-Duggan, C.; Clements, M.J.; Walsh, T.F.; Kuethe, J.T.; Reibarkh, M.; Salowe, S.P.; Sonatore, L.M.; Hajdu, R.; Milligan, J.A.; Visco, D.M.; Zhou, D.; Lingham, R.B.; Stickens, D.; DeMartino, J.A.; Tong, X.; Wolff, M.; Pang, J.; Miller, R.R.; Sherer, E.C.; Hale, J.J. 2016: Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. Journal of Medicinal Chemistry 59(24): 11039-11049
Van der Plas, S.E.; Kelgtermans, H.; De Munck, T.; Martina, Sébastien.L.X.; Dropsit, Sébastien.; Quinton, E.; De Blieck, A.; Joannesse, C.; Tomaskovic, L.; Jans, M.; Christophe, T.; van der Aar, E.; Borgonovi, M.; Nelles, L.; Gees, M.; Stouten, P.; Van Der Schueren, J.; Mammoliti, O.; Conrath, K.; Andrews, M. 2018: Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. Journal of Medicinal Chemistry 61(4): 1425-1435
Chen, W.; Huang, Z.; Wang, W.; Mao, F.; Guan, L.; Tang, Y.; Jiang, H.; Li, J.; Huang, J.; Jiang, L.; Zhu, J. 2017: Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely. Bioorganic and Medicinal Chemistry 25(24): 6467-6478
Navratilova, I.; Aristotelous, T.; Picaud, S.; Chaikuad, A.; Knapp, S.; Filappakopoulos, P.; Hopkins, A.L. 2016: Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. Acs Medicinal Chemistry Letters 7(12): 1213-1218
Shchetynsky, K.; Diaz-Gallo, L-Marcella.; Folkersen, L.; Hensvold, A.Haj.; Catrina, A.Irinel.; Berg, L.; Klareskog, L.; Padyukov, L. 2017: Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis. Arthritis Research and Therapy 19(1): 19
Pu, Y.; Zhang, S.; Chang, Z.; Zhang, Y.; Wang, D.; Zhang, L.; Li, Y.; Zuo, Z. 2017: Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay. Molecular Biosystems 13(2): 363-370
Hidalgo-Figueroa, S.; Navarrete-Vázquez, G.; Estrada-Soto, S.; Giles-Rivas, D.; Alarcón-Aguilar, F.J.; León-Rivera, I.; Giacoman-Martínez, A.; Miranda Pérez, E.; Almanza-Pérez, J.C. 2017: Discovery of new dual PPARγ-GPR40 agonists with robust antidiabetic activity: Design, synthesis and in combo drug evaluation. Biomedicine and PharmacoTherapy 90: 53-61
Armstrong, Z.; Rahfeld, P.; Withers, S.G. 2017: Discovery of New Glycosidases From Metagenomic Libraries. Methods in Enzymology 597: 3-23
Kassab, S.E.; Khedr, M.A.; Ali, H.I.; Abdalla, M.M. 2017: Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities. European Journal of Medicinal Chemistry 141: 306-321
Spalenka, Jérémy.; Escotte-Binet, S.; Bakiri, A.; Hubert, J.; Renault, J-Hugues.; Velard, Fédéric.; Duchateau, S.; Aubert, D.; Huguenin, A.; Villena, I. 2018: Discovery of New Inhibitors of Toxoplasma gondii via the Pathogen Box. Antimicrobial Agents and ChemoTherapy 62(2)
Wavhale, R.D.; Martis, E.A.F.; Ambre, P.K.; Wan, B.; Franzblau, S.G.; Iyer, K.R.; Raikuvar, K.; Macegoniuk, K.; Berlicki, Łukasz.; Nandan, S.R.; Coutinho, E.C. 2017: Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity. Bioorganic and Medicinal Chemistry 25(17): 4835-4844
