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Photo-induced proton-coupled electron transfer and dissociation of isolated flavin adenine dinucleotide mono-anions

Photo-induced proton-coupled electron transfer and dissociation of isolated flavin adenine dinucleotide mono-anions

Physical Chemistry Chemical Physics 19(38): 25829-25833

The intrinsic optical absorption spectrum and photo-dissociation pathways of flavin adenine dinucleotide (FAD) mono-anions isolated in vacuo are probed using photo-induced dissociation (PID) action spectroscopy. The main photo-products are lumichrome and formylmethylflavin. Evidence is presented that the dissociation pathway leading to these products is non-statistical i.e. occurs during the excited state lifetime. This suggests that the stacking of the adenine and alloxazine chromophores, which enables ultra-fast quenching of the flavin excited state by photo-induced electron transfer in aqueous solution, is inhibited in vacuo. These results provide firm experimental confirmation that lumichrome formation from flavins proceeds via photo-induced, intra-molecular proton-coupled electron transfer.

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Accession: 060091660

Download citation: RISBibTeXText

PMID: 28745349

DOI: 10.1039/c7cp04068g

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