+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Kidney transplantation for end-stage renal disease in lupus nephritis, a very safe procedure: a single Latin American transplant center experience

Kidney transplantation for end-stage renal disease in lupus nephritis, a very safe procedure: a single Latin American transplant center experience

Lupus 26(11): 1157-1165

Background Lupus nephritis (LN) is one of the most frequent complications of SLE and occurs in up to 50% of cases depending on the studied population. Of these, approximately 20% progress to end-stage renal disease (ESRD), with the treatment of choice being a kidney transplant. Objective The objective of this study was to describe the clinical outcome of patients transplanted due to LN, compared with patients transplanted for other causes, in a Latin American population from the Fundación Valle del Lili in Cali, Colombia. Methods Observational, retrospective case study with controls matched by age, sex and type of donor in a single center between 1996 and 2014. Results Sixty-five kidney transplants were performed in patients with LN and ESRD. The survival of patients with LN was 98% at 1, 10 and 15 years ( p = .99). For controls by age and sex, survival was also 98% at 15 years post-transplant, and for controls by donor, the survival rate was 100% at 5 years and 98% at 15 years. Graft survival in patients with LN to 1, 5 and 15 years was 92%, 83% and 71%, respectively; for controls by age and sex, it was 90%, 84% and 64%, respectively, and for the controls by donor, it was 89%, 86% and 79%, respectively ( p = .7718). There were no statistically significant differences found in the cumulative incidence of acute graft rejection in the first year, but it was found that acute rejection is a factor that relates to the loss of function of the renal graft ( p = .032). Of the patients transplanted for LN, two (3.1%) experienced a recurrence of the disease. One patient died after a diagnosis of recurrence of LN due to an infection. Conclusions Kidney transplantation is a good option for patients with ESRD due to LN. In this Hispanic population, the survival of patients, graft survival, and cumulative incidence of graft rejection are not different from those of other transplanted patients. In addition, recurrence of LN was rare, showing the benefits of renal transplantation in LN patients with ESRD.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 059902240

Download citation: RISBibTeXText

PMID: 28420067

DOI: 10.1177/0961203317696591

Related references

Factors that influence progression of lupus nephritis to end stage renal disease A single center experience. Pediatric Research 37(4 PART 2): 358A, 1994

Impact of recurrent lupus nephritis on lupus kidney transplantation: a 20-year single center experience. Clinical Rheumatology 31(4): 705-710, 2012

Outcomes in renal transplant recipients with lupus nephritis: experience at a single center. Renal Failure 36(6): 912-915, 2015

Renal transplantation for systemic lupus erythematosus and recurrent lupus nephritis. A single-center experience and a review of the literature. Transplantation 52(5): 805-810, 1991

A single center kidney transplant experience among ten Caucasian females with end-stage renal disease due to scleroderma
. Clinical Nephrology 88(1): 40-44, 2017

Renal transplantation in patients with lupus nephritis: a single-center experience. Transplantation Proceedings 40(1): 143-144, 2008

Outcomes in Renal Transplant Recipients With Lupus Nephritis-A Single-Center Experience and Review of the Literature. Transplantation Proceedings 48(5): 1489-1493, 2016

Latin-American Dialysis and Kidney Transplantation Registry: data on the treatment of end-stage renal disease in Latin America. Giornale Italiano di Nefrologia 25(5): 547-553, 2008

Kidney transplantation alone in end-stage renal disease patients with hepatitis B liver cirrhosis: a single-center experience. Transplantation 99(1): 133-138, 2015

Kidney Transplantation in Korean Patients With End-Stage Renal Disease Aged 65 and Older: A Single-Center Experience. Transplantation Proceedings 49(5): 987-991, 2018

Latin American Dialysis and Transplant Registry: Experience and contributions to end-stage renal disease epidemiology. World Journal of Nephrology 5(5): 389-397, 2016

En-Bloc Transplant of the Liver, Kidney and Pancreas: Experience from a Latin American Transplant Center. American Journal of Case Reports 18: 114-118, 2017

Lupus nephritis in Latin American patients: 10-year results from a single medical center in Argentina. Lupus 25(2): 217-222, 2016

Association of time to kidney transplantation with graft failure among U.S. patients with end-stage renal disease due to lupus nephritis. Arthritis Care & Research 67(4): 571-581, 2015

Autosomal Dominant Polycystic Kidney Disease Transplant Recipients After Kidney Transplantation: A Single-center Experience. Transplantation Proceedings 49(7): 1522-1525, 2017