Chen, G.; Xiao, B.; Chen, L.; Bai, B.; Zhang, Y.; Xu, Z.; Fu, L.; Liu, Z.; Li, X.; Zhao, Y.; Liang, G. 2017: Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury. European Journal of Medicinal Chemistry 139: 726-740
Rožman, K.; Lešnik, S.; Brus, B.; Hrast, M.; Sova, M.; Patin, D.; Barreteau, Hélène.; Konc, J.; Janežič, Dšanka.; Gobec, S. 2017: Discovery of new MurA inhibitors using induced-fit simulation and docking. Bioorganic and Medicinal Chemistry Letters 27(4): 944-949
Loughlin, W.A.; Jenkins, I.D.; Karis, N.David.; Healy, P.C. 2017: Discovery of new nanomolar inhibitors of GPa: Extension of 2-oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors. European Journal of Medicinal Chemistry 127: 341-356
Colmant, A.M.G.; Etebari, K.; Webb, C.E.; Ritchie, S.A.; Jansen, C.C.; van den Hurk, A.F.; Bielefeldt-Ohmann, H.; Hobson-Peters, J.; Asgari, S.; Hall, R.A. 2017: Discovery of new orbiviruses and totivirus from Anopheles mosquitoes in Eastern Australia. Archives of Virology 162(11): 3529-3534
Di Micco, S.; Terracciano, S.; Cantone, V.; Fischer, K.; Koeberle, A.; Foglia, A.; Riccio, R.; Werz, O.; Bruno, I.; Bifulco, G. 2018: Discovery of new potent molecular entities able to inhibit mPGES-1. European Journal of Medicinal Chemistry 143: 1419-1427
McCormick, S. 2017: Discovery of new QTLs underlying hybrid fertility and reproductive isolation in rice. Plant Journal: for Cell and Molecular Biology 92(3): 347-348
Berger, M.; Rehwinkel, H.; Schmees, N.; Schäcke, H.; Edman, K.; Wissler, L.; Reichel, A.; Jaroch, S. 2017: Discovery of new selective glucocorticoid receptor agonist leads. Bioorganic and Medicinal Chemistry Letters 27(3): 437-442
Angeli, A.; Tanini, D.; Peat, T.S.; Di Cesare Mannelli, L.; Bartolucci, G.; Capperucci, A.; Ghelardini, C.; Supuran, C.T.; Carta, F. 2017: Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. Acs Medicinal Chemistry Letters 8(9): 963-968
Huang, S.; Song, C.; Wang, X.; Zhang, G.; Wang, Y.; Jiang, X.; Sun, Q.; Huang, L.; Xiang, R.; Hu, Y.; Li, L.; Yang, S. 2017: Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis. Journal of Chemical Information and Modeling 57(4): 669-679
Huang, Y.; Zhang, Y.; Fan, K.; Dong, G.; Li, B.; Zhang, W.; Li, J.; Sheng, C. 2017: Discovery of new Syk inhibitors through structure-based virtual screening. Bioorganic and Medicinal Chemistry Letters 27(8): 1776-1779
McDaniel, K.F.; Wang, L.; Soltwedel, T.; Fidanze, S.D.; Hasvold, L.A.; Liu, D.; Mantei, R.A.; Pratt, J.K.; Sheppard, G.S.; Bui, M.H.; Faivre, E.J.; Huang, X.; Li, L.; Lin, X.; Wang, R.; Warder, S.E.; Wilcox, D.; Albert, D.H.; Magoc, T.J.; Rajaraman, G.; Park, C.H.; Hutchins, C.W.; Shen, J.J.; Edalji, R.P.; Sun, C.C.; Martin, R.; Gao, W.; Wong, S.; Fang, G.; Elmore, S.W.; Shen, Y.; Kati, W.M. 2017: Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor. Journal of Medicinal Chemistry 60(20): 8369-8384
Zeng, L.; Shin, W-Hee.; Zhu, X.; Park, S.Hoon.; Park, C.; Tao, W.Andy.; Kihara, D. 2017: Discovery of Nicotinamide Adenine Dinucleotide Binding Proteins in the Escherichia coli Proteome Using a Combined Energetic- and Structural-Bioinformatics-Based Approach. Journal of Proteome Research 16(2): 470-480
