+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nitric oxide synthesis modulation - a possible diagnostic and therapeutic target in colorectal cancer



Nitric oxide synthesis modulation - a possible diagnostic and therapeutic target in colorectal cancer



Journal of BUON 22(1): 162-169



Considering the contradictory literature data about the role of nitric oxide (NO) in colon carcinogenesis, the purpose of this study was to examine the changes of L-arginine metabolites in colon cancer and surrounding tissue as possible molecular markers of tumor behavior after surgery and the possibility of NO synthesis modulation in new individualized therapeutic strategies. The study encompassed 50 patients who underwent surgery for colorectal cancer (CRC). The three tissue specimens were taken by surgery (tumor, adjacent and healthy tissue) and the concentrations of NO2+NO3, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were determined in the tissue specimens. The results proved higher NO2+NO3 concentrations in adjacent tissue compared to the tumor, implicating high angiogenic potential of the tumor-surrounding tissue, which could have clinical importance in the assessment of the probability of tumor local recurrence and metastasis. Increased ADMA concentrations in tumor tissue associated with low NO levels, could lead to new therapeutic strategies directed to the use of inhibitors of NO synthesis as ideal candidates for molecular therapy of CRC. ADMA concentration in adjacent tissue was an independent predictor of distant metastasis. The obtained results suggest that determination of the examined biomarkers in CRC and adjacent tissue samples could give useful information about tumor proliferative and angiogenic potential, which in turn could enable individualization of therapy and the choice of proper adjuvant therapy in patients with CRC.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 060020149

Download citation: RISBibTeXText

PMID: 28365950


Related references

Dimethylarginine dimethylaminohydrolase: a new therapeutic target for the modulation of nitric oxide and angiogenesis. Current Opinion in Investigational Drugs 8(9): 736-741, 2007

Nitric oxide scavenging An alternative therapeutic approach to nitric oxide synthesis inhibition in nitric oxide-mediated hypotension of sepsis. Surgical Forum 45: 67-69, 1994

The a, but Not the b, Isoform of the Human Thromboxane A2 Receptor Is a Target for Nitric Oxide-mediated Desensitization. Independent Modulation of TPa Signaling by Nitric Oxide and Prostacyclin. The Journal of Biological Chemistry 278(51): 202, 2003

The α, but not the β, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. INDEPENDENT MODULATION OF TPα SIGNALING BY NITRIC OXIDE AND PROSTACYCLIN. Journal of Biological Chemistry 291(37): 19260, 2016

Regulation of nitric oxide synthesis by abnormal extracellular matrix proteins A possible role for STAT5 as a target for this modulation. Journal of the American Society of Nephrology 11(Program and Abstract Issue): 527A-528A, 2000

Nitric oxide signaling in human ovarian cancer: A potential therapeutic target. Nitric Oxide 54: 30-37, 2016

Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity. Mediators of Inflammation 2016: 1984703, 2016

Nicotinamide Mononucleotide Adenylyl Transferase 2: A Promising Diagnostic and Therapeutic Target for Colorectal Cancer. Biomed Research International 2016: 1804137, 2016

Modulation of vitamin D synthesis and catabolism in colorectal mucosa: a new target for cancer prevention. Anticancer Research 29(9): 3705-3712, 2009

The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin. Journal of Biological Chemistry 278(51): 51190-51202, 2003

Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. Journal of Pharmacology and Experimental Therapeutics 282(2): 1072-1083, 1997

In vitro modulation of inducible nitric oxide synthase gene expression and nitric oxide synthesis by procalcitonin. Critical Care Medicine 29(1): 112-116, 2001

Enhanced modulation of hypotension in endotoxemia by concomitant nitric oxide synthesis inhibition and nitric oxide scavenging. Artificial Cells Blood Substitutes & Immobilization Biotechnology. 25(1-2): 153-162, 1997

Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target. Clinical Cancer Research 19(20): 5557-5563, 2013

Do tobacco stimulate the production of nitric oxide by up regulation of inducible nitric oxide synthesis in cancer: Immunohistochemical determination of inducible nitric oxide synthesis in oral squamous cell carcinoma--a comparative study in tobacco habituers and non-habituers. Journal of Cancer Research and Therapeutics 10(2): 244-250, 2015