+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of sex-hormone levels, sex, body mass index and other host factors on human craniofacial bone regeneration with bioactive tricalcium phosphate grafts



Effect of sex-hormone levels, sex, body mass index and other host factors on human craniofacial bone regeneration with bioactive tricalcium phosphate grafts



Biomaterials 123: 48-62



Little is known regarding the associations between sex-hormone levels, sex, body mass index (BMI), age, other host factors and biomaterial stimulated bone regeneration in the human craniofacial skeleton. The aim of this study was to elucidate the associations between these factors and bone formation after sinus floor augmentation procedures (SFA) utilizing a bioactive tricalcium phosphate (TCP) bone grafting material. We conducted a prospective study in a human population in which 60 male and 60 female participants underwent SFA and dental implant placement using a staged approach. BMI as well as levels of serum estradiol (E2), total testosterone (TT), and the free androgen index (FAI) were measured by radioimmunoassay and electrochemoluminescent-immunoassay. At implant placement, 6 months after SFA, bone biopsy specimens were harvested for hard tissue histology, the amount of bone formation was evaluated by histomorphometry and immunohistochemical analysis of osteogenic marker expression. The Wilcoxon rank-sum U test, Spearman correlations and linear regression analysis were used to explore the association between bone formation and BMI, hormonal and other host factors. BMI and log E2 were significantly positively associated with bone formation in male individuals (p < 0.05). Histomorphometry revealed trends toward greater bone formation and osteogenic marker expression with non-smokers compared to smokers. In male patients, higher E2 levels and higher BMI enhanced TCP stimulated craniofacial i.e. intramembranous bone repair.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 059653799

Download citation: RISBibTeXText

PMID: 28160669

DOI: 10.1016/j.biomaterials.2017.01.035


Related references

Bioactive composite bone cement based on α-tricalcium phosphate/tricalcium silicate. Journal of Biomedical Materials Research. Part B Applied Biomaterials 100(1): 94-102, 2012

Histologic effect of pure-phase beta-tricalcium phosphate on bone regeneration in human artificial jawbone defects. International Journal of Periodontics and Restorative Dentistry 23(1): 69-77, 2003

Combined delivery of bone morphogenetic protein-2 and insulin-like growth factor-1 from nano-poly (γ-glutamic acid)/β-tricalcium phosphate-based calcium phosphate cement and its effect on bone regeneration in vitro. Journal of Biomaterials Applications 32(5): 547-560, 2017

Effect of -tricalcium phosphate and porous hydroxyapatite bone substitutes on bone regeneration in alveolar bone defects around dental implants. Journal of Oral and Maxillofacial Surgery 72(9): E205-E206, 2014

A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2-coated tricalcium phosphate and platelet-rich fibrin-mixed tricalcium phosphate in rabbits. Oral Surgery Oral Medicine Oral Pathology and Oral Radiology 113(5): 583-592, 2012

Effect of luteinizing hormone-releasing hormone analogue on body mass index and serum leptin levels. Acta Paediatrica Suppl. (428): 137, 1999

Bone Defect Regeneration by a Combination of a β-Tricalcium Phosphate Scaffold and Bone Marrow Stromal Cells in a Non-Human Primate Model. Open Biomedical Engineering Journal 10: 2-11, 2016

Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases. Clinical Oral Implants Research 12(4): 379-384, 2001

Effect of expanded bone marrow-derived osteoprogenitor cells seeded into polycaprolactone/tricalcium phosphate scaffolds in new bone regeneration of rabbit mandibular defects. Journal of Materials Science. Materials in Medicine 29(3): 24, 2018

Microstructure, physical properties, and bone regeneration effect of the nano-sized β-tricalcium phosphate granules. Materials Science and Engineering. C Materials for Biological Applications 58: 971-976, 2016

Effects of bioactive glass S53P4 or beta-tricalcium phosphate and bone morphogenetic protein-2 and bone morphogenetic protein-7 on osteogenic differentiation of human adipose stem cells. Journal of Tissue Engineering 3(1): 2041731412467789, 2012

Repair of Complex Craniofacial Bone Defects Using 3D-Printed Tricalcium Phosphate Scaffolds. Journal of Oral and Maxillofacial Surgery 71(9): E89-E90, 2013

Complete subchondral bone defect regeneration with a tricalcium phosphate collagen implant and osteoinductive growth factors: a randomized controlled study in Göttingen minipigs. Journal of Biomedical Materials Research. Part B Applied Biomaterials 102(5): 933-942, 2014

The effect of basic fibroblast growth factor on bone regeneration when released from a novel in situ setting tricalcium phosphate cement. Journal of Biomedical Materials Research. Part a 69(4): 680-685, 2004

Ectopic bone regeneration by human bone marrow mononucleated cells, undifferentiated and osteogenically differentiated bone marrow mesenchymal stem cells in beta-tricalcium phosphate scaffolds. Tissue Engineering. Part C Methods 18(7): 545-556, 2012