Mike, L.A.; Tripathi, A.; Blankenship, C.M.; Saluk, A.; Schultz, P.J.; Tamayo-Castillo, G.; Sherman, D.H.; Mobley, H.L.T. 2017: Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments. Chemical Communications 53(95): 12778-12781
Liang, Q.; Chen, Y.; Yu, K.; Chen, C.; Zhang, S.; Wang, A.; Wang, W.; Wu, H.; Liu, X.; Wang, B.; Wang, L.; Hu, Z.; Wang, W.; Ren, T.; Zhang, S.; Liu, Q.; Yun, C-Hong.; Liu, J. 2017: Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. European Journal of Medicinal Chemistry 131: 107-125
Fales, K.R.; Njoroge, F.George.; Brooks, H.B.; Thibodeaux, S.; Torrado, A.; Si, C.; Toth, J.L.; Mc Cowan, J.R.; Roth, K.D.; Thrasher, K.J.; Frimpong, K.; Lee, M.R.; Dally, R.D.; Shepherd, T.A.; Durham, T.B.; Margolis, B.J.; Wu, Z.; Wang, Y.; Atwell, S.; Wang, J.; Hui, Y-Hua.; Meier, T.I.; Konicek, S.A.; Geeganage, S. 2017: Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. Journal of Medicinal Chemistry 60(23): 9599-9616
Zhou, Y.; Sun, W.; Chen, N.; Xu, C.; Wang, X.; Dong, K.; Zhang, B.; Zhang, J.; Hao, N.; Sun, A.; Wei, H.; He, F.; Jiang, Y. 2017: Discovery of NKCC1 as a potential therapeutic target to inhibit hepatocellular carcinoma cell growth and metastasis. Oncotarget 8(39): 66328-66342
Gao, J.; Bhunia, S.; Wang, K.; Gan, L.; Xia, S.; Ma, D. 2017: Discovery of N-(Naphthalen-1-yl)-N'-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers. Organic Letters 19(11): 2809-2812
Buchynskyy, A.; Gillespie, J.Robert.; Hulverson, M.A.; McQueen, J.; Creason, S.A.; Ranade, R.M.; Duster, N.A.; Gelb, M.H.; Buckner, F.S. 2017: Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors. Bioorganic and Medicinal Chemistry 25(5): 1571-1584
Na, C.Hyun.; Barbhuiya, M.A.; Kim, M-Sik.; Verbruggen, S.; Eacker, S.M.; Pletnikova, O.; Troncoso, J.C.; Halushka, M.K.; Menschaert, G.; Overall, C.M.; Pandey, A. 2018: Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini. Genome Research 28(1): 25-36
Qin, R.; Zhao, J.; Qin, W.; Zhang, Z.; Zhao, R.; Han, J.; Yang, Y.; Li, L.; Wang, X.; Ren, S.; Sun, Y.; Gu, J. 2017: Discovery of Non-invasive Glycan Biomarkers for Detection and Surveillance of Gastric Cancer. Journal of Cancer 8(10): 1908-1916
Park, I.; Londhe, A.M.; Lim, J.Woong.; Park, B-Geon.; Jung, S.Yun.; Lee, J.Yeol.; Lim, S.Min.; No, K.Tai.; Lee, J.; Pae, A.Nim. 2017: Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction. Journal of Computer-Aided Molecular Design 31(10): 929-941
Higaki, S.; Kurihara, Y.; Yoshida, H.; Takahashi, Y.; Shinohara, N. 2017: Discovery of non-spherical heterogeneous radiocesium-bearing particles not derived from Unit 1 of the Fukushima Dai-ichi Nuclear Power Plant, in residences five years after the accident. Journal of Environmental Radioactivity 177: 65-70
