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Highly diastereo- and enantioselective synthesis of spirooxindole-cyclohexaneamides through N,N'-dioxide/Ni(ii)-catalyzed Diels-Alder reactions



Highly diastereo- and enantioselective synthesis of spirooxindole-cyclohexaneamides through N,N'-dioxide/Ni(ii)-catalyzed Diels-Alder reactions



Chemical Communications 53(12): 2060-2063



Highly efficient asymmetric Diels-Alder reactions of methyleneindolinones with 1,3-dienylcarbamates and 1,2-dihydropyridines have been accomplished by using a chiral N,N'-dioxide/nickel(ii) complex as an efficient catalyst. New kinds of spirooxindole-cyclohexaneamides were achieved in up to 99% yield, >95 : 5 dr, and 99% ee.

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Accession: 059799449

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PMID: 28133656

DOI: 10.1039/c6cc10125a


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