+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature

Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature

Bmc Cancer 17(1): 368

ISSN/ISBN: 1471-2407

PMID: 28545511

DOI: 10.1186/s12885-017-3357-7

Gastric hepatoid adenocarcinoma (GHAC) is an atypical form of gastric cancer (GC) that has similar tissue morphology to hepatocellular carcinoma and frequently produces alpha-fetoprotein. We present an exceedingly rare case of GHAC resulting in a spontaneous gastric perforation. A 61-year-old man presented at our institution complaining of abdominal and back pain. A computed tomography scan revealed a spontaneous gastric perforation with a solitary liver tumor and lymph node swelling. Following a diagnosis of advanced-stage GC with a gastric perforation, perforative peritonitis, multiple lymph node metastases, and a solitary metastasis of the lateral segment of the liver, the patient underwent distal gastrectomy. Histopathology of the resected specimen revealed that the tumor cells were arranged in a hepatoid pattern. On immunohistochemical staining, the tumor cells were positive for alpha-fetoprotein and Sal-like protein 4. Thus, the patient was diagnosed with GHAC. Hepatic resection of the solitary liver metastasis was performed. However, recurrence occurred and the patient achieved complete response following tegafur/gimeracil/oteracil-based chemotherapy. GHAC is a highly malignant histological subtype of GC. We reported on an extremely rare case of GHAC resulting in a spontaneous gastric perforation and reviewed the literature, including epidemiological data, treatment regimens, and the association between GHAC and alpha-fetoprotein-producing GC.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 059760959

Download citation: RISBibTeXText

Related references

Alpha-fetoprotein-producing hepatoid gastric adenocarcinoma in a child presenting with spontaneous gastric perforation. Turkish Journal of Pediatrics 56(1): 88-91, 2014

Spontaneous perforation of primary gastric malignant lymphoma: a case report and review of the literature. World Journal of Surgical Oncology 13: 35, 2015

Spontaneous perforation of primary gastric B-cell lymphoma of MALT: a case report and literature review. Clinical Case Reports 4(11): 1049-1052, 2016

Extensive gastric heterotopia of the small intestine resulting in massive gastrointestinal bleeding, bowel perforation, and death: report of a case and review of the literature. Pediatric and Developmental Pathology: the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 3(3): 277-280, 2000

Spontaneous acute tumour lysis syndrome in gastric adenocarcinoma: a case report and literature review. Journal of Gastrointestinal Cancer 45 Suppl. 1: 208-211, 2014

Gastric adenocarcinoma after gastric bypass for morbid obesity: a case report and review of the literature. Case Reports in Medicine 2013: 609727, 2013

Hepatoid carcinoma of the pancreas penetrating into the gastric cavity: a case report and literature review. Pathology International 62(7): 485-490, 2012

Hepatoid adenocarcinoma of the stomach - a different histology for not so different gastric adenocarcinoma: a case report. International Seminars in Surgical Oncology: Isso 6: 13, 2009

P21: Management of delayed diagnosis of gastric perforation after laparoscopic gastric banding - a report of two cases and literature review. Surgery for Obesity and Related Diseases 4(3): 319-320, 2008

Trichobezoar and postpartum gastric perforation: a case report and brief review of literature. Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology 28(4): 438-440, 2008

Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature. Annals of Medical and Health Sciences Research 5(4): 314-316, 2015

Α-fetoprotein producing hepatoid gastric adenocarcinoma with neuroendocrine differentiation: A case report. Medicine 97(37): E12359, 2018

Hepatoid adenocarcinoma of the stomach: A case report of a rare type of gastric cancer. Oncology Letters 11(2): 1077-1080, 2016

Hepatoid Adenocarcinoma of the Gallbladder : Case Report and Literature Review. Journal of Gastrointestinal Cancer 43 Suppl. 1: S139-S144, 2012

Hepatoid Adenocarcinoma of the Lung: A Case Report and Literature Review. Journal of Gastrointestinal Cancer 43 Suppl. 1: S125-S127, 2012