Wu, Y-Jin.; Guernon, J.; McClure, A.; Luo, G.; Rajamani, R.; Ng, A.; Easton, A.; Newton, A.; Bourin, C.; Parker, D.; Mosure, K.; Barnaby, O.; Soars, M.G.; Knox, R.J.; Matchett, M.; Pieschl, R.; Herrington, J.; Chen, P.; Sivarao, D.V.; Bristow, L.J.; Meanwell, N.A.; Bronson, J.; Olson, R.; Thompson, L.A.; Dzierba, C. 2017: Discovery of non-zwitterionic aryl sulfonamides as Na v 1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation. Bioorganic and Medicinal Chemistry 25(20): 5490-5505
Zeng, D-Ying.; Kuang, G-Tao.; Wang, S-Ke.; Peng, W.; Lin, S-Ling.; Zhang, Q.; Su, X-Xuan.; Hu, M-Hao.; Wang, H.; Tan, J-Heng.; Huang, Z-Shu.; Gu, L-Quan.; Ou, T-Miao. 2017: Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry. Journal of Medicinal Chemistry 60(13): 5407-5423
Wang, M.; Fang, Y.; Gu, S.; Chen, F.; Zhu, Z.; Sun, X.; Zhu, J. 2017: Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. European Journal of Medicinal Chemistry 132: 157-172
Ito, M.; Tanaka, T.; Cary, D.R.; Iwatani-Yoshihara, M.; Kamada, Y.; Kawamoto, T.; Aparicio, S.; Nakanishi, A.; Imaeda, Y. 2017: Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. Journal of Medicinal Chemistry 60(8): 3335-3351
Raj, V.; Rai, A.; Singh, A.K.; Keshari, A.K.; Trivedi, P.; Ghosh, B.; Kumar, U.; Kumar, D.; Saha, S. 2018: Discovery of Novel 2-Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment. Anti-Cancer Agents in Medicinal Chemistry 18(5): 719-738
Kohara, T.; Nakayama, K.; Watanabe, K.; Kusaka, S-Ichi.; Sakai, D.; Tanaka, H.; Fukunaga, K.; Sunada, S.; Nabeno, M.; Saito, K-Ichi.; Eguchi, J-Ichi.; Mori, A.; Tanaka, S.; Bessho, T.; Takiguchi-Hayashi, K.; Horikawa, T. 2017: Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors. Bioorganic and Medicinal Chemistry Letters 27(16): 3733-3738
Gu, W.; Dai, Y.; Qiang, H.; Shi, W.; Liao, C.; Zhao, F.; Huang, W.; Qian, H. 2017: Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors. Bioorganic Chemistry 72: 116-122
Boggu, P.Reddy.; Venkateswararao, E.; Manickam, M.; Kim, Y.; Jung, S-Hun. 2017: Discovery of novel 3-(hydroxyalkoxy)-2-alkylchromen-4-one analogs as interleukin-5 inhibitors. European Journal of Medicinal Chemistry 139: 290-304
Zhou, P.; Huang, L.; Zhou, J.; Jiang, B.; Zhao, Y.; Deng, X.; Zhao, Q.; Li, F. 2017: Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents. Bioorganic and Medicinal Chemistry Letters 27(17): 4185-4189
Takai, T.; Koike, T.; Nakamura, M.; Kajita, Y.; Yamashita, T.; Taya, N.; Tsukamoto, T.; Watanabe, T.; Murakami, K.; Igari, T.; Kamata, M. 2016: Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2). Bioorganic and Medicinal Chemistry 24(14): 3192-3206
Mizojiri, R.; Nakata, D.; Satoh, Y.; Morishita, D.; Shibata, S.; Iwatani-Yoshihara, M.; Kosugi, Y.; Kosaka, M.; Takeda, J.; Sasaki, S.; Takami, K.; Fukuda, K.; Kamaura, M.; Sasaki, S.; Arai, R.; Cary, D.R.; Imaeda, Y. 2017: Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1 H )-one Derivatives as Orally eIF4A3-Selective Inhibitors. Acs Medicinal Chemistry Letters 8(10): 1077-1082
