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Impact of early Fontan completion on postoperative outcomes in patients with a functional single ventricle

Impact of early Fontan completion on postoperative outcomes in patients with a functional single ventricle

European Journal of Cardio-Thoracic Surgery: Official Journal of the European Association for Cardio-Thoracic Surgery 51(5): 995-1002

ISSN/ISBN: 1010-7940

PMID: 28329109

DOI: 10.1093/ejcts/ezx019

Our aim was to evaluate whether early timing of total cavopulmonary connection (TCPC) affects postoperative outcomes. Of 460 consecutive TCPC patients, 51 (11.1%) underwent TCPC ≤ 18 months of age (group A), and 409 patients >18 months of age (group B). We compared the clinical outcomes and exercise capacity between groups. Median age at TCPC was 1.4 (interquartile ranges: 1.3-1.5) years in group A and 2.5 (1.9-4.5) years in group B. Duration of intensive care unit stay (6 vs 7 days), hospital stay (20 vs 20 days), and 30-day survival (100 vs 98%) was not significantly different between groups. Estimated survival (95.3 vs 92.1%), freedom from reoperation (93.7 vs 86.3%), freedom from catheter intervention (60.1 vs 77.0%), and freedom from protein losing enteropathy (97.6 vs 93.8%) at 10 years was not significantly different between groups. At last follow-up, no patient in group A but 13 patients in group B exhibited reduced ventricular function ( P  = 0.035). Exercise-capacity testing showed that both peak oxygen uptake (36.4 vs 28.6 ml/kg/min; P  = 0.026) and its percentage of predicted value (82.9 vs 70.0%; P  = 0.004) were significantly higher in group A ( n  = 6, mean postoperative period: 8.9 years) than in group B ( n  = 119, mean postoperative period: 8.7 years). Fontan completion for TCPC can be performed at an early age with a low perioperative risk and good intermediate results. Earlier unloading of the systemic ventricle and earlier elimination of chronic cyanosis by staged cavopulmonary connection might be advantageous for preservation of long-term ventricular function.

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Accession: 059836273

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