+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nicotine biomarkers and rate of nicotine metabolism among cigarette smokers taking buprenorphine for opioid dependency

Nicotine biomarkers and rate of nicotine metabolism among cigarette smokers taking buprenorphine for opioid dependency

Drug and Alcohol Dependence 178: 267-270

Individual differences in the rate of nicotine metabolism contribute to differences in tobacco use, dependence, and efficacy of smoking cessation treatments and can be assessed using the nicotine metabolite ratio (NMR), a validated biomarker for CYP2A6 activity. Despite the high cigarette smoking rates observed in opioid users, no data have been reported on NMR among this population as they has been largely excluded from previous studies that have examined the relationship between tobacco use characteristics and rate of nicotine metabolism. A linear regression model was used to examine the relationship between tobacco use characteristics and NMR among smokers taking buprenorphine for opioid dependency (N=141). The relationship between buprenorphine dose and NMR was also examined. All participants were enrolled in an intervention designed to promote cigarette-smoking cessation, though participants did not need to stop smoking to enroll. Rate of nicotine metabolism assessed using the NMR was positively associated with cigarettes smoked in the past 24h, but was not related to time to first cigarette or past year quit attempts. Dose of buprenorphine was not associated with NMR, suggesting no association with rate of nicotine metabolism. Our results suggest that NMR is related to tobacco use among persons enrolled in opioid treatment, as reported in general population smokers and may be a useful biomarker to include in future research assessing efficacy of tobacco cessation interventions in this population.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 060019318

Download citation: RISBibTeXText

PMID: 28683421

DOI: 10.1016/j.drugalcdep.2017.05.020

Related references

The Influence of Puff Characteristics, Nicotine Dependence, and Rate of Nicotine Metabolism on Daily Nicotine Exposure in African American Smokers. Cancer Epidemiology, Biomarkers and Prevention 25(6): 936-943, 2016

The metabolism of nicotine into two optically-active stereoisomers of nicotine-1'-oxide by animal tissues in vitro and by cigarette smokers. Biochemical Pharmacology 19(3): 733-742, 1970

Opioid Use and Rate of Nicotine Metabolism among Pregnant Smokers. Nicotine and Tobacco Research 2019:, 2019

Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking. Pharmacology Biochemistry and Behavior 148: 1-7, 2016

Effects of Electronic Cigarette Liquid Nicotine Concentration on Plasma Nicotine and Puff Topography in Tobacco Cigarette Smokers: A Preliminary Report. Nicotine and Tobacco Research 18(5): 720-723, 2016

Effect of nicotine chewing gum on plasma nicotine levels of cigarette smokers. Clinical Pharmacology and Therapeutics 35(4): 495-498, 1984

Biomarkers of Tobacco Exposure Decrease After Smokers Switch to an E-Cigarette or Nicotine Gum. Nicotine and Tobacco Research 21(9): 1239-1247, 2019

Effects of smoking abstinence on cigarette craving, nicotine withdrawal, and nicotine reinforcement in smokers with and without schizophrenia. Nicotine and Tobacco Research 16(3): 326-334, 2014

AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking. Journal of Psychopharmacology 27(6): 564-571, 2013

Comparison of plasma nicotine concentrations for nicotine transdermal system nts cigarette smoking and nicotine polacrilex nicotine gum. Clinical Pharmacology and Therapeutics 51(2): 129, 1992

The relationship between nicotine dependence scores and biomarkers of exposure in adult cigarette smokers. Regulatory Toxicology and Pharmacology 60(1): 79-83, 2011

Comparison of nicotine pharmacokinetics in healthy Japanese male smokers following application of the transdermal nicotine patch and cigarette smoking. Biological and Pharmaceutical Bulletin 29(5): 1068-1073, 2006

The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers. Journal of Oral Pathology and Medicine 26(3): 117-123, 1997

Effects of a nicotine-enriched cigarette on nicotine titration, daily cigarette consumption, and levels of carbon monoxide, cotinine, and nicotine. Psychopharmacology 77(2): 164-167, 1982

Nicotine serves as an effective reinforcer of intravenous drug-taking behavior in human cigarette smokers. Psychopharmacology 175(2): 134-142, 2004