+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prognostic significance of hyperfibrinogenemia in patients with esophageal squamous cell carcinoma



Prognostic significance of hyperfibrinogenemia in patients with esophageal squamous cell carcinoma



International Journal of Clinical Oncology 22(3): 461-468



Preoperative hyperfibrinogenemia is associated with inflammatory mediators and a poor prognosis in several types of cancer. However, there is no published information on the monitoring of patients with preoperative hyperfibrinogenemia after surgery. The aim of the study reported here was to assess the clinicopathological and prognostic significance of plasma fibrinogen levels in patients with esophageal squamous cell carcinoma before and after surgical treatment. Plasma fibrinogen levels were analyzed before surgical treatment (endoscopic submucosal dissection and surgery) in 82 patients with esophageal squamous cell carcinoma. The clinicopathological significance of plasma fibrinogen levels and the relationship of plasma fibrinogen levels with several biomarkers were evaluated. The cutoff value for hyperfibrinogenemia was 321 mg/dl. Univariate and multivariate analysis using the Cox proportional hazards model were performed to evaluate the prognostic significance of plasma fibrinogen levels. The changing patterns of plasma fibrinogen were monitored after surgical treatment to evaluate prognostic impact. Hyperfibrinogenemia was significantly associated with advanced pathological stage of cancer and high C-reactive protein levels. Plasma fibrinogen levels significantly decreased after surgical treatment in recurrence-free patients but did not decrease in patients with recurrence. The multivariate analysis indicated that preoperative hyperfibrinogenemia was an independent prognostic factor for poor survival (hazard ratio 1.005, 95% confidence interval 1.000-1.010; P = 0.039). Preoperative hyperfibrinogenemia was associated with inflammatory mediators, tumor progression, and poor survival in patients with esophageal squamous cell carcinoma. The absence of a decrease in plasma fibrinogen levels after surgical treatment may indicate the possibility of tumor recurrence.

(PDF emailed within 0-6 h: $19.90)

Accession: 060139268

Download citation: RISBibTeXText

PMID: 28064398

DOI: 10.1007/s10147-016-1087-5


Related references

Prognostic Significance of the Prognostic Nutritional Index in Patients with Recurrent Esophageal Squamous Cell Carcinoma. Nutrition and Cancer 70(3): 467-473, 2018

Prognostic significance of Glasgow prognostic score in patients undergoing esophagectomy for esophageal squamous cell carcinoma. Saudi Journal of Gastroenterology 20(1): 48-53, 2014

Prognostic significance of CyclinD1 and E-Cadherin in patients with esophageal squamous cell carcinoma: multiinstitutional retrospective analysis. Research Committee on Malignancy of Esophageal Cancer, Japanese Society for Esophageal Diseases. Journal of the American College of Surgeons 192(6): 708-718, 2001

Prognostic significance of CYFRA 21-1 in patients with esophageal squamous cell carcinoma. Journal of the American College of Surgeons 196(4): 573-578, 2003

Prognostic significance of p21 expression in patients with esophageal squamous cell carcinoma. Anticancer Research 33(10): 4329-4335, 2013

Prognostic significance of preoperative CA72-4 in patients with esophageal squamous cell carcinoma. Archives of Iranian Medicine 16(6): 338-342, 2014

Prognostic significance of cyclin D gene in the patients with esophageal squamous cell carcinoma. Proceedings of the American Association for Cancer Research Annual Meeting 35(0): 223, 1994

Significance of the prognostic nutritional index in patients with esophageal squamous cell carcinoma. Therapeutics and Clinical Risk Management 10: 1-7, 2014

Prognostic significance of ICAM-1 expression in patients with esophageal squamous cell carcinoma. Proceedings of the American Association for Cancer Research Annual Meeting 42: 798, 2001

Prognostic significance of SLC9A9 in patients with resectable esophageal squamous cell carcinoma. Tumour Biology 36(9): 6797-6803, 2016

The prognostic significance of tumor laterality in patients with esophageal squamous cell carcinoma. Journal of Surgical Oncology 105(1): 66-70, 2012

Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. Biomed Research International 2015: 417210, 2016

Prognostic significance of serum p53 antibody in patients with esophageal squamous cell carcinoma. Surgery (St Louis) 132(1): 41-47, 2002

Prognostic Significance of Serum CD26 Concentration in Patients with Esophageal Squamous Cell Carcinoma. Archives of Medical Research 47(4): 299-303, 2017

Determination of the prognostic significance of cyclin B1 overexpression in patients with esophageal squamous cell carcinoma. Virchows Archiv 434(2): 153-158, 1999