Hirose, H.; Yamasaki, T.; Ogino, M.; Mizojiri, R.; Tamura-Okano, Y.; Yashiro, H.; Muraki, Y.; Nakano, Y.; Sugama, J.; Hata, A.; Iwasaki, S.; Watanabe, M.; Maekawa, T.; Kasai, S. 2017: Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus. Bioorganic and Medicinal Chemistry 25(15): 4175-4193
Tang, Q.; Wang, L.; Duan, Y.; Wang, W.; Huang, S.; Zhi, J.; Jia, S.; Zhu, W.; Wang, P.; Luo, R.; Zheng, P. 2017: Discovery of novel 7-azaindole derivatives bearing dihydropyridazine moiety as c-Met kinase inhibitors. European Journal of Medicinal Chemistry 133: 97-106
Li, P.; Dorsch, W.; Lauffer, D.J.; Bilimoria, D.; Chauret, N.; Court, J.J.; Das, S.Kumar.; Denis, F.; Mani, N.; Nanthakumar, S.; Nicolas, O.; Rao, B.Govinda.; Ronkin, S.; Selliah, S.; Shawgo, R.S.; Stearns, R.; Tang, Q.; Waal, N.D.; Green, J. 2017: Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates. Acs Medicinal Chemistry Letters 8(2): 251-255
Sakurada, I.; Endo, T.; Hikita, K.; Hirabayashi, T.; Hosaka, Y.; Kato, Y.; Maeda, Y.; Matsumoto, S.; Mizuno, T.; Nagasue, H.; Nishimura, T.; Shimada, S.; Shinozaki, M.; Taguchi, K.; Takeuchi, K.; Yokoyama, T.; Hruza, A.; Reichert, P.; Zhang, T.; Wood, H.B.; Nakao, K.; Furusako, S. 2017: Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors. Bioorganic and Medicinal Chemistry Letters 27(11): 2622-2628
Kling, A.; Jantos, K.; Mack, H.; Hornberger, W.; Drescher, K.; Nimmrich, V.; Relo, A.; Wicke, K.; Hutchins, C.W.; Lao, Y.; Marsh, K.; Moeller, A. 2017: Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. Journal of Medicinal Chemistry 60(16): 7123-7138
Imamura, K.; Tomita, N.; Kawakita, Y.; Ito, Y.; Ono, K.; Nii, N.; Miyazaki, T.; Yonemori, K.; Tawada, M.; Sumi, H.; Satoh, Y.; Yamamoto, Y.; Miyahisa, I.; Sasaki, M.; Satomi, Y.; Hirayama, M.; Nishigaki, R.; Maezaki, H. 2017: Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents. Bioorganic and Medicinal Chemistry 25(14): 3768-3779
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Wu, S.; Sun, Y.; Hu, Y.; Zhang, H.; Hou, L.; Liu, X.; Li, Y.; He, H.; Luo, Z.; Chen, Y.; Wang, Y.; Shi, W.; Shen, L.; Cao, C.; Liang, W.; Xu, Q.; Lv, Q.; Lan, J.; Li, J.; Chen, S. 2017: Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment. Bioorganic and Medicinal Chemistry Letters 27(6): 1458-1462
Yao, T-Ting.; Fang, S-Wei.; Li, Z-Shan.; Xiao, D-Xin.; Cheng, J-Li.; Ying, H-Zhou.; Du, Y-Jun.; Zhao, J-Hao.; Dong, X-Wu. 2017: Discovery of Novel Succinate Dehydrogenase Inhibitors by the Integration of in Silico Library Design and Pharmacophore Mapping. Journal of Agricultural and Food Chemistry 65(15): 3204-3211
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Jiang, L.; Beattie, D.T.; Jacobsen, J.R.; Kintz, S.; Obedencio, G.P.; Saito, D.; Stergiades, I.; Vickery, R.G.; Long, D.D. 2017: Discovery of N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of μ-opioid receptor antagonists. Bioorganic and Medicinal Chemistry Letters 27(13): 2926-2930
