+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial



Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial



Plos one 12(8): E0182155



Understanding the minimal dose of physical activity required to achieve improvement in physical functioning and reductions in disability risk is necessary to inform public health recommendations. To examine the effect of physical activity dose on changes in physical functioning and the onset of major mobility disability in The Lifestyle Interventions and Independence for Elders (LIFE) Study. We conducted a multicenter single masked randomized controlled trial that enrolled participants in 2010 and 2011 and followed them for an average of 2.6 years. 1,635 sedentary men and women aged 70-89 years who had functional limitations were randomized to a structured moderate intensity walking, resistance, and flexibility physical activity program or a health education program. Physical activity dose was assessed by 7-day accelerometry and self-report at baseline and 24 months. Outcomes included the 400 m walk gait speed, the Short Physical Performance Battery (SPPB), assessed at baseline, 6, 12, and 24 months, and onset of major mobility disability (objectively defined by loss of ability to walk 400 m in 15 min). When the physical activity arm or the entire sample were stratified by change in physical activity from baseline to 24 months, there was a dose-dependent increase in the change in gait speed and SPPB from baseline at 6, 12, and 24 months. In addition, the magnitude of change in physical activity over 24 months was related to the reduction in the onset of major mobility disability (overall P < 0.001) (highest versus the lowest quartile of physical activity change HR 0.23 ((95% CI:0.10-0.52) P = 0.001) in the physical activity arm. We observed a dose-dependent effect of objectively monitored physical activity on physical functioning and onset of major mobility disability. Relatively small increases (> 48 minutes per week) in regular physical activity participation had significant and clinically meaningful effects on these outcomes. ClinicalsTrials.gov NCT00116194.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 059628429

Download citation: RISBibTeXText

PMID: 28820909


Related references

Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: a meta-analysis. Ageing Research Reviews 11(1): 136-149, 2012

Effect of Structured Physical Activity and Nutritional Supplementation on Physical Function in Mobility-Limited Older Adults: Results from the VIVE2 Randomized Trial. Journal of Nutrition Health and Aging 21(9): 936-942, 2017

Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA 311(23): 2387-2396, 2014

Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. Journal of the American Geriatrics Society 64(5): 933-943, 2016

Effect on health related quality of life and mood by structured physical activity and nutritional supplementation in mobility-limited older adults: The Vive2 randomized controlled trial. Clinical Nutrition 37: S56-S57, 2018

Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability. Journals of Gerontology. Series A Biological Sciences and Medical Sciences 71(5): 656-662, 2016

Physical Activity and Performance Impact Long-term Quality of Life in Older Adults at Risk for Major Mobility Disability. American Journal of Preventive Medicine 56(1): 141-146, 2019

Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults. Journal of the American Geriatrics Society 65(10): 2251-2256, 2017

Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. Journals of Gerontology. Series B Psychological Sciences and Social Sciences 73(8): 1501-1513, 2018

Nutritional Supplementation With Physical Activity Improves Muscle Composition in Mobility-Limited Older Adults, The VIVE2 Study: A Randomized, Double-Blind, Placebo-Controlled Trial. Journals of Gerontology. Series A Biological Sciences and Medical Sciences 73(1): 95, 2017

Patient-centred physical therapy is (cost-) effective in increasing physical activity and reducing frailty in older adults with mobility problems: a randomized controlled trial with 6 months follow-up. Journal of Cachexia Sarcopenia and Muscle 7(4): 422-435, 2016

Use of accelerometry to measure physical activity in older adults at risk for mobility disability. Journal of Aging and Physical Activity 16(4): 416-434, 2008

Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. Journal of the American Heart Association 4(2):, 2015

Antihypertensive Use and the Effect of a Physical Activity Intervention in the Prevention of Major Mobility Disability Among Older Adults: The LIFE Study. Journals of Gerontology. Series A Biological Sciences and Medical Sciences 71(7): 974-981, 2016

Adapted physical activity is beneficial on balance, functional mobility, quality of life and fall risk in community-dwelling older women: a randomized single-blinded controlled trial. European Journal of Physical and Rehabilitation Medicine 49(3): 301-310, 2013