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Influence of Saccharomyces boulardii Sachets combined with bismuth quadruple therapy for initial Helicobacter pylori eradication


Influence of Saccharomyces boulardii Sachets combined with bismuth quadruple therapy for initial Helicobacter pylori eradication



Zhonghua Yi Xue Za Zhi 97(30): 2353-2356



ISSN/ISBN: 0376-2491

PMID: 28822453

目的: 评价布拉氏酵母菌散联合含铋剂四联疗法根除幽门螺杆菌(H.pylori)的有效性和安全性。 方法: 选取2014年3月至2015年3月于河北医科大学附属第三医院就诊的H.pylori阳性患者240例,按随机数字表法随机分为3组。四联组:枸橼酸铋钾220 mg+雷贝拉唑钠肠溶片10 mg+阿莫西林1 000 mg+呋喃唑酮100 mg,2次/d口服,共10 d;短疗程益生菌组:在上述四联组基础上,自服药第1天始口服布拉氏酵母菌散500 mg,2次/d,共14 d;长疗程益生菌组:在四联组基础上,自服药第1天始口服布拉氏酵母菌散500 mg,2次/d,共28 d;所有用药停药至少4周后行(13)C尿素呼气试验((13)C-UBT)或(14)C-UBT,结果阴性者视为H.pylori根除成功,观察并记录治疗过程中的不良反应。 结果: 四联组、短疗程益生菌组和长疗程益生菌组意向性(ITT)分析的根除率分别为80.0%(64/80)、87.5%(70/80)、87.5%(70/80),差异无统计学意义(P=0.321);3组符合方案(PP)分析的根除率分别为92.8%(64/69)、94.6%(70/74)、95.9%(70/73) ,差异无统计学意义(P=0.717);短疗程益生菌组不良反应的总体发生率以及腹泻、腹胀的发生率均低于四联组,差异有统计学意义(P=0.007、0.003、0.004),长疗程益生菌组不良反应的总体发生率以及腹泻、腹胀的发生率均低于四联组,差异有统计学意义(P=0.005、0.001、0.010),而两益生菌组不良反应发生率比较差异无统计学意义。 结论: 2周或4周布拉氏酵母菌散加入含铋剂四联根除H.pylori方案,均可降低不良反应的总体发生率和腹泻、腹胀的发生率。.

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