Zhang, G.; Cheng, J.; McCorvy, J.D.; Lorello, P.J.; Caldarone, B.J.; Roth, B.L.; Kozikowski, A.P. 2017: Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications. Journal of Medicinal Chemistry 60(14): 6273-6288
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Hücker, S.M.; Ardern, Z.; Goldberg, T.; Schafferhans, A.; Bernhofer, M.; Vestergaard, G.; Nelson, C.W.; Schloter, M.; Rost, B.; Scherer, S.; Neuhaus, K. 2017: Discovery of numerous novel small genes in the intergenic regions of the Escherichia coli O157:H7 Sakai genome. Plos one 12(9): E0184119
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Schilling, M.; Hodel, F.H.; Luber, S. 2017: Discovery of Open Cubane Core Structures for Biomimetic LnCo 3 (OR) 4 Water Oxidation Catalysts. Chemsuschem 10(22): 4561-4569
Xu, J.; Lin, S.; Myers, R.W.; Trujillo, M.E.; Pachanski, M.J.; Malkani, S.; Chen, H-Shen.; Chen, Z.; Campbell, B.; Eiermann, G.J.; Elowe, N.; Farrer, B.T.; Feng, W.; Fu, Q.; Kats-Kagan, R.; Kavana, M.; McMasters, D.R.; Mitra, K.; Tong, X.; Xu, L.; Zhang, F.; Zhang, R.; Addona, G.H.; Berger, J.P.; Zhang, B.; Parmee, E.R. 2017: Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus. Bioorganic and Medicinal Chemistry Letters 27(9): 2063-2068
Anan, K.; Masui, M.; Hara, S.; Ohara, M.; Kume, M.; Yamamoto, S.; Shinohara, S.; Tsuji, H.; Shimada, S.; Yagi, S.; Hasebe, N.; Kai, H. 2017: Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach. Bioorganic and Medicinal Chemistry Letters 27(17): 4194-4198
Zhang, X.; Wall, M.; Sui, Z.; Kauffman, J.; Hou, C.; Chen, C.; Du, F.; Kirchner, T.; Liang, Y.; Johnson, D.L.; Murray, W.V.; Demarest, K. 2017: Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes. Acs Medicinal Chemistry Letters 8(5): 560-565
Sprau, P.O.; Kostin, A.; Kreisel, A.; Böhmer, A.E.; Taufour, V.; Canfield, P.C.; Mukherjee, S.; Hirschfeld, P.J.; Andersen, B.M.; Davis, J.C.Séamus. 2017: Discovery of orbital-selective Cooper pairing in FeSe. Science 357(6346): 75-80
Mishra, P.; Dauphinee, A.N.; Ward, C.; Sarkar, S.; Gunawardena, A.H.L.A.N.; Manjithaya, R. 2017: Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms. Autophagy 13(9): 1556-1572
Cho, P.Yeon.; Park, J-Min.; Hwang, M-Ki.; Park, S.Hye.; Park, Y-Kyu.; Jeon, B-Young.; Kim, T-Soo.; Lee, H-Woo. 2017: Discovery of Parasite Eggs in Archeological Residence during the 15th Century in Seoul, Korea. Korean Journal of Parasitology 55(3): 357-361
Nakajima, T.; Sawada, K. 2017: Discovery of Pb-Free Perovskite Solar Cells via High-Throughput Simulation on the K Computer. Journal of Physical Chemistry Letters 8(19): 4826-4831
Chen, D.; Huang, X.; Zhou, H.; Luo, H.; Wang, P.; Chang, Y.; He, X.; Ni, S.; Shen, Q.; Cao, G.; Sun, H.; Wen, X.; Liu, J. 2017: Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors. European Journal of Medicinal Chemistry 139: 201-213
Bashari, O.; Redko, B.; Cohen, A.; Luboshits, G.; Gellerman, G.; Firer, M.A. 2017: Discovery of peptide drug carrier candidates for targeted multi-drug delivery into prostate cancer cells. Cancer Letters 408: 164-173
