Section 60
Chapter 59,734

Fate of d-Fagomine after Oral Administration to Rats

Amézqueta, S.; Ramos-Romero, S.; Martínez-Guimet, C.; Moreno, A.; Hereu, M.è; Torres, J.L.ís.

Journal of Agricultural and Food Chemistry 65(22): 4414-4420


ISSN/ISBN: 0021-8561
PMID: 28489364
DOI: 10.1021/acs.jafc.7b01026
Accession: 059733932

Download citation:  

D-Fagomine is an iminosugar found in buckwheat that is capable of inhibiting the adhesion of potentially pathogenic bacteria to epithelial mucosa and reducing the postprandial blood glucose concentration. This paper evaluates the excretion and metabolism of orally administered d-fagomine in rats and compares outcomes with the fate of 1-deoxynojirimycin. d-Fagomine and 1-deoxynojirimycin show similar absorption and excretion kinetics. d-Fagomine is partly absorbed (41-84%, dose of 2 mg/kg of body weight) and excreted in urine within 8 h, while the non-absorbed fraction is cleared in feces within 24 h. d-Fagomine is partially methylated (about 10% in urine and 3% in feces). The concentration of d-fagomine in urine from 1 to 6 h after administration is higher than 10 mg/L, the concentration that inhibits adhesion of Escherichia coli. Orally administered d-fagomine is partially absorbed and then rapidly excreted in urine, where it reaches a concentration that may be protective against urinary tract infections.

PDF emailed within 0-6 h: $19.90