Leffler, A.E.; Kuryatov, A.; Zebroski, H.A.; Powell, S.R.; Filipenko, P.; Hussein, A.K.; Gorson, J.; Heizmann, A.; Lyskov, S.; Tsien, R.W.; Poget, Sébastien.F.; Nicke, A.; Lindstrom, J.; Rudy, B.; Bonneau, R.; Holford, Më. 2017: Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Proceedings of the National Academy of Sciences of the United States of America 114(38): E8100-E8109
Sakamoto, K.; Otake, K.; Umemoto, T. 2017: Discovery of peptidic miR-21 processing inhibitor by mirror image phage display: A novel method to generate RNA binding D-peptides. Bioorganic and Medicinal Chemistry Letters 27(4): 826-828
Barnash, K.D.; The, J.; Norris-Drouin, J.L.; Cholensky, S.H.; Worley, B.M.; Li, F.; Stuckey, J.I.; Brown, P.J.; Vedadi, M.; Arrowsmith, C.H.; Frye, S.V.; James, L.I. 2017: Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. Acs Combinatorial Science 19(3): 161-172
Suzuki, S.; Sugawara, Y.; Inada, H.; Tsuji, R.; Inoue, A.; Tanimura, R.; Shimozono, R.; Konno, M.; Ohyama, T.; Higashi, E.; Sakai, C.; Kawai, K. 2017: Discovery of Peripheral κ-Opioid Receptor Agonists as Novel Analgesics. Chemical and Pharmaceutical Bulletin 65(11): 1085-1088
Hall, J.; Brault, A.; Vincent, F.; Weng, S.; Wang, H.; Dumlao, D.; Aulabaugh, A.; Aivazian, D.; Castro, D.; Chen, M.; Culp, J.; Dower, K.; Gardner, J.; Hawrylik, S.; Golenbock, D.; Hepworth, D.; Horn, M.; Jones, L.; Jones, P.; Latz, E.; Li, J.; Lin, L-Ling.; Lin, W.; Lin, D.; Lovering, F.; Niljanskul, N.; Nistler, R.; Pierce, B.; Plotnikova, O.; Schmitt, D.; Shanker, S.; Smith, J.; Snyder, W.; Subashi, T.; Trujillo, J.; Tyminski, E.; Wang, G.; Wong, J.; Lefker, B.; Dakin, L.; Leach, K. 2017: Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. Plos one 12(9): E0184843
Zhu, C.; Wang, L.; Zhu, Y.; Guo, Z.Zhiqiang.; Liu, P.; Hu, Z.; Szewczyk, J.W.; Kang, L.; Chicchi, G.; Ehrhardt, A.; Woods, A.; Seo, T.; Woods, M.; van Heek, M.; Dingley, K.H.; Pang, J.; Salituro, G.M.; Powell, J.; Terebetski, J.L.; Hornak, V.; Campeau, L-Charles.; Orr, R.K.; Ujjainwalla, F.; Miller, M.; Stamford, A.; Wood, H.B.; Kowalski, T.; Nargund, R.P.; Edmondson, S.D. 2017: Discovery of phenyl acetamides as potent and selective GPR119 agonists. Bioorganic and Medicinal Chemistry Letters 27(5): 1124-1128
Wurtz, N.R.; Parkhurst, B.L.; Jiang, W.; DeLucca, I.; Zhang, X.; Ladziata, V.; Cheney, D.L.; Bozarth, J.R.; Rendina, A.R.; Wei, A.; Luettgen, J.M.; Wu, Y.; Wong, P.C.; Seiffert, D.A.; Wexler, R.R.; Priestley, E.Scott. 2016: Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors. Acs Medicinal Chemistry Letters 7(12): 1077-1081
Li, Z.; Liu, C.; Xu, X.; Qiu, Q.; Su, X.; Dai, Y.; Yang, J.; Li, H.; Shi, W.; Liao, C.; Pan, M.; Huang, W.; Qian, H. 2017: Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. European Journal of Medicinal Chemistry 138: 458-479
Liu, J.; Wu, Q.; Li, L.; Xi, X.; Wu, D.; Zhou, M.; Chen, T.; Shaw, C.; Wang, L. 2017: Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs. Molecules 22(9)